49 completed, 9 unknown, 5 recruiting, 4 terminated. 74 Phase 2, 11 Phase 1, 7 Phase 3.
Follow Menstruation Disturbances: new trials by email Literature Review of Menstruation Disturbances trials Research Report on Menstruation Disturbances
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Impact of the Antihistamine Desloratadine on the Quality of Life and Dysmenorrhea in Patients With Endometriosis Desloratadine, Placebo - Endometriosis, Endometriosis (Diagnosis) | Phase 2 | Not yet recruiting | Medical University of Vienna | 60 | 2027-02-01 | 2026-09-18 |
| HMBeacon: A Phase 2 Study to Evaluate ALN-6400 in Adult and Adolescent Female Patients With VWD and HMB ALN-6400 - Von Willebrand Disease (VWD), Heavy Menstrual Bleeding (HMB) | Phase 2 | Recruiting | Alnylam Pharmaceuticals | 24 | 2026-07-30 | 2026-10-26 |
| A Study to Investigate Mibavademab in Adult Women With Functional Hypothalamic Amenorrhea Mibavademab, Placebo - Functional Hypothalamic Amenorrhea, FHA | Phase 2 | Recruiting | Regeneron Pharmaceuticals | 34 | 2026-03-11 | 2026-10-01 |
| A Phase 2 Trial to Investigate Efficacy and Safety of Vipoglanstat in Women With Endometriosis Vipoglanstat, Placebo - Endometriosis | Phase 2 | Active not recruiting | Gesynta Pharma AB | 213 | 2025-10-15 | 2026-10-20 |
| Role of Glucagon-like Peptide-1 Receptor Agonists in Menstrual Irregularities in Adolescent Females With Type 1 Diabetes Mellitus Dulaglutide - Menstrual Irregularities, Type1 Diabetes Mellitus | Phase 1 / Phase 2 | Enrolling by invitation | Ain Shams University | 50 | 2025-08-04 | 2026-06-05 |
| Transdermal Ethinyl Estradiol and Norelgestromin for Irregular Bleeding in Contraceptive Implant Users Transdermal Ethinyl Estradiol/Norelgestromin Patch, Placebo Patch - Menstruation Disturbances, Metrorrhagia | Phase 2 | Recruiting | Chulalongkorn University | 40 | 2025-07-29 | 2025-12-10 |
| Acupuncture for People Experiencing Period Loss Due to Chemotherapy Acupuncture, No Acupuncture - Cancer, Period Problem | Phase 2 | Recruiting | Memorial Sloan Kettering Cancer Center | 60 | 2025-03-31 | 2026-08-17 |
| Chinese Herbal Medicine for Gynecologic Patients Chinese Herbal Medicine (CHM) supplement, Placebo - Dysmenorrhea | Phase 2 | Withdrawn | Icahn School of Medicine at Mount Sinai | 2024-07-01 | 2024-07-23 | |
| PAI-1, tPA, TFPI and HEECs in Uterine Hemostasis Sample Collection and Endometrial Biopsy - Menstrual Bleeding, Heavy | Phase 1 / Phase 2 | Unknown | Oregon Health and Science University | 70 | 2023-07-12 | 2024-08-19 |
| Oral Contraceptives for Treating Premenstrual Dysphoric Disorder in Bipolar Disorder Yaz, Placebo - Premenstrual Dysphoric Disorder, Bipolar Disorder | Phase 2 | Completed | St. Joseph's Healthcare Hamilton | 17 | 2023-02-03 | 2024-09-23 |
| Effect of 'Cramp Bites' on Period Cramps in Women Aged 18-25 Cramp Bites by Aunt Flo's Kitchen - Dysmenorrhea Primary, Dysmenorrhea | Phase 2 / Phase 3 | Completed | Cornell University | 12 | 2022-07-21 | 2024-04-12 |
| Failed Endometrial Ablation Treatment With Implantable Progesterone (FEAT) Study Etonogestrel 68mg implant - Abnormal Uterine Bleeding, Dysmenorrhea | Phase 2 | Withdrawn | Saskatchewan Health Authority - Regina Area | 2022-07-01 | 2025-11-25 | |
| Dark Chocolate, Coconut Water, and Ibuprofen in Managing Primary Dysmenorrhea Ibuprofen 400 mg, Young Coconut Water, Dark Chocolate Bar - Dysmenorrhea Primary, Menstrual Pain | Phase 2 | Completed | Universitas Padjadjaran | 45 | 2022-06-30 | 2023-08-02 |
| Effect of Acupuncture and Low Caloric Diet on Primary Hypothyroidism and Irregular Menstruation in Infertile Women acupuncture, Thyroxine, low caloric diet - Primary Hypothyroidism, Acupuncture | Phase 2 | Completed | Cairo University | 60 | 2020-08-30 | 2023-04-07 |
| Sublingual Tablets With Cannabinoid Combinations for the Treatment of Dysmenorrhea Pure Femme Tablets - Dysmenorrhea, Headache, Migraine | Phase 2 | Unknown | Pure Green | 30 | 2019-09-01 | 2019-09-19 |
