120 completed, 26 recruiting, 23 unknown, 11 terminated. 51 Phase 2, 49 Not applicable, 25 Phase 1, 18 Phase 3, 12 Phase 4.
Follow Telangiectasis: new trials by email Literature Review of Telangiectasis trials Research Report on Telangiectasis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Topical TOR-582 Treatment of Epistaxis in HHT Topical sirolimus ointment - Hereditary Hemorrhagic Telangiectasia (HHT), Epistaxis | Phase 1 | Not yet recruiting | Columbia University | 27 | 2027-03-01 | 2026-11-06 |
| Phase 1b Study of TX002100 in Participants With Hematologic Support-Dependent Hereditary Hemorrhagic Telangiectasia (HHT) TX002100 - Hereditary Hemorrhagic Telangiectasia (HHT) | Phase 1 | Not yet recruiting | Tectonic Operating Company, Inc. | 20 | 2026-12-31 | 2026-10-15 |
| The Effect of 16-week Dietary Intake of Food Supplements Containing Collagen and MSM on Facial Erythema and Other Skin Parameters CPMSM-HD, CPMSM-LD, Placebo - Erythema, Telangiectasis | Not applicable | Recruiting | VIST - Faculty of Applied Sciences | 90 | 2026-11-16 | 2026-11-10 |
| Prevalence of Obstructive Sleep Apnea in HHT and HHT-specific Challenges in OSA-therapy - a Retrospective Cohort Study Hereditary Hemorrhagic Telangiectasia (HHT), Obstructive Sleep Apnea (OSA) | Not yet recruiting | University Hospital, Essen | 1000 | 2026-10-01 | 2026-10-21 | |
| Dermocosmetic Treatment for Facial Redness in Rosacea With or Without Laser Therapy Dermocosmetic tested product, Placebo, Vascular laser treatment - Rosacea, Erythematotelangiectatic, Rosacea Subtype 1 (Erythematotelangiectatic) | Not applicable | Recruiting | ISISPHARMA | 50 | 2026-09-03 | 2026-09-08 |
| A Trial to Assess the Efficacy and Safety of Engasertib in Participants With Moderate to Severe Hereditary Hemorrhagic Telangiectasia (HHT) Engasertib, Placebo - Hereditary Hemorrhagic Telangiectasia | Phase 3 | Recruiting | Vaderis Therapeutics AG | 240 | 2026-09-01 | 2026-09-17 |
| Biomarkers for Babies and Young Children With Ataxia Telangiectasia Ataxia Telangiectasia | Not yet recruiting | University of Nottingham | 56 | 2026-09-01 | 2026-07-16 | |
| Quality of Life in Pediatric Participants With HHT Hereditary Haemorrhagic Telangiectasia (HHT) | Recruiting | Ashley Nelson | 70 | 2026-09-01 | 2026-10-22 | |
| Foam Sclerotherapy With or Without Transdermal Laser for Reticular Veins and Telangiectasias Polidocanol foam sclerotherapy, Transdermal 1064 nm Nd:YAG Laser - Telangiectasias, Reticular Veins | Phase 4 | Recruiting | University of Sao Paulo | 70 | 2026-09-01 | 2026-11-06 |
| Safety and Efficacy of Mutation-targeted Precision Genetic Therapy for Ataxia-Telangiectasia (A-T) Antisense oligonucleotide targeting the ATM gene - Ataxia Telangiectasia | Phase 1 / Phase 2 | Recruiting | Timothy Yu | 10 | 2026-08-01 | 2026-05-28 |
| Harmony-HHT: ATV-1601 in Participants With Hereditary Hemorrhagic Telangiectasia (HHT) ATV-1601, Placebo - Hereditary Hemorrhagic Telangiectasia (HHT), Osler Weber Rendu Disease | Phase 1 / Phase 2 | Recruiting | Atavistik Bio, Inc | 100 | 2026-07-27 | 2026-11-06 |
| DIAG723 in Adults With Hereditary Hemorrhagic Telangiectasia DIAG723, Placebo - Hereditary Hemorrhagic Telangiectasia, Pulmonary Arterial Hypertension | Phase 1 / Phase 2 | Recruiting | Diagonal Therapeutics, Inc. | 93 | 2026-06-04 | 2026-09-08 |
| Nd:YAG Laser Combined With Injection Sclerotherapy Versus Diode Laser in the Treatment of Reticular Veins and Telangiectasias Using CLaCS Technique Nd:YAG laser, Diode laser - Nd:YAG Laser, Sclerotherapy | Not applicable | Recruiting | Ain Shams University | 80 | 2026-06-01 | 2026-07-01 |
| Non-Invasive Detection of Pulmonary Right-to-Left Shunts Using the SONAS Ultrasound Device Transcranial Ultrasound Device - Hereditary Haemorrhagic Telangiectasia, PFO - Patent Foramen Ovale | Not applicable | Recruiting | St. Antonius Hospital | 40 | 2026-01-07 | 2026-02-17 |
| A Trial of TER-1754 in Patients With Hereditary Hemorrhagic Telangiectasia TER-1754, Placebo - Hereditary Hemorrhagic Telangiectasia (HHT) | Phase 1 | Withdrawn | Terremoto Biosciences Inc. | 2025-12-15 | 2026-04-13 | |
| An Phase Ib/II Clinical Trial of TCC1727 Combination Therapy in Advanced Solid Tumors TCC1727 tablet 90mg, TCC1727 tablet 120mg, TCC1727 tablet 160mg - Solid Cancers, NSCLC (Advanced Non-small Cell Lung Cancer) | Phase 1 / Phase 2 | Recruiting | Beijing Tide Pharmaceutical Co., Ltd | 266 | 2025-12-03 | 2026-01-28 |
