20 completed, 14 unknown, 5 recruiting, 1 active not recruiting. 42 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 42 | Completed 20, Unknown 14, Recruiting 5, Active not recruiting 1, Enrolling by invitation 1, Not yet recruiting 1 |
Follow Macular Holes: new trials by email Literature Review of Macular Holes trials Research Report on Macular Holes
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Full-Thickness Macular Hole Surgery: A Comparison of Ten Techniques Pars Plana Vitrectomy (PPV)-Based Macular Hole Surgery, Autologous Platelet-Rich Plasma (PRP), Human Amniotic Membrane (hAM) Graft - Macular Holes | Not applicable | Recruiting | Kazakh Eye Research Institute | 120 | 2026-05-25 | 2026-06-02 |
| Autologous Tenon's Capsule Autograft for Large and Recurrent Full-Thickness Macular Holes Autologous Tenon's Capsule Autograft - Macular Holes, Macular Hole Surgery | Not applicable | Completed | Benha University | 50 | 2025-07-05 | 2026-08-12 |
| Intraocular Gas Tamponade for Treatment of Large Idiopathic Macular Holes Pars plana vitrectomy - Idiopathic Macular Hole, Macular Hole | Not applicable | Enrolling by invitation | The Filatov Institute of Eye Diseases and Tissue Therapy | 100 | 2025-02-01 | 2025-04-17 |
| Comparative Study of Decellularized Human Amniotic Membrane Hydrogel and Inverted Internal Limiting Membrane Flap in Idiopathic Large Macular Holes 25-gauge pars plana vitrectomy with inverted flap technique and SF6 tamponade, 25-gauge pars plana vitrectomy with complete internal limiting membrane peeling with amniotic membrane hydrogel filling and SF6 tamponade - Macular Holes | Not applicable | Recruiting | Walailak University | 26 | 2024-10-01 | 2026-09-09 |
| Small Macular Holes Treated With Air Postoperative intraocular tamponade - Macular Holes | Not applicable | Recruiting | Helse Stavanger HF | 132 | 2024-07-14 | 2024-11-06 |
| PEELED INTERNAL LIMITING MEMBRANE REPOSITION Peeled ILM Reposition, ILM Peeling - Macular Holes | Not applicable | Recruiting | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | 90 | 2024-04-15 | 2024-04-11 |
| GaslEss Macular Hole Surgery Gasless Macular hole surgery, Standard Macular hole surgery - Macular Holes | Not applicable | Not yet recruiting | King's College Hospital NHS Trust | 60 | 2024-01-01 | 2023-12-14 |
| Duration of Face Down Positioning for Full-Thickness Macular Hole Repair 3 Days of face-down positioning, 7 Days of face-down positioning - Macular Holes | Not applicable | Recruiting | St. Joseph's Healthcare Hamilton | 40 | 2023-11-21 | 2024-11-29 |
| Zeiss RESIGHT Disposable Lenses Evaluation Study ZEISS disposable - Retinal Detachment, Macular Pucker | Not applicable | Completed | Universitaire Ziekenhuizen KU Leuven | 120 | 2023-04-11 | 2024-08-26 |
| Platelet-rich Fibrin(PRF) Membrane in Ophthalmic Diseases PRF membrane tamponade surgery in macular hole, ILM peeling in macular hole, PRF membrane grafting in pterygium - Platelet-rich Fibrin, Macular Holes | Not applicable | Unknown | Lei Du | 170 | 2023-01-01 | 2024-01-12 |
| Clinical Study of Translocated Internal Limiting Membrane Flap Reposition for the Treatment of Idiopathic Macular Hole Translocation ILM Flap, ILM Peeling - Macular Holes | Not applicable | Unknown | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | 76 | 2022-07-01 | 2023-10-30 |
| To Evaluate the Therapeutic Efficacy of Hydrated Amniotic Membrane in Promoting Closure of Refractory Macular Holes. Hydrated Amniotic Membrane Plug, ILM filling, Conventional ILM peeling - Macular Holes | Not applicable | Unknown | Oriental Neurosurgery Evidence-Based-Study Team | 80 | 2022-06-01 | 2022-05-31 |
| Double Flap Technique for Macular Hole Surgical intervention - Macular Holes | Not applicable | Completed | Omer Othman Abdullah | 20 | 2022-01-01 | 2023-03-24 |
| Macular Micro Vascular Changes Following Macular Hole Repair : Optical Coherence Tomography Angiography Study pars plana vitrectomy - Macular Holes | Not applicable | Unknown | Fayoum University | 28 | 2021-12-01 | 2024-01-31 |
