22 completed, 11 unknown, 5 withdrawn, 4 recruiting. 19 Not applicable, 10 Phase 2, 6 Phase 4, 5 Phase 1, 2 Phase 3.
Follow Ischemia Reperfusion Injury: new trials by email Literature Review of Ischemia Reperfusion Injury trials Research Report on Ischemia Reperfusion Injury
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Vitamin B6 on Exercise Pressor Reflex on Leg Ischemia-reperfusion Vitamin B6 25 MG, Vitamin B6 50 MG, Vitamin B6 100 MG - Ischemia Reperfusion Injury, Peripheral Artery Disease | Early Phase 1 | Not yet recruiting | Milton S. Hershey Medical Center | 30 | 2027-12-01 | 2026-03-17 |
| A Study to Evaluate the Efficacy and Safety of BX-001N in Preventing Cardiac Surgery-Associated Acute Kidney Injury (CSA-AKI) and Major Adverse Kidney Events (MAKE) BX-001N Experimental group 1, BX-001N Experimental group 2, Placebo group 1 - Ischemia Reperfusion Injury, Cardiac Surgery Associated - Acute Kidney Injury | Phase 2 | Recruiting | Bilix Co.,Ltd. | 50 | 2025-08-26 | 2026-07-01 |
| Differential Impact of Pringle and Portal Vein Occlusion on Myocardial Injury After Non-Cardiac Surgeries. Myocardial Injury After Non-Cardiac Surgery, Ischemia Reperfusion Injury | Completed | Beijing Tsinghua Chang Gung Hospital | 1286 | 2025-03-07 | 2026-06-12 | |
| Hypertonic Lactate After Cardiac Arrest Sodium Lactate Solution - Cardiac Arrest, Ischemia Reperfusion Injury | Phase 2 | Recruiting | Erasme University Hospital | 125 | 2025-02-19 | 2025-02-21 |
| Protecting Autologous Free Flaps From Ischemia/Reperfusion Damage With Cold Storage. University of Wisconsin solution + cold storage, Unperfused free flap under warm ischemia - Ischemia Reperfusion Injury | Not applicable | Unknown | University of Cagliari | 90 | 2024-08-01 | 2024-07-26 |
| Auricular Vagus Stimulation and STEMI TENS - Vagus Nerve Stimulation, Acute Coronary Syndrome | Not applicable | Completed | Bakulev Scientific Center of Cardiovascular Surgery | 110 | 2022-09-01 | 2026-07-20 |
| Intermittent Versus Continuous Surface O2 During HMP of DCD Kidneys Oxygen - Delayed Graft Function, Kidney Transplant; Complications | Phase 3 | Unknown | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | 60 | 2022-03-20 | 2024-05-23 |
| Valproic Acid (VPA) for Acute Kidney Injury (AKI) in Liver Transplant Patients Valproic acid, Isotonic saline solution - Acute Kidney Injury, Ischemia Reperfusion Injury | Phase 2 | Withdrawn | Westat | 2022-01-01 | 2021-10-29 | |
| Valproic Acid (VPA) for Acute Kidney Injury (AKI) in Trauma Patients Valproic Acid Solution, Isotonic saline solution - Acute Kidney Injury, Ischemia Reperfusion Injury | Phase 2 | Withdrawn | Westat | 2022-01-01 | 2021-10-29 | |
| NAD+ Augmentation in Cardiac Surgery Associated Myocardial Injury Trial Niacinamide, Placebo - Ischemia Reperfusion Injury, Myocardial Injury | Phase 2 | Completed | Kaiser Permanente | 331 | 2021-09-13 | 2026-10-26 |
| Remote Ischemic Preconditioning in Cardiac Surgery remote ischemic preconditioning, Sham remote ischemic preconditioning - Ischemia Reperfusion Injury | Not applicable | Unknown | Assiut University | 90 | 2021-04-01 | 2021-04-20 |
| Pneumoperitoneum Preconditioning for the Prevention of Renal Function After Laparoscopic Partial Nephrectomy Pneumoperitoneum preconditioning, Sham-Pneumoperitoneum preconditioning - Ischemia Reperfusion Injury | Not applicable | Unknown | Nanjing First Hospital, Nanjing Medical University | 86 | 2021-01-01 | 2022-10-03 |
| Safety and Efficacy of Treprostinil (Remodulin®) In Reducing Ischemia-Reperfusion Injury During Kidney Transplantation Treprostinil - Ischemia Reperfusion Injury, Delayed Graft Function | Phase 1 / Phase 2 | Recruiting | Rhode Island Hospital | 20 | 2020-11-13 | 2026-04-23 |
| OSA as a Remote Ischemic Preconditioning in Vascular Surgery aorto-bifemoral bypass surgery - Obstructive Sleep Apnea, Vascular Aneurysm | Recruiting | St. Anne's University Hospital Brno, Czech Republic | 100 | 2020-11-01 | 2026-04-27 | |
