8 completed, 1 not yet recruiting, 1 terminated, 1 withdrawn. 7 Not applicable, 2 Phase 2, 2 Phase 3, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 7 | Completed 7 |
| Phase 2 | 2 | Completed 1, Withdrawn 1 |
| Phase 3 | 2 | Terminated 1, Withdrawn 1 |
| Early Phase 1 | 1 | Not yet recruiting 1 |
Follow potassium bicarbonate: new trials by email Literature Review of potassium bicarbonate trials Research Report on potassium bicarbonate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparing Alkalinizing Agents Efficacy on Stone Risk in Patients on a Metabolically Controlled Diet Potassium citrate, Sodium bicarbonate, Litholyte - Kidney Stone | Early Phase 1 | Not yet recruiting | University of Texas Southwestern Medical Center | 15 | 2026-07-01 | 2026-02-13 |
| Study Evaluating Patients With Cystinuria ADV7103, Standard of Care - Cystinuria | Phase 2 / Phase 3 | Withdrawn | Advicenne Pharma | 2024-05-01 | 2024-03-12 | |
| Litholytic Therapy for Coral Urate Nephrolithiasis anhydrous citric acid - 1197.0 mg, potassium bicarbonate - 967.5 mg, sodium citrate anhydrous - 835.5 mg - Urolithiasis | Not applicable | Completed | Moscow State University of Medicine and Dentistry | 49 | 2023-01-01 | 2025-09-09 |
| Study Evaluating Subjects With Distal Renal Tubular Acidosis ADV7103, Placebo - Distal Renal Tubular Acidosis | Phase 3 | Terminated | Advicenne Pharma | 3 | 2021-09-20 | 2026-06-03 |
| Impact of Protein and Alkali Supplementation on Skeletal Muscle in Older Adults whey protein isolate, potassium bicarbonate (KHCO3), microcrystalline cellulose - Age-Related Sarcopenia, Muscle Loss | Not applicable | Completed | Tufts University | 141 | 2021-07-01 | 2025-05-18 |
| Musculoskeletal Effects of Bicarbonate potassium bicarbonate, Inactive placebo capsule - Muscle Loss, Fractures | Phase 2 | Completed | Tufts University | 244 | 2012-01-01 | 2015-10-19 |
| Medium-term Bedrest Whey Protein (MEP) Whey Protein + Potassium bicarbonate, Control - Countermeasure Evaluation | Not applicable | Completed | DLR German Aerospace Center | 10 | 2011-08-01 | 2012-08-02 |
| The Effect of Potassium Bicarbonate on Bone and Several Physiological Systems During Immobilisation Potassium Bicarbonate - Bone Diseases, Metabolic, Acid-Base Imbalance | Not applicable | Completed | DLR German Aerospace Center | 8 | 2010-02-01 | 2017-03-01 |
| Changes in Acid Base Status During High Salt Intake High NaCl + KHCO3, Control: high NaCl - Low Grade Metabolic Acidosis | Not applicable | Completed | DLR German Aerospace Center | 8 | 2007-07-01 | 2012-08-02 |
| Does Potassium Bicarbonate Improve the Effect of Dietary Protein on Bone and Muscle? potassium bicarbonate, Placebo (microcrystalline cellulose) - Osteoporosis, Sarcopenia | Not applicable | Completed | Tufts University | 23 | 2007-02-01 | 2008-08-08 |
| Effect of Potassium Bicarbonate Supplementation on Bone and Muscle in Older Adults Potassium Bicarbonate, Sodium Bicarbonate, Potassium Chloride - Osteoporosis, Sarcopenia | Not applicable | Completed | Tufts University | 171 | 2006-09-01 | 2020-02-17 |
Muscular Atrophy (4) · Osteoporosis (3) · Bone Diseases, Metabolic (2) · Sarcopenia (2) · Acid-Base Imbalance (1) · Acidosis (1) · Acidosis, Renal Tubular (1) · Body Weight Changes (1) · Cardiovascular Abnormalities (1) · Cystinuria (1) · Fractures, Bone (1) · Kidney Calculi (1) · Sprains and Strains (1) · Urolithiasis (1)
Tufts University (4) · DLR German Aerospace Center (3) · Advicenne Pharma (2) · Moscow State University of Medicine and Dentistry (1) · University of Texas Southwestern Medical Center (1)
United States (6) · Germany (3) · Belgium (1) · Canada (1) · France (1) · Russia (1)
Bess Dawson-Hughes, MD (2) · Bess Dawson-Hughes, M.D. (1) · Francisca May, Dr. (1) · Laurence Greenbaum, MD, Ph.D. (1) · Lisa Ceglia, MD (1) · Lisa Ceglia, MD MS (1)
PMID 18940881, PMID 19727904, PMID 19856249, PMID 21046483, PMID 28842733, PMID 29211866, PMID 29546280, PMID 30255228, PMID 41780731, PMID 42640289
R01AG055443 (1), R01AR052322 (1), R01AR060261 (1)