15 completed, 3 withdrawn, 2 recruiting, 1 terminated. 6 Not applicable, 6 Phase 4, 5 Phase 3, 4 Phase 2, 1 Early Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Nifedipine and Enalapril vs Nifedipine and Labetalol for the Treatment of Postpartum Hypertension Study Nifedipine and Enalapril, Nifedipine and Labetalol - Hypertension, Postpartum Preeclampsia | Not applicable | Recruiting | The Cleveland Clinic | 200 | 2026-03-10 | 2026-08-03 |
| Postpartum Evaluation of Nifedipine and Enalapril for Hypertension Enalapril 10mg QD, Nifedipine 30mg XL BID - Hypertension in Pregnancy | Phase 4 | Recruiting | Nebraska Methodist Health System | 850 | 2025-07-11 | 2025-10-22 |
| Intra-lesional ACE Inhibitor for Treatment of Hypertrophic Scars Intralesional enalaprilat injection - Hypertrophic Scar | Phase 2 / Phase 3 | Withdrawn | Nova Scotia Health Authority | 2024-08-01 | 2025-02-17 | |
| Impact of Metformin and Polysorbate 80 on Drug Absorption and Disposition pravastatin and chenodeoxycholic acid, after metformin and placebo, valacyclovir, chenodeoxycholic acid, and enalaprilat, after polysorbate 80 and placebo - Bile Salt Export Pump (BSEP) Transporter, Polysorbate 80 | Phase 4 | Completed | University of Maryland, Baltimore | 18 | 2021-04-01 | 2024-07-16 |
| Comparing ARNI With ACE Inhibitor on Endothelial Function sacubitril/valsartan, Enalapril - Heart Failure With Reduced Ejection Fraction | Phase 4 | Withdrawn | Brigham and Women's Hospital | 2017-06-01 | 2018-10-11 | |
| Genetic Determinants of ACEI Prodrug Activation Enalapril - Healthy Volunteers | Phase 4 | Completed | University of Michigan | 21 | 2017-04-01 | 2026-02-18 |
| Effect of DPP4 Inhibition on Vasoconstriction Sitagliptin, Placebo, Neuropeptide Y - Type 2 Diabetes Mellitus | Phase 4 | Completed | Vanderbilt University | 18 | 2015-12-01 | 2018-08-27 |
| The Use of Ambulatory Blood Pressure Monitors to Assess Angiotensin Converting Enzyme Inhibitors Equivalent dose enalapril, Equivalent dose lisinopril - Hypertension, Resistant to Conventional Therapy | Phase 1 | Unknown | Memorial Health University Medical Center | 20 | 2015-11-01 | 2017-05-25 |
| Chronic Angiotensin Converting Enzyme Inhibitors in Intermediate Risk Surgery ACEI continuation, ACEI omission - Hypotension on Induction | Phase 4 | Completed | University of Nebraska | 291 | 2015-06-01 | 2023-09-25 |
| Estimation of the Long Term Effectiveness of Routine Use of Cardiac Shock Wave Therapy Treatment of CHD risk factors, Aspirin, Isosorbide mononitrate, Atenolol, Enalapril., PCA - Coronary Heart Disease (CHD) | Withdrawn | City Hospital No 40, Saint Petersburg, Russia | 2013-09-01 | 2014-04-08 | ||
| Bevacizumab vs Dacarbazine in Metastatic Melanoma Bevacizumab, Propranolol, Enalapril - Metastatic Malignant Melanoma, Unresectable Malignant Melanoma | Phase 2 | Terminated | Haukeland University Hospital | 2 | 2013-01-01 | 2017-02-24 |
| Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED) Low-dose rtPA, Standard-dose rtPA, Intensive blood pressure (BP) lowering - Ischemic Stroke, High Blood Pressure | Phase 3 | Completed | The George Institute | 4587 | 2012-03-01 | 2021-10-13 |
| Pharmacogenetics of Ace Inhibitor-Associated Angioedema Sitagliptin (DPP4 inhibitor), Substance P,, bradykinin - Hypertension, Diabetes Type 2 | Not applicable | Completed | Vanderbilt University | 44 | 2011-11-01 | 2015-11-04 |
