16 completed, 6 terminated, 3 recruiting, 2 withdrawn. 29 Phase 2, 9 Phase 1, 5 Phase 3.
Follow Kidney Failure: new trials by email Literature Review of Kidney Failure trials Research Report on Kidney Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Use of New Drug QRX-3 for Prevention and Treatment of Chronic Kidney Disease Progression QRX-3 - Chronic Kidney Diseases, Acute Kidney Injury | Phase 2 / Phase 3 | Not yet recruiting | Ebima Clifford Okundaye | 3000 | 2025-10-01 | 2025-09-08 |
| CRISPR-Edited HLA Donor Kidney Transplant to Reduce Rejection Risk Ex Vivo CRISPR-Cas9 Gene Editing of Donor Kidney, Kidney Transplantation with Standard Care - End-Stage Renal Disease, End Stage Renal Disease on Dialysis | Phase 1 / Phase 2 | Recruiting | AMERICAN ORGAN TRANSPLANT AND CANCER RESEARCH INSTITUTE LLC | 90 | 2025-06-01 | 2025-07-08 |
| The Effect of Daratumumab in Patients With Monoclonal Gammopathy of Renal Significance (MGRS) in Finland Daratumumab - Kidney Failure, Paraproteinemias | Phase 2 | Recruiting | Helsinki University Central Hospital | 30 | 2024-01-19 | 2026-09-16 |
| Delayed Tolerance Through Mixed Chimerism Bone Marrow Transplant, Peripheral Blood Stem Cell Collection, Fludarabine - Kidney Failure, Kidney Transplant; Complications | Phase 1 / Phase 2 | Recruiting | Massachusetts General Hospital | 20 | 2023-10-01 | 2026-09-28 |
| SGLT2 Inhibition in Hemodialysis Dapagliflozin 10 MG, Placebo - Kidney Failure, Hemodialysis | Phase 2 | Completed | Medical University of Vienna | 220 | 2022-10-01 | 2026-03-03 |
| Does Terlipressin Improve Renal Outcome After Liver Surgery Terlipressin, Placebo - Kidney Failure | Phase 2 | Withdrawn | University of Zurich | 2020-01-01 | 2017-05-05 | |
| C1INH Inhibitor Preoperative and Post Kidney Transplant to Prevent DGF & IRI C1 Esterase Inhibitor, Placebo - End Stage Renal Disease, Kidney Failure | Phase 1 / Phase 2 | Completed | Cedars-Sinai Medical Center | 70 | 2014-09-01 | 2018-06-25 |
| Quantitative Mass Transfer of SFP-iron From Dialysate to Blood in CKD-HD Patients Soluble Ferric Pyrophosphate, Placebo - Kidney Failure | Phase 1 / Phase 2 | Completed | Rockwell Medical Technologies, Inc. | 12 | 2013-07-01 | 2015-02-16 |
| Eculizumab for Prevention and Treatment of Kidney Graft Reperfusion Injury eculizumab - End-Stage Renal Disease, Kidney Failure | Phase 2 | Completed | Russian Academy of Medical Sciences | 57 | 2012-09-01 | 2018-08-31 |
| Mesenchymal Stem Cells After Renal or Liver Transplantation Mesenchymal Stem Cells - Liver Failure, Kidney Failure | Phase 1 / Phase 2 | Completed | University of Liege | 40 | 2012-02-01 | 2022-06-14 |
| Safety and Efficacy Study of the Venous Window Needle Guide to Access Arteriovenous (AV)Fistulae Venous Window Needle Guide - End Stage Renal Disease, AV Fistula | Phase 2 / Phase 3 | Completed | Vital Access Corp. | 54 | 2011-12-01 | 2016-06-03 |
| Erythropoietin (EPO) to Protect Renal Function After Cardiac Surgery Erythropoietin zeta, Placebo - Kidney Failure, Renal Failure | Phase 2 | Completed | Region Skane | 75 | 2011-10-01 | 2013-10-25 |
| Treatment of Children With Kidney Transplants by Injection of CD4+CD25+FoxP3+ T Cells to Prevent Organ Rejection CD4+CD25+CD127lowFoxP3+ T regulatory cells injection, Alemtuzumab, Mycophenolate mofetil - End-Stage Renal Disease, Kidney Failure | Phase 1 / Phase 2 | Unknown | Pirogov Russian National Research Medical University | 30 | 2011-10-01 | 2011-11-18 |
| Treatment of Early Stage Renal Failure With Active Vitamin D or a Phosphate Binder. Renvela, Etalpha - Kidney Failure | Phase 2 | Completed | Helse Stavanger HF | 21 | 2010-10-01 | 2012-11-09 |
| Donor Simvastatin Treatment in Organ Transplantation Simvastatin 80mg, Control Rx - Heart Failure, Respiratory Failure | Phase 2 / Phase 3 | Completed | Helsinki University Central Hospital | 84 | 2010-06-01 | 2017-09-19 |
