33 completed, 4 unknown, 2 not yet recruiting, 1 terminated. 13 Not applicable, 12 Phase 1, 7 Phase 3, 6 Phase 2, 3 Phase 4.
Follow Ancylostomiasis: new trials by email Literature Review of Ancylostomiasis trials Research Report on Ancylostomiasis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of Emodepside in Participants With Soil-transmitted Helminth Infections emodepside (BAY 44-4400), Mebendazole 100 MG, similar placebo to mebendazole - Trichuris Trichiura; Infection, Hookworm Infection | Phase 3 | Not yet recruiting | Swiss Tropical & Public Health Institute | 315 | 2026-11-06 | 2026-08-14 |
| Efficacy and Safety of Emodepside in Participants With Soil-transmitted Helminth Infections emodepside (BAY 44-4400), matching placebo of emodepside, Mebendazole - Trichuris Trichiura; Infection, Hookworm Infection | Phase 3 | Completed | Swiss Tropical & Public Health Institute | 315 | 2025-11-25 | 2026-10-08 |
| Community Health Education and Hygiene Promotion Added to Deworming Among Ethnic Khmer Children in Vietnam Albendazole 400 mg, Community Health Education and Hygiene Promotion - Soil-transmitted Helminth Infections | Not applicable | Completed | Can Tho University of Medicine and Pharmacy | 704 | 2025-07-01 | 2026-10-02 |
| Immune Responses in the Skin After Hookworm Infection Necator americanus L3 larvae - Necator Americanus Infection | Not applicable | Not yet recruiting | Leiden University Medical Center | 5 | 2024-10-01 | 2024-07-12 |
| Efficacy, Safety and Acceptability of Ivermectin ODT in PSAC Ivermectin 1.5 mg ODT, Ivermectin 3 mg Oral Tablet, Albendazole 400 mg Oral Tablet - Trichuriasis, Ascariasis | Phase 2 | Completed | Jennifer Keiser | 260 | 2024-06-05 | 2025-09-22 |
| Efficacy and Safety of Moxidectin-Albendazole Co-administration in SAC Moxidectin 2 mg Oral Tablet, Albendazole 400 mg Oral Tablet, Placebo Moxidectin - Trichuriasis, Ascariasis | Phase 3 | Completed | Jennifer Keiser | 224 | 2024-05-14 | 2025-09-19 |
| Efficacy and Safety of Emodepside in Adolescents and Adults Infected With Hookworm Emodepside, Albendazole 400mg - Hookworm Infections | Phase 2 | Completed | Jennifer Keiser | 320 | 2022-09-16 | 2023-06-15 |
| Efficacy and Safety of Emodepside in Adults Infected With Trichuris Trichiura and Hookworm Emodepside - Trichuris Trichiura; Infection, Hookworm Infections | Phase 2 | Completed | Jennifer Keiser | 442 | 2021-08-02 | 2022-05-27 |
| Efficacy and Safety of MOX/ALB Co-administration Moxidectin 2 mg Oral Tablet, Albendazole 400 mg Oral Tablet, Ivermectin 3 mg Oral Tablet - Trichuriasis, Ascariasis | Phase 3 | Completed | Jennifer Keiser | 255 | 2021-06-15 | 2024-01-24 |
| Adjunctive Ivermectin Mass Drug Administration for Malaria Control Ivermectin, Placebo, Dihydroartemisinin-piperaquine - Malaria,Falciparum, Neglected Tropical Diseases | Phase 3 | Unknown | London School of Hygiene and Tropical Medicine | 24000 | 2021-05-03 | 2022-02-24 |
| Efficacy and Safety of MOX/ALB vs. IVM/ALB Co-administration moxidectin (8 mg) / albendazole (400 mg), ivermectin (200 µg/kg) / albendazole (400 mg), ALBENDAZOLE 400 Mg ORAL TABLET [ZENTEL] - Trichuriasis, Ascariasis | Phase 2 / Phase 3 | Completed | Jennifer Keiser | 536 | 2021-03-01 | 2024-12-05 |
| Validation of INSPiRED Innovative Smart Diagnostic Devices for the Detection of Parasites Infections. Testing, Performance | Unknown | Centre de Recherche Médicale de Lambaréné | 460 | 2020-03-20 | 2020-08-07 | |
| Efficacy and Safety of a New Chewable Versus the Swallowable Tablet of Mebendazole Against Hookworm Mebendazole - Hookworm Infections | Phase 2 | Completed | Swiss Tropical & Public Health Institute | 397 | 2019-07-12 | 2020-07-20 |
| Monitoring Drug Efficacy and Anthelmintic Resistance in Soil-transmitted Helminth Programs Benzimidazoles - Soil-transmitted Helminth Infections | Completed | University Ghent | 9457 | 2019-05-15 | 2023-08-29 | |