| Reduction of Night-time Blood Pressure in Pediatric Renal Transplant Recipients New Medication: Enalapril, Isradipine, Propranolol - Hypertension Secondary to Kidney Transplant | Phase 2 / Phase 3 | Completed | Northwell Health | 33 | 2009-11-01 | 2021-04-13 |
| Expression and Function of the Renin-Angiotensin System in the Esophagus Candesartan, Enalapril - Barrett's Esophagus | Early Phase 1 | Completed | Göteborg University | 33 | 2009-10-01 | 2016-08-26 |
| Enalapril Maleate and Doxorubicin Hydrochloride in Treating Women With Breast Cancer doxorubicin hydrochloride, enalapril maleate - Breast Cancer | Not applicable | Completed | Masonic Cancer Center, University of Minnesota | 19 | 2009-04-01 | 2019-05-08 |
| The Second Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial Blood pressure management policies - Intracerebral Hemorrhage, Stroke | Not applicable | Completed | The George Institute | 2839 | 2008-09-01 | 2013-12-13 |
| The Acute Effects of the Angiotensin-converting Enzyme Inhibitor Enalaprilat on Flow Distribution Enalaprilat - Hypertension, Congestive Cardiomyopathy | Phase 3 | Completed | The Hospital for Sick Children | 12 | 2008-07-01 | 2015-12-18 |
| A Study to Determine the Effectiveness and Tolerability of MK8141 in Patients With High Blood Pressure (MK-8141-006) MK8141, Comparator: placebo (unspecified), Enalapril - Hypertension | Phase 2 | Completed | Merck Sharp & Dohme LLC | 160 | 2007-10-01 | 2015-10-16 |
| An Extension Study Designed to Assess Effects of Losartan on Proteinuria in Pediatric Populations (MK-0954-326 AM1,EXT1(AM2)) Losartan Potassium, Comparator: Placebo (Losartan), Comparator: amlodipine besylate - Proteinuria | Phase 3 | Completed | Organon and Co | 306 | 2007-06-01 | 2024-05-23 |
Showing 20 of 22. Sign in to see all of them.
Hypertension (7) · Cerebral Hemorrhage (2) · Diabetes Mellitus, Type 2 (2) · Stroke (2) · Barrett Esophagus (1) · Breast Neoplasms (1) · Cardiomyopathy, Dilated (1) · Cholestasis, progressive familial intrahepatic 2 (1) · Cicatrix (1) · Cicatrix, Hypertrophic (1) · Coronary Disease (1) · Diabetes Mellitus (1) · Heart Failure (1) · Hypertension Resistant to Conventional Therapy (1) · Hypertension, Pregnancy-Induced (1)
The George Institute (3) · Vanderbilt University (2) · Brigham and Women's Hospital (1) · City Hospital No 40, Saint Petersburg, Russia (1) · Georgetown University (1) · Göteborg University (1) · Haukeland University Hospital (1) · Masonic Cancer Center, University of Minnesota (1) · Memorial Health University Medical Center (1) · Merck Sharp & Dohme LLC (1) · Nebraska Methodist Health System (1) · Northwell Health (1) · Nova Scotia Health Authority (1) · Organon and Co (1) · The Cleveland Clinic (1)
United States (12) · Australia (3) · China (2) · Argentina (1) · Austria (1) · Belgium (1) · Brazil (1) · Canada (1) · Chile (1) · Finland (1) · France (1) · Germany (1) · Hong Kong (1) · India (1) · Italy (1)
Craig Anderson, PhD (2) · Nancy J Brown, MD (2) · Amol Malshe, M.D. (1) · Anders F Edebo, MD PhD (1) · Anne H. Blaes, MD (1) · Aruna R Natarajan, MD, PhD (1) · Bruce Neal, PhD (1) · Christine B Sethna, MD, EdM (1) · Craig S Anderson, MD (1) · Dmitriy G Lisovetz, MD, CMedSc (1) · Jason F Shiffermiller, MD, MPH (1) · John D. Bucheit, Pharm D (1) · Kyong-Jin Lee, MD (1) · Michael Bezuhly, MD, MSc (1)
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