12 completed, 10 unknown, 2 recruiting, 2 terminated. 6 Phase 1, 5 Not applicable, 4 Phase 2, 3 Phase 4, 2 Phase 3.
Follow Papilledema: new trials by email Literature Review of Papilledema trials Research Report on Papilledema
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Suprachoroidal Injection of Triamcinolone Acetonide in Resistant Diabetic Macular Edema, CRVO, Pseudophakic Cystoid Macular Edema and Diabetic Macular Edema Following Pars Plana Vitrectomy Triamcinolone Acetonide 40Mg/Ml Inj,Susp_#1 - Retinal Edema | Early Phase 1 | Unknown | Tanta University | 100 | 2024-12-01 | 2024-03-05 |
| Optic Nerve Sheath Diameter in Hypertensive Emergency Optic Nerve Sheath Diameter - Hypertensive Emergency, Papilledema | Not yet recruiting | Leiden University Medical Center | 375 | 2024-11-01 | 2024-10-09 | |
| Building Research With Artificial Intelligence in Neuro-Ophthalmology Deep learning algorithm applied on retrospectively collected color fundus photographs - Optic Neuropathy, Optic Neuropathy, Ischemic | Completed | Fondation Ophtalmologique Adolphe de Rothschild | 693 | 2023-10-01 | 2025-09-08 | |
| IIH Intervention: A Clinical Trial Comparing 2 Treatments (Shunts and Stents) Evaluation Of Clinical Effectiveness And Cost Effectiveness CSF shunt, DVSS - IIH - Idiopathic Intracranial Hypertension | Not applicable | Recruiting | University of Birmingham | 80 | 2023-07-18 | 2026-02-27 |
| MR Lymphatic Imaging in Idiopathic Intracranial Hypertention 3T MRI with Gadobutrol injection - Idiopathic Intracranial Hypertension | Not applicable | Completed | Institut National de la Santé Et de la Recherche Médicale, France | 40 | 2023-03-10 | 2026-10-08 |
| The Effect of an Anti-obesity Drug, Semaglutide, as Treatment in New-onset Idiopathic Intracranial Hypertension (IIH) Compared to Standard Weight Management (Dietician) With Regards to Change in Weight and Intracranial Pressure Semaglutide, Very Low Calorie Diet, Dietician counselling - Idiopathic Intracranial Hypertension, Intracranial Pressure | Phase 4 | Completed | Rigmor Højland Jensen | 38 | 2022-09-02 | 2026-02-27 |
| B-Complex: A Nutraceutical SANS Countermeasure Vitamin B-Complex Supplement - Optic Disc Edema, Endothelial Dysfunction | Phase 1 | Recruiting | National Aeronautics and Space Administration (NASA) | 16 | 2022-08-01 | 2025-05-22 |
| High Resolution Optical Coherence Tomography High-resolution optical coherence tomography (High-Res-OCT), Standard spectral domain OCT (SD-OCT) - Retinal Disease, Retinal Detachment | Unknown | Insel Gruppe AG, University Hospital Bern | 550 | 2021-11-30 | 2022-11-29 | |
| VEHICLE Registry: Venous Stenting for IIH in the MENA Region Venous Sinus Stenting Procedure - Idiopathic Intracranial Hypertension (IIH) | Unknown | Middle East North Africa Stroke and Interventional Neurotherapies Organization | 150 | 2021-08-11 | 2024-11-18 | |
| Assessing the Efficacy and Safety fo DEXTENZA, Sustained Release Dexamethasone 0.4 mg Insert(s) for the Treatment of Pain, Inflammation, and Cystoid Macular Edema Following 27 Gauge Vitrectomy With Internal Limiting Membrane Peel for the Treatment of Retinal Edema Associated With Macular Pucker. Dexamethasone Intracanalicular Insert, 0.4 mg, Prednisone acetate 1% - Vitrectomy, Macular Pucker | Phase 4 | Unknown | Kovach Eye Institute | 60 | 2021-04-27 | 2023-06-29 |
| Determination of Normal Measures of Optic Nerve Sheath Diameter in Children Ultrasonic Measurement will be taken from optic nerve sheat diameter and compared-classified. - Optic Papilla Edema | Completed | Cukurova University | 200 | 2020-06-15 | 2025-02-13 | |
| Validation of Non-Invasive Intracranial Pressure (ICP) Monitoring Device Non-invasive ICP measurement - Intracranial Hypertension, Abnormality of Intracranial Pressure | Unknown | Boston Neurosciences | 80 | 2019-03-01 | 2019-03-07 | |
| Endovascular Stenting Treatment for Patients With Internal Jugular Vein Stenosis Venous stenting for internal jugular vein stenosis, One-month routine medical treatment followed by venous stenting for internal jugular vein stenosis - Stent Stenosis, Intracranial Hypertension | Phase 1 | Unknown | Capital Medical University | 60 | 2018-01-01 | 2017-12-14 |
| Cerebral Venous Sinus Thrombosis: Re-exploration of Clinical Assessment Scales Cerebral Venous Sinus Thrombosis, CSF Pressure Increased | Unknown | Capital Medical University | 100 | 2017-06-01 | 2018-02-05 | |
