32 completed, 5 unknown, 4 recruiting, 2 terminated. 46 Phase 3, 9 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 46 | Completed 32, Unknown 5, Recruiting 4, Terminated 2, Withdrawn 2, Active not recruiting 1 |
| Phase 2 | 9 | Completed 5, Recruiting 3, Terminated 1 |
Follow Menopause: new trials by email Literature Review of Menopause trials Research Report on Menopause
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Focusing on the Menopausal Transition to Improve Mid-Life Women's Health Metformin, semaglutide, Anti-hypertensives - Menopause, Menopause Hot Flashes | Phase 2 / Phase 3 | Recruiting | University of Colorado, Denver | 200 | 2026-03-01 | 2026-11-03 |
| Estradiol and Testosterone Subdermal Implants for Menopause Treatment (ESTIME) testosterone pellet (100 mg), Placebo - Menopause, Testosterone Deficiency | Phase 3 | Recruiting | University of Sao Paulo General Hospital | 140 | 2025-12-18 | 2025-12-29 |
| Hydration and Acceptability of the Genital and Skin Mucosa of a Vaginal Moisturizer in Menopausal Women 0.20% sodium hyaluronate gel - Vaginismus, Vaginal Atrophy | Phase 3 | Unknown | Biolab Sanus Farmaceutica | 45 | 2025-03-01 | 2024-08-21 |
| The MUSE Study for Menopausal Arthralgia Menopausal hormone therapy, Exercise training, Menopausal hormone therapy + exercise training - Arthralgia, Menopause | Phase 2 / Phase 3 | Recruiting | National University Hospital, Singapore | 100 | 2024-08-01 | 2024-07-31 |
| Effect of Local Estriol Treatment Before Vaginal Repair Surgery estriol cream - Pelvic Organ Prolapse, Pelvic Floor Disorders | Phase 3 | Active not recruiting | Hatice Tukenmez Kurnaz | 36 | 2024-04-01 | 2025-02-05 |
| Testosterone Effects on Pelvic Floor Muscles Testosterone Enanthate, Placebo - Urinary Incontinence, Menopause | Phase 3 | Withdrawn | Brigham and Women's Hospital | 2021-01-01 | 2022-07-20 | |
| Clinical Trial on the Preventive Effect of Intravaginal Prasterone on Recurrent Urinary Tract Infections in Postmenopausal Women Prasterone, Placebo - Recurrent Urinary Tract Infection, Postmenopause | Phase 3 | Withdrawn | Olivia Cardenas-Trowers, M.D. | 2020-05-01 | 2021-06-30 | |
| Autologous PRP Intra Ovarian Infusion to Restore Ovarian Function in Menopausal Women Autologous PRP intra ovarian infusion, Autologous PFP intra ovarian infusion - Infertility, Female, Anovulatory Infertility | Phase 2 / Phase 3 | Recruiting | Genesis Athens Clinic | 100 | 2019-05-21 | 2026-07-08 |
| Examining Effects of Intrarosa in Women With Genitourinary Syndrome of Menopause/Vulvovaginal Atrophy Intrarosa, Placebos - Menopause, Genitourinary Syndrome of Menopause | Phase 3 | Unknown | Center for Vulvovaginal Disorders | 40 | 2019-03-02 | 2019-01-31 |
| The Vaginal Health Trial Vagifem, Replens, Placebo tablet - Atrophy of Vagina, Menopause | Phase 3 | Completed | Fred Hutchinson Cancer Center | 302 | 2016-04-01 | 2018-07-12 |
| Effect of Oral Estradiol and Progesterone Therapy on Vaginal Cytokines in Postmenopausal Women oral estradiol 1.0 mg, oral progesterone 100 mg - Menopause | Phase 3 | Completed | Intira Sriprasert | 20 | 2015-12-01 | 2020-03-19 |
| A Study To Investigate The Effect Of A Natural Dietary Supplement On Peri-Menopausal Symptoms proprietary formula - Menopause | Phase 2 / Phase 3 | Terminated | Physician Recommended Nutriceuticals | 20 | 2015-03-01 | 2016-08-04 |
| Estradiol Vaginal Softgel Capsules in Treating Symptoms of Vulvar and Vaginal Atrophy in Postmenopausal Women Estradiol, Placebo - Vulvovaginal Atrophy, Menopause | Phase 3 | Completed | TherapeuticsMD | 764 | 2014-09-01 | 2017-05-25 |
| Black Cohosh Extract for Treatment of Moderate to Severe Menopausal Symptoms black cohosh extract, Placebo - Menopause, Quality of Life | Phase 3 | Unknown | Navamindradhiraj University | 60 | 2014-03-01 | 2014-09-25 |
| A Safety and Efficacy Study of the Combination Estradiol and Progesterone to Treat Vasomotor Symptoms Estradiol, Progesterone, Placebo - Menopause | Phase 3 | Completed | TherapeuticsMD | 1845 | 2013-08-05 | 2019-05-06 |
