46 completed, 7 unknown, 5 recruiting, 2 active not recruiting. 18 Phase 1, 16 Phase 3, 11 Not applicable, 9 Phase 2, 8 Phase 4.
Follow drospirenone: new trials by email Literature Review of drospirenone trials Research Report on drospirenone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Randomized Feasibility Trial Comparing Drospirenone and Norethindrone for Postpartum Hypertension Management in Preeclampsia Norethindrone 0.35 MG, Drospirenone - Hypertension, Preeclampsia | Phase 4 | Not yet recruiting | Oregon Health and Science University | 50 | 2026-07-01 | 2025-12-19 |
| A Drug-drug Interaction Study to Evaluate the Effects of Pelabresib on the Pharmacokinetics of Repaglinide, Midazolam, and Combined Oral Contraceptive in Patients With Advanced Malignancies pelabresib, repaglinide, midazolam - Advanced Malignancies | Phase 1 | Recruiting | Novartis Pharmaceuticals | 24 | 2026-06-12 | 2026-10-09 |
| Efficacy of Oral Contraceptive, Progesterone, and Inositol on Menstrual Regulation in PCOS Combined Oral Contraceptive (Ethinylestradiol 0.03 mg + Drospirenone 3 mg), Inositol mid-level volume, Dydrogesterone Pill - Polycystic Ovary Syndrome (PCOS) | Not applicable | Recruiting | Ege University | 150 | 2025-12-01 | 2025-12-18 |
| Ultra-Safe Hormonal Strategy: Transdermal Estradiol Added to Progestins for Endometriosis Drospirenone 4 mg orally, Dienogest 2 mg orally - Endometriosis | Active not recruiting | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | 138 | 2025-08-11 | 2025-10-02 | |
| A Drug-Drug Interaction Study Between HS-10374 Tablets and Drospirenone and Ethinyl Estradiol Tablets(Yasmin®) HS-10374 tablets, Drospirenone and Ethinyl Estradiol tablets - Psoriasis (PsO) | Phase 1 | Completed | Hansoh BioMedical R&D Company | 18 | 2025-05-28 | 2025-09-18 |
| "Quick-starting" of a New Combined Hormonal Contraceptive Pills, 15 mg Estetrol/3 mg Drospirenone VS 20 mcg Ethinylestradiol/75 mcg Gestodene Focusing on Ovulation Inhibition Estetrol 15 mg/Drospirenone 3 mg (24/4), Ethinylestradiol (EE) 20 mcg/Gestodene 75 mcg (21/7) - Ultrasound Finding: Ovulation Inhibition, Ovarian Activities, Cervical Mucus | Not applicable | Completed | Chulalongkorn University | 36 | 2024-05-01 | 2025-05-20 |
| Pharmacokinetics of Drospirenone Only Pills: A Pre- and Post-Bariatric Surgery Study Drospirenone - Contraception | Phase 1 / Phase 2 | Recruiting | Chulalongkorn University | 16 | 2024-04-18 | 2026-03-19 |
| Drospirenone Only Pills and Cervical Mucus Changes: A Pre- and Post-Bariatric Surgery Study Drospirenone - Contraception | Not applicable | Recruiting | Chulalongkorn University | 16 | 2024-04-18 | 2026-03-18 |
| Evaluate the Pharmacokinetics of a Combined Oral Contraceptive (COC) With and Without Obicetrapib Obicetrapib, Obicetrapib + Drospirenone / Ethinyl Estradiol (COC), Drospirenone / Ethinyl Estradiol (COC) - Healthy Volunteers | Phase 1 | Completed | NewAmsterdam Pharma | 30 | 2024-02-05 | 2024-09-19 |
| Evaluation of the Efficacy and Safety of Drospirenone in the Treatment of Adenomyosis Drospirenone 4 MG - Adenomyosis | Unknown | University of Palermo | 40 | 2023-12-30 | 2023-12-18 | |
| Prospective Evaluation on the Role Exerted by Hormonal Contraceptives on 24-h Blood Pressure. A Prospective Observational Study Ethynyl estradiol and Drospirenone, Drospirenone, Estetrol and Drospirenone - Cardiovascular System Diseases (&Amp; [Cardiac]) | Recruiting | Ospedale Policlinico San Martino | 96 | 2023-10-10 | 2025-07-11 | |
| A Study of LY3437943 in Postmenopausal Female Participants Who Are Overweight or Obese LY3437943, Ethinyl Estradiol, Drospirenone - Overweight | Phase 1 | Completed | Eli Lilly and Company | 46 | 2023-09-12 | 2024-07-26 |
| Oral Contraceptives for Treating Premenstrual Dysphoric Disorder in Bipolar Disorder Yaz, Placebo - Premenstrual Dysphoric Disorder, Bipolar Disorder | Phase 2 | Completed | St. Joseph's Healthcare Hamilton | 17 | 2023-02-03 | 2024-09-23 |
