70 completed, 14 unknown, 6 not yet recruiting, 5 recruiting. 65 Not applicable, 9 Phase 2, 3 Phase 1, 2 Phase 4, 1 Phase 3.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| HMB Plus Vitamin D to Preserve Muscle in Older Adults Starting Semaglutide Calcium-HMB Plus Vitamin D3, Matching placebo - Type 2 Diabetes Mellitus (T2DM), Sarcopenia | Phase 2 | Not yet recruiting | Vanderbilt University Medical Center | 90 | 2026-12-01 | 2026-08-28 |
| Resistance Exercise, IL-7 and Immune Phenotypes in Prostate Cancer Supervised Resistance Exercise Programme - Prostate Cancer, Muscle Loss | Not applicable | Not yet recruiting | University of Bath | 40 | 2026-08-01 | 2026-07-23 |
| Combatting Muscle Loss in Obese Adult Patients on GLP-1 Medications Through Dietary Counseling and Exercise During Treatment Evaluates Whether a 12-week Exercise and Individualized Nutrition Program Can Reduce Muscle and Bone Loss and Improve Strength, Fitness, and Function in Obese Adults on GLP-1 Semaglutide, Dietary Counseling, Exercise - GLP - 1, Obesity & Overweight | Phase 4 | Not yet recruiting | William Marsh Rice University | 20 | 2026-04-06 | 2026-04-28 |
| Mortality and Muscle Mass Loss in Critically Ill Patients. Mortality, Muscle Loss | Recruiting | Brno University Hospital | 386 | 2026-03-27 | 2026-10-19 | |
| Plant vs Animal-based Protein Sources as an Anabolic and Metabolic-protective Options for SO in Older Adults Legume-Based High-Protein Diet + Resistance Training, Meat-Based High-Protein Diet + Resistance Training, Mixed Legume and Meat High-Protein Diet + Resistance Training - Sarcopenic Obesity, Obesity and Obesity-related Medical Conditions | Not applicable | Not yet recruiting | Tel-Aviv Sourasky Medical Center | 180 | 2025-09-01 | 2025-06-22 |
| A Study of the Effect of (S)-Pindolol Benzoate (ACM-001.1) on Lean Body Mass (LBM) in Obese Patents During (PROACT 1), and Post-semaglutide Therapy (PROACT 2) (S)-pindolol benzoate, Semaglutide, Placebo to (S)-pindolol benzoate - Obesity, Muscle Loss | Phase 2 | Recruiting | Actimed Therapeutics Ltd | 120 | 2025-06-23 | 2026-02-17 |
| Ultrasound Detection of Body Composition in Critical Care ultrasound detection of body composition - Muscle Loss, Extracellular Fluid Alteration | Recruiting | Ain Shams University | 121 | 2024-12-15 | 2026-09-04 | |
| Branched Chained Amino Acid Supplement in Patients Undergoing Lower Limb Bone Cancer Curettage for Bone Metastasis branched chained amino acid - Muscle Loss | Not applicable | Not yet recruiting | National Taiwan University Hospital | 40 | 2024-09-25 | 2024-09-20 |
| Examining the Effects of Vivo on Physical Function and Glycemic Level in Sedentary Older With Prediabetes. Vivo - PreDiabetes, Older Adult | Not applicable | Completed | Impactiv, Inc. | 74 | 2024-07-09 | 2026-04-22 |
| Galactooligosaccharide and Aging Prebiotic, Placebo control - Muscle Loss | Not applicable | Unknown | University of Bath | 30 | 2024-05-02 | 2024-05-16 |
| Comparison of Computed Tomography Data With Routine Measurements Concerning Bone and Muscle Health of Aged Individuals comparison of CT scan with routinely assessed methods of muscle mass and strength - Sarcopenia, Muscle Loss | Unknown | University Department of Geriatric Medicine FELIX PLATTER | 300 | 2024-05-01 | 2024-07-11 | |
| Testing LiverWatch, a Home-Based Remote-Monitoring Intervention for Advanced Liver Disease LiverWatch Intervention - Cirrhosis, Liver, End Stage Liver DIsease | Not applicable | Active not recruiting | University of Pennsylvania | 110 | 2024-05-01 | 2026-08-10 |
| Dose-Finding Study Evaluating Effect on Body Composition of Enobosarm in Patients Taking a GLP-1 for Chronic Weight Mgmt Enobosarm, Semaglutide - Muscle Loss, Obesity | Phase 2 | Completed | Veru Inc. | 168 | 2024-04-29 | 2025-09-17 |
| Nutritional Therapy in Late-onset Pompe Disease Multi-ingredient supplement (PDT-MIS), Placebo (PLA) - Pompe Disease, Muscle Loss | Phase 2 | Unknown | McMaster University | 28 | 2024-04-01 | 2023-11-14 |
| Pediatric Oncology Nutrition Intervention Trial Oral Nutrition Supplement, Tube Feed, Cyproheptadine - Pediatric Cancer, Nutrition Related Cancer | Phase 2 / Phase 3 | Completed | Corey Hawes | 20 | 2024-01-31 | 2026-10-08 |
