15 completed, 7 unknown, 2 terminated, 1 active not recruiting. 9 Phase 2, 6 Phase 1, 4 Not applicable, 3 Phase 3, 3 Phase 4.
Follow Estriol: new trials by email Literature Review of Estriol trials Research Report on Estriol
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Er:YAG Laser Combined With Vaginal Estriol for Genitourinary Syndrome of Menopause Topical estrogen therapy based on estriol (E3), Active Er:YAG Laser, Sham Er:YAG laser (minimal fluence) - Genitourinary Syndrome of Menopause | Not applicable | Recruiting | University of Nove de Julho | 60 | 2025-12-10 | 2026-04-23 |
| Vaginal Prasterone Versus Estriol in Women With Pelvic Floor Disorders Prasterone (DHEA), Estriol - Pelvic Organ Prolapse (POP), Stress Urinary Incontinence (SUI) | Not applicable | Completed | Poznan University of Medical Sciences | 74 | 2022-10-01 | 2026-10-08 |
| A Randomized Controlled Phase 2 Study to Determine Lowest Efficacious Dose of Ovestin in Vulvar and Vaginal Atrophy Estriol, Placebo - Vaginal Atrophy | Phase 2 | Withdrawn | Aspen USA Inc | 2021-06-05 | 2021-07-23 | |
| Evaluating the Efficacy of Temperature-controlled Radiofrequency (TRF) in the Treatment of Vulvovaginal Atrophy. high frequency fulguration equipment, promestriene vaginal soft capsules - Postmenopausal Vulvovaginal Atrophy | Not applicable | Unknown | Peking University People's Hospital | 200 | 2020-12-08 | 2021-03-22 |
| LASER and Radiofrequency and Genitourinary Syndrome of Menopause LASER, Microablative Radiofrequency, Estriol - Postmenopausal Atrophic Vaginitis, Postmenopausal Symptoms | Not applicable | Active not recruiting | Federal University of São Paulo | 195 | 2019-08-05 | 2025-04-22 |
| Estriol and Trimegestone Dose-response Trial With Single Dose Application of Vaginal Rings Estriol 0.400 mg/day and Trimegestone 0.06 mg/day, Estriol 0.300 mg/day and Trimegestone 0.12 mg/day, Estriol 0.200 mg/day and Trimegestone 0.18 mg/day - Pregnancy | Phase 1 | Completed | Galeno Desenvolvimento de Pesquisas Clínicas | 36 | 2017-11-10 | 2020-05-07 |
| Use of Estriol at Distal Third of Vagina Improving Coital Pain in Post-menopause Women Estriol, Distal estriol, Vaginal Gel - Dyspareunia, Menopause | Phase 1 | Completed | University of Sao Paulo | 125 | 2017-06-01 | 2024-10-16 |
| The Reciprocal Relations Between Psychosocial Characteristics and the Progression of Vestibulodynia Pelvic floor physical therapy, estriol cream (ovestin), Low-level-laser therapy - Localized Provoked Vulvodynia | Completed | Meir Medical Center | 113 | 2016-11-30 | 2022-04-08 | |
| Vaginal Estriol Before and Vaginal Surgery for Prolapse estriol, vaginal surgery - Genital Prolapse | Phase 4 | Unknown | Salvatore Caruso | 88 | 2016-11-01 | 2016-09-19 |
| Study Evaluating the Efficacy and Safety of Three Formulations of Ultra-low Dose Estriol Vaginal Gel (0.005%, 0.002%, 0.0008% Estriol Vaginal Gel) for the Treatment of Vaginal Dryness in Postmenopausal Women With Vulvovaginal Atrophy Estriol, Placebo - Vaginal Atrophy | Phase 2 | Completed | ITF Research Pharma, S.L.U. | 283 | 2016-10-01 | 2019-09-25 |
| Pharmacokinetics and Pharmacodynamics of 3 Dosages of Estriol After Continuous Vaginal Administration for 21 Days Estriol 0.125 mg/day, Estriol 0.250 mg/day, Estriol 0.500 mg/day - Menopause | Phase 1 | Completed | Galeno Desenvolvimento de Pesquisas Clínicas | 31 | 2016-09-23 | 2017-12-06 |
| The Treatment Effect of Chinese Herbal Compound Ointment on Atrophic Vaginitis Chinese Herbal Compound Ointment, Estriol - Atrophic Vaginitis | Phase 1 | Unknown | First Affiliated Hospital, Sun Yat-Sen University | 80 | 2016-02-01 | 2016-04-11 |
| A Clinical Trial to Assess the Safety of 0.005 % Estriol Vaginal Gel in Hormone Receptor-Positive Postmenopausal Women With Early Stage Breast Cancer in Treatment With Aromatase Inhibitor in the Adjuvant Setting estriol, Placebo - Vaginal Atrophy | Phase 2 | Completed | ITF Research Pharma, S.L.U. | 61 | 2015-10-16 | 2019-08-05 |
