297 completed, 73 terminated, 66 recruiting, 62 unknown. 204 Phase 2, 196 Phase 1, 67 Not applicable, 43 Phase 3, 8 Early Phase 1.
Follow Eye Neoplasms: new trials by email Literature Review of Eye Neoplasms trials Research Report on Eye Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Locoregional Administration of TIL and Lymphodepletion in Patients With Melanoma and Liver Metastases Autologous Tumor Infiltrating Lymphocytes, Melphalan, Interleukin-2 - Uveal Melanoma, Metastatic Cutaneous Melanoma | Phase 1 | Not yet recruiting | Vastra Gotaland Region | 6 | 2027-01-31 | 2026-09-09 |
| Locoregional or Systemic Administration of Autologous Tumor Infiltrating Lymphocytes in Patients With Metastatic Melanoma Autologous Tumor Infiltrating Lymphocytes (TIL), Melphalan, Interleukin-2 - Metastatic Uveal Melanoma, Metastatic Cutaneous Melanoma | Phase 1 | Not yet recruiting | Vastra Gotaland Region | 18 | 2027-01-01 | 2026-09-09 |
| Safety and Efficacy Study in Adults With Advanced Solid Tumors Receiving REGN13089-M404-M2980, an Antibody-drug Conjugate That Targets MET Protein on Tumors REGN13089-M404-M2980 - Advanced Solid Tumors | Phase 1 / Phase 2 | Not yet recruiting | Regeneron Pharmaceuticals | 320 | 2026-11-23 | 2026-10-07 |
| Low Dose Dexamethasone for the Prevention of Cytokine Release Syndrome Associated With Tebentafusp Dexamethasone - Uveal Melanoma, Metastatic | Phase 2 | Not yet recruiting | University of California, San Diego | 34 | 2026-11-01 | 2026-09-03 |
| Post-Market Clinical Follow-Up Study on the Rotational Stability of an Intraocular Lens After Cataract Surgery IOL, Cataract | Not yet recruiting | Rayner Intraocular Lenses Limited | 92 | 2026-11-01 | 2026-09-10 | |
| Study of Neoadjuvant RBP-01 In Patients With Primary Uveal Melanoma RBP-01 - Uveal Melanoma | Phase 1 / Phase 2 | Not yet recruiting | ReBio Pharma | 30 | 2026-10-01 | 2026-08-05 |
| Study of Adjuvant Darovasertib and Crizotinib in Participants With Primary Non-metastatic Uveal Melanoma Darovasertib, Crizotinib (Xalkori) - Uveal Melanoma | Phase 3 | Recruiting | IDEAYA Biosciences | 450 | 2026-09-01 | 2026-09-15 |
| A Phase 1 and 2 Study of VMD-102 in Hepatocellular Carcinoma and Other Solid Tumors VMD-102 - Hepatocellular Carcinoma (HCC), Metastatic Uveal Melanoma | Phase 1 / Phase 2 | Recruiting | VM Discovery, Inc. | 111 | 2026-07-16 | 2026-08-19 |
| Neoadjuvant Immunotherapy for Patients With High-risk Eye Melanoma Nivolumab & Ipilimumab - Uveal Melanoma | Phase 1 | Recruiting | Inge Marie Svane | 15 | 2026-06-29 | 2026-07-01 |
| Retinoblastoma Consolidation in Egyptians transpupillary thermotherapy, Cryotherapy, Brachytherapy - Retinoblastoma | Not yet recruiting | Assiut University | 150 | 2026-05-01 | 2026-04-15 | |
| A Long-Term Follow-Up Study of Subjects Completing the AU-011-301(CoMpass) for Early Choroidal Melanoma Observational - Choroidal Melanoma, Indeterminate Lesions | Enrolling by invitation | Aura Biosciences | 100 | 2026-03-27 | 2026-08-19 | |
| Detailed Phenotypic and Genotype Study to Correlate RB1 Mutations Relating to Primary Ocular Tumors and Secondary Extra-ocular Metastasis. Targeted Long-read sequencing - Retinoblastoma Bilateral, Retinoblastoma Unilateral | Recruiting | University of Washington | 100 | 2026-03-16 | 2026-03-18 | |
| Dual-Target CSPG4/GD2 CAR-NK Cells for Advanced Melanoma EB-DTKN-401 allogeneic dual-target CSPG4/GD2 CAR-NK cells, Fludarabine, Cyclophosphamide - Unresectable Melanoma, Metastatic Cutaneous Melanoma | Phase 1 / Phase 2 | Recruiting | Beijing Biotech | 36 | 2026-03-02 | 2026-06-04 |
| A Study Comparing Two Optical Coherence Tomography Devices in People With Ocular Tumors Intalight Dream OCT, Heidelberg Spectralis OCT - Ocular Tumor | Not applicable | Recruiting | Memorial Sloan Kettering Cancer Center | 60 | 2026-02-27 | 2026-05-13 |
| Myopia Progression Control Using Atropine 0.05% After Pediatric Cataract Surgery And Intraocular Lens Implantation Surgery Atropine Eye drops - Pediatric Cataract, IOL Implantation | Not applicable | Not yet recruiting | Cairo University | 50 | 2026-02-01 | 2026-01-23 |
| Tebentafusp and Roginolisib in Uveal Melanoma to Prolong T-cell Homeostasis roginolisib - Uveal Melanoma, Metastatic | Phase 1 | Recruiting | St Vincent's Hospital, Sydney | 8 | 2026-02-01 | 2026-04-23 |
| Immune Response to Percutaneous Hepatic Perfusion With Melphalan for Ocular Melanoma Metastatic to the Liver Melphalan through Percutaneous Hepatic Perfusion - Uveal Melanoma | Not applicable | Recruiting | Massachusetts General Hospital | 10 | 2026-01-27 | 2026-03-11 |
| Neoadjuvant Darovasertib in Primary Uveal Melanoma Darovasertib, Primary Local Therapy - Uveal Melanoma | Phase 3 | Recruiting | IDEAYA Biosciences | 520 | 2026-01-25 | 2026-05-06 |
| Phase 2 Combination of Melphalan/HDS Via PHP + Tebentafusp in Treating Metastatic Uveal Melanoma Melphalan/HDS (Percutaneous Hepatic Perfusion), Tebentafusp - Metastatic Uveal Melanoma | Phase 2 | Recruiting | H. Lee Moffitt Cancer Center and Research Institute | 18 | 2025-12-31 | 2026-03-31 |
| Clinical Trial of CD40L-augmented TIL for Patients With Advanced Melanoma Cyclophosphamide, Fludarabine, Interleukin-2 - Melanoma | Phase 1 / Phase 2 | Recruiting | H. Lee Moffitt Cancer Center and Research Institute | 36 | 2025-12-03 | 2026-06-26 |
Showing 20 of 586. Sign in to see all of them.
