475 completed, 133 unknown, 127 recruiting, 63 not yet recruiting. 613 Not applicable, 59 Phase 2, 53 Phase 4, 39 Phase 3, 26 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Prevalence of Hyperglycemia in Surgical Patients With Pre-diabetes Prediabetes or Diabetes, Surgery Complications | Not yet recruiting | University of Calgary | 750 | 2027-05-01 | 2026-06-23 | |
| Cardiometabolic & Cognitive Effects of Peanut Butter in Prediabetes Peanut butter, Usual diet - Prediabetes | Not applicable | Not yet recruiting | Penn State University | 56 | 2027-01-18 | 2026-07-20 |
| Human Models of Selective Insulin Resistance: Pancreatic Clamp Insulin human, Octreotide Acetate, Glucagon - Insulin Resistance, Hyperinsulinemia | Phase 1 | Not yet recruiting | Columbia University | 36 | 2027-01-01 | 2026-02-06 |
| Time to Healthy Lifestyle Habit Using Digital Health Tools in Adults at Risk of Diabetes Hybrid digital intervention with personalized support., Standard lifestyle education - Prediabetes | Not applicable | Not yet recruiting | Imam Abdulrahman Bin Faisal University | 222 | 2027-01-01 | 2026-06-25 |
| Diabetes Prevention Through Genetics, Familial History and Behavior Change LEGACY DPP, DPP - Prediabetes, Weight Loss | Phase 2 / Phase 3 | Not yet recruiting | Morehouse School of Medicine | 400 | 2027-01-01 | 2026-10-20 |
| The Impact of Continuous Glucose Monitoring on Glucose Variability and Weight Loss in Individuals With Prediabetes and Obesity Continuous Glucose Monitoring (CGM) - Pre Diabetic, Obesity & Overweight | Not applicable | Recruiting | University of Primorska | 34 | 2026-12-15 | 2026-10-22 |
| Optimizing Implementation of the Intensive Diabetes Prevention Program Standard IDPP, Optimized IDPP - Prediabetes, Diabetes Prevention | Not applicable | Not yet recruiting | The Hong Kong Polytechnic University | 170 | 2026-12-02 | 2026-09-17 |
| Continuous Glucose Monitoring and Dietary Self-Management in Adults in Namwon Continuous Glucose Monitoring With Application-Based Biofeedback, Common Standardized Education and Behavioral Goal Setting, Common Digital Health Program and Basic Health Counseling - Prediabetes, Dietary Self-Management | Not applicable | Not yet recruiting | Ji-Yeob Choi | 860 | 2026-11-02 | 2026-10-22 |
| Training Induced Muscle-Adipose EV Communication Acute Resistance Exercise - Prediabetes | Not applicable | Not yet recruiting | Yuan Wen | 40 | 2026-11-01 | 2026-10-02 |
| Whole Food Fibers for Support of Key Gut Bacteria for Human Health Whole food fiber mixture, inulin - Prediabetes or Overweight | Not applicable | Not yet recruiting | Purdue University | 24 | 2026-11-01 | 2026-09-24 |
| Evaluation of the Effectiveness of Implementing a Screening Strategy for the Diagnosis of Prediabetes and Type 2 Diabetes Mellitus in Primary Health Care in a Brazilian Municipality ARISE Strategy - Diabetes Mellitus (Type 2), Prediabetes | Not applicable | Not yet recruiting | epHealth | 45000 | 2026-11-01 | 2026-10-02 |
| Lifestyle Changes, Mushroom Supplementation, and Bupropion to Reduce Adiposity and Cardiometabolic Risk Bupropion 150 mg, Lyophilized powder from edible mushrooms, Lifestyle Management - Cardiometabolic Syndrome, Obesity and Cardiovascular Risk | Phase 3 | Not yet recruiting | Uppsala University | 250 | 2026-10-30 | 2026-09-08 |
| LIfestyle MEtabotype Study B (LIME-B) βHB drink (ketone ester), Carbohydrate drink - Nutritional and Metabolic Diseases, Prediabetes | Not applicable | Recruiting | German Institute of Human Nutrition | 300 | 2026-10-26 | 2026-10-22 |
| LIfestyle MEtabotype Study A Nutritional and Metabolic Diseases, Prediabetes | Recruiting | German Institute of Human Nutrition | 300 | 2026-10-10 | 2026-10-09 | |
| Multimodal Risk Factor Graph Mapping, Metabolic Subtyping, and Digital Intelligent Chronic Disease Management for Prediabetes: An Integrated Cohort and Case-Control Clinical Study Prediabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance) | Not yet recruiting | Nanjing Medical University | 30000 | 2026-10-08 | 2026-10-02 | |
| Pharmacist-Led Continuous Glucose Monitoring for Prediabetes Dexcom Stelo CGM - Prediabetes | Recruiting | University of South Florida | 40 | 2026-10-06 | 2026-10-07 | |