| Feasibility and Safety of Allogeneic Adipose Mesenchymal Stem Cells (aMSCs) Delivery Into Kidney Allografts Procured From Deceased Donors With High Kidney Donor Profile Index (KDPI) Allogeneic adipose derived mesenchymal stem cells - Ischemia Reperfusion Injury | Phase 1 | Withdrawn | Tambi Jarmi | 2020-09-01 | 2023-10-18 | |
| Functional and Metabolic Effects of Ketone Bodies on Human Atrial Tissue in Patients With and Without Heart Failure 3-hydroxybuturate - Heart Failure, Ischemia Reperfusion Injury | Not applicable | Unknown | University of Aarhus | 40 | 2020-06-01 | 2020-05-08 |
| The Effect of Remote Ischemic Preconditioning on Ischemia/Reperfusion Injury in a Liver Transplant Recipient remote ischemic preconditioning (rIC), non remote ischemic preconditioning (non-rIC) - Liver Transplant; Complications, Ischemia Reperfusion Injury | Not applicable | Withdrawn | Copenhagen University Hospital, Rigshospitalet | 2020-04-01 | 2020-10-08 | |
| Role of Oxidative Stress in Ovarian Tissue After CO2-pneumoperitoneum Application-induced I/R laparoscopic salpingo-oophorectomy, Laparoscopic bilateral salpingo-oophorectomy - Oophorectomy, Oxidative Stress | Not applicable | Completed | Ismet Hortu | 30 | 2019-09-01 | 2021-05-25 |
| Abdominal Regional Perfusion in Donation After Cardiac Death for Multi-Organ Transplantation Abdominal Regional Perfusion - Liver Transplant; Complications, Ischemia Reperfusion Injury | Not applicable | Unknown | London Health Sciences Centre | 20 | 2019-06-01 | 2019-05-13 |
| Sevoflurane vs Propofol Effect on Endothelial Damage Markers After Knee Ligament Surgery. Sevoflurane, Propofol - Ischemia Reperfusion Injury | Not applicable | Completed | University of Chile | 16 | 2018-12-20 | 2019-12-12 |
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Reperfusion Injury (46) · Acute Kidney Injury (3) · Delayed Graft Function (2) · Heart Arrest (2) · Hemorrhage (2) · Hypotension (2) · Acute Coronary Syndrome (1) · Aortic Aneurysm (1) · Atrial Fibrillation (1) · Cardiovascular Diseases (1) · Carotid Stenosis (1) · Coronary Disease (1) · Edema (1) · End Stage Liver Disease (1) · Fibrosis (1)
Pathologic Processes (46) · Pathological Conditions, Signs and Symptoms (46) · Postoperative Complications (46) · Vascular Diseases (46) · Cardiovascular Diseases (45) · Female Urogenital Diseases (4) · Female Urogenital Diseases and Pregnancy Complications (4) · Heart Diseases (4) · Kidney Diseases (4) · Male Urogenital Diseases (4) · Urogenital Diseases (4) · Urologic Diseases (4) · Arterial Occlusive Diseases (3) · Nervous System Diseases (3) · Renal Insufficiency (3)
Saline Solution (4) · Atorvastatin (2) · Rosuvastatin Calcium (2) · Sodium Chloride (2) · Tacrolimus (2) · Valproic Acid (2) · treprostinil (2) · Antilymphocyte Serum (1) · Balanced Anesthesia (1) · Cryopreservation (1) · Desflurane (1) · Endarterectomy, Carotid (1) · Estrogens, Conjugated (USP) (1) · Hypothermia, Induced (1) · Ischemic Postconditioning (1)
Radboud University Medical Center (4) · Beijing Tsinghua Chang Gung Hospital (2) · Mansoura University (2) · Medical University of Vienna (2) · University of Aarhus (2) · University of Pecs (2) · Westat (2) · Abhinav Humar, MD (1) · Aristotle University Of Thessaloniki (1) · Asan Medical Center (1) · Assiut University (1) · Bakulev Scientific Center of Cardiovascular Surgery (1) · Baskent University (1) · Bilix Co.,Ltd. (1) · Cliniques universitaires Saint-Luc- Université Catholique de Louvain (1)
United States (9) · Netherlands (4) · Egypt (3) · Turkey (Türkiye) (3) · Austria (2) · Belgium (2) · China (2) · Denmark (2) · South Korea (2) · Chile (1) · Czechia (1) · Germany (1) · Hungary (1) · Norway (1) · Russia (1)
Amr M Yassen, MD (2) · Cristina Rabadan-Diehl, PharmD, PhD (2) · Abele Donati (1) · Abhinav Humar, M.D. (1) · Adriana Cordova, Prof (1) · Anton I Skaro, MD, PhD (1) · Bente Jespersen, Professor (1) · Brian R Davidson, FRCS, MD (1) · Carla Baan, Professor (1) · D.H. Thijssen, PhD (1) · Eleni Koraki, Dr (1)
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