Uveal Melanoma (279) · Intraocular Lymphoma (165) · Burkitt Lymphoma (140) · Lymphoma, Large B-Cell, Diffuse (138) · Lymphoma, Non-Hodgkin (138) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (138) · Lymphoma, Follicular (136) · Melanoma (136) · Leukemia, Lymphocytic, Chronic, B-Cell (135) · Lymphoma, Mantle-Cell (133) · Lymphoma, B-Cell, Marginal Zone (132) · Lymphoma, Large-Cell, Immunoblastic (129) · Lymphoma, Large-Cell, Anaplastic (125) · Lymphoma, T-Cell, Cutaneous (125) · Mycosis Fungoides (120)
Neoplasms by Site (586) · Neoplasms by Histologic Type (564) · Neoplasms (548) · Eye Diseases (434) · Neoplasms, Nerve Tissue (411) · Neuroectodermal Tumors (409) · Neoplasms, Germ Cell and Embryonal (404) · Nevi and Melanomas (293) · Neuroendocrine Tumors (291) · Uveal Diseases (283) · Uveal Neoplasms (277) · Pathological Conditions, Signs and Symptoms (195) · Pathologic Processes (189) · Hemic and Lymphatic Diseases (183)
Carboplatin (35) · Cyclophosphamide (33) · Etoposide (31) · Ipilimumab (31) · Melphalan (28) · Nivolumab (23) · Filgrastim (22) · Vincristine (20) · Peripheral Blood Stem Cell Transplantation (19) · Rituximab (17) · fludarabine phosphate (17) · pembrolizumab (15) · Granulocyte Colony-Stimulating Factor (13) · Topotecan (12) · Cyclosporine (11)
National Cancer Institute (NCI) (59) · Memorial Sloan Kettering Cancer Center (27) · Institut Curie (17) · Fred Hutchinson Cancer Center (15) · M.D. Anderson Cancer Center (14) · Sun Yat-sen University (13) · St. Jude Children's Research Hospital (10) · Case Comprehensive Cancer Center (9) · Aura Biosciences (8) · Jonsson Comprehensive Cancer Center (8) · Barbara Ann Karmanos Cancer Institute (7) · European Organisation for Research and Treatment of Cancer - EORTC (7) · H. Lee Moffitt Cancer Center and Research Institute (7) · Vastra Gotaland Region (7) · Children's Oncology Group (6)
United States (386) · France (51) · Canada (37) · Germany (32) · United Kingdom (29) · Spain (26) · Netherlands (25) · Australia (24) · Italy (23) · China (21) · Switzerland (16) · Belgium (14) · Israel (10) · Austria (9) · Sweden (9)
David Maloney (5) · Jeffrey S. Weber, MD, PhD (5) · Carlos Rodriguez-Galindo, MD (4) · Ajay Gopal (3) · Craig L. Slingluff, MD (3) · Edward A. Neuwelt, MD (3) · Huasheng Yang, Doctor (3) · Ira Dunkel, MD (3) · Jose Lutzky, MD (3) · Rino Seedor, MD (3) · Sapna Patel (3) · Shivaani Kummar, MD (3) · Wen-Jen Hwu, MD, PhD (3) · Abhinav Deol, M.D. (2)
PMID 32499241, PMID 25667295, PMID 29528792, PMID 31401903, PMID 38597586, PMID 11410496, PMID 12039921, PMID 12459649, PMID 12525530, PMID 12684398, PMID 12826605, PMID 12947072, PMID 14630685, PMID 15459300, PMID 15814645, PMID 16087944, PMID 16135477, PMID 16148284, PMID 16283570, PMID 16344433, PMID 16533779, PMID 16863926, PMID 17159027, PMID 17312328, PMID 17337065, PMID 17610262, PMID 17620582, PMID 18048828, PMID 18064739, PMID 18195220, PMID 18293016, PMID 18327587, PMID 18342944, PMID 18391430, PMID 18698002, PMID 18809608, PMID 18978345, PMID 19097774, PMID 19118701, PMID 19542994, PMID 19789320, PMID 19841031, PMID 20142553, PMID 20688739, PMID 20727190, PMID 21106722, PMID 21247755, PMID 21319349, PMID 22027909, PMID 22186988
P30CA015704 (12), P30CA008748 (7), P30CA016672 (5), P30CA022453 (5), N01CM00039 (4), P30CA006973 (4), P30CA015083 (4), P30CA033572 (4), P30CA043703 (4), U01CA062491 (4), U01CA097452 (4), U01CA099168 (4), 2019 (3), N01CM62203 (3), P01CA078902 (3)