43 completed, 6 unknown, 4 not yet recruiting, 4 terminated. 62 Phase 2, 13 Phase 3, 3 Phase 1.
Follow Helminthiasis: new trials by email Literature Review of Helminthiasis trials Research Report on Helminthiasis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Oxfendazole in Mild Parenchymal Brain Cysticercosis Oxfendazole single dose, Oxfendazole three doses, albendazole plus praziquantel regime - Brain Cysticercosis | Phase 2 / Phase 3 | Not yet recruiting | Universidad Peruana Cayetano Heredia | 544 | 2026-12-01 | 2026-05-01 |
| Efficacy and Safety of a Single Dose of Emodepside Compared to a Single Dose of Albendazole in Adolescents and Adults Infected With Trichuris Incognita Emodepside, Albendazole 400 mg - Trichuris Infection | Phase 2 | Not yet recruiting | Jennifer Keiser | 100 | 2026-11-15 | 2026-08-14 |
| Different Treatment Frequencies for Hepatic Fibrosis Due to Schistosomiasis Praziquantel 40 mg/kg per dose given once annually, Praziquantel 40 mg/kg given three times per year - Schistosomiasis, Schistosoma Mansoni | Phase 2 / Phase 3 | Not yet recruiting | Rhode Island Hospital | 600 | 2026-11-01 | 2026-08-12 |
| One and Two Doses of Oxfendazole Versus a Schedule of Two Doses of Triclabendazole in Chronic Fascioliasis Oxfendazole, Triclabendazole - Fascioliasis | Phase 2 | Not yet recruiting | Universidad Peruana Cayetano Heredia | 336 | 2026-08-15 | 2026-06-03 |
| Efficacy and Safety of Oxantel Pamoate in Children Infected With Trichuris Trichiura Oxantel Pamoate, Mebendazole - Trichuris Trichiura; Infection, Hookworm Infection | Phase 2 | Completed | Jennifer Keiser | 163 | 2025-04-16 | 2025-06-08 |
| A Safety and Efficacy Study of Different Doses of Oxfendazole Compared to a Single Dose of Albendazole to Treat Trichuris Trichiura Infection in Adults Albendazole, Oxfendazole - Trichuriasis | Phase 2 | Recruiting | Asociacion Benefica Prisma | 249 | 2024-09-07 | 2026-07-28 |
| Sm-p80 Schistosomiasis Challenge Study Sm-p80 + GLA-SE Vaccine, Placebo, Schistosoma mansoni infection - Schistosoma Mansoni, Schistosomiasis | Phase 2 | Unknown | Leiden University Medical Center | 48 | 2024-09-01 | 2023-10-17 |
| Efficacy of Oxfendazole in the Treatment of Trichuris Trichiura Infection in Adults Oxfendazole, Albendazole - Trichuris Infection | Phase 2 | Withdrawn | Oxfendazole Development Group | 2024-07-01 | 2026-11-06 | |
| A 3- to 5-day Clinical Trial of Levamisole in Loiasis Infected Subjects Levamisole 3 days, Levamisole 5 days, Placebo - Loiasis | Phase 2 / Phase 3 | Unknown | Programme National de Lutte contre l'Onchocercose, Republic of the Congo | 99 | 2024-06-21 | 2024-09-20 |
| Efficacy, Safety and Acceptability of Ivermectin ODT in PSAC Ivermectin 1.5 mg ODT, Ivermectin 3 mg Oral Tablet, Albendazole 400 mg Oral Tablet - Trichuriasis, Ascariasis | Phase 2 | Completed | Jennifer Keiser | 260 | 2024-06-05 | 2025-09-22 |
| Efficacy and Safety of Emodepside in Adults Infected With Strongyloidiasis Stercoralis Emodepside - Strongyloides Stercoralis Infection, Strongyloidiasis | Phase 2 | Completed | Swiss Tropical & Public Health Institute | 202 | 2024-05-20 | 2024-11-20 |
| Safety and Efficacy of Novel Combination Regimens for Treatment of Onchocerciasis Ivermectin w/ Albendazole, Ivermectin + Diethylcarbamazine + Albendazole, Moxidectin + Albendazole - Onchocercal Subcutaneous Nodule, Onchocerciasis | Phase 2 | Active not recruiting | Washington University School of Medicine | 300 | 2024-04-05 | 2025-12-18 |
| Efficacy and Safety of Emodepside in Adolescents and Adults Infected With Hookworm Emodepside, Albendazole 400mg - Hookworm Infections | Phase 2 | Completed | Jennifer Keiser | 320 | 2022-09-16 | 2023-06-15 |
| Anti-Schistosomiasis Sm14-vaccine in Senegal Sm14 recombinant vaccine+ GLA-SE adjuvant - Schistosomiasis Mansoni, Schistosomiasis Haematobium | Phase 2 | Unknown | Oswaldo Cruz Foundation | 120 | 2022-07-01 | 2022-12-21 |
