12 completed, 5 unknown, 2 terminated, 1 withdrawn. 6 Phase 2, 6 Phase 3, 3 Not applicable, 3 Phase 1, 3 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 6 | Completed 5, Withdrawn 1 |
| Phase 3 | 6 | Unknown 3, Completed 2, Terminated 1 |
| Not applicable | 3 | Completed 3 |
| Phase 1 | 3 | Completed 2, Terminated 1 |
| Phase 4 | 3 | Unknown 2, Completed 1 |
Follow black cohosh root extract: new trials by email Literature Review of black cohosh root extract trials Research Report on black cohosh root extract
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Menopause Relief EP-40 in Women With Menopausal Symptoms Menopause Relief EP-40, Low Dose Black Cohosh, High Dose Black Cohosh - Menopause | Phase 2 | Completed | EuroPharma, Inc. | 220 | 2018-10-01 | 2020-04-28 |
| Remifemin Preventing the Climacteric Symptoms in Breast Cancer Remifemin - Effect of Drugs, Safety Issues | Phase 2 | Completed | Zhejiang Cancer Hospital | 85 | 2017-01-04 | 2018-07-06 |
| Black Cohosh for Host Flashes Due to Androgen Deprivation Therapy Black Cohosh, Placebo - Hot Flashes | Phase 2 | Withdrawn | Midwestern Regional Medical Center | 2016-11-01 | 2017-12-26 | |
| Black Cohosh Extract for Treatment of Moderate to Severe Menopausal Symptoms black cohosh extract, Placebo - Menopause, Quality of Life | Phase 3 | Unknown | Navamindradhiraj University | 60 | 2014-03-01 | 2014-09-25 |
| Breast Cancer, Sexuality and Black Cohosh WHOQOL questionnaire, FSFI questionnaire, kupperman scale - Sexuality | Phase 4 | Unknown | Irmandade da Santa Casa de Misericordia de Sao Paulo | 60 | 2014-01-01 | 2017-03-20 |
| A Pilot Pre-operative Window Trial of Black Cohosh in Women With Ductal Carcinoma in Situ Black cohosh - Ductal Carcinoma in Situ | Not applicable | Completed | Yale University | 33 | 2012-06-01 | 2023-10-13 |
| Black Cohosh Extract for the Management of Moderate to Severe Menopausal Symptoms in Thai Women cimicifuga racemosa, placebo - Hot Flashes | Phase 3 | Unknown | Mahidol University | 54 | 2011-12-01 | 2011-12-29 |
| Efficacy and Safety for Cimicifuga/Hypericum Product Cimicifuga + Hiperico, Cimicifuga Herbarium, Aplause® - Perimenopausal Disorder | Phase 3 | Unknown | Phytopharm Consulting Brazil | 210 | 2011-11-01 | 2011-11-29 |
| Effect of Exercise and Phytoestrogen on Bone, Metabolic Syndrome Criteria and Complaints of the Early Menopause exercise, exercise + cimicifuga racemosa, wellness control, placebo - Bone Diseases, Metabolic Syndrome X | Phase 3 | Terminated | University of Erlangen-Nürnberg Medical School | 126 | 2008-04-01 | 2015-05-28 |
| Safety Study of Black Cohosh Use by Postmenopausal Women on the Liver Cimicifuga racemosa extract for the group - Menopause | Not applicable | Completed | Assiut University | 100 | 2008-01-01 | 2009-08-03 |
| Black Cohosh as Alternative Therapy for Treating Menopause-Related Anxiety Black cohosh - Generalized Anxiety Disorder, Menopause | Phase 4 | Completed | University of Pennsylvania | 50 | 2005-07-01 | 2010-03-02 |
| Comparison of the Efficacy and Tolerability of Black Cohosh Vs Tibolone in Patients With Menopausal Symptoms Black Cohosh (iCR) or tibolone - Menopause | Phase 3 | Completed | Schaper & Bruemmer GmbH & Co KG | 240 | 2004-09-01 | 2006-03-06 |
| Black Cohosh in Treating Hot Flashes in Women Who Have or Who Are At Risk of Developing Breast Cancer black cohosh, placebo - Breast Cancer, Hot Flashes | Phase 3 | Completed | Alliance for Clinical Trials in Oncology | 132 | 2003-10-01 | 2016-07-13 |
