22 terminated. 22 Phase 2, 6 Phase 1, 5 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 22 | Terminated 22 |
| Phase 1 | 6 | Terminated 6 |
| Phase 3 | 5 | Terminated 5 |
Follow Lung Injury: new trials by email Literature Review of Lung Injury trials Research Report on Lung Injury
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Adrecizumab (HAM8101) to Improve Prognosis and Outcomes in COVID-19 Trial Adrecizumab (HAM 8101), Placebo - COVID-19 | Phase 2 | Terminated | Universitätsklinikum Hamburg-Eppendorf | 16 | 2022-10-06 | 2024-01-03 |
| Voxelotor for Improving Oxygen Saturation in Adults Voxelotor - Acute Lung Injury, End Stage Lung Disease | Phase 2 | Terminated | Duke University | 3 | 2022-05-03 | 2024-07-24 |
| Inhaled ZYESAMI™ (Aviptadil Acetate) for the Treatment of Severe COVID-19 ZYESAMI™ (aviptadil acetate), Placebo, Nebulized administration of ZYESAMI™ or Placebo - SARS-CoV 2, COVID | Phase 2 / Phase 3 | Terminated | APR Applied Pharma Research s.a. | 144 | 2021-02-15 | 2023-02-03 |
| RAPA-501-Allo Therapy of COVID-19-ARDS RAPA-501-Allo off-the-shelf Therapy of COVID-19, Placebo - Severe COVID-19 Disease | Phase 1 / Phase 2 | Terminated | Rapa Therapeutics LLC | 1 | 2020-12-30 | 2021-11-11 |
| Dociparstat for the Treatment of Severe COVID-19 in Adults at High Risk of Respiratory Failure Dociparstat sodium, Placebo - Coronavirus Disease 2019 (COVID-19), Acute Lung Injury | Phase 2 / Phase 3 | Terminated | Jazz Pharmaceuticals | 27 | 2020-07-08 | 2022-08-30 |
| ZEPLAST- PED: ZEro_PLASma Trial in Small Infants Undergoing Cardiac Surgery Fibrinogen Concentrate Human, Prothrombin Complex Concentrate, Fresh Frozen Plasma - Bleeding, Cardiac Defect | Phase 2 | Terminated | IRCCS Policlinico S. Donato | 40 | 2020-02-27 | 2021-11-03 |
| Inhaled Nitric Oxide for Pulmonary Hypertension and Bronchopulmonary Dysplasia inhaled nitric oxide, Placebo - Pulmonary Hypertension, Bronchopulmonary Dysplasia | Phase 1 / Phase 2 | Terminated | AdventHealth | 32 | 2019-07-15 | 2025-01-15 |
| Randomized Controlled Trial to Evaluate the Safety and Efficacy of Acetaminophen in Preterm Infants Used in Combination With Ibuprofen for Closure of the Ductus Arteriosus Ibuprofen and acetaminophen, Ibuprofen and placebo - Patent Ductus Arteriosus, Preterm Infant | Phase 2 | Terminated | University of South Alabama | 1 | 2018-12-15 | 2026-04-30 |
| Imaging of Peri-operative (periOP) Lung Injury SPECT-CT imaging, AxV-128/Tc, Whipple procedure - Acute Lung Injury, Chronic Obstructive Pulmonary Disease (COPD) | Phase 2 | Terminated | Columbia University | 1 | 2018-06-11 | 2021-09-14 |
| Steroids and Surfactant in Extremely Low Gestation Age Infants Dose Escalation Trial Budesonide in Calfactant - Bronchopulmonary Dysplasia (BPD) | Phase 1 / Phase 2 | Terminated | Cynthia McEvoy | 25 | 2016-09-01 | 2025-04-04 |
| PEEP and V/Q Mismatch in Premature Infants Positive end-expiratory pressure (PEEP) - Respiratory Insufficiency Syndrome of Newborn, Infant, Premature, Diseases | Phase 1 / Phase 2 | Terminated | Children's Hospital of Philadelphia | 12 | 2016-04-11 | 2020-11-17 |
| Nintedanib Compared With Placebo in Treating Against Radiation-Induced Pneumonitis in Patients With Non-small Cell Lung Cancer That Cannot Be Removed by Surgery and Are Undergoing Chemoradiation Therapy Durvalumab, Nintedanib, Placebo - Lung Non-Squamous Non-Small Cell Carcinoma, Radiation-Induced Pneumonitis | Phase 2 | Terminated | Roswell Park Cancer Institute | 8 | 2015-06-29 | 2020-04-06 |
| Study of GSK2862277 in Subjects Undergoing Oesophagectomy Surgery GSK2862277, Placebo - Lung Injury, Acute and Respiratory Distress Syndrome, Adult | Phase 2 | Terminated | GlaxoSmithKline | 35 | 2015-04-28 | 2020-10-27 |
| Treprostinil Sodium Inhalation for Patients At High Risk for ARDS Treprostinil Inhalation Solution, Placebo - Respiratory Distress Syndrome, Adult | Phase 2 | Terminated | University of North Carolina, Chapel Hill | 14 | 2015-02-01 | 2019-10-01 |
