14 completed, 2 not yet recruiting, 1 recruiting. 10 Phase 2, 8 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 10 | Completed 8, Not yet recruiting 1, Recruiting 1 |
| Phase 3 | 8 | Completed 7, Not yet recruiting 1 |
| Phase 4 | 1 | Completed 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of a Single Dose of Emodepside Compared to a Single Dose of Albendazole in Adolescents and Adults Infected With Trichuris Incognita Emodepside, Albendazole 400 mg - Trichuris Infection | Phase 2 | Not yet recruiting | Jennifer Keiser | 100 | 2026-11-15 | 2026-08-14 |
| Follow-up Assessment of Change in Soil-transmitted Helminths Infection Intensity in Uganda Albendazole 400mg, Ivermectin 3 mg - Ascariasis | Phase 3 | Not yet recruiting | Jennifer Keiser | 450 | 2026-10-01 | 2026-10-14 |
| Efficacy and Safety of Ascending Doses of Arpraziquantel in Children Infected With Opisthorchis Viverrini Apraziquantel - Opisthorchis Viverrini | Phase 2 | Recruiting | Jennifer Keiser | 125 | 2026-07-22 | 2026-08-04 |
| Efficacy and Safety of Oxantel Pamoate in Children Infected With Trichuris Trichiura Oxantel Pamoate, Mebendazole - Trichuris Trichiura; Infection, Hookworm Infection | Phase 2 | Completed | Jennifer Keiser | 163 | 2025-04-16 | 2025-06-08 |
| Co-administration of IVM and ALB in School-based Deworming in Uganda Albendazole 400mg, Ivermectin 3 MG - Helminthiasis, Intestinal Worms | Completed | Jennifer Keiser | 8767 | 2024-07-01 | 2024-12-20 | |
| Efficacy, Safety and Acceptability of Ivermectin ODT in PSAC Ivermectin 1.5 mg ODT, Ivermectin 3 mg Oral Tablet, Albendazole 400 mg Oral Tablet - Trichuriasis, Ascariasis | Phase 2 | Completed | Jennifer Keiser | 260 | 2024-06-05 | 2025-09-22 |
| Efficacy and Safety of Moxidectin-Albendazole Co-administration in SAC Moxidectin 2 mg Oral Tablet, Albendazole 400 mg Oral Tablet, Placebo Moxidectin - Trichuriasis, Ascariasis | Phase 3 | Completed | Jennifer Keiser | 224 | 2024-05-14 | 2025-09-19 |
| Efficacy of Ivermectin-albendazole vs Albendazole Alone in School-aged Children Infected With Trichuris Trichiura IVM (200 µg/kg) + ALB (400 mg), ALB (400mg) - Trichuriasis | Phase 3 | Completed | Jennifer Keiser | 161 | 2023-10-09 | 2024-04-10 |
| Efficacy and Safety of Emodepside in Adolescents and Adults Infected With Hookworm Emodepside, Albendazole 400mg - Hookworm Infections | Phase 2 | Completed | Jennifer Keiser | 320 | 2022-09-16 | 2023-06-15 |
| Efficacy and Safety of Moxidectin Versus Ivermectin Against Strongyloides Stercoralis Moxidectin 2 mg, Ivermectin 3 mg, Placebo - Strongyloides Stercoralis Infection | Phase 3 | Completed | Jennifer Keiser | 332 | 2022-02-05 | 2024-01-25 |
| Efficacy and Safety of Emodepside in Adults Infected With Trichuris Trichiura and Hookworm Emodepside - Trichuris Trichiura; Infection, Hookworm Infections | Phase 2 | Completed | Jennifer Keiser | 442 | 2021-08-02 | 2022-05-27 |
| Efficacy and Safety of MOX/ALB Co-administration Moxidectin 2 mg Oral Tablet, Albendazole 400 mg Oral Tablet, Ivermectin 3 mg Oral Tablet - Trichuriasis, Ascariasis | Phase 3 | Completed | Jennifer Keiser | 255 | 2021-06-15 | 2024-01-24 |
| Efficacy and Safety of MOX/ALB vs. IVM/ALB Co-administration moxidectin (8 mg) / albendazole (400 mg), ivermectin (200 µg/kg) / albendazole (400 mg), ALBENDAZOLE 400 Mg ORAL TABLET [ZENTEL] - Trichuriasis, Ascariasis | Phase 2 / Phase 3 | Completed | Jennifer Keiser | 536 | 2021-03-01 | 2024-12-05 |
| Efficacy, Safety, and PK of Ascending Dosages of Moxidectin Versus Ivermectin Against Strongyloides Stercoralis Moxidectin, Ivermectin, Placebo oral tablet - Strongyloides Stercoralis Infection | Phase 2 / Phase 3 | Completed | Jennifer Keiser | 617 | 2019-11-27 | 2024-12-09 |
| Albendazole Dose Finding and Pharmacokinetics in Children and Adults Albendazole, Placebo - Trichuriasis, Hookworm Infections | Phase 2 | Completed | Jennifer Keiser | 700 | 2018-10-23 | 2023-06-12 |
| Efficacy and Safety of IVM/ALB Co-administration Albendazole, Albendazole and Ivermectin - Trichuriasis | Phase 2 / Phase 3 | Completed | Jennifer Keiser | 1673 | 2018-09-09 | 2024-03-20 |
| Efficacy and Safety of a Multi-dose Regimen of Mebendazole Against Hookworm in Children Treatment with one of the two regimens of mebendazole - Hookworm | Phase 4 | Completed | Jennifer Keiser | 186 | 2017-07-25 | 2019-06-17 |
Trichuriasis (10) · Hookworm Infections (8) · Ancylostomiasis (7) · Ascariasis (5) · Helminthiasis (2) · Intestinal Diseases, Parasitic (1)
Albendazole (11) · Ivermectin (9) · moxidectin (5) · Tablets (4) · emodepside (3) · Albumins (1) · Intravital Microscopy (1) · Mebendazole (1) · Therapeutics (1) · oxantel pamoate (1)
Tanzania (8) · Côte d’Ivoire (3) · Laos (3) · Uganda (3) · Cambodia (1)
PMID 37949090, PMID 30885157, PMID 31193620, PMID 32405623, PMID 32668456, PMID 33798487, PMID 34191812, PMID 34296417, PMID 34632308, PMID 34856181, PMID 35217670, PMID 36354034, PMID 37195942, PMID 37195949, PMID 37357904, PMID 38517907, PMID 39153818, PMID 39591454, PMID 40675166, PMID 40975108, PMID 42486129