4 completed, 1 unknown. 5 Phase 1, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 5 | Completed 4, Unknown 1 |
| Phase 2 | 2 | Completed 2 |
Follow Keratoconjunctivitis Sicca: new trials by email Literature Review of Keratoconjunctivitis Sicca trials Research Report on Keratoconjunctivitis Sicca
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety, Tolerability, Plug Retention and Preliminary Efficacy of Tacrolimus-loaded Punctal Plug in Patients With Moderate to Severe Dry Eye Disease - Cohort B punctum plug insertion, Eye Drops, Lubricant - Dry Eye, Keratoconjunctivitis Sicca | Phase 1 | Unknown | Eximore Ltd. | 20 | 2022-09-29 | 2023-09-07 |
| Study of INV-102 Ophthalmic Solution in Adults With Moderate Symptomatic Dry Eye Disease INV-102, Vehicle - Dry Eye Disease | Phase 1 / Phase 2 | Completed | Invirsa, Inc. | 84 | 2022-08-30 | 2026-09-18 |
| Safety and Efficacy of PG101 for Dry Eye Syndrome PG101 - Dry Eye Syndrome | Phase 1 / Phase 2 | Completed | Rhodes Pharmaceuticals, L.P. | 72 | 2013-12-01 | 2014-03-05 |
| A Safety, Tolerability and Pharmacokinetics Study of R932348 Eye Drops in Patients With Dry Eye Disease R348 Ophthalmic Solution, 0.2%, R348 Ophthalmic Solution, 0.5%, R348 Ophthalmic Solution, 1.0% - Keratoconjunctivitis Sicca | Phase 1 | Completed | Rigel Pharmaceuticals | 36 | 2012-11-01 | 2014-08-04 |
| A Dose-Escalation Study to Assess the Safety and Tolerability of LX214 Ophthalmic Solution in Healthy Volunteers, Followed by an Open-Label Evaluation of LX214 in Patients With Keratoconjunctivitis Sicca (KCS) voclosporin ophthalmic solution - Keratoconjunctivitis Sicca | Phase 1 | Completed | Lux Biosciences, Inc. | 35 | 2009-02-01 | 2012-06-22 |
Conjunctival Diseases (5) · Conjunctivitis (5) · Corneal Diseases (5) · Eye Diseases (5) · Keratitis (5) · Keratoconjunctivitis (5) · Lacrimal Apparatus Diseases (5) · Dry Eye Syndromes (2)
Gels (1) · Lubricant Eye Drops (1)
Eximore Ltd. (1) · Invirsa, Inc. (1) · Lux Biosciences, Inc. (1) · Rhodes Pharmaceuticals, L.P. (1) · Rigel Pharmaceuticals (1)
United States (4) · Mexico (1)
Gail Torkildsen, M.D. (1) · Gail Torkildsen, MD (1) · Nallely Ramos Betancourt, Dr. (1) · Robert Shalwitz, MD (1)
PMID 15948994, PMID 16021174, PMID 17054241, PMID 22511024, PMID 24695688, PMID 26783543