610 completed, 177 recruiting, 131 unknown, 84 active not recruiting. 295 Not applicable, 285 Phase 2, 189 Phase 1, 88 Phase 3, 28 Phase 4.
Follow Neoplastic Syndromes, Hereditary: new trials by email Literature Review of Neoplastic Syndromes, Hereditary trials Research Report on Neoplastic Syndromes, Hereditary
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Safety Study of ST316 in Participants With Familial Adenomatous Polyposis (FAP). ST316 IV - Familial Adenomatous Polyposis (FAP) | Phase 1 | Not yet recruiting | Sapience Therapeutics | 40 | 2027-01-04 | 2026-08-12 |
| Assessing the Efficacy of Repeat, Monthly Treatments of Alexandrite Laser for NF1-associated Cutaneous Neurofibromas (cNFs) GentleMax Pro (with skin cooling), GentleMax Pro (without skin cooling) - Neurofibromatosis 1 (NF1), Neurofibromatosis Type I | Not applicable | Suspended | Massachusetts General Hospital | 10 | 2027-01-01 | 2026-06-04 |
| Efficacy of Mirdametinib Alone or Combination With Radiotherapy for Germline and Sporadic NF1-Altered High-Grade Glioma mirdametinib with radiation, mirdametinib - Neurofibromatosis 1 (NF1) | Phase 2 | Not yet recruiting | University of Alabama at Birmingham | 55 | 2027-01-01 | 2026-10-05 |
| Combination of Avutometinib and Defactinib for Treatment of Relapsed, Refractory, Metastatic, or Unresectable Malignant Peripheral Nerve Sheath Tumor avutometinib capsule + defactinib tablet - MPNST (Malignant Peripheral Nerve Sheath Tumor) | Phase 2 | Not yet recruiting | Girish Dhall, MD | 25 | 2027-01-01 | 2026-10-28 |
| Study Aiming to Test Whether Non-invasive Liquid Biopsies Can Safely Reduce Invasive Surveillance Methods in Lynch Syndrome INVITRO DIAGNOSTIC TESTS AND COLONOSCOPY - Lynch Syndrome | Not applicable | Not yet recruiting | UNICANCER | 2000 | 2026-12-01 | 2026-08-03 |
| Selumetinib for NF2-Related Schwannomatosis Selumetinib - Neurofibromatosis Type 2, NF2 | Phase 2 | Not yet recruiting | Beijing Tiantan Hospital | 20 | 2026-12-01 | 2026-10-28 |
| Clinical Genetics Branch Eligibility Screening Survey Melanoma, Li-Fraumeni Syndrome | Not yet recruiting | National Cancer Institute (NCI) | 1000 | 2026-11-03 | 2026-10-29 | |
| Acute Effects of Ketone Monoester Co-Ingestion With Dietary Protein on Whole-Body Phenylalanine Oxidation, Phenylalanine Retention, and Myofibrillar Protein Breakdown Following Resistance Exercise in Older Males Ketone Monoester + Dietary Protein (KET+PRO), Dietary Protein (PRO), Resistance Exercise - Ketosis, Resistance Exercise | Not applicable | Not yet recruiting | McGill University | 18 | 2026-11-01 | 2026-10-20 |
| Acute Effects of Ketone Monoester Co-ingestion With Dietary Protein on Whole-body Phenylalanine Oxidation, Phenylalanine Retention, and Myofibrillar Protein Breakdown Following Resistance Exercise in Young Males. Ketone Monoester + Dietary Protein (KET+PRO), Dietary Protein (PRO), Resistance Exercise - Post-exercise Period, Ketosis | Not applicable | Recruiting | McGill University | 18 | 2026-10-23 | 2026-10-23 |
| Protocol for Non-invasive Gynaecological Surveillance in Lynch Syndrome Lynch Syndrome | Not yet recruiting | University of Edinburgh | 1450 | 2026-10-16 | 2026-10-22 | |
| Preventive Dendritic Cell Vaccination for Lynch Syndrome Carriers Arm A: DC vaccination, Arm B: Placebo vaccination - Lynch Syndrome | Phase 3 | Not yet recruiting | Radboud University Medical Center | 372 | 2026-10-01 | 2026-05-27 |
| Preventive Dendritic Cell Vaccination for Lynch Syndrome DC vaccination - Lynch Syndrome | Phase 1 / Phase 2 | Not yet recruiting | Radboud University Medical Center | 16 | 2026-10-01 | 2026-08-19 |
| Ovarian Cancer Liquid Biopsy for Early Assessment & Detection in Individuals With BRCA1/2 Pathogenic Variants Galleri Multi-Cancer Early Detection (MCED) Blood Test - Ovarian Neoplasms, BRCA 1 Gene Mutation | Not applicable | Not yet recruiting | Weill Medical College of Cornell University | 70 | 2026-10-01 | 2026-10-16 |
| Chinese Multicenter Registry for Peutz-Jeghers Syndrome Peutz-Jeghers Syndrome | Not yet recruiting | First People's Hospital of Hangzhou | 1000 | 2026-10-01 | 2026-10-29 | |
| Cognitive Intervention for Children and Adolescents With NF1 Unstuck and On Target! - Neurofibromatosis 1 (NF1), Executive Function (Cognition) | Not applicable | Not yet recruiting | The Hospital for Sick Children | 60 | 2026-09-28 | 2026-10-13 |
| Observational Study of the Real-world Effectiveness and Safety of Selumetinib Treating Adult Patients With Neurofibromatosis Type 1 (NF1) Who Have Symptomatic, Inoperable Plexiform Neurofibroma (PN) Neurofibromatosis Type 1 (NF1) | Recruiting | AstraZeneca | 800 | 2026-09-28 | 2026-10-22 | |
