Prediabetic State: Clinical Trials

479 completed, 133 unknown, 126 recruiting, 65 not yet recruiting. 617 Not applicable, 59 Phase 2, 54 Phase 4, 39 Phase 3, 26 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	617	Completed 344, Recruiting 85, Unknown 83, Not yet recruiting 36, Active not recruiting 27, Terminated 23, Withdrawn 12, Enrolling by invitation 4, Suspended 3
Phase 2	59	Completed 30, Withdrawn 9, Recruiting 7, Active not recruiting 4, Unknown 4, Terminated 3, Not yet recruiting 2
Phase 4	54	Completed 29, Unknown 8, Recruiting 7, Not yet recruiting 5, Active not recruiting 2, Withdrawn 2, Terminated 1
Phase 3	39	Completed 25, Unknown 5, Not yet recruiting 3, Recruiting 2, Terminated 2, Withdrawn 2
Phase 1	26	Completed 17, Not yet recruiting 2, Recruiting 2, Terminated 2, Withdrawn 2, Active not recruiting 1
Early Phase 1	4	Completed 1, Enrolling by invitation 1, Not yet recruiting 1, Recruiting 1

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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
The Prevalence of Hyperglycemia in Surgical Patients With Pre-diabetes Prediabetes or Diabetes, Surgery Complications		Not yet recruiting	University of Calgary	750	2027-05-01	2026-06-23
Trial of CGM Technology in Persons Living With Prediabetes Stelo CGM - Prediabetes	Not applicable	Not yet recruiting	Wake Forest University Health Sciences	100	2027-04-01	2026-10-23
Cardiometabolic & Cognitive Effects of Peanut Butter in Prediabetes Peanut butter, Usual diet - Prediabetes	Not applicable	Not yet recruiting	Penn State University	56	2027-01-18	2026-07-20
Efficacy of the pA1c®HI Postbiotic in Metabolic Regulation in Healthy Individuals With Hyperglycemia Postbiotic - Hyperglycemias, Prediabetes	Early Phase 1	Not yet recruiting	Genbioma Aplicaciones SL	100	2027-01-07	2026-10-29
Human Models of Selective Insulin Resistance: Pancreatic Clamp Insulin human, Octreotide Acetate, Glucagon - Insulin Resistance, Hyperinsulinemia	Phase 1	Not yet recruiting	Columbia University	36	2027-01-01	2026-02-06
Time to Healthy Lifestyle Habit Using Digital Health Tools in Adults at Risk of Diabetes Hybrid digital intervention with personalized support., Standard lifestyle education - Prediabetes	Not applicable	Not yet recruiting	Imam Abdulrahman Bin Faisal University	222	2027-01-01	2026-06-25
Diabetes Prevention Through Genetics, Familial History and Behavior Change LEGACY DPP, DPP - Prediabetes, Weight Loss	Phase 2 / Phase 3	Not yet recruiting	Morehouse School of Medicine	400	2027-01-01	2026-10-20
The Impact of Continuous Glucose Monitoring on Glucose Variability and Weight Loss in Individuals With Prediabetes and Obesity Continuous Glucose Monitoring (CGM) - Pre Diabetic, Obesity & Overweight	Not applicable	Suspended	University of Primorska	34	2026-12-15	2026-11-04
Optimizing Implementation of the Intensive Diabetes Prevention Program Standard IDPP, Optimized IDPP - Prediabetes, Diabetes Prevention	Not applicable	Not yet recruiting	The Hong Kong Polytechnic University	170	2026-12-02	2026-09-17
Improving the Recruitment and Retention in the Intensive Diabetes Prevention Program at Hong Kong in District Health Centers IDPP With optimized Implementation Strategies, Usual IDPP - Prediabetes / Type 2 Diabetes	Not applicable	Not yet recruiting	The Hong Kong Polytechnic University	170	2026-12-01	2026-11-10
