27 completed, 10 recruiting, 6 unknown, 4 active not recruiting. 23 Not applicable, 7 Phase 3, 6 Phase 2, 4 Phase 4, 1 Phase 1.
Follow Intestinal Failure: new trials by email Literature Review of Intestinal Failure trials Research Report on Intestinal Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of Whey Protein and Resistance Training on Muscle Mass in Patients With Intestinal Failure Whey Protein Supplementation Group, Resistance Training Group - Intestinal Failure, Low Muscle Mass | Not applicable | Not yet recruiting | Wang Xinying | 72 | 2026-08-28 | 2026-08-12 |
| A Study to Investigate the Efficacy and Safety of Apraglutide Compared With Placebo in Adult Participants With Short Bowel Syndrome Associated With Intestinal Failure (SBS-IF) Apraglutide, Placebo - Short Bowel Syndrome (SBS), SBS Associated With Intestinal Failure (SBS-IF) | Phase 3 | Recruiting | VectivBio AG | 124 | 2026-08-01 | 2026-08-04 |
| The LIFT-ECHO Last Mile Project Learn Intestinal Failure Tele-ECHO Program, Standard of Care - Intestinal Failure | Not applicable | Not yet recruiting | Icahn School of Medicine at Mount Sinai | 150 | 2026-07-01 | 2026-03-12 |
| Prognosis and Diagnosis of Acute Gastrointestinal Dysfunction in Cardiac Surgery Patients additional blood testing for specific and non-specific markers of intestinal dysfunction, ultrasound examination of abdominal organs and measurement of intra-abdominal pressure - Gastrointestinal Dysfunction, Cardiac Surgery Intensive Care Treatment | Not applicable | Not yet recruiting | Petrovsky National Research Centre of Surgery | 100 | 2026-03-10 | 2026-02-19 |
| Efficacy And Safety Evaluation of Glepaglutide in Treatment of SBS Glepaglutide, Placebo - Short Bowel Syndrome | Phase 3 | Recruiting | Zealand Pharma | 90 | 2026-02-11 | 2026-09-29 |
| Effect of Parenteral Support on FibroScan in Short Bowel Syndrome Fibroscan - Short Bowel Syndrome, Intestinal Failure | Not yet recruiting | Copenhagen University Hospital, Rigshospitalet | 20 | 2026-02-01 | 2025-10-03 | |
| Effect of GLP-1 on Intestinal Barrier Function in SBS-IF Patients: A Preliminary Exploration. GLP-1 Receptor Agonists - Short Bowel Syndrome (SBS), Intestinal Failure | Not applicable | Completed | Jinling Hospital, China | 20 | 2026-01-24 | 2026-07-14 |
| AI-driven Total Parenteral Nutrition Platform AI-driven total parenteral nutrition (TPN) - Intestinal Failure | Not applicable | Recruiting | Takeoff41, Inc. | 260 | 2026-01-21 | 2026-02-17 |
| Study of Choline Chloride for Injection in Adolescent and Adult Patients With Intestinal Failure Receiving Long Term Parenteral Support Choline Chloride for Injection, Placebo - Choline Deficiency, Liver Injury | Phase 2 / Phase 3 | Recruiting | Protara Therapeutics | 129 | 2025-12-10 | 2026-08-24 |
| Resting Energy Expenditure by Gastrointestinal Functional Status Protocol-Defined Metabolic and Body Composition Assessment - Intestinal Failure, Short Bowel Syndrome | Not applicable | Recruiting | Institute of Oncology Ljubljana | 92 | 2025-10-01 | 2026-07-20 |
| Risk Factors for Catheter-Related Bloodstream Infections in Hospitalized Intestinal Failure Patients Catheter-related Bloodstream Infection, Intestinal Failure | Completed | Jinling Hospital, China | 321 | 2025-01-01 | 2025-09-15 | |
| KiteLock 4% EDTA Lock Solution for the Prevention of Occlusions in Children With Intestinal Failure KiteLock 4% Sterile Catheter Lock Solution, Heparin Lock Solution - Pediatric Intestinal Failure | Not applicable | Recruiting | SterileCare Inc. | 124 | 2024-06-21 | 2026-06-04 |
| Weaning is Winning? (WeWin Study) Weaning off Parenteral Nutrition - Intestinal Failure, Parenteral Nutrition | Recruiting | The Hospital for Sick Children | 120 | 2024-06-01 | 2026-06-24 | |
| Effect of Vitamin D on Skeletal Muscle Function and Qol in Patients With Chronic Intestinal Failure/Insufficiency Vitamin D - Intestinal Failure | Not applicable | Completed | Jinling Hospital, China | 84 | 2024-03-12 | 2025-07-16 |
| Spectral Lighting and Metabolism Spectral Lighting - Intestinal Failure | Not applicable | Enrolling by invitation | Children's Hospital Medical Center, Cincinnati | 32 | 2024-03-01 | 2026-09-15 |
