41 completed, 5 unknown, 3 not yet recruiting, 3 recruiting. 17 Not applicable, 13 Phase 1, 10 Phase 2, 9 Phase 3, 6 Phase 4.
Follow Hookworm Infections: new trials by email Literature Review of Hookworm Infections trials Research Report on Hookworm Infections
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of Emodepside in Participants With Soil-transmitted Helminth Infections emodepside (BAY 44-4400), Mebendazole 100 MG, similar placebo to mebendazole - Trichuris Trichiura; Infection, Hookworm Infection | Phase 3 | Not yet recruiting | Swiss Tropical & Public Health Institute | 315 | 2026-11-06 | 2026-08-14 |
| Combination Therapies for Trichuris Trichiura Infection in Schoolchildren in Honduras Placebo, Albendazole 400 mg, Albendazole Plus Ivermectin - Trichuriasis, Strongyloidiasis | Phase 3 | Not yet recruiting | Mundo Sano Foundation | 368 | 2026-11-01 | 2026-06-23 |
| Efficacy and Safety of Emodepside in Participants With Soil-transmitted Helminth Infections emodepside (BAY 44-4400), matching placebo of emodepside, Mebendazole - Trichuris Trichiura; Infection, Hookworm Infection | Phase 3 | Completed | Swiss Tropical & Public Health Institute | 315 | 2025-11-25 | 2026-10-08 |
| Real World Evaluation of an Albendazole-Ivermectin Coformulation Safety and Effectiveness Pre-screening Phase, Screenig Phase, Randomization - Soil-Transmitted Helminths | Phase 3 | Recruiting | Insud Pharma | 20000 | 2025-09-01 | 2025-09-15 |
| Moxidectin Versus Ivermectin as Mass Drug Administration for the Control of Onchocerciasis and Other Neglected Tropical Diseases Moxidectin, Ivermectin - Onchocerciasis, Ascaris Lumbricoides Infection | Phase 4 | Recruiting | Kirby Institute | 52000 | 2025-08-04 | 2025-11-21 |
| Community Health Education and Hygiene Promotion Added to Deworming Among Ethnic Khmer Children in Vietnam Albendazole 400 mg, Community Health Education and Hygiene Promotion - Soil-transmitted Helminth Infections | Not applicable | Completed | Can Tho University of Medicine and Pharmacy | 704 | 2025-07-01 | 2026-10-02 |
| Efficacy and Safety of Oxantel Pamoate in Children Infected With Trichuris Trichiura Oxantel Pamoate, Mebendazole - Trichuris Trichiura; Infection, Hookworm Infection | Phase 2 | Completed | Jennifer Keiser | 163 | 2025-04-16 | 2025-06-08 |
| Immune Responses in the Skin After Hookworm Infection Necator americanus L3 larvae - Necator Americanus Infection | Not applicable | Not yet recruiting | Leiden University Medical Center | 5 | 2024-10-01 | 2024-07-12 |
| Efficacy, Safety and Acceptability of Ivermectin ODT in PSAC Ivermectin 1.5 mg ODT, Ivermectin 3 mg Oral Tablet, Albendazole 400 mg Oral Tablet - Trichuriasis, Ascariasis | Phase 2 | Completed | Jennifer Keiser | 260 | 2024-06-05 | 2025-09-22 |
| Efficacy and Safety of Moxidectin-Albendazole Co-administration in SAC Moxidectin 2 mg Oral Tablet, Albendazole 400 mg Oral Tablet, Placebo Moxidectin - Trichuriasis, Ascariasis | Phase 3 | Completed | Jennifer Keiser | 224 | 2024-05-14 | 2025-09-19 |
| Evaluating Impact of Improved Floors on Health Sealed washable floor plus behaviour change, Behaviour change intervention, Routine deworming - Diarrhoeal Disease, Hookworm Infection | Not applicable | Completed | London School of Hygiene and Tropical Medicine | 2200 | 2023-04-12 | 2025-01-30 |
| Efficacy and Safety of Emodepside in Adolescents and Adults Infected With Hookworm Emodepside, Albendazole 400mg - Hookworm Infections | Phase 2 | Completed | Jennifer Keiser | 320 | 2022-09-16 | 2023-06-15 |
| Efficacy and Safety of Emodepside in Adults Infected With Trichuris Trichiura and Hookworm Emodepside - Trichuris Trichiura; Infection, Hookworm Infections | Phase 2 | Completed | Jennifer Keiser | 442 | 2021-08-02 | 2022-05-27 |
| Efficacy and Safety of MOX/ALB Co-administration Moxidectin 2 mg Oral Tablet, Albendazole 400 mg Oral Tablet, Ivermectin 3 mg Oral Tablet - Trichuriasis, Ascariasis | Phase 3 | Completed | Jennifer Keiser | 255 | 2021-06-15 | 2024-01-24 |
