20 completed, 9 unknown, 4 active not recruiting, 3 terminated. 25 Not applicable, 4 Phase 3, 3 Phase 2, 2 Phase 1, 2 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study on the Efficacy and Safety of Ultrasound-Guided Peritendinous Injection of Low-Molecular-Weight Hyaluronic Acid (Hyalotend®; 500-730 kDa) for Chronic Non-Calcific Supraspinatus Tendinopathy. Supraespinatus Tendinopathy | Not yet recruiting | University Hospital of the Nuestra Señora de Candelaria | 30 | 2026-07-01 | 2026-07-13 | |
| Performance and Safety of IRIDIUM GARZE in Blepharitis or Blepharconjunctivitis Adjuvant Treatment IRIDIUM GARZE - Blepharitis, Blepharoconjunctivitis | Not applicable | Completed | Fidia Farmaceutici s.p.a. | 80 | 2025-09-17 | 2026-09-25 |
| A Study to Evaluate Efficacy and Safety of Hydeal Cyst® Intravesical Instillations in Patients Treated With Intravesical Chemotherapy or Immunotherapy in Non-muscle Invasive Bladder Cancer Hydeal Cyst® - Non-muscle Invasive Bladder Cancer | Not applicable | Recruiting | Istituto Oncologico Veneto IRCCS | 200 | 2024-12-20 | 2026-08-04 |
| Evaluation of the Performance and Safety of Hyalo Gyn® Gel Compared to Placebo in Postmenopausal Breast Cancer Survivors Hyalo Gyn Vaginal Gel, Placebo - Vulvo Vaginal Atrophy | Not applicable | Active not recruiting | Fidia Farmaceutici s.p.a. | 156 | 2024-08-01 | 2026-02-12 |
| Performance and Safety of HyalganBio® Intra-Articular Injections as Add-On to Physical Exercise for Symptomatic Glenohumeral Osteoarthritis Hyaluronic acid plus Physical Exercise Program (PEP) - Glenohumeral Osteoarthritis | Not applicable | Active not recruiting | Fidia Farmaceutici s.p.a. | 72 | 2024-07-12 | 2026-04-16 |
| Evaluation of Performance and Safety of Eye Drops With Hyaluronic Acid 0.30% and 0.15% BLUgel A, BLUyal A - Dry Eye Syndrome (DES) | Not applicable | Completed | Fidia Farmaceutici s.p.a. | 101 | 2023-06-21 | 2026-09-18 |
| Evaluation of Performance and Safety of Carbopol 980 NF 0.2%- Based Medical Device in the Management of Patients With Glaucomar or Ocular Hypertension and Concomitant Dry Eye Syndrome on Multiple Long-term Topical Hypotensive Therapy Iridium A Gel - Dry Eye Syndrome, Glaucoma and Concomitant Dry Eye Syndrome | Not applicable | Terminated | Fidia Farmaceutici s.p.a. | 65 | 2023-06-14 | 2026-02-25 |
| Evaluation of Performance and Safety of Eye Drops With Hydroxypropyl-methylcellulose and Inositol in Drye Eye Disease MERAMIRT - Dry Eye Disease Associated to Asthenopia and Accommodative Effort in Video Display Terminal Users | Not applicable | Completed | Fidia Farmaceutici s.p.a. | 100 | 2023-02-06 | 2026-09-23 |
| Study of ONCOFID-P-B (PACLITAXEL-HYALURONIC ACID) ONCOFID P-B (PACLITAXEL-HYALURONIC ACID) - Bladder Carcinoma in Situ (CIS) | Phase 3 | Active not recruiting | Fidia Farmaceutici s.p.a. | 130 | 2022-12-29 | 2026-06-23 |
| Assessment of Efficacy and Safety of the Use of Two Eye Gel Products Containing 5% Dexpanthenol in Patients With Moderate to Severe Dry Eye Syndrome Myrialen Gel, Recugel - Dry Eye Disease | Not applicable | Completed | Fidia Farmaceutici s.p.a. | 125 | 2022-11-16 | 2026-09-21 |
| Management of Acute and Chronic Wounds With Hyaluronic Acid Connettivina BIO cream and gauze - Wound Heal, Wound; Foot | Not applicable | Unknown | Fidia Farmaceutici s.p.a. | 170 | 2022-07-29 | 2024-05-09 |