| Pars Plana Vitrectomy With 25-gauge 20000 Cpm, Bevel-tip Cutter 25-gauge, bevel-tip, 20000 cut per minute pars plana vitrectomy - Vitrectomy, Retinal Detachment | Not applicable | Unknown | Peregrine Eye and Laser Institute | 50 | 2021-04-01 | 2021-06-04 |
| Large Macular Hole Closure Rate With Amniotic Membrane Graft With and Without Limitorrhexis Macular hole closure with amniotic membrane with/without internal limiting membrane peeling - Macular Holes | Not applicable | Unknown | Instituto de Oftalmología Fundación Conde de Valenciana | 16 | 2021-03-10 | 2021-10-19 |
| ILM Peeling Versus Inverted Flap Technique for Treatment of Macular Hole: Near Visual Acuity Outcomes 25-gauge pars plana vitrectomy with complete internal limiting membrane peeling and SF6 tamponade, 25-gauge pars plana vitrectomy with inverted flap technique and SF6 tamponade - Macular Holes | Not applicable | Unknown | Faculty Hospital Kralovske Vinohrady | 60 | 2021-01-05 | 2022-08-09 |
| Position Related Changes in Macular Hole Morphology Before and After Surgery Postoperative positioning advice - Macular Holes | Not applicable | Completed | Helse Stavanger HF | 40 | 2021-01-01 | 2023-11-21 |
| Efficacy of Exercise Program for Facedown Posture-related Pain After Retinal Surgery A structured exercise - Macular Holes, Retinal Detachment | Not applicable | Completed | Samsung Medical Center | 70 | 2020-09-03 | 2020-12-16 |
| Comparative Study of Sharkskin Versus Grieshaber Forceps During ILM Peeling Sharkskin, Grieshaber - Epiretinal Membrane, Macular Holes | Not applicable | Unknown | Wills Eye | 100 | 2020-07-06 | 2020-07-07 |
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Retinal Perforations (42) · Retinal Detachment (6) · Epiretinal Membrane (4) · Cataract (2) · Corneal Ulcer (1) · Glaucoma (1) · Musculoskeletal Pain (1) · Pterygium (1) · Vision Disorders (1) · Vitreous Hemorrhage (1)
Eye Diseases (42) · Retinal Diseases (42) · Pathological Conditions, Signs and Symptoms (3) · Lens Diseases (2) · Neurologic Manifestations (2) · Signs and Symptoms (2) · Conjunctival Diseases (1) · Corneal Diseases (1) · Eye Hemorrhage (1) · Eye Infections (1) · Hemorrhage (1) · Infections (1) · Keratitis (1) · Muscular Diseases (1) · Musculoskeletal Diseases (1)
Vitrectomy (4) · ATF7IP protein, human (1) · Air (1) · Gases (1) · Predictive Value of Tests (1) · Surgical Procedures, Operative (1) · Trabeculectomy (1) · Transplantation (1) · Transplantation, Autologous (1)
Helse Stavanger HF (4) · Samsung Medical Center (3) · University of Alexandria (2) · Xinhua Hospital, Shanghai Jiao Tong University School of Medicine (2) · Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo (1) · Benha University (1) · CHU de Quebec-Universite Laval (1) · Faculty Hospital Kralovske Vinohrady (1) · Fayoum University (1) · Federal University of São Paulo (1) · Glostrup University Hospital, Copenhagen (1) · Hospital Oftalmologico de Sorocaba (1) · Instituto de Oftalmología Fundación Conde de Valenciana (1) · Kazakh Eye Research Institute (1) · King's College Hospital NHS Trust (1)
China (7) · Egypt (4) · Norway (4) · South Korea (3) · Austria (2) · Brazil (2) · Canada (2) · Italy (2) · Belgium (1) · Czechia (1) · Denmark (1) · Greece (1) · Iraq (1) · Japan (1) · Kazakhstan (1)
Benoit Cinq-Mars, MD, FRCS(C) (1) · Christiane I Falkner-Radler, MD (1) · Ciro Costagliola (1) · Daniel Rios Esquer, MD (1) · Felipe Esparza Correa, MD (1) · Fenghua Wang (1) · Harvey S Uy, MD (1) · Hua Yan, MD,PhD (1) · Ishtar A Astorga Carballo, MD (1) · Islam Mohalhal, MD (1) · Jacek Robaszkiewicz, dr med. (1) · Jakkrit Juhong, MD. (1) · Jose L Rodriguez Loaiza, MD (1) · Kunho Bae, MD (1) · Lei Du (1)
PMID 18191090, PMID 19846059, PMID 21051731, PMID 28031697, PMID 28255771, PMID 28845304, PMID 29209516, PMID 30071212, PMID 30165894, PMID 30312261, PMID 30953398, PMID 31868775, PMID 32408387, PMID 32985592, PMID 33397654, PMID 33964971, PMID 35179414, PMID 35398546, PMID 39047125, PMID 39060701, PMID 39163327, PMID 40952489, PMID 41448786, PMID 42343490