11 completed, 6 unknown, 1 not yet recruiting. 7 Not applicable, 2 Phase 2, 2 Phase 3, 1 Phase 1, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 7 | Completed 5, Unknown 2 |
| Phase 2 | 2 | Completed 2 |
| Phase 3 | 2 | Completed 2 |
| Phase 1 | 1 | Not yet recruiting 1 |
| Phase 4 | 1 | Unknown 1 |
Follow Acanthosis Nigricans: new trials by email Literature Review of Acanthosis Nigricans trials Research Report on Acanthosis Nigricans
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety Of Fractional Carbon Dioxide Laser Plus Topical Metformin In Treatment Of Acanthosis Nigricans Topical metformin - Acanthosis Nigricans | Phase 1 | Not yet recruiting | Al-Azhar University | 34 | 2026-08-10 | 2026-08-12 |
| Evaluating the Safety and Efficacy of Topical Sirolimus 0.2% to Treat Acanthosis Nigricans Sirolimus 0.2% - Acanthosis Nigricans | Phase 2 | Completed | Narrows Institute for Biomedical Research | 5 | 2025-03-01 | 2025-11-28 |
| Efficacy of Chromium Picolinate in Reducing Acanthosis Nigricans Severity in Adolescents With Insulin Resistance Chromium picolinate, Placebo matching Chromium Picolinate - Insulin Resistance, Acanthosis Nigricans | Not applicable | Completed | Uruk University | 90 | 2025-01-01 | 2026-02-23 |
| Clinical Association Between Obstructive Sleep Apnea, Facial Pigmentation, and Vasovagal Symptoms. In-lab polysomnography, Continuous positive airway pressure, Home sleep study device - Obstructive Sleep Apnea, Vasovagal Syncope | Unknown | Jordan Collaborating Cardiology Group | 200 | 2024-03-10 | 2024-09-19 | |
| The Efficacy Tretinoin Cream in the Treatment of Axillary Hyperpigmentation Associated With Acanthosis Nigricans 0.025% Tretinoin - Acanthosis Nigricans, Hyperpigmentation | Phase 3 | Completed | Srinakharinwirot University | 20 | 2024-02-01 | 2024-08-13 |
| Systemic and Topical Metformin Versus Glycolic Acid Peel for the Treatment of Acanthosis Nigricans systemic metformin, topical intervention, glycolic acid 70% peeling - Acanthosis Nigricans | Not applicable | Completed | Tanta University | 54 | 2023-06-03 | 2026-08-07 |
| Sustainable-psycho-nutritional Intervention Program and Its Effects on Health Outcomes and the Environment Sustainable diet promotion through behavioral change intervention - Gut Microbiota, Hyperglycemia | Not applicable | Unknown | University of Guadalajara | 112 | 2022-10-01 | 2023-11-29 |
| Comparison Of Outcome Of Treatment OF Topical 15%TCA VS Topical 0.05% Tretinoin In Treatment Of Acanthosis Nigricans Topical 15% Trichloroacetic acid - Acanthosis Nigricans | Not applicable | Completed | Jinnah Postgraduate Medical Centre | 80 | 2022-08-01 | 2023-08-23 |
| Study of the Effect of Fractional co2 Laser Versus Q Switched:NdYAG Laser in the Treatment of Acanthosis Nigricans co2 laser - Acanthosis Nigricans | Not applicable | Unknown | Cairo University | 20 | 2021-05-30 | 2021-05-19 |
| The Effect of Laparoscopic Sleeve Gastrectomy on Insulin Secretion Pattern in Morbidly Obese Patients With Acanthosis Nigricans LSG - Morbid Obesity, Acanthosis Nigricans | Unknown | Shen Qu | 138 | 2017-06-01 | 2022-09-07 | |
| Clinical Efficacy and Safety of a Laparoscopic Sleeve Gastrectomy in Obese Patients Laparoscopic sleeve gastrectomy - Obesity | Completed | Shanghai 10th People's Hospital | 300 | 2017-01-01 | 2022-09-14 | |
| Study of Efficacy of Metformin in the Treatment of Acanthosis Nigricans in Children With Obesity Metformin, Placebo - Acanthosis Nigricans | Phase 4 | Unknown | Juan Pablo Castanedo-Cazares | 30 | 2015-06-01 | 2015-05-08 |
| Effect of Melatonin on Body Composition, Glucose Metabolism and Lipid Metabolism melatonin - Acanthosis Nigricans, Obesity | Not applicable | Completed | Shanghai 10th People's Hospital | 16 | 2014-05-01 | 2015-11-16 |