Continuous Glucose Monitoring and Dietary Self-Management in Adults in Namwon Continuous Glucose Monitoring With Application-Based Biofeedback, Common Standardized Education and Behavioral Goal Setting, Common Digital Health Program and Basic Health Counseling - Prediabetes, Dietary Self-Management	Not applicable	Not yet recruiting	Ji-Yeob Choi	860	2026-11-02	2026-10-22
Training Induced Muscle-Adipose EV Communication Acute Resistance Exercise - Prediabetes	Not applicable	Not yet recruiting	Yuan Wen	40	2026-11-01	2026-10-02
Whole Food Fibers for Support of Key Gut Bacteria for Human Health Whole food fiber mixture, inulin - Prediabetes or Overweight	Not applicable	Not yet recruiting	Purdue University	24	2026-11-01	2026-09-24
Different Aerobic-to-Resistance Training Ratios in Adults Aged 50 Years and Older With Prediabetes Combined Aerobic and Resistance Training (3:1), Combined Aerobic and Resistance Training (1:1), Combined Aerobic and Resistance Training (1:3) - Prediabetes	Not applicable	Not yet recruiting	China Institute of Sport Science	212	2026-11-01	2026-11-03
Evaluation of the Effectiveness of Implementing a Screening Strategy for the Diagnosis of Prediabetes and Type 2 Diabetes Mellitus in Primary Health Care in a Brazilian Municipality ARISE Strategy - Diabetes Mellitus (Type 2), Prediabetes	Not applicable	Not yet recruiting	epHealth	45000	2026-11-01	2026-10-30
Lifestyle Changes, Mushroom Supplementation, and Bupropion to Reduce Adiposity and Cardiometabolic Risk Bupropion 150 mg, Lyophilized powder from edible mushrooms, Lifestyle Management - Cardiometabolic Syndrome, Obesity and Cardiovascular Risk	Phase 3	Not yet recruiting	Uppsala University	250	2026-10-30	2026-09-08
LIfestyle MEtabotype Study B (LIME-B) βHB drink (ketone ester), Carbohydrate drink - Nutritional and Metabolic Diseases, Prediabetes	Not applicable	Recruiting	German Institute of Human Nutrition	300	2026-10-26	2026-10-28
Neuromodulation for Metabolic Dysfunction Transcutaneous Spinal Cord Stimulation (tSCS), Sham transcutaneous spinal cord stimulation (tSCS) - Spinal Cord Injuries (SCI), Prediabetes / Type 2 Diabetes	Not applicable	Recruiting	Rahul Sachdeva	120	2026-10-20	2026-10-29
Food-i-Sense Analytics: Integrating AI Into Continuous Glucose Monitoring Data Analysis for Precision Nutrition. Continuous glucose monitoring using a wearable sensor (flash interstitial glucose monitor) - Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Artificial Intelligence Mobile Application		Recruiting	IMDEA Food	471	2026-10-15	2026-11-05
LIfestyle MEtabotype Study A Nutritional and Metabolic Diseases, Prediabetes		Recruiting	German Institute of Human Nutrition	300	2026-10-10	2026-10-09

Showing 20 of 917. Sign in to see all of them.

Narrower conditions

Obesity (248)  ·  Diabetes Mellitus, Type 2 (211)  ·  Diabetes Mellitus (145)  ·  Insulin Resistance (144)  ·  Overweight (139)  ·  Glucose Intolerance (109)  ·  Metabolic Syndrome (69)  ·  Motor Activity (58)  ·  Hypertension (46)  ·  Cardiovascular Diseases (43)  ·  Hyperglycemia (40)  ·  Weight Loss (37)  ·  Dyslipidemias (29)  ·  Body Weight (24)

