25 completed, 25 recruiting, 17 unknown, 5 terminated. 19 Not applicable, 6 Phase 4, 4 Phase 3, 2 Phase 1, 2 Phase 2.
Follow Gender Dysphoria: new trials by email Literature Review of Gender Dysphoria trials Research Report on Gender Dysphoria
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluation of the Variation in Quality of Life During Medical Transition for Transgender People. Gender Dysphoria | Not yet recruiting | University Hospital, Lille | 400 | 2027-01-01 | 2026-05-20 | |
| QAIAx - SGI/SI Smart Health Cities: Microcity Enclave Program (Quantum SI/AGI Agency a/k/a AI City Hall Project - UPSTO App Nos. 64/074,526, 64/063,557, 64/105,164, 63/903,181, 63/729,428, 64/125,360; USPTO EO 9424 Assignment ID: 2101042 / ARN: REEL/FRAME: 76481/0026 - OUSD-R&E, Department of War) AI City Hall Project (AIhealth4u - Public Health Central), AI City Hall Project (QAIAx Microcity A - AI Public Health Central) - Asperger's Disorder, Asperger Disorder | Not applicable | Not yet recruiting | Veterans Recovery Network Inc. | 1000000 | 2026-10-01 | 2026-10-29 |
| Can 3D Modeling Enhance Patient Understanding, Education, and Surgical Outcomes in Gender Affirming Peritoneal Vaginoplasty? Use 3D printed patient specific models for patient education - Vaginoplasty, Gender Dysphoria, Adult | Not yet recruiting | University of Chicago | 20 | 2026-05-01 | 2026-04-21 | |
| Swiss ProspectivE Cohort of TRAnsgender and Gender Diverse Individuals - The SPECTRA Study Group A (start of GAHT), Group B (on-going GAHT), Group C (GAS) - Transgender Individuals, Gender Incongruence | Recruiting | University Hospital, Basel, Switzerland | 600 | 2026-04-20 | 2026-06-30 | |
| GLOW: Gender-Affirming Care and Mental Health: A Longitudinal Study On Quality of Life, Work Life, and Healthcare Outcomes Gender Dysphoria, Adult | Recruiting | Region Skane | 500 | 2025-12-01 | 2026-09-30 | |
| Brain Health in Transgender Adults Magnetic Resonance Imaging, Cognition and Health Tests, Optional Exercise Test - Gender Dysphoria | Recruiting | University of Wisconsin, Madison | 72 | 2025-10-14 | 2026-06-03 | |
| Cardiomodulatory Effects of Gender-Affirming Hormone Therapy Gender Incongruence, Cardiovascular Disease (CVD) Risk Factors | Enrolling by invitation | University Hospital, Akershus | 450 | 2025-09-05 | 2026-01-12 | |
| Gender Affirming Vaginoplasty With Tubularized Augmented Peritoneal Cap (TAPCap) Utilizing Fish Skin Xenograft (Kerecis™) Tubularized augmented peritoneal cap vaginoplasty, Biopsy - Gender Dysphoria, Adult | Recruiting | University Hospitals Cleveland Medical Center | 20 | 2025-07-22 | 2025-12-16 | |
| Cardiovascular Health of Transgender Individuals During the Gender-affirming Pathway Feminizing GAHT, Masculinizing GAHT - Gender Incongruence, Cardiovascular (CV) Risk | Recruiting | IRCCS Azienda Ospedaliero-Universitaria di Bologna | 500 | 2025-07-18 | 2025-09-23 | |
| Topical Estrogen: Brief Intervention to Improve Postoperative Experience for Transgender Men Undergoing Hysterectomy Use of topical estradiol, No intervention - Postoperative Bleeding, Gender Dysphoria | Phase 3 | Recruiting | Women and Infants Hospital of Rhode Island | 48 | 2025-05-01 | 2025-05-13 |
| Evaluating the Efficacy of Force Modulating Tissue Bridge Device in Preventing Hypertrophic Scars Following Gender-Affirming Mastectomy Brijjit® BP100-6 and BP-75, Control: Standard of care and normal wound dressing - Gender Dysphoria, Mastectomy | Not applicable | Terminated | University of California, San Francisco | 7 | 2025-02-03 | 2026-08-25 |
| Trans Care: An Online Intervention to Reduce Symptoms of Gender Dysphoria Trans Care Web App - Gender Dysphoria | Not applicable | Completed | University of Wisconsin, Madison | 312 | 2024-12-12 | 2025-05-22 |
| Metoidioplasty and Phalloplasty Surgery Decision Making MaPS Decision Aid - Gender Dysphoria, Gender Dysphoria, Adult | Not applicable | Enrolling by invitation | Dartmouth-Hitchcock Medical Center | 140 | 2024-10-23 | 2026-09-18 |
| Understanding Perceived Access and Receipt of Gender-affirming Treatments Among Transgender Veterans Gender Dysphoria | Completed | VA Office of Research and Development | 986 | 2024-10-01 | 2026-01-28 | |
| The Effect of Tucking on Semen Quality of Adult Trans Women tucking break - Transgender, Gender Incongruence | Recruiting | Medical University Innsbruck | 40 | 2024-07-17 | 2024-07-31 | |
