29 completed, 12 unknown, 5 recruiting, 5 withdrawn. 16 Not applicable, 11 Phase 2, 9 Phase 3, 5 Phase 1, 3 Phase 4.
Follow Corneal Ulcer: new trials by email Literature Review of Corneal Ulcer trials Research Report on Corneal Ulcer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Fluorometholone Study Adjunctive Topical Fluorometholone (FML) 0.1%, Standard Topical Antibiotic Therapy - Keratitis Bacterial, Corneal Ulcer (Diagnosis) | Phase 2 | Not yet recruiting | Vishal Jhanji | 174 | 2026-10-31 | 2026-06-10 |
| Follow-up Compliance for Corneal Ulcer Patients With SMS Reminder SMS reminder - Corneal Ulcer | Not applicable | Recruiting | Seva Canada Society | 310 | 2026-02-23 | 2026-05-12 |
| Intrastromal Moxifloxacin as an Adjunctive Therapy in Recalcitrant Bacterial Keratitis Intrastromal moxifloxacin injection plus standard topical moxifloxacin therapy, Standard topical moxifloxacin therapy alone - Bacterial Keratitis, Recalcitrant Infectious Keratitis | Not applicable | Recruiting | Minia University | 60 | 2025-10-01 | 2026-09-10 |
| Fungal Ulcer Treatment Augmented With Natamycin and Cyclosporine A Cyclosporine A, Placebo Comparator: Placebo - Fungal Keratitis, Corneal Ulcer | Phase 3 | Recruiting | University of California, San Francisco | 150 | 2025-09-01 | 2026-06-05 |
| Diagnosing Corneal Infection Corneal impression membrane (Millicell Cell Culture Insert, 12mm, hydrophilic PTFE 0.4µm (PICM01250)) - Corneal Ulcer (Diagnosis) | Withdrawn | University of Edinburgh | 2025-02-01 | 2026-02-27 | ||
| Parasitic Ulcer Treatment Trial Polyhexamethylene biguanide (PHMB), Topical corticosteroid, Topical placebo - Acanthamoeba Keratitis | Phase 3 | Recruiting | Jeremy Keenan, MD, MPH | 232 | 2024-07-01 | 2026-10-01 |
| Open-label Trial to Evaluate Efficacy and Safety of rhNGF on Corneal Thickness Via AS-OCT in Neurotrophic Keratitis OXERVATE® 0.002% - Neurotrophic Keratitis, Neurotrophic Keratopathy | Phase 4 | Withdrawn | Dompé Farmaceutici S.p.A | 2024-04-26 | 2024-12-02 | |
| Studying the Effect of Ethanol Applied on the Corneal Surface During PRK Surgery. Corneal Ulcer of Bilateral Eyes | Completed | Minia University | 70 | 2024-03-05 | 2024-08-06 | |
| Efficacy of Locally Delivered Allogeneic Mesenchymal Stromal Cells Mesenchymal Stromal Cells, Control Solution - Corneal Ulcer | Phase 2 | Recruiting | University of Illinois Chicago | 38 | 2023-09-29 | 2026-11-04 |
| Topical Insulin in Neurotrophic Keratopathy After Diabetic Vitrectomy rapid acting insulin - Corneal Ulcer, Neurotrophic Corneal Ulcer | Unknown | Benha University | 30 | 2023-07-15 | 2023-07-11 | |
| AONDA Therapeutic Indication Study I Lotrafilcon A contact lenses - Bullous Keratopathy, Corneal Erosion | Completed | Alcon Research | 55 | 2023-06-28 | 2023-07-20 | |
| Platelet-rich Fibrin(PRF) Membrane in Ophthalmic Diseases PRF membrane tamponade surgery in macular hole, ILM peeling in macular hole, PRF membrane grafting in pterygium - Platelet-rich Fibrin, Macular Holes | Not applicable | Unknown | Lei Du | 170 | 2023-01-01 | 2024-01-12 |
| Use of a Biological Lens of Amniotic Membrane (LV-Visio-AMTRIX) in the Treatment of Trophic Ulcers LV-Visio-AMTRIX - Corneal Ulcer, Persistent Corneal Epithelial Defect | Phase 2 | Withdrawn | TBF Genie Tissulaire | 2022-04-01 | 2022-08-05 | |
| Effect of Various Treatment Modalities on Dendritic Vial Ulcer Acyclovir, Tobramycin, Fluorometholone - Corneal Ulcer | Unknown | Sohag University | 40 | 2022-03-18 | 2022-04-06 | |
| Safety and Effectiveness of the PXL Platinum 330 System With Riboflavin Solution for Refractory Corneal Ulcers PXL Platinum 330 system + Riboflavin 0.25% TE Solution, Sham CXL + Artificial Tears - Keratitis, Corneal Ulcer | Phase 2 / Phase 3 | Unknown | Peschke GmbH | 488 | 2022-03-14 | 2022-10-28 |
| Safety and Effectiveness of the PXL Platinum 330 System With Riboflavin Solution for Previously Untreated Corneal Ulcers Standard of Care Therapy + CXL + Riboflavin 0.23% L Solution, Standard of Care Therapy + Sham CXL + Artificial Tears - Keratitis, Corneal Ulcer | Phase 2 / Phase 3 | Unknown | Peschke GmbH | 468 | 2022-03-14 | 2022-10-28 |