| Children's Healthy Living Community Randomized Trial CHL program, Delayed Optimized CHL program - Obesity, Acanthosis Nigricans | Not applicable | Completed | University of Hawaii | 9840 | 2012-11-01 | 2024-03-04 |
| Adjunctive Metformin Therapy in Double Diabetes Metformin, Placebo - Diabetes Mellitus | Phase 3 | Completed | University of Massachusetts, Worcester | 28 | 2011-02-01 | 2016-03-04 |
| Spectroscopic and Colorimetric Analysis of Acanthosis Nigricans in Patients With Hyperinsulinemia Metformin, Dietary Modification - Acanthosis Nigricans, Hyperinsulinemia | Completed | Henry Ford Health System | 9 | 2009-02-01 | 2012-09-06 | |
| Phase II Study of the Effect of Leuprolide Acetate and Spironolactone on Insulin Resistance in Hyperandrogenic Women With Polycystic Ovarian Disease or Hyperandrogenism Insulin Resistance Acanthosis Nigricans Syndrome leuprolide acetate, spironolactone - Acanthosis Nigricans, Polycystic Ovary Syndrome | Phase 2 | Completed | National Center for Research Resources (NCRR) | 1989-07-01 | 2005-06-24 | |
| Prevalence of Carbohydrate Intolerance in Lean and Obese Children Obesity, Glucose Intolerance | Unknown | National Center for Research Resources (NCRR) | 2005-06-24 |
Obesity (6) · Diabetes Mellitus (2) · Diabetes Mellitus, Type 2 (2) · Hyperinsulinism (2) · Insulin Resistance (2) · Motor Activity (2) · Polycystic Ovary Syndrome (2) · Diabetes Mellitus, Type 1 (1) · Endocrine System Diseases (1) · Feeding Behavior (1) · Glucose Intolerance (1) · Hypercholesterolemia (1) · Hyperglycemia (1) · Hyperpigmentation (1)
Melanosis (18) · Pigmentation Disorders (18) · Skin and Connective Tissue Diseases (18) · Hyperpigmentation (17) · Skin Diseases (17) · Nutritional and Metabolic Diseases (10) · Pathological Conditions, Signs and Symptoms (9) · Signs and Symptoms (8) · Body Weight (7) · Glucose Metabolism Disorders (7) · Metabolic Diseases (7) · Nutrition Disorders (7) · Overnutrition (7) · Overweight (7) · Behavior (3)
Metformin (4) · Tretinoin (2) · Continuous Positive Airway Pressure (1) · Diet Therapy (1) · Lasers, Gas (1) · Leuprolide (1) · Melatonin (1) · Methods (1) · Polysomnography (1) · Spironolactone (1) · Tooth Exfoliation (1) · Trichloroacetic Acid (1) · glycolic acid (1) · picolinic acid (1)
National Center for Research Resources (NCRR) (2) · Shanghai 10th People's Hospital (2) · Al-Azhar University (1) · Cairo University (1) · Henry Ford Health System (1) · Jinnah Postgraduate Medical Centre (1) · Jordan Collaborating Cardiology Group (1) · Juan Pablo Castanedo-Cazares (1) · Narrows Institute for Biomedical Research (1) · Shen Qu (1) · Srinakharinwirot University (1) · Tanta University (1) · University of Guadalajara (1) · University of Hawaii (1) · University of Massachusetts, Worcester (1)
United States (5) · China (2) · Mexico (2) · Egypt (1) · Iraq (1) · Jordan (1) · Pakistan (1) · Thailand (1)
Arucha Treesirichod (1) · Benjamin U Nwosu, MD (1) · Bertha Torres-Alvarez, MD (1) · Fatima E Housni, PhD (1) · Fazia Inam, FCPS (1) · Francisco Goldaracena-Orozco, MD (1) · Ghasak Kais Abdulhussain, BSc, MSc, PhD (Pharmacology) (1) · Iltefat Hamzavi, M.D. (1) · Jared Jagdeo, MD MS (1) · Juan P Castanedo-Cazares, MD (1) · Karen E. Elkind-Hirsch (1) · Nazia Jabeen, FCPS (1) · Parisa Sanawar, FCPS (1) · Rachel Novotny, PhD (1) · Rand M Zaqqa (1)
PMID 26367281, PMID 29706998, PMID 30586845, PMID 30646266, PMID 31116404, PMID 31421157, PMID 33234187, PMID 35235641, PMID 35399676, PMID 35666503, PMID 36469736, PMID 39511506, PMID 39989394, PMID 41796940, PMID 42029999
2018 (1), M01RR006022 (1)