| Study of Inhaled Nitric Oxide (iNO) and Respiratory Outcomes in Late Preterm Infants inhaled nitric oxide, Placebo Comparator - nitrogen gas - Bronchopulmonary Dysplasia | Phase 2 / Phase 3 | Terminated | Tufts Medical Center | 3 | 2013-03-01 | 2017-07-19 |
| Inhaled Nitric Oxide and Neuroprotection in Premature Infants inhaled nitric oxide, oxygen - Prematurity, Bronchopulmonary Dysplasia | Phase 2 / Phase 3 | Terminated | University of Chicago | 273 | 2008-05-01 | 2024-10-17 |
| Drug Study of Albuterol to Treat Acute Lung Injury Albuterol Sulfate, Mini-Bronchoalveolar Lavage (BAL), Placebo - Respiratory Distress Syndrome, Adult | Phase 2 / Phase 3 | Terminated | National Heart, Lung, and Blood Institute (NHLBI) | 282 | 2007-08-01 | 2017-02-10 |
| Level of Continuous Positive Airway Pressure (CPAP) in Preterm Infants After Extubation (L-CPAP Study) Nasal CPAP, level 7 to 9 cmH2O, Nasal CPAP, level 4 to 6 cmH2O - Respiratory Insufficiency of Prematurity | Phase 2 | Terminated | Hamilton Health Sciences Corporation | 23 | 2007-07-01 | 2009-02-10 |
| Early Versus Expectant Treatment of Ureaplasma Infection in Very Low Birth Weight Neonates Azithromycin - Bacteria Infection, Respiratory Tract Infections | Phase 1 / Phase 2 | Terminated | University of Alabama at Birmingham | 7 | 2007-05-01 | 2017-05-17 |
| A Trial of Infant Flow Biphasic Nasal Continuous Airway Pressure (NCPAP) Versus Infant Flow NCPAP for the Facilitation of Extubation in Infants </= 1250 Grams Biphasic Infant flow NCPAP, CPAP - Infant, Premature, Diseases, Bronchopulmonary Dysplasia | Phase 2 | Terminated | Mount Sinai Hospital, Canada | 136 | 2006-04-01 | 2009-05-05 |
Showing 20 of 22. Sign in to see all of them.
Bronchopulmonary Dysplasia (9) · Acute Lung Injury (8) · Respiratory Distress Syndrome (6) · COVID-19 (3) · Premature Birth (3) · Infant, Premature, Diseases (2) · Afibrinogenemia (1) · Apnea (1) · Berylliosis (1) · Carcinoma, Non-Small-Cell Lung (1) · Coronavirus Infections (1) · Cytokine Release Syndrome (1) · Ductus Arteriosus, Patent (1) · Dyspnea (1)
Respiratory Tract Diseases (22) · Lung Diseases (21) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (10) · Infant, Newborn, Diseases (9) · Respiration Disorders (8) · Ventilator-Induced Lung Injury (8) · Infant, Premature, Diseases (7) · Pathological Conditions, Signs and Symptoms (5) · Cardiovascular Diseases (4) · Infections (4) · Wounds and Injuries (4) · Coronaviridae Infections (3) · Female Urogenital Diseases and Pregnancy Complications (3) · Nidovirales Infections (3)
Sodium Chloride (3) · Acetaminophen (1) · Albuterol (1) · Azithromycin (1) · Budesonide (1) · Disulfides (1) · Endothelium-Dependent Relaxing Factors (1) · Factor IX (1) · Fibrinogen (1) · GSK2862277 (1) · Ibuprofen (1) · Immunoglobulin G (1) · Infliximab (1) · Inosine (1) · Oxygen (1)
APR Applied Pharma Research s.a. (1) · AdventHealth (1) · Children's Hospital of Philadelphia (1) · Columbia University (1) · Cynthia McEvoy (1) · Duke University (1) · GlaxoSmithKline (1) · Hamilton Health Sciences Corporation (1) · IRCCS Policlinico S. Donato (1) · Jazz Pharmaceuticals (1) · Maier, Lisa, M.D. (1) · Mount Sinai Hospital, Canada (1) · National Heart, Lung, and Blood Institute (NHLBI) (1) · Rapa Therapeutics LLC (1) · Roswell Park Cancer Institute (1)
United States (17) · Canada (1) · Germany (1) · Italy (1) · United Kingdom (1)
Carlos Guardia, MD (1) · Cynthia McEvoy, MD, MCR (1) · Daniel Fowler, M.D. (1) · Fabien Eyal, MD (1) · Gebhard Wagener, MD (1) · Giulherme M SantAnna, MD (1) · Grace K Dy (1) · Haresh Kirpalani, BM, MSc (1) · Hubert J Ford, MD (1) · Hussnain Mirza, MD (1) · Ian Welsby (1) · Jennifer W Lee, MD, MS (1) · Jonathan C Javitt, MD, MPH (1) · Karel O'Brien, MB, FRCPC (1)
PMID 19117865, PMID 21562125, PMID 22475409, PMID 22974830, PMID 26138630, PMID 27440140, PMID 32006953, PMID 33095030, PMID 35244208, PMID 36408876, PMID 36889516, PMID 39643111
1UL1RR025780 (1), 2014 (1), N01HR056179 (1), P30CA016056 (1), R01HL131960 (1)