17 completed, 16 unknown, 9 recruiting, 3 not yet recruiting. 13 Not applicable, 12 Phase 2, 11 Phase 4, 4 Phase 3, 2 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Osteogenic Potential of Topical Metformin Gel on Cystic Jaw Defects For the Experimental Arm: 1% Metformin Gel, For the Comparator / Control Arm: Placebo Gel - Jaw Cysts, Metformin | Not applicable | Not yet recruiting | Fayoum University | 32 | 2026-10-30 | 2026-10-14 |
| Mitochondrial Redox Modulation in Newly Diagnosed Type 2 Diabetes: A Randomized Controlled Trial Comparing Imeglimin vs. Metformin Monotherapy Imeglimin, Metformin 1000 mg Oral Tablet - Mitochondria, Metformin | Phase 4 | Not yet recruiting | Mansoura University | 176 | 2026-03-01 | 2026-02-27 |
| Interaction Between Inorganic Nitrate Supplementation and Metformin in Individuals With Prediabetes Dietary Supplement: Inorganic Nitrate (Beetroot juice), Dietary supplement: Placebo (Nitrate-depleted beetroot juice) - Males, Females | Not applicable | Recruiting | University of Virginia | 24 | 2026-01-01 | 2026-06-03 |
| Clinical and Biological Signs of Dapagliflozin Overdose in ICU Patients With Metformin Poisoning Drug Overdose, Metformin | Recruiting | Centre Hospitalier de Saint-Denis | 50 | 2025-04-11 | 2025-09-25 | |
| Short-Term Metformin Use in Young, Healthy Adults: Impacts on Exercise Capacity Metformin Hydrochloride, Placebo - Exercise Capacity, Metformin | Phase 4 | Completed | University of Virginia | 14 | 2025-01-31 | 2026-06-17 |
| Study of Acupuncture to Control Weight and Improve Pregnancy Rates in Overweight/Obese PCOS Patients Acupuncture+lifestyle intervention, Metformin+lifestyle intervention - Polycystic Ovary Syndrome, Metformin | Not applicable | Not yet recruiting | RenJi Hospital | 92 | 2024-12-20 | 2024-12-04 |
| Evaluation of the Efficacy and Safety of Metformin in the Myotonic Dystrophy Type 1 (Steinert's Disease) Treatment taken - Steinert's Disease, Myotonic Dystrophy 1 | Phase 3 | Recruiting | Assistance Publique - Hôpitaux de Paris | 142 | 2024-11-29 | 2025-11-24 |
| Metformin in Elderly Patients With Type 2 Diabetes and Muscle Strength, Muscle Mass, and Physical Function: Positive or Negative Correlation? Metformin - Diabete Type 2, Muscle Strength | Completed | Fudan University | 290 | 2024-11-11 | 2026-08-26 | |
| Pilot Study on Evaluating the Geroprotective Effect of Metformin Metformin Hydrochloride tablet, Placebo - Metformin, Aging | Phase 2 | Recruiting | Xuanwu Hospital, Beijing | 130 | 2024-06-30 | 2025-03-21 |
| Chemoradiotherapy With or Without Metformin in Locally Advanced Cervical Cancer Metformin, Radiotherapy, Chemotherapy - Cervical Cancer, Radiotherapy | Phase 2 | Unknown | Peking Union Medical College Hospital | 51 | 2024-04-15 | 2025-01-14 |
| PCOS Immune Function Predicts Metformin Efficacy Metformin - Polycystic Ovary Syndrome, Metformin | Not applicable | Unknown | Shanghai 10th People's Hospital | 100 | 2024-03-16 | 2024-03-22 |
| Effect of Metformin on Healthy Live Birth in Women With Prediabetes Metformin pretreatment before ovarian stimulation, Placebo pretreatment before ovarian stimulation, Metformin pretreatment before endometrial preparation for frozen embryo transfer - Metformin, Prediabetes | Not applicable | Recruiting | Shandong University | 988 | 2024-02-22 | 2024-05-29 |
| Phase 2, Open-label, Single-arm Study on the Use of Metformin as Adjunctive Therapy in High-grade Glioma Metformin - Glioblastoma, IDH-wildtype, Metformin | Phase 2 | Recruiting | University of Milano Bicocca | 25 | 2024-02-12 | 2025-07-25 |
| Chiglitazar/Metformin in Non-obese Women With PCOS Chiglitazar, Metformin - Polycystic Ovary Syndrome, Chiglitazar | Phase 2 / Phase 3 | Completed | Shengjing Hospital | 55 | 2023-11-15 | 2025-01-01 |
| Safety and Feasibility of Metformin for Sepsis Induced AKI Metformin low dose, Metformin high dose, Placebo - Sepsis, Septic Shock | Phase 2 | Completed | Hernando Gomez | 80 | 2023-11-08 | 2026-06-09 |
| PCOS Patients' Immune Alterations Detect the immune function of peripheral blood samples - Polycystic Ovary Syndrom, Metformin | Completed | Shanghai 10th People's Hospital | 162 | 2023-11-03 | 2025-07-11 | |