| The Role of Estrogen in the Neurobiology of Eating Disorders 17-β estradiol transdermal patches with cyclic progesterone, Placebo patch and pill - Eating Disorders, Hypoestrogenemia | Phase 2 | Active not recruiting | Massachusetts General Hospital | 120 | 2019-06-13 | 2026-05-29 |
| Autologous PRP Intra Ovarian Infusion to Restore Ovarian Function in Menopausal Women Autologous PRP intra ovarian infusion, Autologous PFP intra ovarian infusion - Infertility, Female, Anovulatory Infertility | Phase 2 / Phase 3 | Recruiting | Genesis Athens Clinic | 100 | 2019-05-21 | 2026-07-08 |
| Effect of Melatonin on Reduction of Pelvic Pain Melatonin 10 mg, Placebo, Melatonin 20 mg - Dysmenorrhea, Endometriosis | Phase 2 | Completed | Karolinska Institutet | 80 | 2019-03-15 | 2022-04-05 |
| Comparison of Metformin and Pioglitazone in Regulating Menstrual Irregularities and Hyperandrogenism TAB METFORMIN, TAB PIOGLITAZONE - Menstrual Irregularities, Hyperandrogenism | Phase 1 / Phase 2 | Unknown | Dow University of Health Sciences | 110 | 2018-06-18 | 2018-11-29 |
| A Study of Efficacy and Safety of Sepranolone (UC1010) in Patients With Premenstrual Dysphoric Disorder (PMDD) Sepranolone (UC1010) low dose, Sepranolone (UC1010) high dose, Placebo - Premenstrual Dysphoric Disorder | Phase 2 | Completed | Asarina Pharma | 475 | 2018-04-20 | 2020-10-28 |
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Dysmenorrhea (30) · Amenorrhea (14) · Endometriosis (11) · Menorrhagia (11) · Premenstrual Syndrome (10) · Pelvic Pain (9) · Dyspareunia (6) · Premenstrual Dysphoric Disorder (6) · Infertility (4) · Leiomyoma (3) · Pain (3) · Polycystic Ovary Syndrome (3) · Uterine Hemorrhage (3) · Adenomyosis (2)
Pathologic Processes (74) · Pathological Conditions, Signs and Symptoms (74) · Female Urogenital Diseases (34) · Female Urogenital Diseases and Pregnancy Complications (34) · Urogenital Diseases (34) · Genital Diseases (33) · Signs and Symptoms (33) · Genital Diseases, Female (32) · Neurologic Manifestations (30) · Pain (27) · Pelvic Pain (21) · Uterine Diseases (15) · Hemorrhage (14) · Mental Disorders (14)
Progesterone (6) · asoprisnil (6) · Estradiol (5) · Acupuncture Therapy (2) · Estriol (2) · Estrogens, Conjugated (USP) (2) · Estrone (2) · Ethinyl Estradiol (2) · Ibuprofen (2) · Lidocaine (2) · Meloxicam (2) · Norethindrone Acetate (2) · Sugars (2) · Surveys and Questionnaires (2) · drospirenone (2)
Abbott (6) · Bayer (4) · Massachusetts General Hospital (3) · University of Johannesburg (3) · Ain Shams University (2) · Chulalongkorn University (2) · Duramed Research (2) · EVE Medical Systems Ltd. (2) · Milton S. Hershey Medical Center (2) · AbbVie (1) · AbbVie (prior sponsor, Abbott) (1) · Alnylam Pharmaceuticals (1) · Asarina Pharma (1) · Beth Israel Deaconess Medical Center (1) · Boehringer Ingelheim (1)
United States (32) · United Kingdom (7) · Sweden (6) · Poland (4) · South Africa (4) · Canada (3) · Egypt (3) · Israel (3) · Austria (2) · Belgium (2) · Bulgaria (2) · Croatia (2) · Czechia (2) · Germany (2) · Hungary (2)
Agni Pantou, MD (1) · Ana LL Giaponesi (1) · Avner Reshef, Dr. (1) · Bader F Zuberi, FCPS (1) · Benicio N Frey, MD, MSc,PhD (1) · Charlotte Owens, MD (1) · Chrisandra Shufelt, MD (1) · Christos S Mantzoros, MD, ScD (1) · Daniel Dumesic, MD (1) · David Bell (1) · Debra Kimless, M.D. (1)
PMID 37523477, PMID 21464293, PMID 21593494, PMID 21660636, PMID 21698665, PMID 21741057, PMID 21833452, PMID 22232129, PMID 22282904, PMID 22617578, PMID 22728230, PMID 23341491, PMID 23382191, PMID 23921822, PMID 23925396, PMID 24021517, PMID 24703486, PMID 25148234, PMID 25588784, PMID 27733082, PMID 28844356, PMID 30303923, PMID 30439359, PMID 32034419, PMID 32505383, PMID 32559602, PMID 33045195, PMID 33051459, PMID 34218053, PMID 34668986, PMID 36400597, PMID 37267394, PMID 37365881, PMID 37610989, PMID 37623203, PMID 39097160, PMID 39518671, PMID 40294815
2025 (2), 2014 (1), 2016 (1), M01RR001032 (1), R01DK062249 (1), R21MH062379 (1), R34HD048526 (1), U54HD028138 (1)