44 completed, 38 recruiting, 24 unknown, 14 active not recruiting. 52 Not applicable, 11 Phase 2, 6 Phase 1, 6 Phase 3, 4 Early Phase 1.
Follow Colorectal Neoplasms, Hereditary Nonpolyposis: new trials by email Literature Review of Colorectal Neoplasms, Hereditary Nonpolyposis trials Research Report on Colorectal Neoplasms, Hereditary Nonpolyposis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study Aiming to Test Whether Non-invasive Liquid Biopsies Can Safely Reduce Invasive Surveillance Methods in Lynch Syndrome INVITRO DIAGNOSTIC TESTS AND COLONOSCOPY - Lynch Syndrome | Not applicable | Not yet recruiting | UNICANCER | 2000 | 2026-12-01 | 2026-08-03 |
| Protocol for Non-invasive Gynaecological Surveillance in Lynch Syndrome Lynch Syndrome | Not yet recruiting | University of Edinburgh | 1450 | 2026-10-16 | 2026-10-22 | |
| Preventive Dendritic Cell Vaccination for Lynch Syndrome Carriers Arm A: DC vaccination, Arm B: Placebo vaccination - Lynch Syndrome | Phase 3 | Not yet recruiting | Radboud University Medical Center | 372 | 2026-10-01 | 2026-05-27 |
| Preventive Dendritic Cell Vaccination for Lynch Syndrome DC vaccination - Lynch Syndrome | Phase 1 / Phase 2 | Not yet recruiting | Radboud University Medical Center | 16 | 2026-10-01 | 2026-08-19 |
| A Study to Evaluate the Efficacy of VVD-133214 in Combination With Pembrolizumab Compared With Pembrolizumab Alone in Participants With Advanced Cancer of the Colon or Rectum VVD-133214, Pembrolizumab - Colorectal Adenocarcinoma | Phase 2 | Recruiting | Vividion Therapeutics, Inc. | 140 | 2026-09-11 | 2026-10-21 |
| Overcoming Barriers to Uptake of Cascade Screening Let's Talk Genetics Providers, Let's Talk Patients - Lynch Syndrome | Not applicable | Not yet recruiting | UNC Lineberger Comprehensive Cancer Center | 20 | 2026-09-01 | 2026-08-26 |
| A Web-Based Program (Kindred) to Improve the Understanding of Genetic Cancer Risk and Cancer Genetic Testing in African American Families Discussion, Internet-Based Intervention, Survey Administration - BRCA1-Related Hereditary Breast and Ovarian Cancer Syndrome, BRCA2-Related Hereditary Breast and Ovarian Cancer Syndrome | Not applicable | Not yet recruiting | University of Michigan Rogel Cancer Center | 150 | 2026-06-15 | 2026-05-19 |
| Periodontal Disease in Patients With Lynch Syndrome periodontal charting for the diagnosis of periodontitis - Lynch Syndrome, Periodontal Disease | Not yet recruiting | Rotundo Roberto | 25 | 2026-06-01 | 2026-05-22 | |
| Impact of Consumption of Ultra-processed Foods in Individuals at High Risk of Cancer educational workshop on nutrition + additional intervention on UPF tool and how to use it - Breast Cancer, Pancreas Cancer | Not applicable | Recruiting | Gustave Roussy, Cancer Campus, Grand Paris | 170 | 2026-05-04 | 2026-05-08 |
| Evaluation of Capsule Colonoscopy in Patients With Lynch Syndrome colon capsule endoscopy - Lynch Syndrome | Not yet recruiting | Region Skane | 78 | 2026-05-01 | 2026-04-30 | |
| Determining the Prevalence of Muir-Torre Syndrome in Patients With Lynch Syndrome Sampling of suspected skin lesions (in accordance with good care practices)., Constitution of a biobank - Basal Cell Carcinoma of Skin, Site Unspecified, Epidermoid Carcinoma | Not applicable | Recruiting | Centre Hospitalier Universitaire de Nīmes | 150 | 2026-03-13 | 2026-06-22 |
| Population Based Germline Testing for Early Detection and Prevention of Cancer Genetic testing for Cancer Susceptibility Genes (CSGs) (BRCA1, BRCA2, RAD51C, RAD51D, BRIP1, PALB2, MLH1, MSH2, MSH6) and personalised breast and ovarian cancer risk - Breast Cancer Risk, Ovarian Cancer Risk | Not applicable | Recruiting | Queen Mary University of London | 6000 | 2025-12-18 | 2026-03-27 |
| The Danish Bladder Cancer Group 23 Study - A European Study on Cancer in the Upper Urinary Tract Kidney sparing surgery for high-risk upper urinary tract urothelial carcinoma - Upper Urinary Tract Urothelial Carcinoma | Recruiting | Zealand University Hospital | 2500 | 2025-11-26 | 2025-12-22 | |
