17 completed, 1 terminated, 1 unknown, 1 withdrawn. 20 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 20 | Completed 17, Terminated 1, Unknown 1, Withdrawn 1 |
Follow Keratoconjunctivitis Sicca: new trials by email Literature Review of Keratoconjunctivitis Sicca trials Research Report on Keratoconjunctivitis Sicca
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Tolerability and Efficacy Study of Reinnerva/Lubristil+G vs Vismed Reinnerva/Lubristil +G sterile eye drops (artificial tears), Vismed sterile eye drops (artificial tears) - Keratoconjunctivitis Sicca | Not applicable | Completed | Medivis SRL | 40 | 2025-06-09 | 2026-02-19 |
| Medical vs Acupuncture for Dry Eye Artificial tears, Traditional Chinese Medicine Acupuncture - Dry Eye, Acupuncture | Not applicable | Completed | Nadide Koca | 90 | 2024-01-15 | 2025-09-22 |
| Sphenopalatine Ganglion Stimulation for Ocular and Oral Dryness Osteopathic protocol of Sphenopalatine Ganglion Stimulation - Dry Eye Disease, Xerostomia | Not applicable | Completed | Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA | 30 | 2022-01-15 | 2024-11-01 |
| Pilot Study to Investigate the Feasibility, Reliability and Efficacy of Utilizing OCT to Automate PROSE Fitting Ocular surface optical coherence tomography - Keratoconus, Ocular Surface Disease | Not applicable | Completed | Boston Sight | 11 | 2020-12-15 | 2023-10-27 |
| A Randomized Study of Smile Exercise for Dry Eye smile exercise, 0.1% sodium hyaluronate eye drop - Dry Eye, Keratoconjunctivitis Sicca | Not applicable | Completed | Zhongshan Ophthalmic Center, Sun Yat-sen University | 299 | 2020-07-02 | 2024-05-14 |
| Tear Lipid Layer Thickness Changes With Use of Emollient and Non-Emollient Eye Drops Systane Complete, Systane Ultra - Dry Eye Syndromes, Keratoconjunctivitis Sicca | Not applicable | Completed | Ohio State University | 24 | 2018-12-05 | 2019-05-23 |
| Intra-Nasal Mechanical Stimulation (INMEST) as a Treatment of Keratoconjunctivitis Sicca (Dry Eye Syndrome) KCS Medical Device - Keratoconjunctivitis Sicca (KCS) | Not applicable | Completed | Karolinska Institutet | 70 | 2018-02-12 | 2022-12-13 |
| Corneal Tear Film Imaging of the Cornea Before and After Restasis Therapy Tear Film Imager, Restasis - Dry Eye Syndrome, Tear Film Insufficiency | Not applicable | Unknown | Meir Medical Center | 40 | 2018-01-30 | 2018-01-18 |
| Tear Production by Nasal Neurostimulation Compared to Active Control Intranasal Neurostimulator - Dry Eye, Dry Eye Syndromes | Not applicable | Completed | Oculeve, Inc. | 27 | 2016-08-31 | 2021-10-19 |
| Acute Tear Production Following Single Use of the Oculeve Intranasal Neurostimulator Oculeve Intranasal Neurostimulator - Dry Eye Syndrome, Keratoconjunctivitis Sicca | Not applicable | Completed | Oculeve, Inc. | 55 | 2016-06-01 | 2017-10-25 |
| A Study to Evaluate the Safety and Effectiveness of Oculeve Intranasal Lacrimal Neurostimulator in Participants With Dry Eye Syndrome Oculeve Intranasal, Sham, Oculeve Extranasal - Dry Eye Syndrome, Keratoconjunctivitis Sicca | Not applicable | Completed | Oculeve, Inc. | 48 | 2016-01-31 | 2019-04-26 |
| Six Month Study to Evaluate the Safety and Effectiveness of the Intranasal Lacrimal Neurostimulator Intranasal Lacrimal Neurostimulator (Oculeve) - Dry Eye Syndromes, Keratoconjunctivitis Sicca | Not applicable | Completed | Oculeve, Inc. | 97 | 2015-08-31 | 2017-10-31 |
| Laser Therapy to Treat the Dry Mouth of Sjogren's Syndrome Lasertherapy, Sham Lasertherapy - KERATOCONJUNCTIVITIS SICCA, XEROSTOMIA | Not applicable | Completed | Federal University of São Paulo | 66 | 2014-05-01 | 2017-08-03 |
