Knee Osteoarthritis: Clinical Trials

882 completed, 314 unknown, 161 recruiting, 88 not yet recruiting. 1015 Not applicable, 121 Phase 2, 99 Phase 3, 99 Phase 4, 67 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	1015	Completed 568, Unknown 192, Recruiting 100, Not yet recruiting 58, Active not recruiting 45, Terminated 28, Withdrawn 17, Enrolling by invitation 6, Suspended 1
Phase 2	121	Completed 73, Unknown 22, Terminated 7, Not yet recruiting 6, Recruiting 6, Withdrawn 4, Active not recruiting 2, Enrolling by invitation 1
Phase 3	99	Completed 57, Unknown 16, Recruiting 7, Active not recruiting 6, Withdrawn 6, Not yet recruiting 4, Terminated 2, Enrolling by invitation 1
Phase 4	99	Completed 56, Unknown 26, Terminated 6, Not yet recruiting 4, Recruiting 3, Withdrawn 3, Active not recruiting 1
Phase 1	67	Completed 35, Unknown 19, Not yet recruiting 3, Recruiting 3, Active not recruiting 2, Terminated 2, Withdrawn 2, Enrolling by invitation 1
Early Phase 1	10	Completed 4, Unknown 3, Active not recruiting 1, Not yet recruiting 1, Recruiting 1

Follow Knee Osteoarthritis: new trials by email Literature Review of Knee Osteoarthritis trials Research Report on Knee Osteoarthritis

