25 completed, 16 unknown, 4 recruiting, 4 terminated. 28 Not applicable, 15 Phase 2, 6 Phase 3, 5 Phase 1, 5 Phase 4.
Follow Hypertrophic Scar: new trials by email Literature Review of Hypertrophic Scar trials Research Report on Hypertrophic Scar
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| An Innovative Image-Based Method for Extensibility Assessment Traditional physical therapy - Hypertrophic Scar | Not applicable | Completed | Cairo University | 90 | 2025-08-15 | 2026-10-15 |
| Cost-Effectiveness of ESWT Plus Rehabilitation vs Rehabilitation Alone in Post-Burn Scars ESWT Combined with Standard Rehabilitation, Standard Rehabilitation Therapy Alone - Hypertrophic Scar | Not applicable | Recruiting | Al Hayah University In Cairo | 104 | 2025-04-22 | 2025-04-06 |
| Evaluating the Efficacy of Force Modulating Tissue Bridge Device in Preventing Hypertrophic Scars Following Gender-Affirming Mastectomy Brijjit® BP100-6 and BP-75, Control: Standard of care and normal wound dressing - Gender Dysphoria, Mastectomy | Not applicable | Terminated | University of California, San Francisco | 7 | 2025-02-03 | 2026-08-25 |
| Pulsed High Intensity Laser Versus Extracorporeal Shockwave Therapy on Hypertrophic Scar Post Burn pulsed high intensity laser therapy, Extracorporeal shockwave therapy - Hypertrophic Scar | Not applicable | Not yet recruiting | Cairo University | 60 | 2025-01-26 | 2025-01-31 |
| Differential Pressure Distribution Orthosis by 3D Printing Process in the Treatment of Post-burn Hypertrophic Scarring 3D scan measurment - Burns, Hypertrophic Scar | Not applicable | Recruiting | Centre Hospitalier Régional Metz-Thionville | 25 | 2025-01-10 | 2026-06-24 |
| Intra-lesional ACE Inhibitor for Treatment of Hypertrophic Scars Intralesional enalaprilat injection - Hypertrophic Scar | Phase 2 / Phase 3 | Withdrawn | Nova Scotia Health Authority | 2024-08-01 | 2025-02-17 | |
| Effectiveness of Dry Needling in Linear Scar Tissue True dry needling, Sham dry needling - Scar Tissue, Hypertrophic Scar | Not applicable | Unknown | Iran University of Medical Sciences | 80 | 2023-10-10 | 2024-10-01 |
| COMPARISON STUY OF KINESIOTAPE AND LOW-LEVEL LASER THERAPY ON HYPERTROPHIC SCAR Kinesio Tape, Low-Level Laser Therapy (LLLT), 905-nm pulsed Ga-As, Standardized Scar Care (concomitant for all arms) - Hypertrophic Scar, Burn Scar (Post-burn) | Not applicable | Completed | Cairo University | 60 | 2023-10-05 | 2025-10-07 |
| Comparative Study Between Intralesional Corticosteroid Injection Alone and Combined Intralesional Corticosteroid Injection With Either Long-pluse Nd YAG or Erbium Yag for Treating Hypertrophic or Keloid Scars Triamcinolone acetonide injection, Fotona dynamis: Long pulse Nd YAG + Er YAG laser, Fotona Dynamis: Long pulse Nd YAG + Er YAG laser - Hypertrophic Scar, Keloid | Not applicable | Completed | Somdech Phra Nangchao Sirikit Hospital | 20 | 2023-05-01 | 2025-12-04 |
| Microneedling vs. 5-Fluorouracil or Steroid Injections for Hypertrophic Scars and Keloids Microneedling with 5-Fluorouracil, Intralesional 5-fluorouracil, Intralesional Triamcinolone Acetonide - Keloid Scars, Hypertrophic Scar | Phase 4 | Completed | Alexandria University | 60 | 2023-01-12 | 2026-07-22 |
| Botulinum Toxin Type a Iontophoresis for Postburn Hypertrophic Scar Iontophoresis drug delivery device, Traditional physical therapy - Hypertrophic Scar | Not applicable | Unknown | Cairo University | 76 | 2022-08-01 | 2023-06-06 |
| Piezoelectric Drived Microneedling in Treating Refractory Skin Diseases Triamcinolone acetonide(scar)/5-ALA(others), Piezoelectric drived microneedling, 5-ALA (a photosensitizer for photodynamic therapy). - Skin Diseases, Hypertrophic Scar | Not applicable | Unknown | Xiangya Hospital of Central South University | 20 | 2022-07-30 | 2022-08-05 |
| A Study to Evaluate the Safety, Tolerability and Efficacy of AK3280 Cream on Hypertrophic Scar AK3280 Cream, Placebo cream - Hypertrophic Scar | Phase 1 / Phase 2 | Completed | Shanghai Ark Biopharmaceutical Co., Ltd. | 30 | 2022-07-08 | 2026-06-22 |
| Randomized Controlled Trial Examining the Efficacy of Botulinum Toxin in Biopsy Scar Minimization Botulinum Toxin, Normal saline - Scar, Hypertrophic Scar | Phase 2 / Phase 3 | Active not recruiting | Henry Ford Health System | 12 | 2022-06-01 | 2026-01-15 |
