10 completed, 4 unknown, 3 recruiting, 2 terminated. 19 Phase 1, 9 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 19 | Completed 10, Unknown 4, Recruiting 3, Terminated 2 |
| Phase 2 | 9 | Completed 5, Recruiting 2, Terminated 1, Unknown 1 |
Follow Kidney Failure: new trials by email Literature Review of Kidney Failure trials Research Report on Kidney Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of the Effect of Haemodialysis on the Pharmacokinetics, Safety, and Tolerability of Balcinrenone/Dapagliflozin Balcinrenone/dapagliflozin - Kidney Failure | Phase 1 | Completed | AstraZeneca | 10 | 2026-08-06 | 2026-10-20 |
| CRISPR-Edited HLA Donor Kidney Transplant to Reduce Rejection Risk Ex Vivo CRISPR-Cas9 Gene Editing of Donor Kidney, Kidney Transplantation with Standard Care - End-Stage Renal Disease, End Stage Renal Disease on Dialysis | Phase 1 / Phase 2 | Recruiting | AMERICAN ORGAN TRANSPLANT AND CANCER RESEARCH INSTITUTE LLC | 90 | 2025-06-01 | 2025-07-08 |
| CAR-T Cell Therapy for Desensitization in Kidney Transplantation Cyclophosphamide, CART-BCMA, huCART19 - Kidney Transplant, Kidney Failure | Phase 1 | Recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 20 | 2024-05-09 | 2026-10-08 |
| Delayed Tolerance Through Mixed Chimerism Bone Marrow Transplant, Peripheral Blood Stem Cell Collection, Fludarabine - Kidney Failure, Kidney Transplant; Complications | Phase 1 / Phase 2 | Recruiting | Massachusetts General Hospital | 20 | 2023-10-01 | 2026-09-28 |
| Safety, Tolerability, and Feasibility of Empagliflozin Therapy in Dialysis-dependent ESKD Empagliflozin, Placebo - End-stage Kidney Disease, Kidney Disease, Chronic | Phase 1 | Completed | University of Utah | 62 | 2023-03-21 | 2026-10-30 |
| CINRYZE as a Donor Pre-treatment Strategy in Kidney Recipients of KDPI>60% Placebo saline solution, Heparin, CINRYZE - Kidney Failure | Phase 1 | Unknown | University of Wisconsin, Madison | 72 | 2020-12-01 | 2020-10-22 |
| Evaluate the Safety, Tolerability, and PK of EP547 in Healthy Subjects and Subjects With Cholestatic or Uremic Pruritus EP547, Placebo - Pruritus, Cholestasis | Phase 1 | Completed | Escient Pharmaceuticals, Inc | 89 | 2020-09-07 | 2025-08-08 |
| Patient-Derived Stem Cell Therapy for Diabetic Kidney Disease Autologous adipose-derived mesenchymal stem/stromal cells (MSC) Lower Dose, Autologous adipose-derived mesenchymal stem/stromal cells (MSC) Higher Dose - Diabetic Kidney Disease, Diabetic Nephropathies | Phase 1 | Terminated | Mayo Clinic | 2 | 2019-10-23 | 2025-08-17 |
| RUCONEST® as a Therapeutic Strategy to Reduce the Incidence of Delayed Graft Function rhC1INH, Saline Solution - Kidney Failure | Phase 1 | Unknown | University of Wisconsin, Madison | 20 | 2019-06-21 | 2020-12-14 |
| A Study of Experimental Medication BMS-986231 in Patients With Different Levels of Kidney Function BMS-986231 - Myocardial Failure, Cardiac Failure | Phase 1 | Completed | Bristol-Myers Squibb | 48 | 2018-03-15 | 2019-09-11 |
| C1INH Inhibitor Preoperative and Post Kidney Transplant to Prevent DGF & IRI C1 Esterase Inhibitor, Placebo - End Stage Renal Disease, Kidney Failure | Phase 1 / Phase 2 | Completed | Cedars-Sinai Medical Center | 70 | 2014-09-01 | 2018-06-25 |
| Quantitative Mass Transfer of SFP-iron From Dialysate to Blood in CKD-HD Patients Soluble Ferric Pyrophosphate, Placebo - Kidney Failure | Phase 1 / Phase 2 | Completed | Rockwell Medical Technologies, Inc. | 12 | 2013-07-01 | 2015-02-16 |
| Mesenchymal Stem Cells After Renal or Liver Transplantation Mesenchymal Stem Cells - Liver Failure, Kidney Failure | Phase 1 / Phase 2 | Completed | University of Liege | 40 | 2012-02-01 | 2022-06-14 |
