87 completed, 5 withdrawn, 4 unknown, 2 not yet recruiting. 28 Phase 2, 27 Phase 3, 23 Not applicable, 13 Phase 4, 7 Phase 1.
Follow Keratoconjunctivitis: new trials by email Literature Review of Keratoconjunctivitis trials Research Report on Keratoconjunctivitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Dose Regimen Study of BRM421 Ophthalmic Solution in Patients With Dry Eye Disease BRM421 Ophthalmic Solution, 0.03%, Artificial Tear, BRM421 Ophthalmic Solution, 0.06% - Dry Eye Disease (DED), Keratoconjunctivitis Sicca | Phase 2 | Not yet recruiting | BRIM Biotechnology Inc. | 99 | 2025-12-01 | 2025-10-20 |
| Tolerability and Efficacy Study of Reinnerva/Lubristil+G vs Vismed Reinnerva/Lubristil +G sterile eye drops (artificial tears), Vismed sterile eye drops (artificial tears) - Keratoconjunctivitis Sicca | Not applicable | Completed | Medivis SRL | 40 | 2025-06-09 | 2026-02-19 |
| Corneal Topography in Vernal Keratoconjunctivitis pentacam - Keratoconjunctivitis | Not yet recruiting | Assiut University | 44 | 2025-06-01 | 2024-12-24 | |
| Study of INV-102 Ophthalmic Solution in Adults With Moderate to Severe Dry Eye Disease INV-102, Vehicle - Dry Eye Disease | Phase 2 | Completed | Invirsa, Inc. | 109 | 2024-03-27 | 2026-09-18 |
| Vizol S DIGI EYE Efficacy and Safety Study in Patients With Dry Eye Vizol S DIGI EYE eye drops, 0,9% saline solution, eye drops - Dry Eye Disease (DED) | Phase 3 | Completed | Jadran Galenski laboratorij d.d. | 86 | 2024-03-20 | 2025-07-03 |
| Medical vs Acupuncture for Dry Eye Artificial tears, Traditional Chinese Medicine Acupuncture - Dry Eye, Acupuncture | Not applicable | Completed | Nadide Koca | 90 | 2024-01-15 | 2025-09-22 |
| AONDA Therapeutic Indication Study I Lotrafilcon A contact lenses - Bullous Keratopathy, Corneal Erosion | Completed | Alcon Research | 55 | 2023-06-28 | 2023-07-20 | |
| Phase 4 Study Evaluating the Safety of the Nasal Guide With Tyrvaya Nasal Guide - Dry Eye, Keratoconjunctivitis Sicca | Phase 4 | Completed | Oyster Point Pharma, Inc. | 30 | 2023-06-14 | 2025-05-06 |
| Safety, Tolerability, Plug Retention and Preliminary Efficacy of Tacrolimus-loaded Punctal Plug in Patients With Moderate to Severe Dry Eye Disease - Cohort B punctum plug insertion, Eye Drops, Lubricant - Dry Eye, Keratoconjunctivitis Sicca | Phase 1 | Unknown | Eximore Ltd. | 20 | 2022-09-29 | 2023-09-07 |
| Study of INV-102 Ophthalmic Solution in Adults With Moderate Symptomatic Dry Eye Disease INV-102, Vehicle - Dry Eye Disease | Phase 1 / Phase 2 | Completed | Invirsa, Inc. | 84 | 2022-08-30 | 2026-09-18 |
| Vizol S Lipid Balance Efficacy and Safety Study in Patients With Dry Eye Vizol S LIPID BALANCE eye drops, ophthalmic saline eye drops - Dry Eye Disease | Phase 3 | Completed | Jadran Galenski laboratorij d.d. | 64 | 2022-06-01 | 2024-03-21 |
| Safety Study of Tivanisiran to Treat Dry Eye Tivanisiran sodium ophthalmic solution, Vehicle ophthalmic solution - Dry Eye Disease | Phase 3 | Completed | Sylentis, S.A. | 301 | 2022-03-24 | 2026-09-09 |
| Sphenopalatine Ganglion Stimulation for Ocular and Oral Dryness Osteopathic protocol of Sphenopalatine Ganglion Stimulation - Dry Eye Disease, Xerostomia | Not applicable | Completed | Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA | 30 | 2022-01-15 | 2024-11-01 |
| Safety and Efficacy of Pilocarpine Ophthalmic Topical Cream for the Treatment of Dry Eye Disease Pilocarpine Ophthalmic Topical Cream, Dose 1, Pilocarpine Ophthalmic Topical Cream, Dose 2, Pilocarpine Ophthalmic Topical Cream, Dose 3 - Dry Eye Disease, Kerato Conjunctivitis Sicca | Phase 2 | Completed | Glaukos Corporation | 226 | 2022-01-03 | 2023-07-12 |
