5 unknown, 3 completed, 1 active not recruiting, 1 not yet recruiting. 11 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 11 | Unknown 5, Completed 3, Active not recruiting 1, Not yet recruiting 1, Recruiting 1 |
Follow Metformin: new trials by email Literature Review of Metformin trials Research Report on Metformin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Mitochondrial Redox Modulation in Newly Diagnosed Type 2 Diabetes: A Randomized Controlled Trial Comparing Imeglimin vs. Metformin Monotherapy Imeglimin, Metformin 1000 mg Oral Tablet - Mitochondria, Metformin | Phase 4 | Not yet recruiting | Mansoura University | 176 | 2026-03-01 | 2026-02-27 |
| Short-Term Metformin Use in Young, Healthy Adults: Impacts on Exercise Capacity Metformin Hydrochloride, Placebo - Exercise Capacity, Metformin | Phase 4 | Completed | University of Virginia | 14 | 2025-01-31 | 2026-06-17 |
| Metabolic Responses of Metformin and Genetic Polymorphisms of SLC22A1 Gene in PCOS Metformin Hydrochloride - Polycystic Ovary Syndrome, Metformin | Phase 4 | Active not recruiting | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | 150 | 2023-05-27 | 2026-10-07 |
| Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes Metformin XR, Placebo - Prediabetic State, Atherosclerosis | Phase 4 | Recruiting | VA Office of Research and Development | 7410 | 2023-04-03 | 2025-12-17 |
| Treatment With Metformin in Chinese Children With Alport Syndrome Metformin, Placebo - Alport Syndrome, Metformin | Phase 4 | Unknown | Peking University First Hospital | 78 | 2023-01-03 | 2022-12-19 |
| Metformin in Children With Fragile X Syndrome Metformin, Placebo - Fragile X Syndrome, Metformin | Phase 4 | Completed | Children's Hospital of Fudan University | 37 | 2021-12-29 | 2026-08-25 |
| Comparison of Berberine and Metformin for the Treatment for MS in Schizophrenia Patients Berberine, Metformin - Schizophrenia, Metabolic Syndrome | Phase 4 | Unknown | Tianjin Anding Hospital | 100 | 2021-12-01 | 2022-02-16 |
| Perioperative Continuation of Metformin Therapy in Patients With Typ 2 Diabetes Mellitus Undergoing Non-cardiac Surgery Metformin Hydrochloride - Hyperglycemia, Metformin | Phase 4 | Unknown | Kepler University Hospital | 400 | 2020-02-01 | 2020-02-26 |
| Effect of Metformin as add-on Therapy on Glycemic Control and Other Outcomes in Type 1 Diabetes Metformin - Type 1 Diabetes Mellitus, Metformin | Phase 4 | Unknown | Shenzhen People's Hospital | 20 | 2018-01-01 | 2018-07-20 |
| Metformin Induces a Dietary Restriction-like State in Human metformin 0.85 twice daily for 6 months, Calorie restriction - Overweight Subjects, Metformin | Phase 4 | Unknown | Xiang Guang-da | 60 | 2016-04-01 | 2016-04-26 |
| A Pharmacokinetic Evaluation of Metformin in Relation to the Polymorphism A270S in Healthy Caucasian Volunteers Metformin - Metformin, Organic Cation Transporter 2 | Phase 4 | Completed | University of Southern Denmark | 50 | 2010-08-01 | 2010-12-29 |
Diabetes Mellitus, Type 2 (3) · Atherosclerosis (1) · Cerebrovascular Disorders (1) · Coronary Artery Disease (1) · Diabetes Mellitus, Type 1 (1) · Fragile X Syndrome (1) · Hyperglycemia (1) · Hyperlactatemia (1) · Metabolic Syndrome (1) · Nephritis, Hereditary (1) · Peripheral Arterial Disease (1) · Polycystic Ovary Syndrome (1) · Prediabetic State (1) · Schizophrenia (1)
Endocrine System Diseases (6) · Glucose Metabolism Disorders (6) · Metabolic Diseases (6) · Nutritional and Metabolic Diseases (6) · Diabetes Mellitus (5) · Congenital Abnormalities (2) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · Female Urogenital Diseases (2) · Female Urogenital Diseases and Pregnancy Complications (2) · Nervous System Diseases (2) · Urogenital Diseases (2) · Adnexal Diseases (1) · Arterial Occlusive Diseases (1) · Arteriosclerosis (1) · Autoimmune Diseases (1)
Metformin (9) · Berberine (1) · Caloric Restriction (1) · Tablets (1) · Tolbutamide (1) · imeglimin (1)
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh (1) · Children's Hospital of Fudan University (1) · Kepler University Hospital (1) · Mansoura University (1) · Peking University First Hospital (1) · Shenzhen People's Hospital (1) · Tianjin Anding Hospital (1) · University of Southern Denmark (1) · University of Virginia (1) · VA Office of Research and Development (1) · Xiang Guang-da (1)
China (4) · United States (2) · Bangladesh (1) · Denmark (1) · Egypt (1)
Fengyi Yuan (1) · Gregory G. Schwartz, PhD MD (1) · Guangda Xiang, MD,PhD (1) · Jason D Allen, PhD (1) · Jens Meier, MD (1) · Kim Broesen, Professor (1) · Muhammad A Hasanat, MPhil, MD (1)
PMID 20660041, PMID 24533710, PMID 30959948, PMID 33269554, PMID 33855213, PMID 41291951