16 completed, 4 unknown, 2 recruiting, 1 not yet recruiting. 10 Not applicable, 6 Phase 2, 4 Phase 3, 1 Phase 1, 1 Phase 4.
Follow Systolic Murmurs: new trials by email Literature Review of Systolic Murmurs trials Research Report on Systolic Murmurs
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| PlaCEUS: Feasibility Study of Contrast-enhanced Ultrasound to Visualize Maternal Uterine Spiral Arteries Postpartum. SonoVue (sulphur hexafluoride microbubbles) - Spiral Arteries, Uterine Artery Hemodynamics | Not applicable | Recruiting | Maxima Medical Center | 5 | 2025-12-17 | 2026-02-19 |
| A Study Protocol to Assess the Effectiveness of Nurse-Led Telehealth Intervention for Hypertension Control in Nepal Nurse-led Telehealth Intervention - Hypertension Combined Diastolic and Systolic | Not applicable | Not yet recruiting | Kathmandu University School of Medical Sciences | 706 | 2025-11-01 | 2025-07-28 |
| A Study of Modified Release RTN-001 In Patients With Uncontrolled Hypertension RTN-001, Matching placebo control - Uncontrolled Hypertension | Phase 2 | Recruiting | Retension Pharmaceuticals. Inc. | 280 | 2025-10-31 | 2026-10-02 |
| Potassium Supplementation to Reduce Blood Pressure High potassium water, Control low potassium water - Prehypertension | Not applicable | Completed | Oxford Brookes University | 40 | 2022-07-30 | 2024-04-04 |
| Ferric Carboximaltose on Intra-myocardial Iron Load in Patients With Heart Failure Ferric carboxymaltose - Cardiac Failure, Systolic Heart Failure | Phase 4 | Unknown | Hospital Moinhos de Vento | 20 | 2019-08-30 | 2019-07-12 |
| Compression Wraps as Adjuvant Therapy in Management of Acute Systolic Heart Failure ACE compression wrap - Heart Failure; With Decompensation | Not applicable | Terminated | Henry Ford Health System | 32 | 2019-08-15 | 2022-03-29 |
| Comparison of Blood Pressure Measurement With an Omron HEM-907 Device in a Clinical Setting and a Research Setting Sequence: Clinical/Research, Sequence: Research/Clinical - Hypertension | Not applicable | Completed | Institut de Recherches Cliniques de Montreal | 70 | 2017-11-27 | 2018-04-11 |
| Assessment of Left Atrial Mechanical Function With a True 3D Ultrasouns Arry and Comparison With the Transthoracic and Transesophageal Echocardiography transesophageal investigation - Comparison of 3D Monitored Changes of Left Atrial Volume Before and After Ablation With Conventional Transesophageal Echocardiography | Not applicable | Unknown | Klinik Hirslanden, Zurich | 100 | 2017-11-01 | 2019-10-08 |
| eMurmur ID - Clinical Performance Evaluation Automated Heart Murmur Detection AI - Heart Murmurs, Pathologic Murmurs | Completed | CSD Labs GmbH | 120 | 2017-01-04 | 2018-07-18 | |
| Minding GOALS: An Internet-Assisted Mind-Body-Behavior Program for Blood Pressure Control GOALS, Minding GOALS - Hypertension | Not applicable | Completed | University of Pittsburgh | 76 | 2016-09-01 | 2018-07-06 |
| Blind Assessment of the Concordance Between the Administered Treatment and the Recommendations of a Medical Algorithm Decision Support Software in Systolic Heart Failure Patients with systolic heart failure - Hearth Failure, Systolic | Unknown | Central Hospital, Nancy, France | 300 | 2015-07-01 | 2016-09-14 | |
| Changes in Cardiac Deformation Following Physiologic Alterations and Inotropic Support. Levosimendan, Milrinone - Heart Failure, Diastolic, Aortic Valve Stenosis | Not applicable | Completed | Sahlgrenska University Hospital | 30 | 2014-03-01 | 2017-05-09 |
| Automated Algorithm Based Analysis of Phonocardiograms of Newborns Computer aided auscultation (CAA) - Heart Murmurs, Mitral Valve Prolapse | Completed | CSD Labs GmbH | 220 | 2013-11-01 | 2018-07-17 | |
| Automatic Differentiation of Innocent and Pathologic Murmurs in Pediatrics Computer Aided Auscultation (CAA) - Heart Murmurs, Mitral Valve Prolapse | Completed | CSD Labs GmbH | 106 | 2013-11-01 | 2018-07-18 | |