| Levocarnitine for Dry Eye in Sjogren's Syndrome Levocarnitine, Placebo - Sjogren's Syndrome, Keratoconjunctivitis Sicca | Phase 2 | Completed | Vanderbilt University Medical Center | 15 | 2021-11-17 | 2025-12-04 |
| Tivanisiran for Dry Eye in Subjects With Sjögren's Syndrome Tivanisiran sodium ophthalmic solution, Vehicle ophthalmic solution - Dry Eye Disease, Sjögren Syndrome | Phase 3 | Completed | Sylentis, S.A. | 203 | 2021-05-25 | 2024-02-20 |
| Treatment of Dry Eye Disease Using Pro-ocular™ - A Proof of Concept, Safety, and Efficacy Study Pro-ocular™ Topical Gel, Placebo Topical Gel - Dry Eye Syndrome, Keratoconjunctivitis Sicca | Phase 2 | Unknown | PharmaDax Inc. | 80 | 2021-05-20 | 2021-05-14 |
| Tolerability Comparison of Flarex to Lotemax SM Fluorometholone Acetate Ophthalmic Suspension 0.1%, Loteprednol Etabonate Ophthalmic Gel 0.38% - Ocular Inflammation, Keratoconjunctivitis | Phase 4 | Completed | Harrow Inc | 40 | 2021-05-01 | 2026-09-22 |
| Differential Diagnosis of Sjögren's Versus Non-Sjögren's Dry Eye Questionnaires, Tear fluid sampling, Impression Cytology - Keratoconjunctivitis Sicca, Dry Eye Syndromes | Completed | Johns Hopkins University | 92 | 2021-01-11 | 2023-01-05 | |
| Pilot Study to Investigate the Feasibility, Reliability and Efficacy of Utilizing OCT to Automate PROSE Fitting Ocular surface optical coherence tomography - Keratoconus, Ocular Surface Disease | Not applicable | Completed | Boston Sight | 11 | 2020-12-15 | 2023-10-27 |
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Keratoconjunctivitis Sicca (85) · Dry Eye Syndromes (73) · Sjogren's Syndrome (10) · Conjunctivitis (5) · Corneal Diseases (5) · Conjunctivitis, Allergic (4) · Eye Diseases (4) · Keratitis (4) · Xerophthalmia (4) · Hyperemia (3) · Pain (3) · Xerostomia (3) · Conjunctival Diseases (2) · Fatigue (2)
Conjunctival Diseases (99) · Eye Diseases (97) · Keratitis (97) · Conjunctivitis (96) · Corneal Diseases (96) · Lacrimal Apparatus Diseases (90) · Dry Eye Syndromes (19) · Immune System Diseases (15) · Mouth Diseases (12) · Salivary Gland Diseases (12) · Skin and Connective Tissue Diseases (12) · Stomatognathic Diseases (12) · Arthritis (10) · Connective Tissue Diseases (10)
Lubricant Eye Drops (7) · Cyclosporins (5) · Loteprednol Etabonate (5) · Cyclosporine (4) · rebamipide (4) · Ophthalmic Solutions (3) · lifitegrast (3) · CF101 (2) · Carboxymethylcellulose Sodium (2) · Fluorometholone (2) · Glycerol (2) · Hyaluronic Acid (2) · Sodium Chloride (2) · Tacrolimus (2) · Visomitin (2)
Allergan (5) · Oculeve, Inc. (4) · Sun Pharmaceutical Industries Limited (4) · Kala Pharmaceuticals, Inc. (3) · Mimetogen Pharmaceuticals USA, Inc. (3) · Mitotech, SA (3) · Rigel Pharmaceuticals (3) · Astellas Pharma Inc (2) · Can-Fite BioPharma (2) · Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA (2) · Invirsa, Inc. (2) · Jadran Galenski laboratorij d.d. (2) · Johns Hopkins University (2) · Kubota Vision Inc. (2) · Ohio State University (2)
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Gail Torkildsen, MD (4) · Garth Cumberlidge, PhD (2) · Gary Foulks, MD (2) · Jodi Luchs, MD (2) · Lawrence T Friedhoff, MD, PhD (2) · Michelle Senchyna (2) · Robert Shalwitz, MD (2) · Anne Marie Lynge Pedersen, PhD, DDS (1) · Chris Starr, MD (1) · Christine Shieh, MD (1)
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R34EY017626 (1)