| Au-Ag-Cu2O NG With PTT Anti Drug-resistant Microbial Keratitis Hollow gold and silver alloy cuprous oxide shell nano-shell hydrogel, Voriconazole eye drops, Normal saline - Keratitis, Ulcerative, Antibiotic Resistance, Microbial | Early Phase 1 | Unknown | Second Affiliated Hospital, Zhejiang University, School of Medicine | 20 | 2021-08-01 | 2022-03-07 |
| Improving the Follow up Rate for Pediatric Patients Counseling group, SMS and phone call reminder group - CNLDO - Congenital Nasolacrimal Duct Obstruction, Amblyopia | Not applicable | Completed | Seva Foundation | 264 | 2021-02-15 | 2022-03-10 |
| The Use of Naltrexone Hydrochloride to Promote Healing in Patients With Resistant Non-infectious Corneal Ulcer Naltrexone Hydrochloride, Carboxy methyl cellulose - Cornea Ulcer | Not applicable | Completed | Minia University | 50 | 2021-01-01 | 2023-06-29 |
| Platelet Rich Plasma as a Treatment For Resistant Corneal Ulcers Autologous platelet-rich plasma (PRP) eye drops - Cornea Ulcer | Phase 4 | Completed | Alaa Gamal | 14 | 2021-01-01 | 2022-08-25 |
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Keratitis (11) · Corneal Diseases (6) · Corneal Dystrophies, Hereditary (4) · Eye Diseases (3) · Pterygium (3) · Bacterial Infections (2) · Conjunctivitis (2) · Corneal Opacity (2) · Corneal Perforation (2) · Disease (2) · Eye Infections, Fungal (2) · Mycoses (2) · Ulcer (2) · Acanthamoeba Keratitis (1)
Infections (55) · Eye Infections (54) · Eye Diseases (52) · Corneal Diseases (49) · Keratitis (44) · Conjunctival Diseases (6) · Bacterial Infections and Mycoses (5) · Nervous System Diseases (5) · Pathological Conditions, Signs and Symptoms (5) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (4) · Craniocerebral Trauma (4) · Eye Diseases, Hereditary (4) · Facial Injuries (4) · Genetic Diseases, Inborn (4) · Pathologic Processes (4)
Riboflavin (4) · Adrenal Cortex Hormones (2) · Fluorometholone (2) · Lubricant Eye Drops (2) · Moxifloxacin (2) · Natamycin (2) · Ophthalmic Solutions (2) · Voriconazole (2) · cenegermin (2) · Abortion, Induced (1) · Acyclovir (1) · Anti-Bacterial Agents (1) · Anti-Inflammatory Agents (1) · Biological Dressings (1) · Corneal Cross-Linking (1)
University of California, San Francisco (6) · Minia University (3) · Dompé Farmaceutici S.p.A (2) · National Taiwan University Hospital (2) · Peschke GmbH (2) · TBF Genie Tissulaire (2) · ACRO Biomedical Co. Ltd (1) · Alaa Gamal (1) · Alcon Research (1) · Aravind Eye Care System (1) · Asia Cornea Society (1) · Benha University (1) · Centro Hospitalar de Vila Nova de Gaia/Espinho, E.P.E. (1) · Chulalongkorn University (1) · Cornea Consultants Of Nashville (1)
United States (19) · India (9) · Egypt (7) · China (5) · France (5) · Nepal (4) · Taiwan (4) · United Kingdom (3) · Brazil (2) · Germany (2) · Thailand (2) · Belarus (1) · Indonesia (1) · Italy (1) · Japan (1)
Bala Ambati (2) · NV Prajna, DNB, FRC Ophth (2) · Nisha Acharya, MD, MS (2) · Tom Lietman, MD (2) · Yvette Viscuso (2) · Ahmed Gomaa (1) · Ali R Djalilian, MD (1) · Andres Garralda Luquin, MD (1) · Andreza Werli-Alvarenga, RN, MD, PhD (1) · Brad Kligman, MD (1) · Carlos Lopez Gutierrez, MD (1) · Charlotte E Joslin, OD, PhD (1) · Christophe Baudouin, MD (1) · Danielle Robertson, OD, PhD (1)
PMID 32557558, PMID 34483270, PMID 35024776, PMID 10832689, PMID 11285665, PMID 11520759, PMID 12131029, PMID 12386069, PMID 12515932, PMID 15355406, PMID 15829742, PMID 16575115, PMID 16926355, PMID 17258535, PMID 17657018, PMID 18204773, PMID 18245962, PMID 18608899, PMID 18829631, PMID 19097643, PMID 1985498, PMID 20847116, PMID 20944931, PMID 21836342, PMID 21987582, PMID 22159005, PMID 22395880, PMID 22447793, PMID 22959881, PMID 23062001, PMID 23307105, PMID 23385795, PMID 23702779, PMID 24315294, PMID 24612976, PMID 24618327, PMID 25764482, PMID 25955359, PMID 2597070, PMID 26448169, PMID 26531051, PMID 27054515, PMID 27631025, PMID 27787540, PMID 28426856, PMID 28579539, PMID 28817744, PMID 30025986, PMID 31619359, PMID 33031809
U10EY018573 (2), R01EY031033 (1), U10EY015114 (1), U10EY022880 (1), UG1EY033284 (1)