81 completed, 29 unknown, 12 recruiting, 6 terminated. 77 Not applicable, 6 Phase 2, 5 Phase 3, 4 Phase 4, 2 Early Phase 1.
Follow this condition Literature Review of Retinal Perforations trials Research Report on Retinal Perforations
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Full-Thickness Macular Hole Surgery: A Comparison of Ten Techniques Pars Plana Vitrectomy (PPV)-Based Macular Hole Surgery, Autologous Platelet-Rich Plasma (PRP), Human Amniotic Membrane (hAM) Graft - Macular Holes | Not applicable | Recruiting | Kazakh Eye Research Institute | 120 | 2026-05-25 | 2026-06-02 |
| Outcomes of Macular Hole Surgery With Inverted Flap With vs Without Post op Posturing With SF6 in Macular Hole More Than 400 Micrometres Macular Hole Surgery With Inverted Internal Limiting Membrane Flap and SF6 Gas Tamponade, Face-Down Postoperative Positioning, No Face-Down Postoperative Positioning - Macular Hole | Not applicable | Active not recruiting | Lahore General Hospital | 52 | 2026-05-01 | 2026-09-10 |
| Retinal Clinical Assessment With AI-derived Quantitative Information AI-derived retinal quantitative information-assisted reporting - no Obvious Abnormalities, Diabetic Retinopathy (DR) | Not yet recruiting | Beijing Tongren Hospital | 29 | 2026-04-15 | 2026-04-29 | |
| Surgical Procedure Efficiency Evaluation stuDy UNITY VCS, CONSTELLATION - Cataract, Vitreous Hemorrhage | Recruiting | Alcon Research | 180 | 2026-02-09 | 2026-08-13 | |
| UNITY VCS Vitreoretinal Surgery UNITY Vitreoretinal Cataract System (VCS), CONSTELLATION Vision System, Vitreoretinal ophthalmic surgery - Epiretinal Membrane, Macular Hole | Not applicable | Withdrawn | Alcon Research | 2026-01-01 | 2025-12-12 | |
| Autologous Tenon's Capsule Graft for Refractory Macular Holes Autologous Tenon's Capsule Graft Placement - Macular Hole Surgery | Not applicable | Recruiting | Benha University | 20 | 2025-12-14 | 2026-09-30 |
| Comparison Between Outcomes of Closure of Idiopathic Macular Hole Using Autologus Tenon Capsule Graft and Internal Limiting Membrane Flap Techniques (Pilot Study) vitrectomy under topical anesthesia [Proparacaine HCL (Alcaine®)] - Macular Hole Surgery, ILM Peeling | Not applicable | Recruiting | Ain Shams University | 20 | 2025-11-09 | 2026-06-08 |
| Retinal Detachment Prevention (Laser Prophylaxis) in Stickler Syndrome (SS) Prophylactic (non-invasive) Laser Retinopexy - Stickler Syndrome Type 1, Stickler Syndrome Type 2 | Not applicable | Recruiting | Helen Keller Eye Research Foundation | 500 | 2025-10-30 | 2026-07-01 |
| No Endotamponade for Macular Hole Repair: the NEMAR Study Conventional surgery, ILM flap with no gas tamponade - Macular Hole, Macular Hole Surgery | Not applicable | Recruiting | Chinese University of Hong Kong | 180 | 2025-09-16 | 2025-09-30 |
| Autologous Tenon's Capsule Autograft for Large and Recurrent Full-Thickness Macular Holes Autologous Tenon's Capsule Autograft - Macular Holes, Macular Hole Surgery | Not applicable | Completed | Benha University | 50 | 2025-07-05 | 2026-08-12 |
| Comparison of Efficacy Between ILM Forceps Internal limiting membrane (ILM) Peeling with Sharkskin Forceps, Internal limiting membrane (ILM) Peeling with Standard Forceps - Macular Holes, Epiretinal Membrane | Phase 4 | Unknown | University of British Columbia | 56 | 2025-07-01 | 2025-03-30 |
| Intraocular Gas Tamponade for Treatment of Large Idiopathic Macular Holes Pars plana vitrectomy - Idiopathic Macular Hole, Macular Hole | Not applicable | Enrolling by invitation | The Filatov Institute of Eye Diseases and Tissue Therapy | 100 | 2025-02-01 | 2025-04-17 |
| Head Position Monitoring After Pars Planar Vitrectomy gyroscope embedded eye-sheild - Retinal Detachment, Macular Hole | Active not recruiting | Seoul National University Hospital | 100 | 2024-11-28 | 2025-05-22 | |
| Minimal Vitrectomy and ILM Flap with Sodium Hyaluronate Gel for MH minimal posterior pole vitrectomy combined with a sodium hyaluronate gel-covered internal limiting membrane(ILM) flap with balanced saline filling and postoperative supine position, Conventional vitrectomy combined with inner limiting membrane flap flip coverage with sterile air filling and postoperative prone position - Macular Hole, Macular Hole Surgery | Not applicable | Enrolling by invitation | Jie Zhong | 52 | 2024-11-01 | 2024-11-12 |
| Comparative Study of Decellularized Human Amniotic Membrane Hydrogel and Inverted Internal Limiting Membrane Flap in Idiopathic Large Macular Holes 25-gauge pars plana vitrectomy with inverted flap technique and SF6 tamponade, 25-gauge pars plana vitrectomy with complete internal limiting membrane peeling with amniotic membrane hydrogel filling and SF6 tamponade - Macular Holes | Not applicable | Recruiting | Walailak University | 26 | 2024-10-01 | 2026-09-09 |
| Small Macular Holes Treated With Air Postoperative intraocular tamponade - Macular Holes | Not applicable | Recruiting | Helse Stavanger HF | 132 | 2024-07-14 | 2024-11-06 |
| PEELED INTERNAL LIMITING MEMBRANE REPOSITION Peeled ILM Reposition, ILM Peeling - Macular Holes | Not applicable | Recruiting | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | 90 | 2024-04-15 | 2024-04-11 |
| Efficacy and Safety of Myopic Macular Hole Closure Surgery Without Endotamponade Agent ILM flap with no endotamponade technique - Macular Hole, Myopia | Not applicable | Completed | Chinese University of Hong Kong | 20 | 2024-01-18 | 2026-10-21 |
| GaslEss Macular Hole Surgery Gasless Macular hole surgery, Standard Macular hole surgery - Macular Holes | Not applicable | Not yet recruiting | King's College Hospital NHS Trust | 60 | 2024-01-01 | 2023-12-14 |
| Duration of Face Down Positioning for Full-Thickness Macular Hole Repair 3 Days of face-down positioning, 7 Days of face-down positioning - Macular Holes | Not applicable | Recruiting | St. Joseph's Healthcare Hamilton | 40 | 2023-11-21 | 2024-11-29 |
Showing 20 of 137. Sign in to see all of them.
