5 completed, 3 recruiting, 3 unknown, 1 terminated. 12 Phase 2, 2 Phase 3, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 12 | Completed 5, Recruiting 3, Unknown 3, Terminated 1 |
| Phase 3 | 2 | Completed 1, Unknown 1 |
| Phase 1 | 1 | Completed 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pilot Study on Evaluating the Geroprotective Effect of Metformin Metformin Hydrochloride tablet, Placebo - Metformin, Aging | Phase 2 | Recruiting | Xuanwu Hospital, Beijing | 130 | 2024-06-30 | 2025-03-21 |
| Chemoradiotherapy With or Without Metformin in Locally Advanced Cervical Cancer Metformin, Radiotherapy, Chemotherapy - Cervical Cancer, Radiotherapy | Phase 2 | Unknown | Peking Union Medical College Hospital | 51 | 2024-04-15 | 2025-01-14 |
| Phase 2, Open-label, Single-arm Study on the Use of Metformin as Adjunctive Therapy in High-grade Glioma Metformin - Glioblastoma, IDH-wildtype, Metformin | Phase 2 | Recruiting | University of Milano Bicocca | 25 | 2024-02-12 | 2025-07-25 |
| Chiglitazar/Metformin in Non-obese Women With PCOS Chiglitazar, Metformin - Polycystic Ovary Syndrome, Chiglitazar | Phase 2 / Phase 3 | Completed | Shengjing Hospital | 55 | 2023-11-15 | 2025-01-01 |
| Safety and Feasibility of Metformin for Sepsis Induced AKI Metformin low dose, Metformin high dose, Placebo - Sepsis, Septic Shock | Phase 2 | Completed | Hernando Gomez | 80 | 2023-11-08 | 2026-06-09 |
| Effect of Metformin as Add-on Therapy to Ibuprofen on Disease Activity in Knee Osteoarthritis Patients. Metformin 500 Mg extended release Oral Tablet, Placebo oral tablet - Knee Osteoarthritis, Metformin | Phase 2 | Unknown | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | 68 | 2023-10-15 | 2023-11-14 |
| Metformin to Prevent Preterm Birth in Twin Pregnancy Metformin, Placebo oral tablet - Preterm Birth, Premature Obstetric Labor | Phase 2 / Phase 3 | Unknown | The University of Hong Kong | 790 | 2022-06-01 | 2022-06-23 |
| Effect of Tofogliflozin on UACR Compared to Metformin Hydrochloride in Diabetic Kidney Disease (TRUTH-DKD) Tofogliflozin, Metformin - T2DM (Type 2 Diabetes Mellitus), Metformin | Phase 2 | Recruiting | Shinshu University | 120 | 2021-09-22 | 2022-07-22 |
| Metformin in Dengue With Obesity Metformin - Dengue, Viral Infection | Phase 1 / Phase 2 | Completed | Oxford University Clinical Research Unit, Vietnam | 120 | 2020-07-27 | 2023-08-31 |
| The POWERED Study: Prophylaxis With Metformin to Prevent PTDM Metformin, Placebo - Post-transplant Diabetes Mellitus, New Onset Diabetes After Transplant | Phase 2 | Completed | Barts & The London NHS Trust | 60 | 2019-01-25 | 2022-10-18 |
| Implication of Metformin Plus Aromatase Inhibitor in Obese Postmenopausal Breast Cancer Women Metformin - Metformin, Breast Cancer | Phase 2 | Completed | Tanta University | 45 | 2014-02-01 | 2021-09-23 |
| Efficacy of Metformin in Achieving Glycaemia Goals as Recommended for the Treatment of Gestational Diabetes in Non Obese Women Metformin, Rapid acting analog insulin Intermediate acting NPH Insulin - Gestational Diabetes, Metformin | Phase 2 | Terminated | University Hospital, Strasbourg, France | 84 | 2012-06-01 | 2018-08-27 |
Acute Kidney Injury (1) · Breast Neoplasms (1) · Dengue (1) · Diabetes Mellitus, Type 2 (1) · Diabetes, Gestational (1) · Glioblastoma (1) · Glioma (1) · Hypoxia (1) · Kidney Failure, Chronic (1) · Neoplasms (1) · Obesity (1) · Obstetric Labor, Premature (1) · Osteoarthritis, Knee (1) · Overweight (1) · Polycystic Ovary Syndrome (1)
Female Urogenital Diseases and Pregnancy Complications (6) · Urogenital Diseases (6) · Female Urogenital Diseases (4) · Pathological Conditions, Signs and Symptoms (4) · Endocrine System Diseases (3) · Neoplasms (3) · Nutritional and Metabolic Diseases (3) · Diabetes Mellitus (2) · Genital Diseases (2) · Genital Diseases, Female (2) · Glucose Metabolism Disorders (2) · Infections (2) · Kidney Diseases (2) · Male Urogenital Diseases (2) · Metabolic Diseases (2)
Metformin (12) · 6-((4-ethylphenyl)methyl)-3',4',5',6'-tetrahydro-6'-(hydroxymethyl)spiro(isobenzofuran-1(3H),2'-(2H)pyran)-3',4',5'-triol (1) · Drug Therapy (1) · Positron Emission Tomography Computed Tomography (1) · Radiotherapy (1) · chiglitazar (1)
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh (1) · Barts & The London NHS Trust (1) · Hernando Gomez (1) · Oxford University Clinical Research Unit, Vietnam (1) · Peking Union Medical College Hospital (1) · Shengjing Hospital (1) · Shinshu University (1) · Tanta University (1) · The University of Hong Kong (1) · University Hospital, Strasbourg, France (1) · University of Milano Bicocca (1) · Xuanwu Hospital, Beijing (1)
China (3) · Bangladesh (1) · France (1) · Italy (1) · Japan (1) · United Kingdom (1) · United States (1) · Vietnam (1)
Guoguang Zhao, professor (1) · Hernando Gomez, MD (1) · Jing Li, professor (1) · Kieran McCafferty, M.B., B.Chir (1) · Koichiro Kuwahara, MD, PhD (1) · Md.Delowar Hossain, MD (1) · Nathalie Jeandidier, MD (1) · Sophie Yacoub, PhD. MD (1)
PMID 33083561, PMID 36562831, PMID 38688665, PMID 38837240, PMID 40591696, PMID 41252113, PMID 41331576
R01DK133142 (1)