112 completed, 33 unknown, 21 terminated, 16 recruiting. 69 Not applicable, 44 Phase 3, 26 Phase 4, 11 Phase 2, 5 Phase 1.
Follow Menorrhagia: new trials by email Literature Review of Menorrhagia trials Research Report on Menorrhagia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Ginger on Heavy Menstrual Bleeding in Women With Coagulation Disorders Ginger, Placebo - Women With Coagulation Disorders | Early Phase 1 | Not yet recruiting | University of Valladolid | 74 | 2028-02-01 | 2026-05-19 |
| Ultrasound-Guided Radiofrequency Ablation for Focal Adenomyosis Myoblate Radiofrequency Ablation System (Mygen V-1000 generator) - Adenomyosis, Adenomyoma of Uterus | Not applicable | Not yet recruiting | University Hospital Pilsen | 41 | 2026-11-01 | 2026-10-30 |
| Heavy Menstrual Bleeding and Dysmenorrhea Among Undergraduate Females in the Faculty of Medicine of Assiut University Dysmenorrhea, Heavy Menstrual Bleeding | Not yet recruiting | Assiut University | 486 | 2026-10-01 | 2026-10-01 | |
| HMBeacon: A Phase 2 Study to Evaluate ALN-6400 in Adult and Adolescent Female Patients With VWD and HMB ALN-6400 - Von Willebrand Disease (VWD), Heavy Menstrual Bleeding (HMB) | Phase 2 | Recruiting | Alnylam Pharmaceuticals | 24 | 2026-07-30 | 2026-10-26 |
| Cyclobenzaprine for Postoperative Pain in Minimally Invasive Hysterectomy Cyclobenzaprine - Minimally Invasive Surgical Procedures, Abnormal Uterine Bleeding, Unspecified | Phase 4 | Not yet recruiting | Christiana Care Health Services | 36 | 2026-07-01 | 2026-06-24 |
| Delivering tAN to Reduce HMB: The LUNA Study Sparrow Link, Sparrow Link (Sham) - Heavy Menstrual Bleeding | Not applicable | Recruiting | Spark Biomedical, Inc. | 80 | 2026-03-06 | 2026-10-20 |
| Clinical Spectrum and Management of Von Willebrand Disease Among Children in Assiut Governorate Tranexamic Acid, Von Willebrand Factor-Containing Concentrates - Von Willebrand Disease (VWD), Inherited Bleeding Disorders in Children | Not yet recruiting | Assiut University | 25 | 2026-03-01 | 2026-02-13 | |
| Effectiveness of an mHealth Innovation on the Impact of Menstrual Complaints in Adolescents Menstrual Tracker and Education Application - Dysmenorrhea, Heavy Menstrual Bleeding | Not applicable | Not yet recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 874 | 2026-02-16 | 2026-03-09 |
| Reframing Endometrial Physiology by Advanced Integrated Research Menorrhagia Due to Benign Causes | Recruiting | University Hospital Southampton NHS Foundation Trust | 100 | 2026-02-06 | 2026-04-30 | |
| to Evaluate the Efficacy and Safety of KLH-2109 in Patients With Uterine Fibroids and Menorrhagia KLH-2109+ Leurprorelin acetate Placebo, KLH-2109 Placebo + Leurprorelin acetate - Menorrhagia, Uterine Fibroids | Phase 3 | Recruiting | JW Pharmaceutical | 254 | 2026-02-03 | 2026-05-01 |
| Evaluating the Reliability and Validity of the Arabic Version of the SAMANTA Questionnaire: A Step Toward Improved Diagnosis of Heavy Menstrual Bleeding Heavy Menstrual Bleeding | Not yet recruiting | Assiut University | 120 | 2025-12-01 | 2025-12-05 | |
| Prevalence and Impact on Quality of Life, Academic Performance, and Blood Indices of Heavy Menstrual Bleeding Among Female Students in Assiut University, Egypt Menorrhagia | Not yet recruiting | Assiut University | 340 | 2025-11-01 | 2025-09-23 | |
| Heavy Menstrual Bleeding Progestin Treatment in Bleeding Disorders Study Levonorgestrel Intrauterine System, Norethindrone Acetate - Heavy Menstrual Bleeding, Bleeding Disorder | Recruiting | Oregon Health and Science University | 300 | 2025-09-24 | 2026-11-02 | |
| Impact of Ehlers-Danlos Syndrome on Gynaecological Health Ehlers-Danlos Syndrome (EDS) | Recruiting | University Hospital, Rouen | 156 | 2025-07-07 | 2026-06-10 | |
| Moderate Aerobic Exercise for Managing Menstrual Cycle Symptoms Moderate Aerobic Exercise - Premenstrual Syndrome, Menstrual Cycle | Not applicable | Recruiting | University of Colorado, Colorado Springs | 35 | 2025-07-01 | 2025-07-24 |
| Myo-Inositol and D-Chiro-Inositol for Menstrual Irregularities and Hormone Changes in Women With Polycystic Ovarian Syndrome Myo-Inositol and D-Chiro-Inositol Combination Therapy, placebo (folic acid) - Polycystic Ovary Syndrome (PCOS), Myo-inositol | Phase 4 | Completed | Nishtar Medical University | 60 | 2025-06-01 | 2026-07-14 |
