30 completed, 3 unknown, 1 recruiting. 13 Not applicable, 2 Phase 4, 1 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 13 | Completed 12, Unknown 1 |
| Phase 4 | 2 | Unknown 2 |
| Phase 2 | 1 | Recruiting 1 |
| Phase 3 | 1 | Completed 1 |
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Tirabrutinib Maintenance Versus Placebo in Patients With Primary CNS Lymphoma in Complete Remission (JCOG2104) Tirabrutinib, Placebo - Primary Central Nervous System Lymphoma | Phase 2 | Recruiting | Kyorin University | 92 | 2023-10-06 | 2026-08-05 |
| Efficacy of Tolvaptan on ADPKD Patients Tolvaptan - Autosomal Dominant Polycystic Kidney Disease | Not applicable | Unknown | Kyorin University | 118 | 2016-10-01 | 2020-06-05 |
| Bevacizumab Alone Versus Dose-dense Temozolomide Followed by Bevacizumab for Recurrent Glioblastoma, Phase III Temozolomide, Bevacizumab - Glioblastoma, Recurrence | Phase 3 | Completed | Kyorin University | 146 | 2016-07-11 | 2026-08-07 |
| Evaluation of Retinal Microstructure Detected With Intraoperative Optical Coherence Tomography During Vitrectomy Vitrectomy - Macular Disease | Completed | Kyorin University | 100 | 2015-12-12 | 2019-02-20 | |
| To Compare Anti-VEGF Monotherapy With Anti-VEGF and EPM Grid Laser Combination Therapy for Diabetic Macular Edema End-Point-Management grid laser, ranibizumab, Bevacizumab - Diabetic Macula Edema | Phase 4 | Unknown | The University of Hong Kong | 60 | 2015-06-01 | 2016-04-19 |
| Clinical Implications of DNA Analysis on ADPKD Autosomal Dominant Polycystic Kidney Disease | Completed | Kyorin University | 80 | 2014-01-01 | 2017-03-03 | |
| Optical Coherence Tomography-based Positioning for Macular Hole Surgery Macular hole surgery - Macular Hole Surgery | Completed | Kyorin University | 125 | 2013-05-01 | 2016-01-08 | |
| Fundus Autofluorescence After Vitrectomy for Epiretinal Membrane Vitrectomy with internal limiting membrane removal - Epiretinal Membrane | Completed | Kyorin University | 91 | 2013-04-01 | 2015-12-11 | |
| Epiretinal Proliferation in Eyes With Full Thickness Macular Hole Vitrectomy - Macular Disease | Completed | Kyorin University | 390 | 2013-03-01 | 2017-12-18 | |
| Surgical Outcomes for Proliferative Diabetic Retinopathy by Preoperative Glycemic Control and Renal Function Vitrectomy - Proliferative Diabetic Retinopathy | Completed | Kyorin University | 251 | 2013-01-01 | 2018-05-11 | |
| MicroRNA Expression Profile in Human Vitreous of Patients With Various Vitreoretinal Diseases Requiring Vitrectomy MicroRNA Expression Profile in Human Vitreous of Various Vitreoretinal Diseases | Completed | Kyorin University | 8 | 2012-08-01 | 2015-04-01 | |
| Vitrectomy and Scleral Shortening for Macular Hole Retinal Detachment or Myopic Traction Maculopathy Vitrectomy with scleral shortening - Macular Hole Retinal Detachment, Myopic Traction Maculopathy | Completed | Kyorin University | 16 | 2012-06-01 | 2015-08-19 | |
| Inverted Internal Limiting Membrane Flap Technique for Macular Hole Retinal Detachment in Highly Myopic Eyes Vitrectomy - Macular Hole Retinal Detachment | Not applicable | Completed | Kyorin University | 32 | 2012-04-01 | 2017-01-10 |
| MicroRNA Expression in Human Blood Serum and Vitreous Body human vitreous and blood serum sampling, PCR - MicroRNA Expression Profile in Human Vitreous | Completed | Kyorin University | 8 | 2011-10-01 | 2015-04-01 | |
| Efficacy Study of Water Drinking on PKD Progression. Autosomal Dominant Polycystic Kidney Disease, Disease Progression | Completed | Kyorin University | 30 | 2011-04-01 | 2018-03-15 | |
| Submacular Hemorrhage Associated With Retinal Arterial Macro Aneurysm Vitrectomy for submacular hemorrhage, subretinal injection of tissue-plasminogen activator - Submacular Hemorrhage, Ruptured Retinal Arterial Macro Aneurysms | Not applicable | Completed | Kyorin University | 22 | 2011-01-01 | 2014-04-22 |
| Ultrastructure Analysis of Excised Internal Limiting Membrane in Eyes of Highly Myopia With Myopic Traction Maculopathy Vitrectomy with internal limiting membrane peeling - Myopic Traction Maculopathy | Completed | Kyorin University | 7 | 2010-06-01 | 2015-08-19 | |
| Distinction of Cone Outer Segment Tips by Spectral-Domain Optical Coherence Tomography in Normal Eyes Optical coherence tomography - Healthy | Completed | Kyorin University | 37 | 2010-03-01 | 2012-08-02 | |
| Asymmetrical Recovery of Cone Outer Segment Tips and Foveal Displacement After Macular Hole Surgery Vitrectomy - Macular Hole | Not applicable | Completed | Kyorin University | 35 | 2009-07-01 | 2013-10-10 |
| Optical Coherence Tomography in Gas-filled Eyes Vitreous surgery - Macular Hole | Completed | Kyorin University | 37 | 2009-04-01 | 2013-01-03 |
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Retinal Perforations (5) · Polycystic Kidney, Autosomal Dominant (4) · Macular Degeneration (3) · Disease Progression (2) · Epiretinal Membrane (2) · Diabetes Insipidus (1) · Diabetic Retinopathy (1) · Down Syndrome (1) · Entropion (1) · Glioblastoma (1) · Hypertension (1) · Low Tension Glaucoma (1) · Patient Compliance (1) · Recurrence (1) · Retinal Detachment (1)
Vitrectomy (18) · Tomography, Optical Coherence (4) · Bevacizumab (2) · Lasers (1) · Polymerase Chain Reaction (1) · Ranibizumab (1) · Temozolomide (1) · Tolvaptan (1) · candesartan (1) · cilnidipine (1) · tirabrutinib (1)
Japan (30) · China (1)
Makoto Inoue, MD (15) · Akito Hirakata, MD (4) · Eiji Higashihara, M.D. (2) · Eiji Higashihara, MD (2) · Ian Wong, FRCOphth (1) · Makoto INoue, MD (1) · Motoo Nagane, M.D., Ph.D. (1)
PMID 18372389, PMID 22018706, PMID 24106115, PMID 24736052, PMID 24831720, PMID 26202442, PMID 28983800, PMID 39356039