| Efficacy and Safety of the Use of Ophthalmic Viscosurgical Devices (OVD) FIDIAL PLUS vs IAL®-F During Cataract Surgery FIDIAL PLUS, IAL®-F - Cataract | Not applicable | Completed | Fidia Farmaceutici s.p.a. | 50 | 2022-07-23 | 2023-10-02 |
| Assessment of Efficacy of a Single Intra-articular Injection of HYALUBRIX 60 in Knee Osteoarthritis HYALUBRIX 60 - Knee Osteoarthritis | Not applicable | Unknown | Fidia Farmaceutici s.p.a. | 60 | 2022-06-16 | 2024-07-29 |
| Evaluate Performance and Safety of Hyalo4 Skin in Acute and Chronic Wounds Hyalo4 Skin Gel - Wound Heal | Unknown | Fidia Farmaceutici s.p.a. | 170 | 2022-03-24 | 2023-10-27 | |
| Prediction AlgoriThm for regeneraTive Medicine Approach in knEe OA: New Decision-making Process Based on Patient pRofiliNg (PATTERN) KIT BMAC, at-SVF FIDIA - Osteoarthritis, Knee | Not applicable | Active not recruiting | Istituto Clinico Humanitas | 240 | 2021-09-27 | 2025-05-02 |
| An Open Label, Randomized-controlled Trial to Assess Efficacy Safety of HYALODISC With Physical Exercise Program Intradiscal injection - Degenerative Disc Disease(DDD) | Not applicable | Unknown | Fidia Farmaceutici s.p.a. | 42 | 2021-07-02 | 2023-10-02 |
| Clinical Investigation to Evaluate the Safety and Performance of ConnettivinaBio Plus Cream Compared to ConnettivinaBio Cream in the Management of Wounds in Patients at High Risk of Infection ConnettivinaBio Plus cream, ConnettivinaBio cream - Wounds | Not applicable | Unknown | Fidia Farmaceutici s.p.a. | 80 | 2021-06-10 | 2023-10-18 |
| Comparative Study of Two Hyaluronic Acid Formulation in the Management of Knee Osteoarthritis Hymovis ONE, Monovisc - Osteoarthritis, Knee | Not applicable | Completed | Fidia Farmaceutici s.p.a. | 350 | 2020-09-16 | 2024-07-30 |
| Hyaluronic Acid Sodium Salt and Hydeal-D in the Management of LUTS After TURBT for NMIBC. Hyaluronic Acid (HA) sodium salt and Hydeal-D - Non-muscle Invasive Bladder Cancer (NMIBC) | Not applicable | Terminated | Fidia Farmaceutici s.p.a. | 54 | 2020-08-19 | 2023-10-05 |
| Investigation to Evaluate the Clinical Safety and Effectiveness of WET® Gel WET® gel - Nose Dry Feeling of | Not applicable | Completed | Fidia Farmaceutici s.p.a. | 58 | 2020-01-31 | 2023-10-23 |
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Osteoarthritis, Knee (7) · Dry Eye Syndromes (3) · Osteoarthritis (3) · Non-Muscle Invasive Bladder Neoplasms (2) · Accidental Injuries (1) · Blepharitis (1) · Breast Neoplasms (1) · Bronchiolitis Obliterans Syndrome (1) · Cataract (1) · Cicatrix, Hypertrophic (1) · Depressive Disorder, Major (1) · Foot Injuries (1) · Glaucoma (1) · Inflammation (1) · Intervertebral Disc Degeneration (1)
Diclofenac (3) · diclofenac hydroxyethylpyrrolidine (2) · Citalopram (1) · Sodium Chloride (1) · Surveys and Questionnaires (1) · liposom (1)
Italy (27) · United States (4) · Slovakia (3) · Spain (3) · France (2) · Germany (2) · Belgium (1) · Czechia (1) · Hungary (1) · Poland (1) · Puerto Rico (1) · Switzerland (1) · Taiwan (1) · United Kingdom (1)
Nicola Giordan (6) · Abenaa M. Brewster, MD, MHS, BS (1) · Cynthia Secchieri, PhD (1) · Eva Koetsier (1) · Leonardo Mastropasqua, MD (1) · Lin Ching Tsai, PhD (1) · Michele Iester, MD (1) · Nicola Rosa, MD (1) · Rita Mencucci, MD (1) · Stefano Marcia (1) · Valter Santilli (1)