| Improved Self Management in Uncontrolled Systolic Hypertension smartphone-assisted health coaching, Lifestyle counseling - Systolic Hypertension | Phase 3 | Unknown | York University | 65 | 2013-01-01 | 2014-01-10 |
| Efficacy and Safety of Human Neuregulin-1 to Treat Stable Chronic Heart Failure Placebo, rhNRG-1 Dose 1, rhNRG-1 Dose 2 - Chronic Heart Failure | Phase 2 | Completed | Zensun Sci. & Tech. Co., Ltd. | 67 | 2012-01-01 | 2025-02-10 |
| Systolic Blood Pressure Intervention Trial Intensive control of SBP, Standard control of SBP - Hypertension | Not applicable | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 9361 | 2010-10-01 | 2021-01-08 |
| Safety of Phenylephrine Hydrochloride, Acetaminophen, Dimethindene Maleate Compared to Phenylephrine Hydrochloride Alone in Healthy Volunteers Phenylephrine HCL, Phenylephrine HCL/Acetaminophen/Dimethindene Maleate - Heart Rate, Blood Pressure | Phase 1 / Phase 2 | Withdrawn | Novartis | 2010-09-01 | 2016-03-03 | |
| Hyperuricemia on Hypertension and Metabolic Syndrome Allopurinol, placebo - Systolic and Diastolic Blood Pressure Levels, Uric Acid Levels | Phase 2 | Completed | Instituto Nacional de Cardiologia Ignacio Chavez | 40 | 2010-07-01 | 2014-07-24 |
| Effects of Aliskiren, Ramipril, and the Combination on Levels of Angiotensin II in Patients With Decompensated Systolic Heart Failure aliskiren, ramipril, Placebo to aliskiren - Heart Failure | Phase 2 | Completed | Novartis Pharmaceuticals | 123 | 2009-05-01 | 2012-07-26 |
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Heart Murmurs (11) · Hypertension (9) · Heart Failure (6) · Heart Failure, Systolic (2) · Mitral Valve Prolapse (2) · Aortic Valve Stenosis (1) · Arrhythmias, Cardiac (1) · Cardiomyopathies (1) · Chronic Disease (1) · Cognitive Dysfunction (1) · Dementia (1) · Edema (1) · Heart Defects, Congenital (1) · Heart Failure, Diastolic (1)
Pathological Conditions, Signs and Symptoms (25) · Signs and Symptoms (25) · Cardiovascular Diseases (21) · Heart Murmurs (14) · Heart Diseases (12) · Vascular Diseases (10) · Pathologic Processes (4) · Heart Valve Diseases (3) · Disease Attributes (2) · Heart Failure (2) · Heart Valve Prolapse (2) · Aortic Valve Disease (1) · Brain Diseases (1) · Cardiovascular Abnormalities (1) · Central Nervous System Diseases (1)
Allopurinol (1) · Amlodipine, Valsartan Drug Combination (1) · Dimethindene (1) · Milrinone (1) · Mindfulness-Based Stress Reduction (1) · NPPA protein, human (1) · Oxymetazoline (1) · Ramipril (1) · Simendan (1) · aliskiren (1) · ferric carboxymaltose (1)
Novartis (4) · CSD Labs GmbH (3) · Central Hospital, Nancy, France (1) · Daiichi Sankyo (1) · Henry Ford Health System (1) · Hospital Moinhos de Vento (1) · Institut de Recherches Cliniques de Montreal (1) · Instituto Nacional de Cardiologia Ignacio Chavez (1) · Kathmandu University School of Medical Sciences (1) · Klinik Hirslanden, Zurich (1) · Maxima Medical Center (1) · National Heart, Lung, and Blood Institute (NHLBI) (1) · Novartis Pharmaceuticals (1) · Oxford Brookes University (1) · Pennington Biomedical Research Center (1)
United States (10) · Canada (5) · Germany (3) · Brazil (2) · Austria (1) · France (1) · Mexico (1) · Nepal (1) · Netherlands (1) · Poland (1) · Russia (1) · Sweden (1) · Switzerland (1) · United Kingdom (1)
Lillian Lai, MD (2) · Alfred Cheung, MD (1) · Archana Shrestha, PhD (1) · Barry Greenberg, MD (1) · Biljana Pavlovic-Surjancev, MD, PhD (1) · Bill Cushman, MD (1) · Carisi A Polanczyk, MD ScD (1) · David M. Reboussin, PhD (1) · Donna H. Ryan, MD (1) · Gerhard Pichler, MD (1) · Jackson T Wright, MD (1) · Jay Besse, BS (1) · Kathleen M McTigue, MD, MS, MPH (1) · Lee Arcement, MD (1)
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268200900040C-1-0-1 (1), R34HL123500 (1)