| A Study of the Pharmacokinetics of Black Cohosh Black cohosh - Hot Flashes | Phase 1 | Terminated | National Center for Complementary and Integrative Health (NCCIH) | 12 | 2003-08-01 | 2009-12-11 |
| Black Cohosh Extract in Postmenopausal Breast Health Black Cohosh Extract (BCE) - Menopause, Hot Flashes | Phase 1 / Phase 2 | Completed | National Center for Complementary and Integrative Health (NCCIH) | 73 | 2003-07-01 | 2007-12-07 |
| Use of Black Cohosh and Red Clover for the Relief of Menopausal Symptoms Cimicifuga racemosa, Trifolium pratense, Black cohosh - Hot Flashes, Menopause | Phase 2 | Completed | National Center for Complementary and Integrative Health (NCCIH) | 112 | 2003-04-01 | 2007-10-12 |
| Herbal Alternatives for Menopause Symptoms (HALT Study) Black cohosh, Multibotanical preparation, Multibotanical preparation + dietary soy counseling - Vasomotor Symptoms Associated With Menopause | Phase 4 | Unknown | Kaiser Permanente | 351 | 2001-06-01 | 2005-09-15 |
| Single-Dose Study of Black Cohosh and Red Clover Cimicifuga racemosa, Trifolium pratense - Menopause | Phase 1 | Completed | National Center for Complementary and Integrative Health (NCCIH) | 30 | 2001-02-01 | 2007-03-02 |
| Alternative Therapies for Menopause: A Randomized Trial Hormone Replacement Therapy, Cimicifuga racemosa (Black Cohosh), Multibotanical phytoestrogen formula - Menopause, Hot Flashes | Not applicable | Completed | National Institute on Aging (NIA) | 355 | 2000-07-01 | 2009-12-11 |
| Effects of Black Cohosh on Menopausal Hot Flashes Black Cohosh - Postmenopause, Hot Flashes | Phase 2 | Completed | National Center for Complementary and Integrative Health (NCCIH) | 1999-09-01 | 2006-08-18 |
Hot Flashes (10) · Breast Neoplasms (3) · Anxiety Disorders (1) · Bone Diseases (1) · Carcinoma, Intraductal, Noninfiltrating (1) · Coronary Disease (1) · Depression (1) · Generalized Anxiety Disorder (1) · Metabolic Syndrome (1) · Motor Activity (1) · Osteoporosis (1) · Osteoporosis, Postmenopausal (1) · Primary Ovarian Insufficiency (1) · Sexual Dysfunction, Physiological (1) · Sexuality (1)
National Center for Complementary and Integrative Health (NCCIH) (5) · Alliance for Clinical Trials in Oncology (1) · Assiut University (1) · EuroPharma, Inc. (1) · Irmandade da Santa Casa de Misericordia de Sao Paulo (1) · Kaiser Permanente (1) · Mahidol University (1) · Midwestern Regional Medical Center (1) · National Institute on Aging (NIA) (1) · Navamindradhiraj University (1) · Phytopharm Consulting Brazil (1) · Schaper & Bruemmer GmbH & Co KG (1) · University of Erlangen-Nürnberg Medical School (1) · University of Pennsylvania (1) · Yale University (1)
United States (9) · Brazil (2) · China (2) · Thailand (2) · Egypt (1) · Georgia (1) · Germany (1)
Patsama Vichinsartvichai, MD (2) · Barbara A. Pockaj, MD (1) · Carla Vanin, MD MSc PhD (1) · Dr. Fredi Kronenberg (1) · Edward Sauter, MD (1) · Erin Hofstatter, MD (1) · Evan Pisick, MD (1) · Heather S Shaw, MD (1) · Jay D. Amsterdam, MD (1) · Katherine M Newton, PhD (1) · Lali Phkhaladze, PhD, MD (1) · Michael Bebenek, MS (1)
PMID 16186076, PMID 16782922, PMID 17179056, PMID 19609225, PMID 19745648, PMID 30935866, PMID 36444764
P50AT000090 (1), P50AT000155 (1), R01AG017057 (1), R21AT002289 (1)