36 completed, 1 active not recruiting, 1 not yet recruiting, 1 recruiting. 20 Phase 3, 9 Phase 2, 6 Phase 1, 2 Phase 4, 1 Early Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Glucagon-like Peptide 2 (GLP-2) in Undernourished Women Improving From Histology-Confirmed Environmental Enteric Dysfunction (EED) Teduglutide 0.05 dose - Environmental Enteric Dysfunction | Phase 2 | Not yet recruiting | International Centre for Diarrhoeal Disease Research, Bangladesh | 55 | 2026-07-01 | 2026-04-17 |
| A Study of Teduglutide in Chinese Adults With Short Bowel Syndrome Teduglutide - Short Bowel Syndrome | Phase 3 | Active not recruiting | Takeda | 13 | 2025-06-26 | 2026-09-08 |
| TED_ORG: Study on Short Bowel Syndrome Teduglutide (ALX-0600), No Treatment Added - Short Bowel Syndrome (SBS) | Not applicable | Recruiting | Meyer Children's Hospital IRCCS | 50 | 2024-10-30 | 2026-02-10 |
| Pilot Study to Investigate the Effect of Teduglutide on Temporary Ileostomy Function and Complications Teduglutide, Placebo - Ileostomy - Stoma | Phase 3 | Withdrawn | Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) | 2022-06-02 | 2023-02-23 | |
| A Study of Teduglutide in Japanese Children With Short Bowel Syndrome Aged 4 Months or Older Teduglutide - Short Bowel Syndrome | Phase 3 | Completed | Takeda | 3 | 2022-01-04 | 2024-05-16 |
| A Study of Teduglutide in Japanese People With Short Bowel Syndrome Teduglutide - Short Bowel Syndrome | Completed | Takeda | 250 | 2021-09-01 | 2026-08-07 | |
| Pediatric Teduglutide Registry Teduglutide - Short Bowel Syndrome | Completed | Boston Children's Hospital | 142 | 2021-05-18 | 2023-12-11 | |
| A Study to Evaluate the Bioavailability of Teduglutide Administered Subcutaneously by Syringe Injection Versus Pen Injector in Healthy Adult Participants Teduglutide, Syringe Injection, Pen injector - Healthy Volunteers | Phase 1 | Completed | Shire | 64 | 2021-01-13 | 2022-10-04 |
| Quality of Life in Patients With Short Bowel Syndrome Treated Without and With Teduglutide - a Prospective Nested Matched Pair Analysis Teduglutide - Short Bowel Syndrome, Intestinal Failure | Unknown | Charite University, Berlin, Germany | 40 | 2020-09-01 | 2021-02-01 | |
| Therapeutic Approaches to Malnutrition Enteropathy Colostrum high protein powder (Neovite), N-Acetyl Glucosamine (GInNAC), Teduglutide - Severe Acute Malnutrition | Phase 2 | Completed | Queen Mary University of London | 125 | 2020-05-04 | 2021-09-27 |
| Teduglutide for Enterocutaneous Fistula (ECF) Teduglutide, Standard of Care - Postoperative Fistula | Phase 2 | Completed | Daniel Dante Yeh | 6 | 2019-01-31 | 2021-10-06 |
| Glucagon-like Peptide-2 Mediated Secretion of Stored Enteral Lipids Teduglutide, Placebo - Hyperlipidemias | Phase 2 / Phase 3 | Completed | University Health Network, Toronto | 21 | 2019-01-17 | 2022-05-25 |
| Bridging Intestinal Failure With Teduglutide - a Case Report Teduglutide - Short Bowel Syndrome | Completed | Medical University of Vienna | 1 | 2019-01-01 | 2021-06-07 | |
| Plasma Lipoprotein Response to Glucagon-like Peptide-2 Teduglutide, Placebo - Hyperlipidemias | Phase 2 / Phase 3 | Completed | University Health Network, Toronto | 10 | 2018-09-21 | 2022-06-14 |
