35 completed, 21 unknown, 7 recruiting, 1 active not recruiting. 42 Not applicable, 3 Phase 4, 2 Phase 2, 1 Early Phase 1.
Follow Macular Holes: new trials by email Literature Review of Macular Holes trials Research Report on Macular Holes
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Full-Thickness Macular Hole Surgery: A Comparison of Ten Techniques Pars Plana Vitrectomy (PPV)-Based Macular Hole Surgery, Autologous Platelet-Rich Plasma (PRP), Human Amniotic Membrane (hAM) Graft - Macular Holes | Not applicable | Recruiting | Kazakh Eye Research Institute | 120 | 2026-05-25 | 2026-06-02 |
| Surgical Procedure Efficiency Evaluation stuDy UNITY VCS, CONSTELLATION - Cataract, Vitreous Hemorrhage | Recruiting | Alcon Research | 180 | 2026-02-09 | 2026-08-13 | |
| Autologous Tenon's Capsule Autograft for Large and Recurrent Full-Thickness Macular Holes Autologous Tenon's Capsule Autograft - Macular Holes, Macular Hole Surgery | Not applicable | Completed | Benha University | 50 | 2025-07-05 | 2026-08-12 |
| Comparison of Efficacy Between ILM Forceps Internal limiting membrane (ILM) Peeling with Sharkskin Forceps, Internal limiting membrane (ILM) Peeling with Standard Forceps - Macular Holes, Epiretinal Membrane | Phase 4 | Unknown | University of British Columbia | 56 | 2025-07-01 | 2025-03-30 |
| Intraocular Gas Tamponade for Treatment of Large Idiopathic Macular Holes Pars plana vitrectomy - Idiopathic Macular Hole, Macular Hole | Not applicable | Enrolling by invitation | The Filatov Institute of Eye Diseases and Tissue Therapy | 100 | 2025-02-01 | 2025-04-17 |
| Comparative Study of Decellularized Human Amniotic Membrane Hydrogel and Inverted Internal Limiting Membrane Flap in Idiopathic Large Macular Holes 25-gauge pars plana vitrectomy with inverted flap technique and SF6 tamponade, 25-gauge pars plana vitrectomy with complete internal limiting membrane peeling with amniotic membrane hydrogel filling and SF6 tamponade - Macular Holes | Not applicable | Recruiting | Walailak University | 26 | 2024-10-01 | 2026-09-09 |
| Small Macular Holes Treated With Air Postoperative intraocular tamponade - Macular Holes | Not applicable | Recruiting | Helse Stavanger HF | 132 | 2024-07-14 | 2024-11-06 |
| PEELED INTERNAL LIMITING MEMBRANE REPOSITION Peeled ILM Reposition, ILM Peeling - Macular Holes | Not applicable | Recruiting | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | 90 | 2024-04-15 | 2024-04-11 |
| GaslEss Macular Hole Surgery Gasless Macular hole surgery, Standard Macular hole surgery - Macular Holes | Not applicable | Not yet recruiting | King's College Hospital NHS Trust | 60 | 2024-01-01 | 2023-12-14 |
| Duration of Face Down Positioning for Full-Thickness Macular Hole Repair 3 Days of face-down positioning, 7 Days of face-down positioning - Macular Holes | Not applicable | Recruiting | St. Joseph's Healthcare Hamilton | 40 | 2023-11-21 | 2024-11-29 |
| Zeiss RESIGHT Disposable Lenses Evaluation Study ZEISS disposable - Retinal Detachment, Macular Pucker | Not applicable | Completed | Universitaire Ziekenhuizen KU Leuven | 120 | 2023-04-11 | 2024-08-26 |
| Platelet-rich Fibrin(PRF) Membrane in Ophthalmic Diseases PRF membrane tamponade surgery in macular hole, ILM peeling in macular hole, PRF membrane grafting in pterygium - Platelet-rich Fibrin, Macular Holes | Not applicable | Unknown | Lei Du | 170 | 2023-01-01 | 2024-01-12 |
| Autologous Platelet-rich Plasma as a Treatment for Macular Holes Pars plana vitrectomy, with or without epiretinal membrane peeling, plus PRGF membrane implantation - Macular Holes, Macular Hole of Left Eye (Disorder) | Completed | Clinica Oftalmologica Paredes | 13 | 2022-10-25 | 2024-03-21 | |
| Efficacy and Safety Evaluation of MONOBLUE DUAL View and MONOBLUE ILM View Vital Stains Macular Holes, Macular Pucker | Completed | Universitaire Ziekenhuizen KU Leuven | 100 | 2022-07-05 | 2022-08-26 | |
| Clinical Study of Translocated Internal Limiting Membrane Flap Reposition for the Treatment of Idiopathic Macular Hole Translocation ILM Flap, ILM Peeling - Macular Holes | Not applicable | Unknown | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | 76 | 2022-07-01 | 2023-10-30 |