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Evaluating the Effect of Adipose Tissue Processed With the SyntrFuge™ System for Knee Osteoarthritis SyntrFuge System, Triamcinolone Injection - Knee Osteoarthritis	Not applicable	Not yet recruiting	Syntr Health Technologies, Inc.	180	2027-12-01	2026-08-20
Duloxetine and aeRobic Exercise to Improve Function in VEterans With Knee Osteoarthritis (DRIVE) Exercise, Duloxetine, Placebo - Knee Osteoarthritis, Pain	Phase 2	Not yet recruiting	VA Office of Research and Development	102	2027-03-01	2026-06-16
Zynrelef Versus Adductor Canal Block ZYNRELEF 400Mg-12Mg Extended-Release Solution, Ultrasound-Guided Adductor Canal Block, Ropivacaine 0.5% Injectable Solution - Knee Osteoarthritis, Arthritis Knee	Phase 4	Not yet recruiting	University of Miami	120	2027-01-01	2026-06-12
Heart Rate Variability Guided Physical Activity and Exercise Prescription in Individuals With Knee Osteoarthritis HRV-guided home exercise prescription, Traditional Home Exercise - Knee Osteoarthritis	Not applicable	Not yet recruiting	The Hong Kong Polytechnic University	240	2027-01-01	2026-02-12
Mechanical Alignment Versus Kinematic Alignment Total Knee Arthroplasty Total knee arthroplasty - Knee Osteoarthritis	Not applicable	Not yet recruiting	Loyola University	96	2027-01-01	2026-08-27
IMAGES: Identifying Metabolic Imaging Association With Genicular Artery Embolization Success Embolization - Knee Osteoarthritis, Knee Discomfort	Not applicable	Not yet recruiting	Lucas R. Cusumano, MD	25	2026-12-30	2026-09-21
Efficacy of Autologous Adipose Derived Stromal Vascular Fraction for Musculoskeletal Conditions stromal vascular fraction injection in the osteoarthritic knee - Knee Osteoarthritis	Not applicable	Not yet recruiting	Dubai Health Authority	300	2026-12-30	2025-08-26
Clinical Importance of Occult Suprapatellar Effusion in Knee Osteoarthritis Static and Dynamic Suprapatellar Ultrasonography - Knee Osteoarthritis		Not yet recruiting	Mardin Artuklu University	105	2026-11-30	2026-10-20
The ACT-ON: A Geriatric 5-Ms-Guided Physical Therapy Intervention for Knee Osteo-Arthritis in Older Adults. Geriatric 5Ms framework, Exercises PT - Rehabilitation, Excercise	Not applicable	Not yet recruiting	King Saud University	40	2026-11-15	2026-08-31
Effects of Music During Walking on Pain and Muscle Activation in People With Chronic Pain Due to Knee Osteoarthritis Rhythmic Auditory Stimulation with music, Rhythmic Auditory Stimulation with metronome, Control - Knee Osteoarthritis	Not applicable	Not yet recruiting	Boston University Charles River Campus	20	2026-11-01	2026-08-28
Inulin Supplementation for Reducing Inflammation and Knee Pain in Older Adults With Osteoarthritis inulin, Maltodextrin (Placebo) - Knee Osteoarthritis	Phase 2	Not yet recruiting	Yale University	84	2026-11-01	2026-07-07
Person-Centred Digital Rehabilitation for Knee Osteoarthritis Knee Osteoarthritis, Physical Activity Behaviour		Not yet recruiting	Mälardalen University	500	2026-11-01	2026-10-15
Effects of Visual and Vestibular Rehabilitation in Individuals With Knee Osteoarthritis Conventional Physiotherapy, Visual Rehabilitation, Vestibular Rehabilitation - Knee Osteoarthritis, Visual Rehabilitation	Not applicable	Not yet recruiting	Istanbul Aydın University	42	2026-10-28	2026-10-22
Low-Dose Radiotherapy for Painful Knee Osteoarthritis Low-Dose Radiotherapy (LDRT) - Knee Osteoarthritis	Not applicable	Not yet recruiting	Universidad Rey Juan Carlos	283	2026-10-15	2026-10-21
3-Needle vs 5-Needle of Genicular Nerve Block on Pain and Quality of Life in Knee Osteoarthritis 3-nerve-targeted group, 5-nerve-targeted group - 3-Needle, 5-Needle	Not applicable	Recruiting	Tanta University	80	2026-10-04	2026-10-06
US-Guided Saphenous Block in Knee OA Intra-articular corticosteroid injection, Ultrasound-Guided High-Volume Saphenous Nerve Block, Home-Based Exercise Program - Knee Osteoarthritis, Osteoarthritis, Knee	Not applicable	Not yet recruiting	Gaziler Physical Medicine and Rehabilitation Education and Research Hospital	60	2026-10-02	2026-10-09
Intraosseous Tranexamic Acid for Reducing Blood Loss in Total Knee Arthroplasty Tranexamic Acid, Normal Saline - Knee Osteoarthritis	Phase 4	Not yet recruiting	The Second Affiliated Hospital of Kunming Medical University	70	2026-10-01	2026-10-09
NANOVAE to Treat Knee Osteoarthritis (KOA) NANOVAE - Acellular Allogenic Human Amniotic Fluid (hAF), 0.9% Sodium Chloride Injection, USP - Knee Osteoarthritis	Phase 1 / Phase 2	Not yet recruiting	Nova Vita Laboratory	24	2026-10-01	2026-04-13
Neurofeedback for Pain Sensitization in Knee Osteoarthritis FWR Down-Conditioning Neurofeedback, Sham Feedback - Knee Osteoarthritis	Not applicable	Not yet recruiting	Northeastern University	50	2026-10-01	2026-09-22
Daycase Hip and Knee Arthroplasty in Møre and Romsdal Trial Total Hip Arthroplasty, Total Knee Arthroplasty, Unicondylar knee artrhoplasty - Knee Osteoarthritis, Hip Osteoarthritis		Not yet recruiting	Helse Møre og Romsdal HF	300	2026-10-01	2026-09-22

Showing 20 of 1618. Sign in to see all of them.

Narrower conditions

Osteoarthritis, Knee (1618)  ·  Osteoarthritis (253)  ·  Pain (112)  ·  Motor Activity (73)  ·  Osteoarthritis, Hip (54)  ·  Arthritis (42)  ·  Chronic Pain (30)  ·  Pain, Postoperative (30)  ·  Joint Diseases (26)  ·  Knee Injuries (25)  ·  Musculoskeletal Diseases (16)  ·  Obesity (15)  ·  Agnosia (14)  ·  Kinesiophobia (14)  ·  Arthritis, Rheumatoid (12)