| Ocular Point of Care Ultrasound (POCUS) to Detect Optic Disc Swelling in Comparison to Ophthalmologic Examination Point of care ocular ultrasound - Papilledema Associated With Increased Intracranial Pressure | Not applicable | Unknown | michal roll | 300 | 2017-01-01 | 2016-12-14 |
| aICP in Glaucoma and Papilledema Non-invasive ICP measurement (Vittamed 305) - Open-angle Glaucoma, Papilledema | Not applicable | Unknown | Kantonsspital Aarau | 60 | 2015-04-01 | 2015-04-08 |
| Safety and Effectiveness of 11b-Hydroxysteroid Dehydrogenase Type 1 Inhibitor (AZD4017) to Treat Idiopathic Intracranial Hypertension. AZD4017, Placebo - Idiopathic Intracranial Hypertension | Phase 2 | Completed | University of Birmingham | 31 | 2014-04-25 | 2021-10-27 |
| Antiacne Medications Pseudotumor Cerebri Retinal nerve fibre layer measurement - Optic Disc Swelling | Phase 4 | Unknown | University of Zurich | 310 | 2014-04-01 | 2014-05-29 |
| Ocular Manifestations in Rheumatic Diseases No intervention used - Uveitis, Conjunctivitis | Completed | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 5000 | 2013-05-01 | 2022-04-12 | |
| Prolensa (Bromfenac) 0.07% QD vs. Ilevro (Nepafenac) 0.3% QD for Treatment of Ocular Inflammation Post Cataract Surgery Prolensa (bromfenac 0.07%), Ilevro (nepafenac 0.3%) - Cataract, Retinal Edema | Not applicable | Completed | Melissa Toyos | 50 | 2013-04-01 | 2018-11-14 |
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Pseudotumor Cerebri (8) · Headache (4) · Intracranial Hypertension (4) · Macular Edema (4) · Obesity (3) · Tinnitus (3) · Uveitis (3) · Vision Disorders (3) · Blindness (2) · Epiretinal Membrane (2) · Glaucoma (2) · Idiopathic Juxtafoveal Retinal Telangiectasia (2) · Optic Nerve Diseases (2) · Optic Neuritis (2)
Cranial Nerve Diseases (28) · Eye Diseases (28) · Nervous System Diseases (28) · Optic Nerve Diseases (26) · Brain Diseases (12) · Central Nervous System Diseases (12) · Pathological Conditions, Signs and Symptoms (11) · Cardiovascular Diseases (7) · Intracranial Hypertension (7) · Signs and Symptoms (7) · Vascular Diseases (7) · Neurologic Manifestations (6) · Pathologic Processes (5) · Retinal Diseases (5) · Sensation Disorders (5)
Ranibizumab (2) · 2-(1-(5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl)-3-piperidyl)acetic acid (1) · Acetaminophen (1) · Acetazolamide (1) · Aspirin (1) · Calcium Dobesilate (1) · Codeine (1) · Dexamethasone (1) · Ibuprofen (1) · Interleukin 1 Receptor Antagonist Protein (1) · Naproxen (1) · Triamcinolone Acetonide (1) · bromfenac (1) · butalbital (1) · nepafenac (1)
Capital Medical University (2) · National Eye Institute (NEI) (2) · University of Birmingham (2) · Boston Neurosciences (1) · Cukurova University (1) · Fondation Ophtalmologique Adolphe de Rothschild (1) · Insel Gruppe AG, University Hospital Bern (1) · Institut National de la Santé Et de la Recherche Médicale, France (1) · Kantonsspital Aarau (1) · Kovach Eye Institute (1) · Leiden University Medical Center (1) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (1) · Melissa Toyos (1) · Middle East North Africa Stroke and Interventional Neurotherapies Organization (1) · National Aeronautics and Space Administration (NASA) (1)
United States (10) · Switzerland (3) · Egypt (2) · France (2) · United Kingdom (2) · Canada (1) · China (1) · Denmark (1) · Germany (1) · Iran (1) · Saudi Arabia (1) · Turkey (Türkiye) (1)
Alexandra Sinclair, MbChb PhD (1) · Amin E Nawar, Lecturer (1) · Arnd Heiligenhaus, MD (1) · Behrouz Nikbin, MD (1) · Fereydoun Davatchi, MD (1) · Hanspeter Killer, MD (1) · Hormoz Shams, MD (1) · Janet Pope, MD (1) · John Khadem, MD (1) · Klara Landau, Prof MD (1) · Melissa Toyos, MD (1) · Michael Wall, MD (1) · Oussama Habra, MD (1) · Ran Meng, MD, PhD (1) · Raphaela T Goldbach-Mansky, M.D. (1)
PMID 16899778, PMID 22294344, PMID 23773637, PMID 24756302, PMID 24756514, PMID 24781936, PMID 25223501, PMID 25370510, PMID 25370513, PMID 26024112, PMID 26335066, PMID 26582161, PMID 26618282, PMID 26778344, PMID 26934136, PMID 27143789, PMID 27694262, PMID 28118536, PMID 28130349, PMID 28492874, PMID 28923789, PMID 30868419, PMID 33098644, PMID 33281736, PMID 35469288, PMID 36240084, PMID 36438589, PMID 37740611, PMID 40576025, PMID 40604486, PMID 42487032
U10EY017281 (1), U10EY017387 (1), ZIAAR041138-08 (1)