| Adjunctive Ivermectin Mass Drug Administration for Malaria Control Ivermectin, Placebo, Dihydroartemisinin-piperaquine - Malaria,Falciparum, Neglected Tropical Diseases | Phase 3 | Unknown | London School of Hygiene and Tropical Medicine | 24000 | 2021-05-03 | 2022-02-24 |
| Efficacy and Safety of MOX/ALB vs. IVM/ALB Co-administration moxidectin (8 mg) / albendazole (400 mg), ivermectin (200 µg/kg) / albendazole (400 mg), ALBENDAZOLE 400 Mg ORAL TABLET [ZENTEL] - Trichuriasis, Ascariasis | Phase 2 / Phase 3 | Completed | Jennifer Keiser | 536 | 2021-03-01 | 2024-12-05 |
| Validation of INSPiRED Innovative Smart Diagnostic Devices for the Detection of Parasites Infections. Testing, Performance | Unknown | Centre de Recherche Médicale de Lambaréné | 460 | 2020-03-20 | 2020-08-07 | |
| Study of the Efficacy of Oxfendazole Compared to Albendazole in the Treatment of Trichuris Trichiura Infection in Adults oxfendazole, albendazole - Helminthiasis | Phase 2 | Withdrawn | Johns Hopkins Bloomberg School of Public Health | 2019-11-01 | 2019-08-15 | |
| Efficacy and Safety of a New Chewable Versus the Swallowable Tablet of Mebendazole Against Hookworm Mebendazole - Hookworm Infections | Phase 2 | Completed | Swiss Tropical & Public Health Institute | 397 | 2019-07-12 | 2020-07-20 |
| Monitoring Drug Efficacy and Anthelmintic Resistance in Soil-transmitted Helminth Programs Benzimidazoles - Soil-transmitted Helminth Infections | Completed | University Ghent | 9457 | 2019-05-15 | 2023-08-29 |
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Ancylostomiasis (41) · Trichuriasis (15) · Ascariasis (8) · Anemia, Iron-Deficiency (6) · Neglected Diseases (6) · Helminthiasis (5) · Hypersensitivity (4) · Malaria (4) · Strongyloidiasis (3) · Anemia (2) · Disease (2) · Enterobiasis (2) · Health Education (2) · Intestinal Diseases, Parasitic (2)
Secernentea Infections (56) · Strongylida Infections (56) · Infections (55) · Nematode Infections (55) · Parasitic Diseases (54) · Helminthiasis (51) · Adenophorea Infections (16) · Enoplida Infections (16) · Hemic and Lymphatic Diseases (9) · Pathologic Processes (9) · Pathological Conditions, Signs and Symptoms (9) · Ascaridida Infections (8) · Hematologic Diseases (8) · Disease Attributes (7)
Albendazole (18) · Mebendazole (7) · Ivermectin (6) · Tablets (4) · emodepside (4) · moxidectin (4) · Bay 44-4400 (2) · Hepatitis B Vaccines (2) · Therapeutics (2) · oxantel pamoate (2) · ASP-1 protein, Necator americanus (1) · Ascorbic Acid (1) · Benzimidazoles (1) · Blood Specimen Collection (1) · CPG-oligonucleotide (1)
Baylor College of Medicine (11) · Jennifer Keiser (9) · London School of Hygiene and Tropical Medicine (4) · Swiss Tropical & Public Health Institute (4) · Albert B. Sabin Vaccine Institute (3) · Leiden University Medical Center (2) · University Ghent (2) · Albert Schweitzer Hospital (1) · Bird, Christopher (1) · Brugmann University Hospital (1) · Can Tho University of Medicine and Pharmacy (1) · Centers for Disease Control and Prevention (1) · Centre de Recherche Médicale de Lambaréné (1) · Insud Pharma (1) · Johns Hopkins Bloomberg School of Public Health (1)
Tanzania (11) · United States (8) · Brazil (5) · Gabon (5) · Kenya (4) · Côte d’Ivoire (3) · Ghana (3) · Laos (3) · Netherlands (3) · Vietnam (3) · Angola (1) · Australia (1) · Bangladesh (1) · Cambodia (1) · Ethiopia (1)
David Diemert, MD (5) · Ayola Adegnika, MD (3) · David J Diemert, MD (3) · Jennifer Keiser, PhD (3) · Bruno Levecke, PhD (2) · Jennifer Keiser, Professor (2) · Ahmed K. Al-Delaimy, MSc (1) · Alejandro Javier Krolewiecki, PhD, MD (1) · Alejandro Krolewiecki, MD (1) · Alexander Loukas, PhD (1) · Anna R Last, MBChB PhD (1) · Armando E Gonzalez, DVM, PhD (1) · Byron Arana, MD (1) · Charles Mwandawiro, PhD (1) · Christian Salmon, DrSc (1)
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U01AI129789 (1)