Broader conditions

Rheumatic Diseases (1612)  ·  Musculoskeletal Diseases (1602)  ·  Joint Diseases (1592)  ·  Arthritis (1576)  ·  Osteoarthritis (1365)  ·  Pathological Conditions, Signs and Symptoms (276)  ·  Signs and Symptoms (242)  ·  Neurologic Manifestations (221)  ·  Behavior (91)  ·  Pain (81)  ·  Pathologic Processes (73)  ·  Nervous System Diseases (51)  ·  Wounds and Injuries (37)  ·  Postoperative Complications (34)  ·  Mental Disorders (32)

Interventions

Exercise (61)  ·  Arthroplasty, Replacement, Knee (41)  ·  Hyaluronic Acid (37)  ·  Sodium Chloride (32)  ·  Physical Therapy Modalities (24)  ·  Saline Solution (22)  ·  Ropivacaine (21)  ·  Adrenal Cortex Hormones (17)  ·  Resistance Training (17)  ·  Exercise Therapy (16)  ·  Transcutaneous Electric Nerve Stimulation (15)  ·  Celecoxib (13)  ·  Triamcinolone Acetonide (12)  ·  Bupivacaine (11)  ·  Low-Level Light Therapy (11)

Sponsors

Riphah International University (59)  ·  Cairo University (24)  ·  Istituto Ortopedico Rizzoli (19)  ·  Chinese University of Hong Kong (12)  ·  Poznan University of Medical Sciences (12)  ·  Assiut University (11)  ·  Tanta University (11)  ·  University of British Columbia (11)  ·  Hacettepe University (10)  ·  London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (10)  ·  The Hong Kong Polytechnic University (10)  ·  University of Iowa (10)  ·  University of Sao Paulo General Hospital (10)  ·  Assistance Publique - Hôpitaux de Paris (9)  ·  Federal University of São Paulo (9)

Countries

United States (340)  ·  Turkey (Türkiye) (151)  ·  Pakistan (92)  ·  China (80)  ·  Canada (77)  ·  Egypt (66)  ·  France (62)  ·  Italy (55)  ·  Spain (46)  ·  Taiwan (45)  ·  United Kingdom (45)  ·  Denmark (41)  ·  Poland (37)  ·  Brazil (36)  ·  South Korea (35)

Top investigators

Jianhao Lin, MD (6)  ·  Neil A Segal, MD, MS (5)  ·  Yusuf Yazici, M.D. (5)  ·  Ahmed Farrag, PhD (4)  ·  Deepak Kumar, PT, PhD (4)  ·  Malgorzata Reysner, MD PhD (4)  ·  Michael Tim-Yun Ong (4)  ·  Muhammad Kashif (4)  ·  Prakash Jayabalan, MD, PhD (4)  ·  Ru-Lan Hsieh, MD (4)  ·  Chenchen Wang, MD, MSc (3)  ·  Christopher Centeno, MD (3)

Results publications

PMID 15039276, PMID 23559821, PMID 39495154, PMID 19734131, PMID 21518322, PMID 22220431, PMID 25822648, PMID 26403468, PMID 27681448, PMID 28566193, PMID 3068365, PMID 31985507, PMID 32147282, PMID 32318673, PMID 34239634, PMID 36269595, PMID 37573322, PMID 37778085, PMID 10352653, PMID 10369853, PMID 1101375, PMID 11229463, PMID 11354213, PMID 11532840, PMID 11589257, PMID 11642645, PMID 11808971, PMID 11824968, PMID 12538372, PMID 12608674, PMID 12916575, PMID 12970463, PMID 14679827, PMID 14710506, PMID 15050897, PMID 15051595, PMID 15146420, PMID 15278105, PMID 15611487, PMID 15712981, PMID 16169000, PMID 16271901, PMID 16531440, PMID 16568327, PMID 16832639, PMID 16845545, PMID 16921694, PMID 17159170, PMID 17265490, PMID 17266764

NIH funding

2016 (2), K23AG030945 (2), 1P2CHD086851-01 (1), 1UG3AR077360-01 (1), 1UM1AR062800-01 (1), 2005 (1), 2008 (1), 2009 (1), 2014 (1), 2017 (1), 2018 (1), 2019 (1), 2023 (1), K01AG064041 (1), K23AT009568 (1)