| Safety Trial of Single Versus Multiple Dose Thymoglobulin Induction in Kidney Transplantation Single-dose rabbit Anti-thymocyte Globulin induction, Divided-dose rabbit Anti-thymocyte Globulin induction - End-Stage Renal Disease, Kidney Failure | Phase 2 | Completed | Wright State University | 99 | 2010-03-01 | 2015-12-07 |
| Desensitization of Highly Sensitized Deceased Donor Renal Transplantation Candidates IVIg and rituximab - Kidney Failure | Phase 2 | Terminated | Johns Hopkins University | 20 | 2009-09-01 | 2017-06-01 |
| Safety and Efficacy Study of Add On Aliskiren in Patients With Heart Failure and Renal Impairment Aliskiren, Placebo - Heart Failure, Kidney Failure | Phase 2 | Terminated | University Medical Center Groningen | 41 | 2009-04-01 | 2013-05-17 |
| Pharmacokinetics of LCP-Tacro(TM) Once Daily And Prograf® Twice A Day in Adult De Novo Kidney Transplant Patients Tacrolimus (Tacro™), Prograf - Kidney Failure, Renal Failure | Phase 2 | Completed | Veloxis Pharmaceuticals | 63 | 2008-09-01 | 2015-05-19 |
| Phosphorus and Calcium Removal During Long Hemodialysis Treatment Sessions NxStage System One (NxStage Medical, Lawrence, MA) - Kidney Failure | Phase 2 | Withdrawn | Indiana University | 2008-03-01 | 2016-03-01 |
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Renal Insufficiency (29) · Kidney Failure, Chronic (6) · Kidney Diseases (4) · Renal Insufficiency, Chronic (3) · Fibrosis (2) · Heart Failure (2) · Liver Failure (2) · Rejection, Psychology (2) · Acute Kidney Injury (1) · Arteriovenous Fistula (1) · Bronchiolitis Obliterans Syndrome (1) · Camurati-Engelmann Syndrome (1) · Carcinoma, Renal Cell (1) · Cardio-Renal Syndrome (1) · Delayed Graft Function (1)
Female Urogenital Diseases (29) · Female Urogenital Diseases and Pregnancy Complications (29) · Male Urogenital Diseases (29) · Urogenital Diseases (29) · Urologic Diseases (29) · Kidney Diseases (25) · Pathologic Processes (12) · Pathological Conditions, Signs and Symptoms (12) · Chronic Disease (8) · Disease Attributes (8) · Renal Insufficiency, Chronic (5) · Cardiovascular Diseases (4) · Heart Diseases (3) · Behavior (2) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2)
Kidney Transplantation (3) · Sirolimus (3) · Tacrolimus (3) · Alemtuzumab (2) · Mycophenolic Acid (2) · Rituximab (2) · thymoglobulin (2) · Acetylcysteine (1) · Bone Marrow Transplantation (1) · Cell- and Tissue-Based Therapy (1) · Complement C1 Inhibitor Protein (1) · Cyclophosphamide (1) · Cyclosporine (1) · Everolimus (1) · Immunoglobulins, Intravenous (1)
Helsinki University Central Hospital (2) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (2) · AMERICAN ORGAN TRANSPLANT AND CANCER RESEARCH INSTITUTE LLC (1) · Cedars-Sinai Medical Center (1) · Ebima Clifford Okundaye (1) · Hamilton Health Sciences Corporation (1) · Helse Stavanger HF (1) · Indiana University (1) · Johns Hopkins University (1) · Maquet Cardiovascular (1) · Massachusetts General Hospital (1) · Medical University of Vienna (1) · Minneapolis Veterans Affairs Medical Center (1) · Pfizer (1) · Pirogov Russian National Research Medical University (1)
United States (16) · Finland (2) · Russia (2) · Austria (1) · Belgium (1) · Canada (1) · China (1) · Netherlands (1) · Norway (1) · Sweden (1) · Switzerland (1)
Ashley Vo, PharmD (1) · George W. Burke, III, MD (1) · Gregg Stone, MD (1) · Henrik Bjursten, M.D. Ph.D (1) · Karl B Lemstrom, MD, PhD (1) · Ken Abrams, MD (1) · Luis Sanchez, MD (1) · Manfred Hecking, MD, PhD (1) · Mark Crawford, BA (1) · Michael Kraus, M.D. (1) · Michael M Kaabak, MD (1) · Michael M. Kaabak, M.D. Ph.D. (1) · Pierre-Alain Clavien, MD PhD (1)
PMID 18513531, PMID 22742720, PMID 23903014, PMID 24833247, PMID 25594553, PMID 25965717, PMID 26093871, PMID 26696251, PMID 28284916, PMID 29191961, PMID 31352795, PMID 37370204, PMID 40576086