488 completed, 187 unknown, 142 recruiting, 89 terminated. 248 Phase 2, 241 Not applicable, 131 Phase 1, 125 Phase 3, 51 Phase 4.
Follow Bile Duct Diseases: new trials by email Literature Review of Bile Duct Diseases trials Research Report on Bile Duct Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| TRANScriptional Pathways Of Surgical Pain Modulated by Music Therapy Exposure (TRANSPOSE) Music-assisted relaxation and imagery (MARI) - Surgery, Stomach Cancer | Not applicable | Not yet recruiting | Case Comprehensive Cancer Center | 20 | 2027-01-01 | 2026-08-05 |
| FEAST and HOPE: Redox PSC Pilot Study N-Acetyl Cysteine (NAC), Alpha-Lipoic Acid (ALA), Nicotinamide Riboside (NR) - Primary Sclerosing Cholangitis (PSC) | Phase 2 | Not yet recruiting | Brigham and Women's Hospital | 15 | 2027-01-01 | 2026-10-27 |
| A Study of Fatigue, Itching and Daily Activities in People With Primary Biliary Cholangitis Starting Elafibranor Elafibranor - Primary Biliary Cholangitis (PBC) | Not yet recruiting | Ipsen | 50 | 2026-11-02 | 2026-10-30 | |
| Nemolizumab for the Treatment of Moderate to Severe Chronic Hepatic Pruritus Nemolizumab-ilto - Chronic Hepatic Pruritus, Cholestatic Liver Disease | Phase 2 | Not yet recruiting | Mayo Clinic | 15 | 2026-11-01 | 2026-09-28 |
| J-LINX: Japan LINerixibat eXtension Study Linerixibat - Pruritus | Phase 3 | Not yet recruiting | GlaxoSmithKline | 40 | 2026-10-09 | 2026-10-06 |
| Vancomycin Efficacy in Response to Dysbiosis in Atypical Colitis Oral Vancomycin - Ulcerative Colitis (UC), Primary Sclerosing Cholangitis (PSC) | Phase 2 | Not yet recruiting | Tampere University Hospital | 140 | 2026-10-01 | 2026-09-10 |
| Tolerability of Enteral NAC in Infants N-Acetylcysteine - Biliary Atresia | Phase 1 | Not yet recruiting | Sanjiv Harpavat | 12 | 2026-10-01 | 2026-03-04 |
| EUS Examination Using EndoSound Vision System vs. Standard Echoendoscope Endoscopic ultrasound examination - Pancreatic Disease, Pancreatic Cancer | Not applicable | Recruiting | Orlando Health, Inc. | 140 | 2026-10-01 | 2026-10-20 |
| Study of Seladelpar and Cilofexor in Participants With Primary Biliary Cholangitis Seladelpar, PTM Seladelpar, Cilofexor Dose B - Primary Biliary Cholangitis | Phase 2 | Recruiting | Gilead Sciences | 132 | 2026-10-01 | 2026-10-27 |
| SumMET: Study of [225Ac]Ac-FL-261 in Participants With Solid Tumors Overexpressing c-MET [225Ac]Ac-FL-261 - Solid Tumor, NSCLC | Phase 1 / Phase 2 | Recruiting | Full-Life Technologies UK Limited | 208 | 2026-10-01 | 2026-10-29 |
| Rifaximin for Prevention of Recurrent Mild-to-moderate Ascending Cholangitis After Biliary-enteric Anastomosis Rifaximin combined with standard care, Standard Care (in control arm) - Cholangitis, Ascending Cholangitis | Phase 4 | Not yet recruiting | Ruijin Hospital | 60 | 2026-10-01 | 2026-10-30 |
| Individualized Drainage Strategy Based on Risk Stratification in Children Undergoing Surgery for Choledochal Cyst: A Prospective Randomized Controlled Trial Robot-Assisted Roux-en-Y Hepaticojejunostomy with Drainage Management - Children Following Robot-assisted Roux-en-Y Hepaticojejunostomy for Choledochal Cysts, Choledochal Cyst | Not applicable | Not yet recruiting | Xueqiang Yan | 80 | 2026-09-01 | 2026-09-17 |
| Umbilical Cord Mesenchymal Stem Cell Therapy for Biliary Atresia Umbilical Cord-Mesenchymal Stem Cells (UC-MSC), Kasai Portoenterostomy - Biliary Atresia, Kasai Operation | Phase 1 | Recruiting | Dr Cipto Mangunkusumo General Hospital | 40 | 2026-09-01 | 2026-09-09 |
| Phase I/II Trial of Human Umbilical Cord Mesenchymal Stromal Cells for UDCA-Refractory Primary Biliary Cholangitis Standard background therapy, Placebo, hUC-MSC Dose Level 1 - Primary Biliary Cholangitis | Phase 1 / Phase 2 | Not yet recruiting | Beijing 302 Hospital | 68 | 2026-08-31 | 2026-08-31 |
| Study of Saroglitazar Magnesium for PBC Patients With Incomplete Response or Intolerant to UDCA Therapy Saroglitazar Magnesium 1 mg, Placebo - Primary Biliary Cholangitis | Phase 3 | Recruiting | Zydus Therapeutics Inc. | 90 | 2026-08-11 | 2026-09-15 |
| Precision Integrated Strategies and Efficacy Evaluation for Biliary Tract Cancers: An Umbrella Platform Study FGFR Inhibitor, IDH1 mutation inhibitor, KRAS mutation inhibitor - Bile Duct Carcinoma, Cholangiocarcinoma | Phase 2 | Not yet recruiting | Zhejiang University | 240 | 2026-08-10 | 2026-07-28 |