| Qing'E Formula Therapy on Menopausal Symptoms Qing'E pills, Placebo - Menopause | Phase 2 / Phase 3 | Completed | Shanghai University of Traditional Chinese Medicine | 240 | 2013-03-01 | 2019-04-05 |
| Therapy to Prevent Sexual Pain in Breast Cancer Survivors Topical liquid lidocaine, Topical saline - Vulvodynia, Dyspareunia | Phase 3 | Completed | OHSU Knight Cancer Institute | 50 | 2011-12-01 | 2017-04-14 |
| Boceprevir/PegIFN α-2b/Riba in HCV+ Gt1 Menopausal Women, Nonresponders to PegIFN/Riba or Treatment-naives (MEN_BOC) Pegylated Interferon, Ribavirin, Boceprevir - Chronic Hepatitis C, Menopause | Phase 3 | Unknown | University of Modena and Reggio Emilia | 240 | 2011-11-01 | 2012-10-02 |
| Perimenopausal Estrogen Replacement Therapy Study Estradiol, Placebo - Perimenopause, Menopause | Phase 2 / Phase 3 | Completed | University of North Carolina, Chapel Hill | 172 | 2010-10-01 | 2017-08-22 |
| Study to Assess Efficacy of Risedronate in Preventing Bone Loss in Postmenopausal Women Treated for Breast Cancer Risedronate, Placebo - Breast Cancer, Menopause | Phase 3 | Completed | Hospices Civils de Lyon | 20 | 2009-11-01 | 2013-10-31 |
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Hot Flashes (6) · Dyspareunia (5) · Osteoporosis (5) · Bone Diseases, Metabolic (4) · Breast Neoplasms (2) · Amenorrhea (1) · Arthralgia (1) · Blushing (1) · Cardiovascular Diseases (1) · Depression (1) · Diabetes Mellitus (1) · Fever (1) · Fractures, Bone (1) · Heart Diseases (1) · Hepatitis C, Chronic (1)
Pathological Conditions, Signs and Symptoms (13) · Female Urogenital Diseases (10) · Female Urogenital Diseases and Pregnancy Complications (10) · Signs and Symptoms (10) · Urogenital Diseases (10) · Male Urogenital Diseases (8) · Genital Diseases (7) · Genital Diseases, Female (7) · Mental Disorders (7) · Musculoskeletal Diseases (7) · Metabolic Diseases (6) · Nutritional and Metabolic Diseases (6) · Sexual Dysfunction, Physiological (6) · Sexual Dysfunctions, Psychological (6) · Bone Diseases (5)
Estradiol (12) · Progesterone (4) · Dehydroepiandrosterone (2) · Estrogens, Conjugated (USP) (2) · Medroxyprogesterone Acetate (2) · Mirtazapine (2) · black cohosh root extract (2) · Angiotensin Receptor Antagonists (1) · Antihypertensive Agents (1) · Diet, Fat-Restricted (1) · Estrogens (1) · Exercise (1) · Gabapentin (1) · Genistein (1) · Hormone Replacement Therapy (1)
Novo Nordisk A/S (6) · Wyeth is now a wholly owned subsidiary of Pfizer (3) · Duramed Research (2) · Merck Sharp & Dohme LLC (2) · TherapeuticsMD (2) · Bayer (1) · Biolab Sanus Farmaceutica (1) · Boehringer Ingelheim (1) · Brigham and Women's Hospital (1) · Center for Vulvovaginal Disorders (1) · Centro A.F. de Estudios Tecnologicos, S.A. (1) · Columbia University (1) · Federal University of São Paulo (1) · Fred Hutchinson Cancer Center (1) · Genesis Athens Clinic (1)
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Adi Cohen, MD (1) · Agni Pantou, MD (1) · Andrea Z LaCroix, PhD (1) · Caroline Mitchell, MD, MPH (1) · David F Archer, MD (1) · Debra Butt, MSc MD CCFP (1) · Edmund Baracat, PhD (1) · Elizabeth Shane, MD (1)
PMID 18165394, PMID 18978105, PMID 20859151, PMID 30712391, PMID 17453860, PMID 17487652, PMID 17577003, PMID 1791769, PMID 18053998, PMID 18178111, PMID 18202966, PMID 19252451, PMID 20888118, PMID 21824950, PMID 23635731, PMID 24438370, PMID 24807329, PMID 25469044, PMID 25835751, PMID 26215946, PMID 27187320, PMID 28355090, PMID 29322164, PMID 29554173, PMID 29738424, PMID 29889748, PMID 30238814, PMID 30586005, PMID 30601452, PMID 30994576, PMID 31364889, PMID 31688572, PMID 31838497, PMID 31913228, PMID 32706883, PMID 32740481, PMID 32932401, PMID 33038141, PMID 33110039, PMID 33288437, PMID 33367735, PMID 33675793, PMID 34054104, PMID 35213517, PMID 35353163, PMID 36374501, PMID 37402281, PMID 37619252, PMID 38979716
2004 (2), 2023 (1), R01AR048932 (1), R01HL045167 (1), R01MH087619 (1)