| Safety, Efficacy and Pharmacokinetic Study of Teduglutide in Infants 4 to 12 Months of Age With Short Bowel Syndrome Teduglutide, Standard Medical Therapy, Syringe - Short Bowel Syndrome | Phase 3 | Completed | Shire | 10 | 2018-08-31 | 2021-05-11 |
| An Extension Study of Teduglutide in Japanese Participants With Short Bowel Syndrome Who Completed 24 Weeks of Treatment in SHP633-306 or TED-C14-004 Teduglutide, Syringe, Needle - Short Bowel Syndrome | Phase 3 | Completed | Takeda | 11 | 2018-07-09 | 2023-03-15 |
| Study of Teduglutide in Japanese Participants With Short Bowel Syndrome Teduglutide, Syringe, Needle - Short Bowel Syndrome | Phase 3 | Completed | Shire | 7 | 2018-07-06 | 2020-08-04 |
| Characterization of the Long-term Safety, Efficacy, and Pharmacodynamics Revestive® in the Management of Short Bowel Syndrome Pediatric Patients Teduglutide - Short Bowel Syndrome | Phase 4 | Completed | Assistance Publique - Hôpitaux de Paris | 25 | 2018-07-02 | 2025-09-11 |
| Treatment of Patients With Teduglutide (GLP-2) for GVHD and Analysis of Paneth Cells of GVHD Patients Teduglutide - Graft Versus Host Disease | Early Phase 1 | Completed | University of Freiburg | 6 | 2017-12-06 | 2023-11-29 |
| L-NMMA on GLP-2 Mediated Intestinal Lipoprotein Release Teduglutide + Normal Saline, Teduglutide + L-NMMA, Placebo + L-NMMA - Hyperlipidemias | Phase 2 / Phase 3 | Completed | University Health Network, Toronto | 10 | 2017-09-27 | 2020-03-27 |
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Short Bowel Syndrome (25) · Hyperphagia (7) · Hyperlipidemias (3) · Crohn Disease (2) · Intestinal Failure (2) · Atherosclerosis (1) · Graft vs Host Disease (1) · Inflammation (1) · Intestinal Diseases (1) · Malnutrition (1) · Renal Insufficiency (1) · Severe Acute Malnutrition (1)
Shire (19) · Takeda (4) · University Health Network, Toronto (3) · Medical University of Vienna (2) · Nycomed (2) · Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) (1) · Assistance Publique - Hôpitaux de Paris (1) · Boston Children's Hospital (1) · Charite University, Berlin, Germany (1) · Daniel Dante Yeh (1) · International Centre for Diarrhoeal Disease Research, Bangladesh (1) · Massachusetts General Hospital (1) · Mayo Clinic (1) · Meyer Children's Hospital IRCCS (1) · Queen Mary University of London (1)
United States (19) · Canada (10) · Germany (8) · United Kingdom (8) · Japan (7) · France (6) · Italy (5) · Denmark (4) · Poland (4) · Belgium (3) · Netherlands (3) · Finland (2) · Spain (2) · Austria (1) · China (1)
Andrew Prendergast, PhD (1) · Beatrice Amadi, MD (1) · Daniel D Yeh, MD (1) · Gary F Lewis, MD (1) · Gary Lewis, MD (1) · James McCormick, DO (1) · Janet Lo, MD, MMSc (1) · Lissette Jimenez (1) · Michael Camilleri, MD (1) · Mutsa Bwakura-Dangarembizi, MB (1) · Paul Kelly, MD (1) · Robert Zeiser, Prof. Dr. (1)
PMID 37364133, PMID 21317170, PMID 24134154, PMID 27507402, PMID 27855998, PMID 37889619, PMID 16099790, PMID 22982184, PMID 23274148, PMID 23333663, PMID 23587733, PMID 24517114, PMID 26223941, PMID 29174926, PMID 29761915, PMID 31495952, PMID 31727642, PMID 31784300, PMID 32341691, PMID 35871951, PMID 37270289, PMID 38632262, PMID 38873891, PMID 41324792, PMID 41454663, PMID 41858082, PMID 42754721
2004 (2), 2017 (2), 2008 (1), 2009 (1), 2016 (1), R01HL123351 (1), UL1TR000135 (1)