| Pilot Study to Clinical Evaluate Device Prototypes in Dry Eye Patients Lacrima medical Prototypes - Dry Eye Syndrome | Not applicable | Withdrawn | Lacrima Medical LTD | 2014-02-01 | 2016-03-08 | |
| Omega-3 Fatty Acid Supplements and Dry Eye Omega-3 Fatty Acid, Soybean Soft Gels - Keratoconjunctivitis Sicca | Not applicable | Terminated | Ohio State University | 35 | 2010-05-01 | 2012-03-20 |
| Efficacy and Safety Study of Nutritional Supplements for Treatments of Dry Eye Hydroeye, Inactive Capsule - Keratoconjunctivitis Sicca | Not applicable | Completed | Virginia Eye Consultants | 62 | 2008-09-01 | 2012-02-20 |
| Tear Film Break-up Time After Instillation of Artificial Tears glycerin, polyethylene glycol 400/propylene glycol - Keratoconjunctivitis Sicca | Not applicable | Completed | Calm Water Therapeutics LLC | 16 | 2008-06-01 | 2012-10-26 |
| Goblet Cell Response and Dry Eye Symptoms After PRK and LASIK PRK with conjunctival impression cytology before and after surgery, LASIK with conjunctival impression cytology before and after surgery - Keratoconjunctivitis Sicca | Not applicable | Completed | Walter Reed National Military Medical Center | 146 | 2008-01-01 | 2024-09-20 |
| Acupuncture Treatment of Dry Eye Acupuncture, Sham acupuncture - Keratoconjunctivitis Sicca, Xeropthalmia | Not applicable | Completed | Walter Reed Army Medical Center | 20 | 2007-11-01 | 2011-08-30 |
| Effects of Systane Versus Saline in Maintaining Tear Film Stability at Determined Time Points Systane Ocular Drops (OTC), Placebo - Saline Drops - Keratoconjunctivitis Sicca | Not applicable | Completed | University of Texas Southwestern Medical Center | 12 | 2006-01-01 | 2008-06-23 |
Dry Eye Syndromes (13) · Corneal Diseases (2) · Eye Diseases (2) · Sjogren's Syndrome (2) · Xerostomia (2) · Blepharitis (1) · Conjunctival Diseases (1) · Corneal Injuries (1) · Dilatation, Pathologic (1) · Keratitis (1) · Keratoconjunctivitis (1) · Keratoconus (1) · Lacrimal Apparatus Diseases (1) · Xerophthalmia (1)
Conjunctivitis (20) · Conjunctival Diseases (19) · Keratitis (19) · Keratoconjunctivitis (19) · Lacrimal Apparatus Diseases (19) · Corneal Diseases (18) · Eye Diseases (18) · Dry Eye Syndromes (7) · Mouth Diseases (3) · Salivary Gland Diseases (3) · Stomatognathic Diseases (3) · Arthritis (2) · Arthritis, Rheumatoid (2) · Autoimmune Diseases (2) · Connective Tissue Diseases (2)
Acupuncture Therapy (1) · Cyclosporins (1) · Fatty Acids, Omega-3 (1) · Glycerol (1) · Keratomileusis, Laser In Situ (1) · Lubricant Eye Drops (1) · Postoperative Period (1)
Oculeve, Inc. (4) · Ohio State University (2) · Boston Sight (1) · Calm Water Therapeutics LLC (1) · Federal University of São Paulo (1) · Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA (1) · Karolinska Institutet (1) · Lacrima Medical LTD (1) · Medivis SRL (1) · Meir Medical Center (1) · Nadide Koca (1) · University of Texas Southwestern Medical Center (1) · Virginia Eye Consultants (1) · Walter Reed Army Medical Center (1) · Walter Reed National Military Medical Center (1)
United States (11) · Brazil (1) · China (1) · Israel (1) · Italy (1) · Spain (1) · Sweden (1) · Turkey (Türkiye) (1)
Daniel Brocks, MD (1) · Edward Holland, MD (1) · Fani Segev, M.D. (1) · Gail Torkildsen, MD (1) · Harrison D. Cavanagh, M.D. (1) · James V. Aquavella, MD (1) · Jan-Erik Juto, M.D., Ph.D. (1) · Joe Wakil, M.D. (1) · John D Sheppard, M.D. (1) · Kelly K Nichols, OD, MPH, PhD (1) · Michael J Mines, MD (1) · Michelle Senchyna (1) · Nadide Koca (1) · Neil Friedman, MD (1) · Penelope Edwards, MPH, CNS (1)