| Treatment of Challenging Macular Holes Using Plasma Rich in Growth Factors Plasma rich in growth factors ( PRGF ) - Macular Holes | Phase 2 | Unknown | Minia University | 40 | 2022-06-01 | 2023-11-02 |
| To Evaluate the Therapeutic Efficacy of Hydrated Amniotic Membrane in Promoting Closure of Refractory Macular Holes. Hydrated Amniotic Membrane Plug, ILM filling, Conventional ILM peeling - Macular Holes | Not applicable | Unknown | Oriental Neurosurgery Evidence-Based-Study Team | 80 | 2022-06-01 | 2022-05-31 |
| Double Flap Technique for Macular Hole Surgical intervention - Macular Holes | Not applicable | Completed | Omer Othman Abdullah | 20 | 2022-01-01 | 2023-03-24 |
| Macular Micro Vascular Changes Following Macular Hole Repair : Optical Coherence Tomography Angiography Study pars plana vitrectomy - Macular Holes | Not applicable | Unknown | Fayoum University | 28 | 2021-12-01 | 2024-01-31 |
| Postoperative Same Day Closure of Giant Macular Hole With Silicone Oil Macular Hole Surgery - Macular Holes, Vitrectomy | Completed | Ahalia Foundation Eye Hospital | 32 | 2021-05-01 | 2025-04-08 |
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Retinal Perforations (67) · Epiretinal Membrane (14) · Retinal Detachment (12) · Cataract (4) · Vision Disorders (3) · Vitreous Hemorrhage (3) · Diabetic Retinopathy (2) · Macular Degeneration (2) · Central Serous Chorioretinopathy (1) · Corneal Ulcer (1) · Disease Progression (1) · Eye Neoplasms (1) · Glaucoma (1) · Musculoskeletal Pain (1) · Ocular Hypertension (1)
Eye Diseases (67) · Retinal Diseases (66) · Pathological Conditions, Signs and Symptoms (8) · Nervous System Diseases (5) · Lens Diseases (4) · Neurologic Manifestations (4) · Pathologic Processes (4) · Signs and Symptoms (4) · Eye Hemorrhage (3) · Hemorrhage (3) · Retinal Degeneration (3) · Sensation Disorders (3) · Cardiovascular Diseases (2) · Cranial Nerve Diseases (2) · Diabetes Complications (2)
Vitrectomy (6) · ATF7IP protein, human (1) · Air (1) · Analgesia (1) · Color (1) · Gases (1) · Hypnotics and Sedatives (1) · Intercellular Signaling Peptides and Proteins (1) · Predictive Value of Tests (1) · Surgical Procedures, Operative (1) · Tomography, Optical Coherence (1) · Trabeculectomy (1) · Transplantation (1) · Transplantation, Autologous (1) · Weights and Measures (1)
Helse Stavanger HF (4) · Samsung Medical Center (3) · Glostrup University Hospital, Copenhagen (2) · Kyorin University (2) · National Taiwan University Hospital (2) · Second Affiliated Hospital, Zhejiang University, School of Medicine (2) · Sun Yat-sen University (2) · Universitaire Ziekenhuizen KU Leuven (2) · University of Alexandria (2) · Vienna Institute for Research in Ocular Surgery (2) · Xinhua Hospital, Shanghai Jiao Tong University School of Medicine (2) · Ahalia Foundation Eye Hospital (1) · Alcon Research (1) · Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo (1) · Benha University (1)
China (12) · Egypt (5) · Norway (4) · Austria (3) · Brazil (3) · Canada (3) · Italy (3) · South Korea (3) · Belgium (2) · Denmark (2) · Japan (2) · United Kingdom (2) · Colombia (1) · Czechia (1) · France (1)
Amrutha S, DNB (1) · Aysu Karatay Arsan, MD (1) · Benoit Cinq-Mars, MD, FRCS(C) (1) · Bryon McKay, MD, PhD (1) · Christiane I Falkner-Radler, MD (1) · Chung-May Yang, MD (1) · Ciro Costagliola (1) · Cynthia A Toth, MD (1) · Daniel Rios Esquer, MD (1) · Felipe Esparza Correa, MD (1) · Fenghua Wang (1) · Harvey S Uy, MD (1) · Hua Yan, MD,PhD (1) · Ishtar A Astorga Carballo, MD (1) · Islam Mohalhal, MD (1)
PMID 14769600, PMID 17031291, PMID 17475704, PMID 18191090, PMID 18386040, PMID 19846059, PMID 2025167, PMID 20541263, PMID 20970769, PMID 21051731, PMID 21082892, PMID 21296818, PMID 21718735, PMID 22605481, PMID 22780955, PMID 23419525, PMID 23607419, PMID 23630198, PMID 24265016, PMID 24418265, PMID 24608926, PMID 24871366, PMID 25125599, PMID 25426026, PMID 25856858, PMID 26339036, PMID 26398430, PMID 26418444, PMID 26569390, PMID 26650818, PMID 27686625, PMID 27701378, PMID 27901042, PMID 28031697, PMID 28255771, PMID 28659587, PMID 28845304, PMID 29209516, PMID 30071212, PMID 30165894, PMID 30312261, PMID 30953398, PMID 31198606, PMID 31868775, PMID 32408387, PMID 32985592, PMID 33029387, PMID 33397654, PMID 33964971, PMID 35179414
U01EY028079 (1)