33 completed, 27 unknown, 12 recruiting, 5 terminated. 21 Not applicable, 21 Phase 2, 7 Phase 1, 7 Phase 3, 2 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Gene-Modified Stem Cell Therapy for Subjects With Transfusion-dependent Beta-thalassemia FT007 - Transfusion-dependent Beta-Thalassemia | Phase 2 | Recruiting | Fondazione Telethon | 9 | 2026-07-06 | 2026-07-27 |
| Gene-Modified Stem Cell Therapy for Children With Autosomal Recessive Osteopetrosis (ARO) FT024 - Osteopetrosis | Phase 1 / Phase 2 | Recruiting | Fondazione Telethon | 8 | 2026-06-20 | 2026-06-24 |
| Test to Treat TB: Impact of Sputum Sequencing-guided Individualised Therapy on Outcomes in Drug-resistant Tuberculosis Targeted sequencing using the GenoScreen Deeplex assay - Tuberculosis, Multidrug-Resistant | Not applicable | Not yet recruiting | University of Cape Town | 280 | 2026-06-01 | 2026-05-06 |
| Production of Stem Cells for the Generation of Pancreatic Cells Biological - skin biopsy, blood draw, or urine collection for iPSC generation - Diabetes | Not applicable | Recruiting | Ospedale San Raffaele | 100 | 2026-03-01 | 2026-03-18 |
| Personalizing Adoptive Cell Transfer for Solid Tumors: Towards a New Patient-tailored Treatment Option Carcinoma, Non-Small-Cell Lung | Not yet recruiting | Ospedale San Raffaele | 20 | 2025-05-01 | 2025-04-10 | |
| HappyMums Mobile Application Study Pregnancy, Antenatal Depression | Recruiting | King's College London | 1000 | 2025-02-18 | 2025-12-09 | |
| Utility of Low Intensity Pulsed Ultrasound Stimulation (LIPUS) to Modulate the Release of Mediators Capable of Reflecting the Inflammatory State in the Affected Colonic Tract of Ulcerative Colitis Patients LIPUS stimulation - Ulcerative Colitis | Not applicable | Unknown | Istituto Clinico Humanitas | 90 | 2024-11-01 | 2024-08-26 |
| A Clinical Gene Therapy Study With Hematopoietic Stem Cells for the Treatment, With Single Dose of Temferon, of Patients Suffering From Metastatic Renal Cell Carcinoma Temferon, Pembrolizumab, Cabozantinib - Clear Cell RCC | Phase 1 / Phase 2 | Terminated | Genenta Science | 10 | 2024-10-22 | 2026-02-09 |
| Detection of Lipoarabinomannan in Urine Evaluation of the STANDARDTMF TBLAMFIA and Its Impact on the Initial TB Diagnosis STANDARDTM F TB LAM FIA - Tuberculosis, Diagnoses Disease | Unknown | Ospedale San Raffaele | 550 | 2024-10-01 | 2024-09-26 | |
| Predicting the Risk of Diabetic Neurodegenerative Disorders by Artificial Intelligence Tools Based on Retinal Imaging Retinal imaging - Diabete Mellitus, Cognitive Impairment | Recruiting | Ospedale San Raffaele | 250 | 2024-08-30 | 2025-03-14 | |
| Tirzepatide Monotherapy in Patients With Wolfram Syndrome Type 1 Tirzepatide - Wolfram Syndrome | Phase 2 | Unknown | Ospedale San Raffaele | 10 | 2024-01-01 | 2024-02-22 |
| Middle Meningeal Artery Embolization (MMAE) Outcomes for Chronic Subdural Hematoma (cSDH) Chronic Subdural Hematoma | Recruiting | Montefiore Medical Center | 5000 | 2023-12-05 | 2026-09-21 | |
| National Database of the Virtual Institute of Cerebrovascular Diseases Collection of clinical, radiological, and biological data from patients' medical records - Cerebrovascular Disease | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 285600 | 2023-09-01 | 2023-07-13 | |
| Effect of Minocycline on Inflammation in Depressed Patients Minocycline - Depression | Phase 2 | Unknown | IRCCS Centro San Giovanni di Dio Fatebenefratelli | 60 | 2023-08-28 | 2024-01-17 |