| Determine the Prevalence of Exocrine Pancreatic Insufficiency (EPI) in Pediatric and Adult Participants With Alagille Syndrome After Liver Transplantation Fecal Fat - Exocrine Pancreatic Insuficiency | Recruiting | Digestive Care, Inc. | 30 | 2026-08-03 | 2026-10-27 | |
| Study on Clinical and Pathological Features of Primary Biliary Cholangitis and Risk Factors Related to Disease Progression PBC | Not yet recruiting | Beijing Municipal Administration of Hospitals | 300 | 2026-08-01 | 2026-08-04 | |
| Elafibranor Pregnancy Surveillance Program: A Study to Evaluate the Safety of Elafibranor During Pregnancy Elafibranor - Pregnancy Related | Recruiting | Ipsen | 3 | 2026-07-29 | 2026-10-23 | |
| A Study to Observe the Long-term Safety of Odevixibat in Patients With Alagille Syndrome (ALGS) Who Are Receiving Ongoing Treatment Alagille Syndrome | Recruiting | Ipsen | 30 | 2026-07-10 | 2026-10-23 |
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Bile Duct Neoplasms (251) · Liver Cirrhosis, Biliary (214) · Cholangitis, Sclerosing (147) · Cholestasis (138) · Pancreatic Neoplasms (134) · Choledocholithiasis (108) · Gallbladder Neoplasms (105) · Cholangiocarcinoma (98) · Biliary Atresia (75) · Cholangitis (75) · Carcinoma, Hepatocellular (71) · Stomach Neoplasms (69) · Liver Neoplasms (54) · Colonic Neoplasms (50)
Digestive System Diseases (1029) · Biliary Tract Diseases (1027) · Pathological Conditions, Signs and Symptoms (399) · Liver Diseases (361) · Pathologic Processes (325) · Neoplasms (292) · Neoplasms by Site (288) · Digestive System Neoplasms (284) · Cholestasis (249) · Cholestasis, Intrahepatic (239) · Biliary Tract Neoplasms (232) · Fibrosis (209) · Liver Cirrhosis (205) · Neoplasms by Histologic Type (192)
Gemcitabine (41) · Ursodeoxycholic Acid (37) · Cholangiopancreatography, Endoscopic Retrograde (30) · Cisplatin (24) · fish oil triglycerides (23) · Capecitabine (22) · Fluorouracil (19) · Oxaliplatin (17) · maralixibat (16) · obeticholic acid (15) · Fenofibrate (14) · Leucovorin (14) · Vancomycin (13) · Blood Specimen Collection (10) · Cholecystectomy, Laparoscopic (10)
National Cancer Institute (NCI) (27) · Mayo Clinic (24) · Mirum Pharmaceuticals, Inc. (24) · Gilead Sciences (17) · Intercept Pharmaceuticals (14) · Ipsen (13) · Stanford University (12) · Xijing Hospital of Digestive Diseases (12) · GlaxoSmithKline (10) · National Taiwan University Hospital (10) · Assistance Publique - Hôpitaux de Paris (9) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (9) · Children's Hospital Medical Center, Cincinnati (8) · RenJi Hospital (8) · Seoul National University Hospital (8)
United States (426) · China (154) · United Kingdom (97) · Canada (96) · Germany (85) · France (84) · Italy (68) · South Korea (66) · Spain (66) · Belgium (49) · Australia (45) · Netherlands (38) · Poland (38) · Austria (27) · Japan (27)
Ed Doo, MD (8) · Michel Kahaleh, MD (8) · Lisa Henn, PhD (6) · John Magee, MD (5) · Katrina Loh, MD (5) · Li Yang, MD (5) · Lynda Szczech, MD (4) · Tim F Greten, M.D. (4) · Averell Sherker, MD (3) · Christopher L Bowlus, MD (3) · Cynthia Levy, MD (3)
PMID 25543678, PMID 38780109, PMID 42002216, PMID 17509029, PMID 19286178, PMID 23054338, PMID 26561627, PMID 26725209, PMID 28249726, PMID 29519540, PMID 29533266, PMID 29847616, PMID 29954008, PMID 30979521, PMID 31863440, PMID 32059815, PMID 32633158, PMID 32707155, PMID 32716060, PMID 33006765, PMID 33038344, PMID 34508767, PMID 34695449, PMID 35391541, PMID 37953500, PMID 38055647, PMID 38661512, PMID 40439725, PMID 41804276, PMID 42176183, PMID 10022591, PMID 10051462, PMID 10102814, PMID 10343514, PMID 10347106, PMID 10526025, PMID 10655252, PMID 11132910, PMID 11906641, PMID 12145577, PMID 12183720, PMID 12196376, PMID 12360466, PMID 12393999, PMID 1294807, PMID 15017671, PMID 15067627, PMID 15128074, PMID 15269615, PMID 15468571
2016 (7), 2019 (7), 2023 (7), U01DK062456 (7), 2014 (6), 2015 (6), U01DK062436 (5), U01DK062445 (5), U01DK062452 (5), U01DK062453 (5), U01DK062466 (5), U01DK062470 (5), U01DK062481 (5), U01DK062497 (5), U01DK062500 (5)