| Na-GST-1/Alhydrogel With or Without CpG 10104 in Gabonese Adults Na-GST-1, CPG 10104 - Hookworm Infection, Hookworm Disease | Phase 1 | Completed | Baylor College of Medicine | 24 | 2018-02-01 | 2021-01-13 |
| Repeated Controlled Human Hookworm Infection 50 Necator americanus L3 larvae, 100 Necator americanus L3 larvae, 150 Necator americanus L3 larvae - Necator Americanus Infection | Not applicable | Completed | Meta Roestenberg | 24 | 2018-01-10 | 2020-11-18 |
| Mebendazole Study Against Hookworm Infections in Children and Adolescents in Ghana Mebendazole - Hookworm Infections | Phase 4 | Withdrawn | PATH | 2017-09-01 | 2017-11-17 | |
| Efficacy and Safety of a Multi-dose Regimen of Mebendazole Against Hookworm in Children Treatment with one of the two regimens of mebendazole - Hookworm | Phase 4 | Completed | Jennifer Keiser | 186 | 2017-07-25 | 2019-06-17 |
| Establishing a Controlled Human Hookworm Infection Model at Leiden University Medical Center Necator americanus L3 larvae - Necator Americanus Infection | Not applicable | Completed | Leiden University Medical Center | 4 | 2017-04-01 | 2021-12-21 |
| Study of Co-administered Na-APR-1 (M74) and Na-GST-1 in Gabonese Children Na-GST-1/Alhydrogel, Na-APR-1 (M74)/Alhydrogel, Hepatitis B Vaccine - Hookworm Disease, Hookworm Infection | Phase 1 | Completed | Baylor College of Medicine | 60 | 2017-01-01 | 2025-01-13 |
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Hookworm Infections (24) · Trichuriasis (9) · Anemia, Iron-Deficiency (6) · Ascariasis (6) · Neglected Diseases (6) · Hypersensitivity (3) · Malaria (3) · Anemia (2) · Disease (2) · Enterobiasis (2) · Health Education (2) · Helminthiasis (2) · Intestinal helminthiasis (2) · Strongyloidiasis (2)
Parasitic Diseases (41) · Secernentea Infections (41) · Strongylida Infections (41) · Infections (40) · Nematode Infections (40) · Helminthiasis (39) · Hookworm Infections (17) · Adenophorea Infections (9) · Enoplida Infections (9) · Hemic and Lymphatic Diseases (9) · Pathologic Processes (9) · Pathological Conditions, Signs and Symptoms (9) · Hematologic Diseases (8) · Disease Attributes (7) · Metabolic Diseases (7)
Albendazole (11) · Mebendazole (5) · Ivermectin (4) · Tablets (4) · emodepside (4) · moxidectin (3) · Bay 44-4400 (2) · Hepatitis B Vaccines (2) · ASP-1 protein, Necator americanus (1) · Ascorbic Acid (1) · Benzimidazoles (1) · Blood Specimen Collection (1) · CPG-oligonucleotide (1) · D-Worm (1) · GLA-AF adjuvant (1)
Baylor College of Medicine (9) · Jennifer Keiser (7) · Albert B. Sabin Vaccine Institute (3) · London School of Hygiene and Tropical Medicine (3) · Swiss Tropical & Public Health Institute (3) · Leiden University Medical Center (2) · University Ghent (2) · Bird, Christopher (1) · Brugmann University Hospital (1) · Can Tho University of Medicine and Pharmacy (1) · Centers for Disease Control and Prevention (1) · Centre de Recherche Médicale de Lambaréné (1) · McGill University Health Centre/Research Institute of the McGill University Health Centre (1) · Meta Roestenberg (1) · PATH (1)
Tanzania (10) · Brazil (5) · United States (5) · Gabon (4) · Netherlands (3) · Vietnam (3) · Ghana (2) · Kenya (2) · Laos (2) · Australia (1) · Bangladesh (1) · Cambodia (1) · Côte d’Ivoire (1) · Ethiopia (1) · Guatemala (1)
David Diemert, MD (4) · Ayola Adegnika, MD (3) · Bruno Levecke, PhD (2) · David J Diemert, MD (2) · Jennifer Keiser, PhD (2) · Jennifer Keiser, Professor (2) · Ahmed K. Al-Delaimy, MSc (1) · Alexander Loukas, PhD (1) · Anna R Last, MBChB PhD (1) · Byron Arana, MD (1) · Christian Salmon, DrSc (1) · Christopher K Bird, MBBS (1) · David Parenti, MD (1) · Dianne Jones, BAppSc (1) · Gary Simon, M.D., Ph.D (1)
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