| Evaluation of Fractional CO2 Laser Treatment Efficacy and Comparison to Vaginal Estrogen Therapy in Postmenopausal Women With Vulvovaginal Atrophy CO2 laser, Estrogen, Placebo of Estrogen - Vulvovaginal Atrophy | Phase 3 | Completed | Faculdade de Medicina do ABC | 45 | 2015-03-01 | 2016-06-28 |
| Vaginal Estrogens Comparative Trial on Pelvic Organ Prolapse Patients Conjugated Estrogen, Promestriene, Estriol - Vaginitis Atropic, Pelvic Organ Prolapse | Phase 4 | Completed | Universidade Federal do Paraná | 69 | 2013-11-26 | 2019-05-01 |
| Estriol Treatment in Multiple Sclerosis (MS): Effect on Cognition estriol, Placebo, Norethindrone - Relapsing-remitting Multiple Sclerosis, Secondary-progressive Multiple Sclerosis | Phase 2 | Unknown | University of California, Los Angeles | 64 | 2011-10-01 | 2019-11-06 |
| North American Study of Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT) Sterile saline, Bevacizumab, Estriol - Telangiectasia, Hereditary Hemorrhagic, Epistaxis | Phase 2 | Completed | James Gossage | 123 | 2011-08-01 | 2018-10-19 |
| Clinical Study of Vaginal Lactobacilli and Estriol (Gynoflor®) for Atrophic Vaginitis in Breast Cancer Patients Estriol 0.03 mg, lyophylized lactobacillus - Atrophic Vaginitis | Phase 1 | Completed | Medinova AG | 16 | 2011-04-01 | 2024-10-15 |
| Postpartum Dyspareunia Resulting From Vaginal Atrophy Estriol 0.1% vaginal cream - Vulvovaginal Atrophy, Dyspareunia Among Puerperal Women | Completed | Meir Medical Center | 117 | 2011-03-01 | 2015-04-08 | |
| Topical Estriol for Vaginal Health estriol, Placebo - Vaginal Health | Phase 1 | Completed | Gynuity Health Projects | 104 | 2009-06-01 | 2011-03-04 |
Showing 20 of 27. Sign in to see all of them.
Atrophic Vaginitis (5) · Multiple Sclerosis (2) · Multiple Sclerosis, Relapsing-Remitting (2) · Pelvic Organ Prolapse (2) · Premenstrual Syndrome (2) · Breast Neoplasms (1) · Dyspareunia (1) · Endometrial Hyperplasia (1) · Epistaxis (1) · Multiple Sclerosis, Chronic Progressive (1) · Prolapse (1) · Sexual Dysfunction, Physiological (1) · Telangiectasia, Hereditary Hemorrhagic (1) · Urinary Incontinence, Stress (1) · Urinary Tract Infections (1)
EVE Medical Systems Ltd. (2) · Galeno Desenvolvimento de Pesquisas Clínicas (2) · ITF Research Pharma, S.L.U. (2) · Meir Medical Center (2) · University of California, Los Angeles (2) · Aspen USA Inc (1) · Faculdade de Medicina do ABC (1) · Federal University of São Paulo (1) · First Affiliated Hospital, Sun Yat-Sen University (1) · Gynuity Health Projects (1) · Italfarmaco S.A (1) · James Gossage (1) · Jeanne Drisko, MD, CNS, FACN (1) · Maire Mac Bride (1) · Medinova AG (1)
Brazil (6) · United States (6) · Israel (4) · Spain (3) · China (2) · Sweden (2) · Belgium (1) · Canada (1) · Czechia (1) · Germany (1) · Hungary (1) · Italy (1) · Poland (1) · South Korea (1)
Gilberto De Nucci, MD (2) · Rhonda Voskuhl, M.D. (2) · Ahinoam Lev-Sagie, MD (1) · Anne Cross, M.D. (1) · Anthony Reder, M.D. (1) · Antonio Cianci, Prof (1) · Avner Reshef, Dr. (1) · Barbara Giesser, M.D. (1) · Corey Ford, M.D. (1) · Dean Wingerchuk, M.D. (1) · Dina Jacobs, M.D. (1) · Elliot Frohman, M.D. (1) · Gareth Parry, M.D. (1) · Gilbert Donders, Prof. Dr. (1) · Jacob Cohen, Dr. (1)
PMID 37431855, PMID 37619252, PMID 10782451, PMID 12050564, PMID 14583935, PMID 15189832, PMID 15779109, PMID 15804736, PMID 17262148, PMID 19170834, PMID 22914208, PMID 23848490, PMID 23985562, PMID 24605832, PMID 24718774, PMID 25333211, PMID 25427450, PMID 26079974, PMID 26223323, PMID 26621682, PMID 27599329, PMID 32459035, PMID 38085184, PMID 40709601, PMID 42276807, PMID 6880820
2014 (1), 2015 (1), R01NS051591 (1), UL1TR000135 (1)