Epiretinal Membrane (37) · Retinal Detachment (28) · Macular Degeneration (7) · Vitreous Hemorrhage (6) · Cataract (5) · Diabetic Retinopathy (5) · Glaucoma (3) · Retinal Diseases (3) · Retinal Vein Occlusion (3) · Vision Disorders (3) · Central Serous Chorioretinopathy (2) · Fuchs' Endothelial Dystrophy (2) · Myopia (2) · Myopia, Degenerative (2)
Eye Diseases (136) · Retinal Diseases (134) · Pathological Conditions, Signs and Symptoms (15) · Pathologic Processes (10) · Retinal Degeneration (8) · Cardiovascular Diseases (6) · Endocrine System Diseases (6) · Eye Hemorrhage (6) · Hemorrhage (6) · Nervous System Diseases (6) · Vascular Diseases (6) · Diabetes Complications (5) · Diabetes Mellitus (5) · Diabetic Angiopathies (5) · Lens Diseases (5)
Vitrectomy (13) · Gases (2) · Ophthalmic Solutions (2) · Tomography, Optical Coherence (2) · Transplantation (2) · coomassie Brilliant Blue (2) · microplasmin (2) · ATF7IP protein, human (1) · Air (1) · Analgesia (1) · Calcium Dobesilate (1) · Color (1) · Hypnotics and Sedatives (1) · Indocyanine Green (1) · Indomethacin (1)
Helse Stavanger HF (7) · Kyorin University (5) · Vienna Institute for Research in Ocular Surgery (5) · Federal University of São Paulo (4) · Samsung Medical Center (4) · Alcon Research (3) · Assistance Publique - Hôpitaux de Paris (3) · Centre Hospitalier Universitaire Dijon (3) · National Taiwan University Hospital (3) · Xinhua Hospital, Shanghai Jiao Tong University School of Medicine (3) · Benha University (2) · Chinese University of Hong Kong (2) · Clinica Oftalmologica Paredes (2) · Glostrup University Hospital, Copenhagen (2) · Minia University (2)
China (17) · United States (16) · Egypt (9) · France (9) · Japan (8) · Norway (7) · Austria (6) · Brazil (5) · Italy (5) · South Korea (5) · Germany (4) · Hong Kong (4) · Taiwan (4) · United Kingdom (4) · Belgium (3)
Vegard Forsaa, MD (4) · Chung-May Yang, MD (2) · Justis P Ehlers, MD (2) · Makoto Inoue, MD (2) · Oliver Findl, Prof (2) · Se Woong Kang, M.D. (2) · Simon KH Szeto, MBChB, FRCOphth (2) · Ahmad Fauzan (1) · Allen C Ho, MD (1) · Alok S Bansal, MD (1) · Amrutha S, DNB (1) · Amy Schaberg, BSN (1) · Aysu Karatay Arsan, MD (1) · Benoit Cinq-Mars, MD, FRCS(C) (1)
PMID 32408387, PMID 14769600, PMID 17031291, PMID 17475704, PMID 18191090, PMID 18386040, PMID 18515577, PMID 18657796, PMID 19823863, PMID 19846059, PMID 2025167, PMID 20541263, PMID 20615492, PMID 20970769, PMID 21051731, PMID 21082892, PMID 21296818, PMID 21718735, PMID 21878847, PMID 21941363, PMID 22275808, PMID 22605481, PMID 22780955, PMID 23419525, PMID 23607419, PMID 23620091, PMID 23630198, PMID 24158005, PMID 24265016, PMID 24418265, PMID 24441951, PMID 24608926, PMID 24736052, PMID 24782469, PMID 24871366, PMID 25055146, PMID 25077834, PMID 25125599, PMID 25426026, PMID 25525173, PMID 25856858, PMID 26114817, PMID 26339036, PMID 26398430, PMID 26418444, PMID 26569390, PMID 26650818, PMID 27686625, PMID 27701378, PMID 27901042
K23EY022947 (1), R01EY013178 (1), U01EY028079 (1)