| Neurocutaneous Syndromes in Children: Prevalence and Clinical Characteristics Sturge-Weber Syndrome, Neurocutaneous Syndromes | Not yet recruiting | Assiut University | 100 | 2026-09-20 | 2026-09-28 | |
| A Study to Evaluate the Efficacy of VVD-133214 in Combination With Pembrolizumab Compared With Pembrolizumab Alone in Participants With Advanced Cancer of the Colon or Rectum VVD-133214, Pembrolizumab - Colorectal Adenocarcinoma | Phase 2 | Recruiting | Vividion Therapeutics, Inc. | 140 | 2026-09-11 | 2026-10-21 |
| EHR Intervention to Increase HBOC Genetic Testing ELISABETH Evidence-Informed Program (EIP) - Breast Cancer, Ovarian Cancer | Not applicable | Recruiting | Columbia University | 55 | 2026-09-01 | 2026-10-15 |
| Psychological Support and Psycho-Emotional Trajectories in Cancer Genetics. Patients undergoing their first cancer genetic testing consultation who choose to utilise the clinical psychological support offered by the unit, Patients undergoing their first cancer genetic testing consultation who choose to follow the care pathway without utilising the systematically offered clinical psychological support. - Psychological Distress, Genetic Testing | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 220 | 2026-09-01 | 2026-07-10 |
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Wilms Tumor (199) · Multiple Endocrine Neoplasia Type 1 (193) · Neurofibromatosis 1 (174) · Colorectal Neoplasms, Hereditary Nonpolyposis (144) · Neuroblastoma (118) · Tuberous Sclerosis (114) · Adenomatous Polyposis Coli (92) · Sarcoma (87) · Neoplasms (81) · Breast Neoplasms (72) · Colorectal Neoplasms (64) · Osteosarcoma (61) · Hereditary Breast and Ovarian Cancer Syndrome (60) · Rhabdomyosarcoma (60) · Neurofibromatoses (57)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1182) · Genetic Diseases, Inborn (1173) · Neoplasms (1101) · Neoplasms by Site (785) · Neoplasms by Histologic Type (681) · Nervous System Diseases (445) · Neoplasms, Nerve Tissue (419) · Endocrine System Diseases (367) · Neurodegenerative Diseases (362) · Heredodegenerative Disorders, Nervous System (360) · Urogenital Diseases (359) · Neurocutaneous Syndromes (356) · Endocrine Gland Neoplasms (354) · Neoplasms, Multiple Primary (348)
Everolimus (30) · Sirolimus (30) · Surveys and Questionnaires (24) · Specimen Handling (23) · AZD 6244 (22) · Vincristine (19) · Biopsy (18) · Cyclophosphamide (18) · Magnetic Resonance Spectroscopy (18) · Carboplatin (17) · Blood Specimen Collection (14) · Etoposide (14) · Filgrastim (14) · Doxorubicin (13) · Radiotherapy (12)
National Cancer Institute (NCI) (104) · Children's Oncology Group (30) · M.D. Anderson Cancer Center (29) · Massachusetts General Hospital (21) · Novartis Pharmaceuticals (21) · Assistance Publique - Hôpitaux de Paris (16) · Bayer (13) · AstraZeneca (12) · Memorial Sloan Kettering Cancer Center (12) · University of Alabama at Birmingham (12) · Children's Hospital Medical Center, Cincinnati (11) · Fred Hutchinson Cancer Center (10) · NYU Langone Health (10) · University of California, Los Angeles (10) · The Hospital for Sick Children (9)
United States (679) · Canada (91) · France (88) · United Kingdom (76) · Italy (63) · Australia (61) · China (61) · Netherlands (61) · Germany (54) · Spain (54) · Puerto Rico (37) · Belgium (36) · Israel (27) · Denmark (22) · Poland (21)
Brigitte C Widemann, M.D. (13) · Staci M Peron, Ph.D. (7) · AeRang Kim, MD, PhD (6) · Ana-Maria Vranceanu, PhD (5) · Ervin Epstein, MD (5) · Girish Dhall, MD (4) · Smita Jha, M.D. (4) · Brian H. Kushner, MD (3) · Cathy Shachaf, PhD (3) · Christine Alvarez, MD (3) · Darcy Krueger, MD, PhD (3) · David Steffin, MD (3)
PMID 31401903, PMID 28029918, PMID 29023494, PMID 32187457, PMID 37119510, PMID 37933882, PMID 15683544, PMID 17105749, PMID 19556464, PMID 21996156, PMID 22353803, PMID 25209242, PMID 26851632, PMID 27869650, PMID 28230061, PMID 28409229, PMID 29343557, PMID 29802852, PMID 30053159, PMID 30291925, PMID 31010905, PMID 31449468, PMID 31582003, PMID 31912454, PMID 32271919, PMID 33354735, PMID 33863389, PMID 34541874, PMID 34957550, PMID 35007270, PMID 36055959, PMID 38396300, PMID 38908005, PMID 38996393, PMID 39163973, PMID 39399024, PMID 40018627, PMID 41916615, PMID 10463285, PMID 11136411, PMID 15175957, PMID 15459300, PMID 15542800, PMID 15645403, PMID 15654272, PMID 15814645, PMID 15868587, PMID 15951961, PMID 16088908, PMID 16129848
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