| Menstrual Cup for Early Endometrial Cancer Detection in Lynch Syndrome Menstrual cup use - Endometrial Cancer, Lynch Syndrome | Not applicable | Recruiting | Jessica D. St. Laurent, MD | 25 | 2025-11-20 | 2026-06-10 |
| Clinical Validation of Sophia Genetics Assay Sophia Herditary Cancer Solution - Ovarian Cancer, Breast Cancer | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 248 | 2025-09-15 | 2025-09-08 | |
| Initial Testing of a Behavioral Intervention About Genetic Services for Families at Risk of Lynch Syndrome Information Letter and Booklet, Information Letter - Cascade Testing, Lynch Syndrome | Not applicable | Recruiting | University of Alabama at Birmingham | 185 | 2025-09-15 | 2026-07-21 |
| First in Human Pilot Study to Assess the Safety and Efficacy of Dendritic Cells Loaded With Frameshift Derived Neopeptides for the Prevention of Cancer in of Lynch Syndrome Carriers Autologous Tolerogenic Dendritic cells - Lynch Syndrome | Phase 1 | Recruiting | Fundacion Clinic per a la Recerca Biomédica | 20 | 2025-09-04 | 2026-04-13 |
| Assessing Uterine Cancer Risk in Lynch Syndrome Carriers Using Vaginal Self-sampling and a Health Questionnaire Vaginal DNA swab, microbiome swab and pH test - Endometrial Cancer, Lynch Syndrome | Not applicable | Recruiting | University of British Columbia | 30 | 2025-08-29 | 2026-09-03 |
| Using Visual Arrays to Support Understanding of Genetic Risk Visual Array, Narrative Visual Array, Choice - Decision Aid | Not applicable | Completed | Stephanie B. Seminara, MD | 1045 | 2025-07-28 | 2026-09-24 |
| FITting Non-invasive Tests in Lynch Syndrome Surveillance Fecal immunochemical test - Colorectal Cancer | Not applicable | Recruiting | University of Chicago | 400 | 2025-07-10 | 2026-10-21 |
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Colorectal Neoplasms (38) · Colonic Neoplasms (20) · Endometrial Neoplasms (20) · Hereditary Breast and Ovarian Cancer Syndrome (16) · Neoplastic Syndromes, Hereditary (10) · Ovarian Neoplasms (10) · Turcot syndrome (10) · Breast Neoplasms (9) · Peutz-Jeghers Syndrome (9) · Pancreatic Neoplasms (8) · Adenomatous Polyposis Coli (7) · Neoplasms (6) · Prostatic Neoplasms (6) · Rectal Neoplasms (6)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (145) · Neoplasms by Site (145) · Digestive System Diseases (144) · Digestive System Neoplasms (144) · Gastrointestinal Diseases (144) · Gastrointestinal Neoplasms (144) · Intestinal Diseases (144) · Intestinal Neoplasms (144) · Metabolic Diseases (144) · Nutritional and Metabolic Diseases (144) · Colonic Diseases (143) · DNA Repair-Deficiency Disorders (143) · Genetic Diseases, Inborn (142) · Neoplasms (139) · Neoplastic Syndromes, Hereditary (135)
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PMID 15951961, PMID 16632260, PMID 17682000, PMID 20142594, PMID 20181032, PMID 20379742, PMID 20733131, PMID 20840664, PMID 21212064, PMID 22062356, PMID 23254892, PMID 23451840, PMID 23825568, PMID 24484606, PMID 24916333, PMID 25047061, PMID 25209657, PMID 25833335, PMID 28107763, PMID 29802810, PMID 30538291, PMID 30730411, PMID 31028782, PMID 31197699, PMID 31307542, PMID 31498154, PMID 31520613, PMID 31537406, PMID 31666284, PMID 31676359, PMID 32414353, PMID 32641470, PMID 32887653, PMID 32958357, PMID 33161160, PMID 33984519, PMID 34086597, PMID 34149034, PMID 34678156, PMID 35689290, PMID 35705312, PMID 36670100, PMID 36946440, PMID 37025481, PMID 37027812, PMID 37099777, PMID 37126135, PMID 37516165, PMID 37760576, PMID 37787643
2025 (2), P30CA016672 (2), UG1CA242609 (2), 1KL2TR002490-01 (1), 2016 (1), 2018 (1), K01CA255137 (1), N01CN00034 (1), P30CA015704 (1), P30CA060553 (1), P30CA068485 (1), P50CA134254 (1), P50HD104224 (1), R00CA277584 (1), R01CA071754 (1)