| Efficacy and Tolerance of Treatment With Bevacizumab for Severe Liver Involvement With High Cardiac Output in Hereditary Hemorrhagic Telangiectasia Within the French Hereditary Hemorrhagic Telangiectasia Network Bevacizumab - Hereditary Hemorrhagic Telangiectasia (HHT), Pulmonary Hypertension | Enrolling by invitation | Poitiers University Hospital | 111 | 2025-10-15 | 2026-03-03 | |
| Body Donation in HHT body donation in HHT - Hereditary Hemorrhagic Telangiectasia | Not applicable | Recruiting | University Hospital, Essen | 5 | 2025-10-01 | 2026-09-17 |
| Immunological Effects of Iron Supplementation in HHT Disease Blood test at D0, Blood test at D+3 months - Hereditary Haemorrhagic Telangiectasia | Not applicable | Recruiting | Hospices Civils de Lyon | 155 | 2025-09-24 | 2025-10-03 |
| CLaCS Using 0.2% Aetoxysklerol Foam and 70% Glucose for the Treatment of Lower Limb Telangiectasias CLaCS - Varicose Veins of Lower Limb, Spider Veins | Phase 2 | Not yet recruiting | Charles University, Czech Republic | 240 | 2025-09-01 | 2025-07-18 |
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Telangiectasia, Hereditary Hemorrhagic (106) · Ataxia Telangiectasia (42) · Epistaxis (30) · Rosacea (10) · Arteriovenous Malformations (8) · Retinal Telangiectasis (8) · Ataxia (7) · Erythema (6) · Genetic Diseases, Inborn (6) · Hyperpigmentation (6) · Rare Diseases (6) · Vascular Malformations (6) · Anemia (5) · Hematologic Diseases (5)
Vascular Diseases (204) · Cardiovascular Diseases (202) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (153) · Congenital Abnormalities (116) · Hemic and Lymphatic Diseases (110) · Cardiovascular Abnormalities (107) · Hemorrhagic Disorders (107) · Hemostatic Disorders (107) · Hematologic Diseases (105) · Vascular Malformations (100) · Pathological Conditions, Signs and Symptoms (72) · Pathologic Processes (54) · Nervous System Diseases (52) · Signs and Symptoms (52)
Bevacizumab (12) · Ranibizumab (7) · Surveys and Questionnaires (7) · Blood Specimen Collection (5) · Lasers, Dye (5) · Lasers (3) · Sodium Chloride (3) · acetylleucine (3) · nicotinamide-beta-riboside (3) · pazopanib (3) · pomalidomide (3) · Argon Plasma Coagulation (2) · Brimonidine Tartrate (2) · Calcium Dobesilate (2) · Capsules (2)
Hospices Civils de Lyon (20) · Imperial College London (13) · Unity Health Toronto (8) · University Hospital, Essen (8) · Johann Wolfgang Goethe University Hospital (6) · Johns Hopkins University (4) · National Center for Research Resources (NCRR) (4) · Quince Therapeutics S.p.A. (4) · Cure HHT (3) · Cutera Inc. (3) · Hospital Italiano de Buenos Aires (3) · IntraBio Inc (3) · University of California, San Diego (3) · University of Nottingham (3) · University of Sao Paulo (3)
United States (66) · France (32) · United Kingdom (23) · Germany (20) · Canada (14) · Brazil (10) · Italy (9) · Spain (9) · Israel (8) · Denmark (7) · Switzerland (7) · Argentina (5) · Australia (5) · Netherlands (5) · Norway (5)
Claire L Shovlin (6) · Stefan Zielen, Prof. Dr. (5) · Claire L Shovlin, PhD FRCP (3) · Marie E Faughnan, MD MSc FRCPC (3) · Alan Guttmacher (2) · Claire Shovlin (2) · David Coman, MBBS FRACP (2) · Dirk Thye, MD (2) · James Gossage, MD (2) · Joshua R. Korzenik (2) · Keith McCrae, MD (2) · Lawrence A. Yannuzzi, MD (2) · Nelson Wolosker, MD, PhD (2)
PMID 18000608, PMID 24586400, PMID 22169361, PMID 24146883, PMID 24676541, PMID 27107394, PMID 30657990, PMID 32573726, PMID 34477998, PMID 35165143, PMID 35316832, PMID 37586837, PMID 37731378, PMID 40739200, PMID 11890075, PMID 12563216, PMID 12754343, PMID 15994879, PMID 16763896, PMID 16934683, PMID 17659962, PMID 17981912, PMID 18385173, PMID 18518871, PMID 19841031, PMID 20701797, PMID 21471070, PMID 21953065, PMID 22144182, PMID 22396517, PMID 22875082, PMID 22927201, PMID 23404156, PMID 23426563, PMID 23445111, PMID 23455486, PMID 23839181, PMID 24236946, PMID 24354965, PMID 24458873, PMID 24481211, PMID 24595923, PMID 24637882, PMID 24686867, PMID 25005464, PMID 25007365, PMID 25040799, PMID 25656498, PMID 26433381, PMID 26547562
2017 (3), 2015 (2), 2018 (2), 2025 (2), U54NS065705 (2), 2009 (1), 2016 (1), 2019 (1), R01HL053261 (1), R01HL053487 (1)