| Changing the Future of Intestinal Failure in Intestinal Chronic Inflammation (INT-FAIL) analysis of predictive factors of IF in patients with Crohn's disease through the characterization of "multiomics" parameters - Intestinal Failure, Inflammatory Bowel Diseases | Not applicable | Active not recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 254 | 2024-02-29 | 2025-03-21 |
| Video Training Supplementation for Patients Discharged on Home Parental Nutrition Educational video - Intestinal Failure | Not applicable | Completed | University of Chicago | 25 | 2024-01-01 | 2026-05-08 |
| Level of Deprivation Assessment in a Population of Short-bowel Syndrome Patients With Intestinal Failure Short Bowel Syndrome, Intestinal Failure | Completed | Central Hospital, Nancy, France | 92 | 2023-12-28 | 2024-04-30 | |
| A Feasibility Study to Evaluate Safety and Probable Benefit of the Eclipse XL1 System for Distraction Enterogenesis in Adult and Pediatric Patients With Short Bowel Syndrome Distraction Enterogenesis in Adult Patients with Short Bowel Syndrome - Short Bowel Syndrome | Not applicable | Recruiting | Eclipse Regenesis, Inc. | 40 | 2023-09-15 | 2026-08-12 |
| Effect of Nocturnal Parenteral Nutrition on Bone Turnover and Energy Metabolism Parenteral nutrition - Intestinal Failure, Osteoporosis | Not applicable | Unknown | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 20 | 2023-07-13 | 2023-10-23 |
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Short Bowel Syndrome (22) · Hyperphagia (19) · Cholestasis (4) · Intestinal Atresia (3) · Crohn Disease (2) · Digestive System Diseases (2) · Enterocolitis, Necrotizing (2) · Intestinal Fistula (2) · Liver Diseases (2) · Osteoporosis (2) · Bone Diseases, Metabolic (1) · Choline Deficiency (1) · Constipation (1) · Dehydration (1)
Gastrointestinal Diseases (58) · Intestinal Diseases (58) · Digestive System Diseases (57) · Pathological Conditions, Signs and Symptoms (37) · Pathologic Processes (24) · Malabsorption Syndromes (21) · Postoperative Complications (21) · Signs and Symptoms (20) · Signs and Symptoms, Digestive (20) · Nutritional and Metabolic Diseases (7) · Metabolic Diseases (5) · Bile Duct Diseases (4) · Biliary Tract Diseases (4) · Gastroenteritis (4) · Pathological Conditions, Anatomical (4)
apraglutide (4) · fish oil triglycerides (3) · Parenteral Nutrition (2) · SMOFlipid (2) · teduglutide (2) · BaseLine dental cement (1) · Blood Specimen Collection (1) · Chlorhexidine (1) · Choline (1) · Ciprofloxacin (1) · Citrulline (1) · Clarithromycin (1) · ClinOleic (1) · Clindamycin (1) · Diet, Fat-Restricted (1)
VectivBio AG (4) · Boston Children's Hospital (3) · Copenhagen University Hospital, Rigshospitalet (3) · Jinling Hospital, China (3) · The Hospital for Sick Children (3) · Institute of Oncology Ljubljana (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Alberta Children's Hospital (1) · Assistance Publique - Hôpitaux de Paris (1) · Catherine Cibulskis, MD (1) · Central Hospital, Nancy, France (1) · Charite University, Berlin, Germany (1) · Children's Hospital Los Angeles (1) · Children's Hospital Medical Center, Cincinnati (1) · Christopher Duggan (1)
United States (25) · Denmark (10) · France (10) · United Kingdom (8) · Belgium (7) · Canada (6) · Germany (6) · Italy (5) · Netherlands (5) · Poland (5) · China (4) · Czechia (4) · Hungary (4) · Spain (4) · Argentina (3)
Tomasz Masior (3) · Patrick J Javid, MD (2) · Xinying Wang, MD (2) · Alastair Forbes (1) · Alexandra Carey, MD (1) · Alexandra N Carey, MD (1) · Alfredo Papa, MD (1) · Amanda Fifi, MD (1) · Biren P Modi, MD MPH (1) · Carol Semrad, MD (1) · Christopher Duggan, MD, MPH (1) · Darla Shores, MD (1) · David Sigalet, MD PhD (1)
PMID 12324199, PMID 19914380, PMID 22683685, PMID 22698933, PMID 24345866, PMID 25272324, PMID 25311444, PMID 25934046, PMID 26373705, PMID 26791189, PMID 26838529, PMID 27072665, PMID 28086227, PMID 28900017, PMID 29907355, PMID 29954418, PMID 30642738, PMID 36965196, PMID 37270289, PMID 38777478, PMID 38837803, PMID 39461299, PMID 40158842, PMID 40554263, PMID 41449463, PMID 41903849, PMID 42235100
2017 (1), R44DK127658 (1)