3 completed, 3 not yet recruiting, 1 active not recruiting, 1 recruiting. 9 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Early Phase 1 | 9 | Completed 3, Not yet recruiting 3, Active not recruiting 1, Recruiting 1, Unknown 1 |
Follow Muscle Hypertonia: new trials by email Literature Review of Muscle Hypertonia trials Research Report on Muscle Hypertonia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Collagenase Injection for Spasticity Management XIAFLEX Collagenase injection - Spasticity | Early Phase 1 | Not yet recruiting | The University of Texas Health Science Center, Houston | 15 | 2026-09-01 | 2026-07-09 |
| A Novel Medical System for Quantitative Diagnosis and Personalized Precision Botulinum Neurotoxin Injection in Chronic Pelvic Pain Management High Density Surface Electromyographic, precision botulinum neurotoxin injection guidance medical device, Botulinum Neurotoxin - Interstitial Cystitis, Chronic Pain | Early Phase 1 | Not yet recruiting | HillMed Inc. | 46 | 2025-09-15 | 2025-08-19 |
| Early Botulinum Toxin for Muscle Stiffness Reduction in First-Time Stroke Patients: Improving Recovery and Independence Botulinum Toxin Type A (BoNT-A) - Spasticity, Stroke | Early Phase 1 | Active not recruiting | Instituto Mexicano del Seguro Social | 200 | 2025-01-28 | 2025-02-10 |
| Effect of Neural Constraints on Movement in Stroke Tizanidine, Placebo - Stroke | Early Phase 1 | Recruiting | Northwestern University | 64 | 2024-08-23 | 2026-10-05 |
| Neuromodulation to Reduce Muscle Stiffness Following Spinal Cord Injury Transcutaneous spinal stimulation at 100 Hz, Transcutaneous spinal stimulation at 50 Hz, Transcutaneous spinal stimulation at 50 Hz and single dose of baclofen - Spinal Cord Injuries, Spinal Cord Injury | Early Phase 1 | Unknown | University of Mississippi Medical Center | 16 | 2024-03-01 | 2024-07-01 |
| Radial Extracorporeal Shock Wave Therapy as an Adjunct to Botulinum Toxin Type A for Post-Stroke Lower Limb Spasticity (SOLUTION) Radial shock Wave therapy (3000 pulses, 5 Hz, 2.5 bar)., ARM B: Sham-radial shock Wave therapy, Ultrasound-guided abobotulinumtoxin A - Stroke, Spasticity as Sequela of Stroke | Early Phase 1 | Completed | Parc de Salut Mar | 20 | 2024-02-01 | 2026-10-15 |
| Central Nervous System Stimulants and Physical Function in Children With Cerebral Palsy Methylphenidate, Modafinil, Placebo - Neurodevelopmental Disorders, Cerebral Palsy | Early Phase 1 | Not yet recruiting | Kuwait University | 30 | 2023-05-01 | 2023-03-08 |
| Non-invasive Spinal Cord Stimulation for Spasticity Control and Augmentation of Voluntary Motor Control in Individuals With Multiple Sclerosis transcutaneous spinal cord stimulation - Multiple Sclerosis | Early Phase 1 | Completed | Medical University of Vienna | 15 | 2017-12-27 | 2023-10-19 |
| Evaluation of BOTOX® With Rehabilitation Therapy for the Treatment of Wrist and Hand Spasticity in Post-Stroke Patients Botox and rehab, Placebo and rehab - Stroke | Early Phase 1 | Completed | Emory University | 25 | 2007-10-01 | 2013-08-13 |
Muscle Spasticity (8) · Stroke (4) · Cerebral Palsy (1) · Chronic Pain (1) · Cystitis, Interstitial (1) · Multiple Sclerosis (1) · Neurodevelopmental Disorders (1) · Paralysis (1) · Pelvic Floor Disorders (1) · Spinal Cord Injuries (1)
Nervous System Diseases (9) · Neurologic Manifestations (9) · Neuromuscular Manifestations (9) · Pathological Conditions, Signs and Symptoms (9) · Signs and Symptoms (9) · Muscular Diseases (8) · Musculoskeletal Diseases (8) · Central Nervous System Diseases (6) · Brain Diseases (5) · Cardiovascular Diseases (4) · Cerebrovascular Disorders (4) · Vascular Diseases (4) · Autoimmune Diseases (1) · Autoimmune Diseases of the Nervous System (1)
Botulinum Toxins, Type A (2) · tizanidine (2) · Baclofen (1) · Botulinum Toxins (1) · Methylphenidate (1) · Modafinil (1) · Rehabilitation (1) · abobotulinumtoxinA (1) · incobotulinumtoxinA (1)
Emory University (1) · HillMed Inc. (1) · Instituto Mexicano del Seguro Social (1) · Kuwait University (1) · Medical University of Vienna (1) · Northwestern University (1) · Parc de Salut Mar (1) · The University of Texas Health Science Center, Houston (1) · University of Mississippi Medical Center (1)
United States (5) · Austria (1) · Kuwait (1) · Mexico (1) · Spain (1)
Anwar B Almutairi, PT, PhD (1) · Byron Milton, MD (1) · Julius Dewald, DPT, PhD (1) · Jun Yao, PhD (1) · Matthias J Krenn, Ph.D. (1) · Sheng Li, MD, PhD (1) · Steven L Wolf, PhD, PT (1)
PMID 20360543, PMID 22200394, PMID 26276377, PMID 27547509, PMID 27871449, PMID 29753889, PMID 33057730, PMID 33106968, PMID 33156735, PMID 33551975, PMID 33923397, PMID 33978513, PMID 38441919
R01HD039343 (1)