| Effect of Nd-YAG Laser on Hypertrophic Scar Nd- YAG laser at 532nm wavelength - Hypertrophic Scar | Not applicable | Completed | Cairo University | 40 | 2022-05-01 | 2024-04-04 |
| Class I Medical Device on Post-surgical Scars Kaloidon Plus, silicone gel - Cicatrix, Post-Surgical Complication | Not applicable | Completed | University of Rome Tor Vergata | 64 | 2022-05-01 | 2022-09-14 |
| Safety, Tolerability, Pharmacokinetics, Immunogenicity and Efficacy of STP705 in Adult Patients With Hypertrophic Scars STP705 - Hypertrophic Scar | Phase 1 / Phase 2 | Withdrawn | Sirnaomics | 2021-12-07 | 2026-07-29 | |
| Zinc Oxide Versus Petrolatum Following Skin Surgery Topical zinc oxide vs. petrolatum post-surgical scars - Surgical Incision, Surgery--Complications | Early Phase 1 | Recruiting | Melissa Pugliano-Mauro | 30 | 2021-09-01 | 2026-09-02 |
| Study to Evaluate Efficacy of OLX10010 in Reducing Recurrence of Hypertrophic Scarring After Scar Revision Surgery OLX10010 - Hypertrophic Scar | Phase 2 | Completed | Olix Pharmaceuticals, Inc. | 22 | 2021-08-19 | 2024-02-21 |
| Regenerative Effects of Human Stem Cell Media After Laser Therapy in Hypertrophic Scar human stem cell conditioned media was applied after non-ablative laser therapy, normal saline was applied after non ablative laser therapy - Stem Cell Media, Hypertrophic Scar | Not applicable | Unknown | Hangang Sacred Heart Hospital | 30 | 2021-08-10 | 2021-08-13 |
Showing 20 of 55. Sign in to see all of them.
Cicatrix, Hypertrophic (55) · Cicatrix (19) · Keloid (14) · Burns (8) · Hyperpigmentation (2) · Acne Vulgaris (1) · Alopecia Areata (1) · Breast Diseases (1) · Dermoid Cyst (1) · Fibrosis (1) · Gender Dysphoria (1) · Gigantomastia (1) · Granuloma Annulare (1) · Hypertrophy (1) · Keratoacanthoma (1)
Pathologic Processes (55) · Pathological Conditions, Signs and Symptoms (55) · Fibrosis (54) · Cicatrix (36) · Skin and Connective Tissue Diseases (18) · Collagen Diseases (14) · Connective Tissue Diseases (14) · Wounds and Injuries (9) · Skin Diseases (5) · Infections (2) · Neoplasms (2) · Pigmentation Disorders (2) · Acneiform Eruptions (1) · Alopecia (1) · Cysts (1)
Botulinum Toxins (3) · Saline Solution (3) · Athletic Tape (2) · Botulinum Toxins, Type A (2) · Lidocaine (2) · Percutaneous Collagen Induction (2) · Sodium Chloride (2) · Triamcinolone Acetonide (2) · abobotulinumtoxinA (2) · Adrenal Cortex Hormones (1) · Enalaprilat (1) · Ethanol (1) · Extracorporeal Shockwave Therapy (1) · Fluorouracil (1) · Gels (1)
Cairo University (6) · Hangang Sacred Heart Hospital (2) · Henry Ford Health System (2) · Hugel (2) · Massachusetts General Hospital (2) · Nova Scotia Health Authority (2) · RXi Pharmaceuticals, Corp. (2) · Sirnaomics (2) · Vanderbilt University Medical Center (2) · Al Hayah University In Cairo (1) · Alexandria University (1) · Centre Hospitalier Régional Metz-Thionville (1) · Chinese University of Hong Kong (1) · Fidia Farmaceutici s.p.a. (1) · Foundation University Islamabad (1)
United States (21) · Egypt (7) · China (4) · Canada (3) · South Korea (3) · Honduras (2) · Hong Kong (2) · Italy (2) · Taiwan (2) · Brazil (1) · France (1) · Iran (1) · Mexico (1) · Pakistan (1) · Slovenia (1)
David Ozog, MD (2) · Jonathan Friedstat, MD (2) · Pamela Pavco, PhD (2) · A M Abd Elbaky, Professor (1) · Alexander Meves, MD (1) · Alexander Neumeister, MD (1) · Ana B Albuquerqu, master (1) · Anthony Papp, MD, PhD (1) · Brian Berman, M.D., Ph.D (1) · Brian Drolet, MD (1) · Caroline Kettering, MD (1) · Cecilia Li-tsang (1) · Edlene L Ribeiro, doctorate (1)
PMID 10077078, PMID 11242330, PMID 11348456, PMID 12845617, PMID 15253184, PMID 16079683, PMID 18534768, PMID 18555763, PMID 18843115, PMID 19215252, PMID 19341651, PMID 19621835, PMID 19802513, PMID 20009818, PMID 20440184, PMID 21332916, PMID 22090252, PMID 22177632, PMID 22907286, PMID 23027220, PMID 23102873, PMID 23716460, PMID 24501476, PMID 24898579, PMID 27292082, PMID 27639820, PMID 28539239, PMID 28654594, PMID 29401161, PMID 30087573, PMID 30548742, PMID 31155638, PMID 31164358, PMID 31307501, PMID 31385893, PMID 31513335, PMID 31881614, PMID 32813130, PMID 32917473, PMID 33632992, PMID 33760691, PMID 35115845, PMID 35943226, PMID 37629638, PMID 38837237, PMID 41039790, PMID 42723368, PMID 7917152