| Exhaled Breath Aerosol for the Etiological Diagnosis of Respiratory Tract Infections: a Pilot Study medical device for exhaled breath aerosols (XBAs) collection - Respiratory Diseases | Completed | Ospedale San Raffaele | 45 | 2023-05-15 | 2025-02-06 | |
| Biomarker-driven Phenotypic Dissection of Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis, Motor Neuron Disease | Recruiting | Istituto Auxologico Italiano | 200 | 2023-04-11 | 2025-05-07 | |
| Cost-effectiveness Evaluation of Robotic Surgery in the Removal of Lung Lesions in the ATS of Milan Robotic surgery, Video-assisted thoracoscopy, Open surgery - Lung Cancer | Unknown | Agenzia di Tutela della Salute della Città Metropolitana di Milano | 5400 | 2023-03-01 | 2023-02-01 | |
| Internal Biodegradable Stent Versus Non-Stent in Patients at High-Risk of Developing Fistula After Pancreatoduodenectomy Biodegradable Stent - Pancreatoduodenectomy, Clinically Relevant Postoperative Pancreatic Fistula | Not applicable | Completed | Ospedale San Raffaele | 122 | 2023-01-25 | 2026-06-17 |
| TB-CAPT EXULTANT - HIV Concentrated urine with Xpert Ultra, Stool with Xpert Ultra - Tuberculosis, HIV Coinfection | Not applicable | Completed | Foundation for Innovative New Diagnostics, Switzerland | 1172 | 2022-09-05 | 2025-04-04 |
| Triage Test for All Oral DR-TB Regimen (TRiAD Study) Xpert® MTB/XDR - Drug Resistant Tuberculosis, MDR-TB | Completed | Centre for the AIDS Programme of Research in South Africa | 786 | 2022-05-26 | 2025-06-26 |
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Diabetes Mellitus (6) · Hypertension (6) · Tuberculosis (6) · Diabetes Mellitus, Type 1 (4) · Lung Neoplasms (4) · Amyotrophic Lateral Sclerosis (3) · COVID-19 (3) · Cognitive Dysfunction (3) · HIV Infections (3) · Leukodystrophy, Metachromatic (3) · Lysosomal Storage Diseases (3) · Motor Neuron Disease (3) · Pancreatic Neoplasms (3) · Respiratory Insufficiency (3) · Alzheimer Disease (2)
Analgesia, Epidural (2) · Exercise (2) · Propofol (2) · Ropivacaine (2) · Sirolimus (2) · Sufentanil (2) · Ventilation (2) · Acetaminophen (1) · Amiloride (1) · Blood Specimen Collection (1) · Calcium Dobesilate (1) · Canrenoic Acid (1) · Cognitive Training (1) · Conversion to Open Surgery (1) · Cyclophosphamide (1)
Italy (67) · South Africa (5) · United Kingdom (3) · Canada (2) · Poland (2) · Tanzania (2) · United States (2) · Australia (1) · Croatia (1) · Ethiopia (1) · Finland (1) · Germany (1) · Mozambique (1) · Nigeria (1) · Spain (1)
Lorenzo Piemonti, MD (7) · Elena Bignami, MD (3) · Gianpaolo Balzano, MD (3) · Lorenzo Dagna, MD (3) · Giancarlo Comi, MD (2) · Massimo Agostoni, MD (2) · Paola Maffi, MD (2) · Adrian Saftoiu, MD PhD FASGE (1) · Alessandro Armuzzi, MD (1) · Andrea Salonia, MD, PhD (1) · Anthony Feinstein, MD (1) · Antonio Secchi, MD (1) · Benedetta Vai, PhD (1)
PMID 30130323, PMID 38446574, PMID 40267426, PMID 42777242, PMID 17825587, PMID 17896838, PMID 18674932, PMID 20441419, PMID 21084848, PMID 21557809, PMID 2326846, PMID 23274902, PMID 23733196, PMID 23751451, PMID 25286053, PMID 26049781, PMID 26695701, PMID 27289174, PMID 27327404, PMID 28358727, PMID 28552158, PMID 28592276, PMID 30100052, PMID 30477541, PMID 30549450, PMID 30554828, PMID 30981783, PMID 31072380, PMID 31390004, PMID 31440838, PMID 31803481, PMID 32443981, PMID 32813051, PMID 34487721, PMID 34595972, PMID 34741240, PMID 35016208, PMID 35065785, PMID 35078125, PMID 35939096, PMID 36177837, PMID 36436069, PMID 36881147, PMID 36933030, PMID 37244942, PMID 37739574, PMID 37916484, PMID 38426484, PMID 38754979, PMID 38936143
2009 (1), 2017 (1), 2018 (1), 2023 (1), 2025 (1)