| Efficacy and Safety of Dingkundan Combined With Combination Oral Contraceptives in the Treatment of PCOS DingKunDan(GuangYuYuan), Drospirenone and Ethinylestradiol Tablets (Ⅱ) - PCOS | Not applicable | Completed | Guangdong Women and Children Hospital | 120 | 2023-02-01 | 2024-05-30 |
| A Study of Milvexian in Healthy Adult Females Milvexian, Midazolam, Ethinylestradiol - Healthy Female | Phase 1 | Completed | Janssen Pharmaceutica N.V., Belgium | 20 | 2023-01-25 | 2025-03-30 |
| The Use of Drospirenone/Estetrol in Random Start Rapid Endometrial Preparation drospirenone/estetrol 3mg/14.2mg - Endometrial Polyp, Endometrial Diseases | Phase 4 | Completed | University of Palermo | 80 | 2023-01-01 | 2024-04-08 |
| Efficacy, Safety, and Tolerability of LPRI-CF113 as an Oral Contraceptive in Females Drospirenone - Contraception, Change in Bone Mineral Density | Phase 3 | Completed | Insud Pharma | 1542 | 2022-08-02 | 2025-10-08 |
| LF111 or Drospirenone Chew vs Non-hormonal Contraceptive Methods on Bone Mineral Density in Adolescent and Adult Women drospirenone 4 mg oral tablet or drospirenone 3.5 mg chewable tablet - Change in Bone Mineral Density, Bone Loss | Phase 4 | Active not recruiting | Insud Pharma | 1536 | 2022-03-28 | 2026-04-09 |
| The Association of Hormonal Intake and Demographic Factors With Breast Cancer Risk. An Egyptian Case-controlled Study Dydrogesterone Tablets, Norethisterone acetate, Ethinyl estradiol, Drospirenone and ethinyl estradiol - Observational Study | Unknown | NewGiza University | 200 | 2021-11-16 | 2021-11-26 | |
| Study in Women on the Effect of JNJ-64530440 on Oral Contraceptive and Midazolam, and the Effect of a High-fat Meal on JNJ-64530440 Drospirenone/Ethinylestradiol, Midazolam, JNJ-64530440 - Healthy | Phase 1 | Withdrawn | Janssen Research & Development, LLC | 2021-06-01 | 2021-03-26 |
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Polycystic Ovary Syndrome (6) · Acne Vulgaris (3) · Obesity (3) · Adenomyosis (2) · Bipolar Disorder (2) · Depression (2) · Hot Flashes (2) · Overweight (2) · Premenstrual Syndrome (2) · Anxiety Disorders (1) · Bone Diseases, Metabolic (1) · Cardiovascular Diseases (1) · Contraception Behavior (1) · Dysmenorrhea (1) · Endometriosis (1)
Bayer (17) · Estetra (5) · Chulalongkorn University (4) · Janssen Research & Development, LLC (3) · Massachusetts General Hospital (3) · Insud Pharma (2) · Teva Pharmaceuticals USA (2) · University of Palermo (2) · Adana Numune Training and Research Hospital (1) · Ain Shams Maternity Hospital (1) · Cairo University (1) · Catholic University of the Sacred Heart (1) · Center for Epidemiology and Health Research, Germany (1) · Denusa Wiltgen (1) · Ege University (1)
United States (21) · Germany (7) · Italy (7) · China (5) · Netherlands (4) · Thailand (4) · Belgium (3) · Canada (3) · Brazil (2) · Egypt (2) · Russia (2) · Turkey (Türkiye) (2) · Argentina (1) · Austria (1) · Czechia (1)
Enrico Colli, MD (3) · Anthony R Godfrey, Pharm.D. (2) · Christine Klipping (2) · Punyawee Utaipatanacheep (2) · Ahmed Maged, MD (1) · Alexandra B Kimball, MD, MPH (1) · Alexandra B. Kimball, MD, MPH (1) · Andrea Dunaif, MD (1) · Angelo Cagnacci, MD, PhD (1) · Benicio N Frey, MD, MSc,PhD (1) · Carmen Georgescu (1)
PMID 33008401, PMID 10560680, PMID 11245554, PMID 19461456, PMID 21721590, PMID 26232513, PMID 27467196, PMID 28433989, PMID 29634911, PMID 31493139, PMID 32202076, PMID 32312141, PMID 36103980, PMID 36316023, PMID 37023457, PMID 37544572, PMID 7500749, PMID 7500750, PMID 9673838, PMID 11056261, PMID 11433905, PMID 12633759, PMID 12841897, PMID 15471507, PMID 16985015, PMID 17434015, PMID 18827119, PMID 21277674, PMID 21288628, PMID 21903192, PMID 22067789, PMID 22067790, PMID 22228322, PMID 22713099, PMID 22901973, PMID 22909145, PMID 23046709, PMID 23531117, PMID 23534865, PMID 23610531, PMID 23963307, PMID 23963309, PMID 24105072, PMID 24105751, PMID 24341612, PMID 2449395, PMID 25017924, PMID 26073333, PMID 26405263, PMID 27093642
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