| Sexual Functioning After Erection Prosthesis Placement in Post Phalloplasty Transgender Persons Questionnaire - Transgenderism, Erectile Dysfunction | Recruiting | University Hospital, Ghent | 150 | 2024-07-15 | 2024-10-15 | |
| Erectile Aid Use in Post-phalloplasty and Post-metoidioplasty Transgender Patients Questionnaire - Transgenderism, Erectile Dysfunction | Recruiting | University Hospital, Ghent | 1000 | 2024-07-06 | 2024-10-15 | |
| Evaluation of the Effectiveness of Hormonal Treatment in Adolescents Suffering From Gender Dysphoria hormonal treatment with cross sex hormones (testosterone or oestrogenes) started at 14 years old +/- 6 months, Cross sex hormones ( œstrogenes or testosterone) started at 15.5 years old +/- 6 months - Gender Dysphoria | Phase 3 | Recruiting | Assistance Publique - Hôpitaux de Paris | 60 | 2024-06-25 | 2026-08-10 |
| Trans Care: An Online Intervention to Reduce Symptoms of Gender Dysphoria Trans Care Web App - Gender Dysphoria | Not applicable | Completed | University of Wisconsin, Madison | 138 | 2024-05-23 | 2024-09-19 |
| Voice Outcome of Glottoplasty, Cricothyroid Approximation, Thyroplasty, and Chondrolaryngoplasty Phonosurgery, Mastectomy/breast augmentation - Surgery, Larynx | Not applicable | Recruiting | University Ghent | 290 | 2024-04-10 | 2024-06-03 |
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Transsexualism (13) · Erectile Dysfunction (4) · Sexual Dysfunction, Physiological (4) · Infertility (3) · Prosthesis Failure (3) · Acquired Immunodeficiency Syndrome (2) · Cardiovascular Diseases (2) · Coitus (2) · Communication Disorders (2) · Depression (2) · Hypogonadism (2) · Insulin Resistance (2) · Mental Disorders (2) · Sexual Behavior (2)
Sexual Dysfunctions, Psychological (82) · Mental Disorders (80) · Behavior (21) · Sexual Behavior (15) · Sexuality (13) · Genital Diseases (12) · Urogenital Diseases (12) · Pathological Conditions, Signs and Symptoms (11) · Pathologic Processes (7) · Genital Diseases, Male (5) · Male Urogenital Diseases (5) · Neurologic Manifestations (5) · Postoperative Complications (5) · Signs and Symptoms (5) · Nervous System Diseases (4)
Estradiol (8) · Cyproterone Acetate (3) · Testosterone (3) · Lynestrenol (2) · Magnetic Resonance Imaging (2) · Mastectomy (2) · Pain Measurement (2) · Sodium Chloride (2) · testosterone 17 beta-cypionate (2) · testosterone undecanoate (2) · 5-alpha Reductase Inhibitors (1) · Anesthetics, Local (1) · Biopsy (1) · Bupivacaine (1) · Canrenoic Acid (1)
Central Hospital, Nancy, France (7) · University Hospital, Ghent (6) · Medical University of Vienna (5) · Amsterdam UMC, location VUmc (3) · University Ghent (3) · University of California, San Francisco (3) · University of Colorado, Denver (3) · University of Wisconsin, Madison (3) · Universitätsklinikum Hamburg-Eppendorf (3) · Copenhagen University Hospital, Rigshospitalet (2) · University of Pittsburgh (2) · Assistance Publique - Hôpitaux de Paris (1) · Cedars-Sinai Medical Center (1) · Centre Hospitalier Henri Laborit (1) · Dartmouth-Hitchcock Medical Center (1)
United States (29) · France (11) · Belgium (9) · Austria (7) · Germany (4) · Netherlands (4) · Sweden (3) · China (2) · Denmark (2) · Norway (2) · Switzerland (2) · Brazil (1) · Canada (1) · Israel (1) · Italy (1)
Evelien D'haeseleer, PhD (2) · Kyle Orwig, PhD (2) · Stephanie Budge, PhD, LP (2) · Alexandra Kautzky-Willer, Prof, MD (1) · Ben-tuo Zeng (1) · Bettina Winzeler, PD Dr. (1) · Birgit Derntl, Prof. Dr. (1) · Clara Leyns, PhD (1) · Corina Lelutiu-Weinberger, PhD (1) · Daniela Ulrich, Assoc Prof, MD PhD (1) · Esther A Kim, MD (1) · Esther Kim, MD (1)
PMID 10518082, PMID 12763518, PMID 14671159, PMID 21971775, PMID 22777369, PMID 23407778, PMID 24007716, PMID 24947034, PMID 2528051, PMID 25497691, PMID 26276103, PMID 26835611, PMID 27379911, PMID 27916515, PMID 28945902, PMID 30252728, PMID 30776252, PMID 30907672, PMID 31242705, PMID 31465627, PMID 32413907, PMID 32926454, PMID 33251587, PMID 33527671, PMID 34176757, PMID 34224431, PMID 34781041, PMID 35105559, PMID 35123055, PMID 36089115, PMID 37204748, PMID 37220393, PMID 37553914, PMID 37581673, PMID 38130980, PMID 38216784, PMID 38340593, PMID 38421210, PMID 38823625, PMID 39419729, PMID 40090622, PMID 40153614, PMID 40204312, PMID 40495044, PMID 41001883, PMID 41580775, PMID 41628614, PMID 41891088
2019 (2), 2025 (1), K23HL151868 (1), R01DK137994 (1)