| Effect of Metformin as Add-on Therapy to Ibuprofen on Disease Activity in Knee Osteoarthritis Patients. Metformin 500 Mg extended release Oral Tablet, Placebo oral tablet - Knee Osteoarthritis, Metformin | Phase 2 | Unknown | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | 68 | 2023-10-15 | 2023-11-14 |
| Metabolic Responses of Metformin and Genetic Polymorphisms of SLC22A1 Gene in PCOS Metformin Hydrochloride - Polycystic Ovary Syndrome, Metformin | Phase 4 | Active not recruiting | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | 150 | 2023-05-27 | 2026-10-07 |
| Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes Metformin XR, Placebo - Prediabetic State, Atherosclerosis | Phase 4 | Recruiting | VA Office of Research and Development | 7410 | 2023-04-03 | 2025-12-17 |
| Effects of GLP-1RA on Body Weight, Metabolism and Fat Distribution in Overweight/Obese Patients With Type 2 Diabetes Mellitus Liraglutide, Semaglutide, Metformin - Metformin, Obesity, Abdominal | Not applicable | Unknown | RenJi Hospital | 300 | 2023-02-23 | 2023-05-16 |
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Diabetes Mellitus, Type 2 (8) · Polycystic Ovary Syndrome (5) · Prediabetic State (5) · Acidosis, Lactic (2) · Atherosclerosis (2) · Insulin Resistance (2) · Metabolic Syndrome (2) · Motor Activity (2) · Acute Kidney Injury (1) · Breast Neoplasms (1) · Cerebrovascular Disorders (1) · Coronary Artery Disease (1) · Dengue (1) · Diabetes Mellitus (1) · Diabetes Mellitus, Type 1 (1)
Endocrine System Diseases (22) · Nutritional and Metabolic Diseases (22) · Metabolic Diseases (20) · Glucose Metabolism Disorders (17) · Diabetes Mellitus (16) · Female Urogenital Diseases and Pregnancy Complications (11) · Urogenital Diseases (11) · Female Urogenital Diseases (9) · Neoplasms (9) · Pathological Conditions, Signs and Symptoms (7) · Cysts (6) · Genital Diseases (6) · Genital Diseases, Female (6) · Adnexal Diseases (5) · Gonadal Disorders (5)
Metformin (35) · Exercise (3) · 6-((4-ethylphenyl)methyl)-3',4',5',6'-tetrahydro-6'-(hydroxymethyl)spiro(isobenzofuran-1(3H),2'-(2H)pyran)-3',4',5'-triol (1) · Berberine (1) · Caloric Restriction (1) · Codeine (1) · Dosage Forms (1) · Drug Therapy (1) · Hydroxymethylglutaryl-CoA Reductase Inhibitors (1) · Liraglutide (1) · Positron Emission Tomography Computed Tomography (1) · Radiotherapy (1) · Sodium-Glucose Transporter 2 Inhibitors (1) · Standard of Care (1) · Tablets (1)
RenJi Hospital (3) · Assistance Publique - Hôpitaux de Paris (2) · Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh (2) · Shanghai 10th People's Hospital (2) · Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey (2) · University of Southern Denmark (2) · University of Virginia (2) · Barts & The London NHS Trust (1) · Centre Hospitalier de Saint-Denis (1) · Chang Gung Memorial Hospital (1) · Children's Hospital of Fudan University (1) · Department of Medical Services Ministry of Public Health of Thailand (1) · Fayoum University (1) · Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico (1) · Fudan University (1)
China (17) · France (4) · United States (4) · Bangladesh (2) · Denmark (2) · Egypt (2) · Italy (2) · Turkey (Türkiye) (2) · Japan (1) · Poland (1) · Spain (1) · Taiwan (1) · Thailand (1) · United Kingdom (1) · Vietnam (1)
Manna Zhang, doctor (2) · Antoni Szczepanik, PhD (1) · Fengyi Yuan (1) · Gregory G. Schwartz, PhD MD (1) · Guangda Xiang, MD,PhD (1) · Guoguang Zhao, professor (1) · Hernando Gomez, MD (1) · Jason Allen, PhD (1) · Jason D Allen, PhD (1) · Jens Meier, MD (1) · Jing Li, professor (1) · Jing-Yuan Fang, Professor (1) · Kieran McCafferty, M.B., B.Chir (1)
PMID 12441176, PMID 16054041, PMID 17130214, PMID 20215446, PMID 20660041, PMID 21908880, PMID 21953589, PMID 23034133, PMID 24103089, PMID 24533710, PMID 26789102, PMID 27416781, PMID 27527232, PMID 30959948, PMID 33083561, PMID 33269554, PMID 33855213, PMID 36562831, PMID 38015017, PMID 38688665, PMID 38837240, PMID 39548448, PMID 40591696, PMID 41252113, PMID 41291951, PMID 41331576, PMID 42825099
2019 (1), 2023 (1), R01DK133142 (1)