| Impact of Skeletal Muscle Quality and Loss on the Outcome of Liver Transplantation Liver Transplantation, Muscle Loss | Not yet recruiting | Zhejiang University | 800 | 2024-01-01 | 2024-01-03 | |
| YOOMI: Effect of Gamified Physical Therapy Exercise Software on Inpatient Mobility Yoomi Physical Therapy Software - Weakness, Muscle, Delirium in Old Age | Not applicable | Completed | Rutgers, The State University of New Jersey | 30 | 2023-11-29 | 2026-08-07 |
| D3-Creatine and Skeletal Muscle in Older Adults Aging, Muscle Loss | Recruiting | McMaster University | 350 | 2023-10-01 | 2024-10-08 | |
| The Cartilage and Muscle Thickness on Knee Pain in Patients With Rheumatoid Arthritis Ultrasonographic Measurements - Rheumatoid Arthritis, Knee Pain Chronic | Completed | Sisli Hamidiye Etfal Training and Research Hospital | 130 | 2023-09-28 | 2023-11-21 | |
| KetoNiFast: Cyclic Enteral Daytime Feeding With Ketogenic Nighttime Fasting Cyclic enteral feeding with nighttime fasting and exogenous ketone salt supplementation (ß-hydroxybutyrate) - Nutrition, Muscle Loss | Not applicable | Unknown | University Hospital of Cologne | 130 | 2023-09-01 | 2024-08-06 |
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Muscular Atrophy (102) · Sarcopenia (18) · Muscle Weakness (14) · Critical Illness (9) · Obesity (9) · Motor Activity (6) · Frailty (5) · Malnutrition (5) · Weight Loss (5) · Bone Diseases, Metabolic (4) · Neoplasms (4) · Osteoporosis (3) · Body Weight Changes (2) · Cachexia (2) · End Stage Liver Disease (2)
Atrophy (102) · Nervous System Diseases (102) · Neurologic Manifestations (102) · Neuromuscular Manifestations (102) · Pathological Conditions, Anatomical (102) · Pathological Conditions, Signs and Symptoms (102) · Signs and Symptoms (101) · Pathologic Processes (32) · Nutritional and Metabolic Diseases (27) · Musculoskeletal Diseases (25) · Muscular Diseases (16) · Nutrition Disorders (15) · Body Weight (14) · Metabolic Diseases (14) · Disease Attributes (11)
Resistance Training (6) · Whey (5) · Carnitine (3) · semaglutide (3) · Carbohydrates (2) · Creatine (2) · Diet, High-Protein (2) · Dietary Supplements (2) · Enteral Nutrition (2) · Exercise (2) · Leucine (2) · Whey Proteins (2) · beta-hydroxyisovaleric acid (2) · potassium bicarbonate (2) · ACVR2B protein, human (1)
Bispebjerg Hospital (5) · McMaster University (4) · National Yang Ming Chiao Tung University (4) · Karolinska University Hospital (3) · United States Army Research Institute of Environmental Medicine (3) · Chang Gung Memorial Hospital (2) · Gdansk University of Physical Education and Sport (2) · Hasan Kalyoncu University (2) · Jinling Hospital, China (2) · Maastricht University Medical Center (2) · National Taiwan University Hospital (2) · Tufts University (2) · University of Aarhus (2) · University of Bath (2) · University of Erlangen-Nürnberg Medical School (2)
United States (22) · Taiwan (11) · Denmark (9) · United Kingdom (8) · Canada (5) · Turkey (Türkiye) (5) · Germany (4) · Netherlands (4) · Sweden (4) · Spain (3) · Belgium (2) · Czechia (2) · Israel (2) · Brazil (1) · Colombia (1)
Liang-Kung Chen, MD.PhD. (3) · Olav Rooyackers, PhD (3) · Charlotte Suetta, Professor (2) · Lars Holm, Assoc. prof. (2) · Stefan M Pasiakos, Ph.D. (2) · Andrea Lorenzo, PhD (1) · Andreas M. Fischer, PD Dr. (1) · Andreas Ziegler, PhD stud (1) · Anne Gylling, PhD stud (1) · Annie SB Moreira, PhD (1) · Arabella Fischer, MD (1)
PMID 27507236, PMID 10359390, PMID 12464864, PMID 20392703, PMID 20739716, PMID 21093718, PMID 21389329, PMID 21448087, PMID 22549749, PMID 23739654, PMID 23965841, PMID 24166063, PMID 24284444, PMID 24641883, PMID 24737560, PMID 25479571, PMID 26474292, PMID 26718415, PMID 26825278, PMID 27124248, PMID 27913559, PMID 28054322, PMID 28095426, PMID 28261109, PMID 28842733, PMID 29211866, PMID 29895309, PMID 29955707, PMID 30077342, PMID 30089525, PMID 30208857, PMID 30289425, PMID 30587866, PMID 30618820, PMID 30704412, PMID 30717697, PMID 30858985, PMID 31547952, PMID 31722892, PMID 32277977, PMID 32690175, PMID 33376179, PMID 33564844, PMID 34168292, PMID 34596901, PMID 34620081, PMID 35363152, PMID 36639540, PMID 36918892, PMID 37256861
2018 (1), R01AG055443 (1), R01AR060261 (1), R44AG076087 (1), UL1TR001998 (1)