| Clinical Trial Evaluating the Safety and Efficacy of Moxidectin 2 mg Ivermectin-controlled in Loa Loa Microfilaremic Patients Moxidectin 2 MG Oral Tablet, Ivermectin 3Mg Tab, Placebo oral tablet - Onchocerciasis, Ocular, Loiasis | Phase 2 | Completed | Center for Research on Filariasis and Other Tropical Diseases, Cameroon | 72 | 2022-04-07 | 2025-02-24 |
| Evaluation of Effectiveness of ALBENDAZOLIVERMECTIN Coformulation vs ALBENDAZOLE for Treatment of Intestinal Worms Albendazole and Ivermectin fixed dose coformulation, Albendazole - Helminthes; Infestation, Intestinal | Phase 2 / Phase 3 | Terminated | Barcelona Institute for Global Health | 1001 | 2022-01-20 | 2025-09-22 |
| Emodepside Phase II Trial for Treatment of Onchocerciasis emodepside, matching placebo of emodepside, ivermectin - Onchocerciasis | Phase 2 | Unknown | Drugs for Neglected Diseases | 578 | 2021-08-30 | 2024-03-05 |
| Efficacy and Safety of Emodepside in Adults Infected With Trichuris Trichiura and Hookworm Emodepside - Trichuris Trichiura; Infection, Hookworm Infections | Phase 2 | Completed | Jennifer Keiser | 442 | 2021-08-02 | 2022-05-27 |
| Study to Assess Adverse Events, Change in Disease Activity and How Oral ABBV-4083 Capsules When Given Alone or In Combination With Albendazole Capsules Moves in The Body of Adult Participants With Onchocerca Volvulus Infection ABBV-4083, Placebo for ABBV-4083, Albendazole - Onchocerciasis | Phase 2 | Terminated | AbbVie | 153 | 2021-05-22 | 2024-09-19 |
| Clinical Evaluation of Ujiplus® Against Schistosoma Mansoni Ujiplus®, Praziquantel 400mg - Schistosoma Mansoni | Phase 2 / Phase 3 | Completed | Kenya Medical Research Institute | 400 | 2021-05-06 | 2022-07-12 |
Showing 20 of 62. Sign in to see all of them.
Schistosomiasis (13) · Trichuriasis (11) · Hookworm Infections (9) · Onchocerciasis (8) · Onchocerciasis, Ocular (7) · Ancylostomiasis (6) · Elephantiasis, Filarial (6) · Loiasis (5) · Schistosomiasis haematobia (4) · Filariasis (3) · Neurocysticercosis (3) · Schistosomiasis mansoni (3) · Ascariasis (2) · Mansonelliasis (2)
Infections (61) · Parasitic Diseases (61) · Nematode Infections (36) · Secernentea Infections (31) · Vector Borne Diseases (30) · Spirurida Infections (20) · Trematode Infections (18) · Filariasis (17) · Adenophorea Infections (11) · Enoplida Infections (11) · Skin and Connective Tissue Diseases (11) · Skin Diseases (10) · Strongylida Infections (10) · Skin Diseases, Infectious (9)
Albendazole (23) · Ivermectin (13) · Praziquantel (9) · moxidectin (6) · Diethylcarbamazine (5) · emodepside (5) · oxfendazole (5) · Tablets (4) · Albumins (2) · Azithromycin (2) · Doxycycline (2) · Levamisole (2) · Mebendazole (2) · SM14 protein, Schistosoma mansoni (2) · glucopyranosyl lipid-A (2)
Jennifer Keiser (8) · National Institute of Allergy and Infectious Diseases (NIAID) (7) · Universidad Peruana Cayetano Heredia (4) · Oswaldo Cruz Foundation (3) · Swiss Tropical & Public Health Institute (3) · Baylor College of Medicine (2) · Kenya Medical Research Institute (2) · Programme National de Lutte contre l'Onchocercose, Republic of the Congo (2) · Rhode Island Hospital (2) · Washington University School of Medicine (2) · AbbVie (1) · Albert Schweitzer Hospital (1) · Alejandro Krolewiecki (1) · Asociacion Benefica Prisma (1) · Barcelona Institute for Global Health (1)
Tanzania (8) · Uganda (5) · Ghana (4) · United States (4) · Peru (3) · Senegal (3) · Cameroon (2) · Côte d’Ivoire (2) · Democratic Republic of the Congo (2) · Gabon (2) · India (2) · Kenya (2) · Laos (2) · Mali (2) · Papua New Guinea (2)
Elijah M Songok, PhD (2) · Gary Weil, MD (2) · Hector H Garcia, MD, PhD (2) · Jennifer Keiser, PhD (2) · Miriam Tendler, MD, PhD (2) · Alejandro J Krolewiecki, MD, PhD (1) · Alexander Loukas, PhD (1) · Alexander Y Debrah, PhD (1) · Alison Elliot (1) · Allen Nalugwa, PhD (1) · Amy D Klion, M.D. (1) · Annette Olsen, PhD (1)
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R01AI184979 (1), R01HD095562 (1), R01NS054805 (1), U01AI129789 (1), U01AI155323 (1)