| Effects of Different Fish Oil Types on Type 2 Diabetes Risk Factors in High-Risk Adults Fish Oil, Corn oil control - Type 2 Diabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance) | Phase 2 | Recruiting | May Faraj, PDt, PhD | 84 | 2026-10-05 | 2026-10-08 |
| Studies of Blood Glucose and the Microbiome in Tumors and Cysts of the Pancreas Pancreatic Neoplasms, Pancreatic Cysts | Not yet recruiting | Umeå University | 100 | 2026-10-01 | 2026-09-25 | |
| Enhancing Mental and Physical Health of Women Veterans 3.0 EBQI Booster (EBQI/B), EBQI Booster + External Facilitation (EBQI/B+EF) - Cardiovascular Diseases, Overweight | Not applicable | Not yet recruiting | VA Office of Research and Development | 18 | 2026-10-01 | 2026-01-21 |
| Precision Nutrition for Obesity and Prediabetes Prevention in Under-supported Communities Precision Nutrition Intervention, Standard Nutrition Counseling - Obesity & Overweight, Prediabetes | Not applicable | Not yet recruiting | Prairie View A&M University | 100 | 2026-10-01 | 2026-09-30 |
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Obesity (247) · Diabetes Mellitus, Type 2 (207) · Diabetes Mellitus (144) · Insulin Resistance (144) · Overweight (138) · Glucose Intolerance (109) · Metabolic Syndrome (69) · Motor Activity (58) · Hypertension (46) · Cardiovascular Diseases (43) · Hyperglycemia (39) · Weight Loss (37) · Dyslipidemias (29) · Body Weight (24)
Endocrine System Diseases (907) · Nutritional and Metabolic Diseases (907) · Metabolic Diseases (899) · Glucose Metabolism Disorders (898) · Diabetes Mellitus (767) · Pathological Conditions, Signs and Symptoms (339) · Signs and Symptoms (310) · Body Weight (276) · Nutrition Disorders (275) · Overnutrition (274) · Hyperinsulinism (186) · Overweight (136) · Behavior (113) · Hyperglycemia (96) · Vascular Diseases (80)
Metformin (48) · Exercise (30) · Diet (17) · dapagliflozin (11) · Continuous Glucose Monitoring (10) · semaglutide (9) · Cholecalciferol (8) · Glucose (8) · Glucose Tolerance Test (8) · Resistance Training (8) · Standard of Care (8) · High-Intensity Interval Training (7) · Control Groups (6) · Linagliptin (6) · Sitagliptin Phosphate (6)
Johns Hopkins University (12) · Stanford University (12) · VA Office of Research and Development (11) · Diabetes Foundation, India (10) · Ohio State University (10) · University of Toronto (10) · Columbia University (9) · Indiana University (8) · John Sievenpiper (8) · University of Alabama at Birmingham (8) · University of California, Los Angeles (8) · University of Michigan (8) · Northwestern University (7) · German Institute of Human Nutrition (6) · Kaiser Permanente (6)
United States (389) · Canada (56) · China (47) · Germany (30) · Spain (28) · Mexico (26) · Turkey (Türkiye) (20) · Denmark (19) · United Kingdom (19) · India (17) · South Korea (17) · Taiwan (15) · Italy (12) · Sweden (12) · France (11)
David JA Jenkins, MD, PhD, DSc (7) · John L Sievenpiper, MD, PhD (7) · Joshua R Cook, MD, PhD (6) · Russell J de Souza, ScD, RD (6) · Cyril WC Kendall, PhD (4) · Adrian Vella, MD (3) · David Crowley, MD (3) · David S Black, PhD MPH (3) · Fumiko Higashikawa, PhD (3) · Jill Crandall, MD (3) · John L Sievenpiper, MD,PhD,FRCPC (3) · Philip Kern, MD (3) · Rodolfo Guardado-Mendoza, MDPhD (3)
PMID 31301210, PMID 33436401, PMID 34131047, PMID 34135015, PMID 36938582, PMID 11832527, PMID 20208057, PMID 29941497, PMID 29941498, PMID 30117761, PMID 30200935, PMID 31178433, PMID 31384309, PMID 31919539, PMID 33210751, PMID 34131048, PMID 34274407, PMID 35894078, PMID 37625586, PMID 39800653, PMID 40717199, PMID 41187013, PMID 41885866, PMID 10480510, PMID 10580071, PMID 10857969, PMID 11157685, PMID 11234459, PMID 11373354, PMID 11874952, PMID 12547866, PMID 12573493, PMID 12752315, PMID 13679495, PMID 14514569, PMID 14578255, PMID 15031036, PMID 15189754, PMID 15649575, PMID 1574446, PMID 1578097, PMID 15823385, PMID 15851636, PMID 16249549, PMID 16249553, PMID 16391903, PMID 16505522, PMID 16644654, PMID 16983057, PMID 17315136
2023 (5), 2015 (4), P50MD017344 (4), K12DK133995 (3), P30DK063608 (3), P50MD017338 (3), 2014 (2), 2025 (2), K23DK140614 (2), OT2HL158287 (2), P20GM144269 (2), P20GM156679 (2), P30DK116074 (2), P50HL083762 (2), U01DK094406 (2)