Broader conditions

Endocrine System Diseases (913)  ·  Nutritional and Metabolic Diseases (913)  ·  Metabolic Diseases (905)  ·  Glucose Metabolism Disorders (904)  ·  Diabetes Mellitus (772)  ·  Pathological Conditions, Signs and Symptoms (340)  ·  Signs and Symptoms (311)  ·  Body Weight (277)  ·  Nutrition Disorders (276)  ·  Overnutrition (275)  ·  Hyperinsulinism (186)  ·  Overweight (136)  ·  Behavior (113)  ·  Hyperglycemia (96)  ·  Vascular Diseases (79)

Interventions

Metformin (48)  ·  Exercise (30)  ·  Diet (17)  ·  dapagliflozin (12)  ·  Continuous Glucose Monitoring (10)  ·  Resistance Training (9)  ·  semaglutide (9)  ·  Cholecalciferol (8)  ·  Glucose (8)  ·  Glucose Tolerance Test (8)  ·  Standard of Care (8)  ·  High-Intensity Interval Training (7)  ·  Control Groups (6)  ·  Linagliptin (6)  ·  Sitagliptin Phosphate (6)

Sponsors

Johns Hopkins University (12)  ·  Stanford University (12)  ·  VA Office of Research and Development (11)  ·  Diabetes Foundation, India (10)  ·  Ohio State University (10)  ·  University of Toronto (10)  ·  Columbia University (9)  ·  Indiana University (8)  ·  John Sievenpiper (8)  ·  University of Alabama at Birmingham (8)  ·  University of California, Los Angeles (8)  ·  University of Michigan (8)  ·  Northwestern University (7)  ·  German Institute of Human Nutrition (6)  ·  Kaiser Permanente (6)

Countries

United States (390)  ·  Canada (56)  ·  China (51)  ·  Germany (30)  ·  Spain (29)  ·  Mexico (26)  ·  Turkey (Türkiye) (20)  ·  Denmark (19)  ·  United Kingdom (19)  ·  India (17)  ·  South Korea (17)  ·  Taiwan (15)  ·  Italy (12)  ·  Sweden (12)  ·  France (11)

Top investigators

David JA Jenkins, MD, PhD, DSc (7)  ·  John L Sievenpiper, MD, PhD (7)  ·  Joshua R Cook, MD, PhD (6)  ·  Russell J de Souza, ScD, RD (6)  ·  Cyril WC Kendall, PhD (4)  ·  Adrian Vella, MD (3)  ·  David Crowley, MD (3)  ·  David S Black, PhD MPH (3)  ·  Fumiko Higashikawa, PhD (3)  ·  Jill Crandall, MD (3)  ·  John L Sievenpiper, MD,PhD,FRCPC (3)  ·  Philip Kern, MD (3)  ·  Rodolfo Guardado-Mendoza, MDPhD (3)

Results publications

PMID 31301210, PMID 33436401, PMID 34131047, PMID 34135015, PMID 36938582, PMID 11832527, PMID 20208057, PMID 29941497, PMID 29941498, PMID 30117761, PMID 30200935, PMID 31178433, PMID 31384309, PMID 31919539, PMID 33210751, PMID 34131048, PMID 34274407, PMID 35894078, PMID 37625586, PMID 39800653, PMID 40717199, PMID 41187013, PMID 41885866, PMID 10480510, PMID 10580071, PMID 10857969, PMID 11157685, PMID 11234459, PMID 11373354, PMID 11874952, PMID 12547866, PMID 12573493, PMID 12752315, PMID 13679495, PMID 14514569, PMID 14578255, PMID 15031036, PMID 15189754, PMID 15649575, PMID 1574446, PMID 1578097, PMID 15823385, PMID 15851636, PMID 16249549, PMID 16249553, PMID 16391903, PMID 16505522, PMID 16644654, PMID 16983057, PMID 17315136

NIH funding

2023 (5), 2015 (4), P50MD017344 (4), K12DK133995 (3), P30DK063608 (3), P50MD017338 (3), 2014 (2), 2025 (2), K23DK140614 (2), OT2HL158287 (2), P20GM144269 (2), P20GM156679 (2), P30DK116074 (2), P50HL083762 (2), U01DK094406 (2)