| Treatment of Children With Kidney Transplants by Injection of CD4+CD25+FoxP3+ T Cells to Prevent Organ Rejection CD4+CD25+CD127lowFoxP3+ T regulatory cells injection, Alemtuzumab, Mycophenolate mofetil - End-Stage Renal Disease, Kidney Failure | Phase 1 / Phase 2 | Unknown | Pirogov Russian National Research Medical University | 30 | 2011-10-01 | 2011-11-18 |
| Far Infrared Treatment for Kidney Diseases Far Infrared Radiation (5μm to 20μm wavelength) - Kidney Failure | Phase 1 | Unknown | GAAD Medical Research Institute Inc. | 10 | 2008-02-01 | 2009-01-05 |
| Validation of Serum Creatinine Dosage and Renal Clearance Calculation of inuline clearance, Measuring serum creatinine - Kidney Failure | Phase 1 | Completed | University Hospital, Ghent | 30 | 2006-05-01 | 2011-06-02 |
| An Open-Label Study To Assess The Pharmacokinetics, Safety And Toleration Of Vfend®; Following Multiple Dosing With Vfend Vfend®; I.V. - Kidney Failure | Phase 1 / Phase 2 | Terminated | Pfizer | 1 | 2005-06-01 | 2008-09-29 |
| Using Donor Stem Cells and Alemtuzumab to Prevent Organ Rejection in Kidney Transplant Patients Alemtuzumab, Mycophenolate mofetil, Sirolimus - Kidney Transplantation, Kidney Disease | Phase 1 / Phase 2 | Completed | University of Miami | 9 | 2004-09-01 | 2012-10-02 |
| Acetylcysteine in the Prevention of Renal Failure After Bypass Surgery N-Acetylcysteine - Kidney Failure | Phase 1 / Phase 2 | Completed | Minneapolis Veterans Affairs Medical Center | 102 | 2003-04-01 | 2007-09-19 |
Renal Insufficiency (19) · Kidney Failure, Chronic (5) · Renal Insufficiency, Chronic (3) · Delayed Graft Function (2) · Kidney Diseases (2) · Acute Kidney Injury (1) · Bronchiolitis Obliterans Syndrome (1) · Carcinoma, Renal Cell (1) · Cholestasis (1) · Diabetes Mellitus, Type 1 (1) · Diabetes Mellitus, Type 2 (1) · Diabetic Nephropathies (1) · Fibrosis (1) · Heart Failure (1) · Liver Diseases (1)
Female Urogenital Diseases (19) · Female Urogenital Diseases and Pregnancy Complications (19) · Male Urogenital Diseases (19) · Urogenital Diseases (19) · Urologic Diseases (19) · Kidney Diseases (17) · Pathological Conditions, Signs and Symptoms (9) · Pathologic Processes (8) · Chronic Disease (6) · Disease Attributes (6) · Renal Insufficiency, Chronic (3) · Digestive System Diseases (2) · Immune System Diseases (2) · Adenocarcinoma (1) · Autoimmune Diseases (1)
Kidney Transplantation (3) · Alemtuzumab (2) · Cyclophosphamide (2) · Mycophenolic Acid (2) · Saline Solution (2) · Sirolimus (2) · Tacrolimus (2) · Acetylcysteine (1) · Bone Marrow Transplantation (1) · Cell- and Tissue-Based Therapy (1) · Complement C1 Inhibitor Protein (1) · Cyclosporine (1) · Everolimus (1) · Heparin (1) · Rituximab (1)
University of Wisconsin, Madison (2) · AMERICAN ORGAN TRANSPLANT AND CANCER RESEARCH INSTITUTE LLC (1) · AstraZeneca (1) · Bristol-Myers Squibb (1) · Cedars-Sinai Medical Center (1) · Escient Pharmaceuticals, Inc (1) · GAAD Medical Research Institute Inc. (1) · Massachusetts General Hospital (1) · Mayo Clinic (1) · Minneapolis Veterans Affairs Medical Center (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · Pfizer (1) · Pirogov Russian National Research Medical University (1) · Rockwell Medical Technologies, Inc. (1) · University Hospital, Ghent (1)
United States (11) · Belgium (2) · Australia (1) · Canada (1) · China (1) · Czechia (1) · New Zealand (1) · Poland (1) · Russia (1)
Alfred Garfall, MD (1) · Ali Naji, MD, Ph.D. (1) · Arjan Van der Tol, MD (1) · Ashley Vo, PharmD (1) · George W. Burke, III, MD (1) · Ken Nedd, M.D. (1) · Kwasi Donyina, Ph.D. (1) · LaTonya J Hickson, MD (1) · Luis Fernandez (1) · Luis Fernandez, MD (1) · Michael M. Kaabak, M.D. Ph.D. (1) · Raymond D Pratt, MC FACP (1) · Raymond Van Holder, MD, PhD (1)
PMID 18513531, PMID 23903014, PMID 28284916, PMID 38995690, PMID 41141513, PMID 42235014
R01DK131265 (1)