| Multicenter Observational Cohort Study on the Epidemiology of Therapeutic Strategies in Patients Affected by Adenomyosis This is a non-interventional study. Treatment allocation will not be influenced by the study protocol. - Adenomyosis of Uterus, Uterine Diseases | Recruiting | SCHETTINI SERGIO | 200 | 2025-06-01 | 2026-03-17 | |
| A Clinical Study of the Aqua Therapeutics Thermal Therapy Vapor Ablation System in Premenopausal Women With Abnormal Uterine Bleeding Aqua Therapeutics Thermal Therapy Vapor Ablation System (ATTTVAS) - Menorrhagia | Not applicable | Recruiting | Aqua Therapeutics, Inc. | 43 | 2025-04-08 | 2026-10-30 |
| Transcutaneous Auricular Neurostimulation as a Treatment for Women With Heavy Menstrual Bleeding: A Dose-finding Trial Volta System - Heavy Menstrual Bleeding | Not applicable | Completed | Spark Biomedical, Inc. | 40 | 2025-02-14 | 2025-09-26 |
| HIFU Versus Myomectomy for the Treatment of Symptomatic Uterine Fibroids High-Intensity Focused Ultrasound (HIFU), myomectomy - Uterine Fibroids (UF) | Not applicable | Recruiting | Chinese University of Hong Kong | 112 | 2025-02-06 | 2026-03-27 |
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Leiomyoma (59) · Metrorrhagia (27) · Dysmenorrhea (17) · Adenomyosis (13) · Uterine Hemorrhage (10) · Endometriosis (8) · Hemostatic Disorders (8) · von Willebrand Diseases (8) · Hemorrhage (7) · Pelvic Pain (7) · Anemia, Iron-Deficiency (5) · Menstruation Disturbances (5) · Myoma (5) · Hemophilia A (4)
Female Urogenital Diseases (202) · Female Urogenital Diseases and Pregnancy Complications (202) · Genital Diseases (202) · Pathologic Processes (202) · Pathological Conditions, Signs and Symptoms (202) · Urogenital Diseases (202) · Genital Diseases, Female (201) · Uterine Diseases (201) · Menstruation Disturbances (197) · Hemorrhage (195) · Uterine Hemorrhage (192) · Neoplasms (62) · Neoplasms by Histologic Type (61) · Neoplasms, Connective and Soft Tissue (60) · Neoplasms, Muscle Tissue (60)
Tranexamic Acid (19) · Levonorgestrel (13) · Estradiol (9) · estradiol, norethindrone drug combination (9) · Norethindrone Acetate (8) · asoprisnil (7) · elagolix (7) · Medroxyprogesterone Acetate (6) · Uterine Artery Embolization (6) · relugolix (5) · Hysterectomy (4) · Uterine Myomectomy (4) · ulipristal acetate (4) · vilaprisan (4) · Iron (3)
Bayer (18) · AbbVie (8) · Assiut University (8) · Abbott (7) · Ferring Pharmaceuticals (5) · Gynesonics (5) · Minerva Surgical, Inc. (5) · Myovant Sciences GmbH (5) · Acessa Health, Inc. (3) · Baylor College of Medicine (3) · Birmingham Women's NHS Foundation Trust (3) · Ethicon, Inc. (3) · Oregon Health and Science University (3) · University of Sao Paulo (3) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (2)
United States (85) · Canada (17) · Netherlands (12) · United Kingdom (12) · China (10) · Czechia (10) · Brazil (9) · Mexico (9) · Poland (8) · Egypt (7) · France (7) · Germany (7) · Hungary (7) · Israel (7) · Italy (7)
David Toub, MD (3) · Navid Khodaparast, PhD (2) · ObsEva SA (2) · Abimbola O. Famuyide, MBBS (1) · Adam Magos, BSc MD FRCOG (1) · Ahmed Ali Mohamed Nasr, M.D (1) · Allison Wheeler (1) · Almereau Prollius, MD (1) · Amanda Yunker, DO (1)
PMID 31971678, PMID 34878624, PMID 36357960, PMID 37477173, PMID 37863160, PMID 21043553, PMID 23188490, PMID 30865281, PMID 32835865, PMID 33544889, PMID 33596357, PMID 33650259, PMID 34553161, PMID 34582715, PMID 35415708, PMID 35675604, PMID 36116480, PMID 37183454, PMID 39381651, PMID 39466126, PMID 40326221, PMID 40543832, PMID 12423842, PMID 15547547, PMID 15958000, PMID 16880310, PMID 17012455, PMID 17197583, PMID 17671809, PMID 18055721, PMID 18567277, PMID 18752459, PMID 19111789, PMID 19682342, PMID 19955104, PMID 20378611, PMID 20472114, PMID 20733445, PMID 20859150, PMID 20942615, PMID 21173651, PMID 21475963, PMID 21777897, PMID 21833452, PMID 21867401, PMID 22748952, PMID 22959906, PMID 23340271, PMID 23395927, PMID 24613404
2016 (3), 2017 (2), 2018 (2), 2014 (1), 2023 (1), 2025 (1), R21HD091337 (1), U01HL133815 (1)