124 completed, 17 unknown, 8 not yet recruiting, 8 recruiting. 37 Phase 2, 35 Not applicable, 31 Phase 3, 23 Phase 1, 19 Phase 4.
Follow Nematode Infections: new trials by email Literature Review of Nematode Infections trials Research Report on Nematode Infections
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of a Single Dose of Emodepside Compared to a Single Dose of Albendazole in Adolescents and Adults Infected With Trichuris Incognita Emodepside, Albendazole 400 mg - Trichuris Infection | Phase 2 | Not yet recruiting | Jennifer Keiser | 100 | 2026-11-15 | 2026-08-14 |
| Efficacy and Safety of Emodepside in Participants With Soil-transmitted Helminth Infections emodepside (BAY 44-4400), Mebendazole 100 MG, similar placebo to mebendazole - Trichuris Trichiura; Infection, Hookworm Infection | Phase 3 | Not yet recruiting | Swiss Tropical & Public Health Institute | 315 | 2026-11-06 | 2026-08-14 |
| Combination Therapies for Trichuris Trichiura Infection in Schoolchildren in Honduras Placebo, Albendazole 400 mg, Albendazole Plus Ivermectin - Trichuriasis, Strongyloidiasis | Phase 3 | Not yet recruiting | Mundo Sano Foundation | 368 | 2026-11-01 | 2026-06-23 |
| Follow-up Assessment of Change in Soil-transmitted Helminths Infection Intensity in Uganda Albendazole 400mg, Ivermectin 3 mg - Ascariasis | Phase 3 | Not yet recruiting | Jennifer Keiser | 450 | 2026-10-01 | 2026-10-14 |
| Better Options for Lymphatic Filariasis Treatment MoxDA - Moxidectin + Diethylcarbamzine (DEC) + Albendazole, IDA - Ivermectin + DEC + albendazole - Lymphatic Filariasis, Scabies | Phase 3 | Recruiting | Medicines Development for Global Health | 5100 | 2026-09-28 | 2026-10-07 |
| Expanding Access to Preventive Chemotherapy Among Mobile and Migrant Populations Modified Mass Administration of Medicines Strategy, Albendazole 400 mg, Praziquantel 40 mg/kg - Onchocerciasis (River Blindness), Schistosomiasis | Not applicable | Recruiting | Uwemedimo Friday Ekpo | 5760 | 2026-07-01 | 2026-07-16 |
| Early Detection and AI-Based Management of Skin-Related Neglected Tropical Diseases in Sub-Saharan Africa by Frontline Health Workers A mobile app with AI functionality for diagnosing skin-related NTDs - Skin and Connective Tissue Diseases, Neglected Tropical Diseases | Not applicable | Not yet recruiting | Kenya Medical Research Institute | 2420 | 2026-05-01 | 2026-04-02 |
| Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective Dengue, Chikungunya | Recruiting | Institut Pasteur du Cambodge | 10000 | 2025-12-18 | 2026-01-22 | |
| Efficacy and Safety of Emodepside in Participants With Soil-transmitted Helminth Infections emodepside (BAY 44-4400), matching placebo of emodepside, Mebendazole - Trichuris Trichiura; Infection, Hookworm Infection | Phase 3 | Completed | Swiss Tropical & Public Health Institute | 315 | 2025-11-25 | 2026-10-08 |
| Integrating Mental Health Into Neglected Tropical Disease Care in Ghana WHO Essential Care package for mental health and NTDs - Leprosy, Lymphatic Filariases | Not applicable | Not yet recruiting | Liverpool School of Tropical Medicine | 200 | 2025-11-01 | 2025-11-25 |
| Controlled Human Infection Study of Orally Administered Trichuris Trichiura Eggs in Naïve Adults Trichuris trichiura Egg Inoculum - Whipworm, Trichuriasis | Phase 1 | Recruiting | George Washington University | 18 | 2025-09-10 | 2026-06-04 |
| Strongyloidiasis at CHRU Nancy: Evaluation of the Performance of Serological Tests and Disease-associated Characteristics Strongyloides serology - Strongyloidiasis | Completed | Central Hospital, Nancy, France | 80 | 2025-09-05 | 2025-12-22 | |
| Real World Evaluation of an Albendazole-Ivermectin Coformulation Safety and Effectiveness Pre-screening Phase, Screenig Phase, Randomization - Soil-Transmitted Helminths | Phase 3 | Recruiting | Insud Pharma | 20000 | 2025-09-01 | 2025-09-15 |
| Moxidectin Versus Ivermectin as Mass Drug Administration for the Control of Onchocerciasis and Other Neglected Tropical Diseases Moxidectin, Ivermectin - Onchocerciasis, Ascaris Lumbricoides Infection | Phase 4 | Recruiting | Kirby Institute | 52000 | 2025-08-04 | 2025-11-21 |
| Community Health Education and Hygiene Promotion Added to Deworming Among Ethnic Khmer Children in Vietnam Albendazole 400 mg, Community Health Education and Hygiene Promotion - Soil-transmitted Helminth Infections | Not applicable | Completed | Can Tho University of Medicine and Pharmacy | 704 | 2025-07-01 | 2026-10-02 |
| Efficacy and Safety of Oxantel Pamoate in Children Infected With Trichuris Trichiura Oxantel Pamoate, Mebendazole - Trichuris Trichiura; Infection, Hookworm Infection | Phase 2 | Completed | Jennifer Keiser | 163 | 2025-04-16 | 2025-06-08 |
| Safety, Tolerability and PK of Single and Multiple Doses of Oxantel Pamoate Tablets Oxantel Pamoate, Placebo - Healthy | Phase 1 | Completed | Swiss Tropical & Public Health Institute | 45 | 2025-01-27 | 2025-08-28 |
| 21-day Double-blind Trial of Albendazole in Adults With Loa Loa Microfilaremia Albendazole 400mg, Placebo - Loiasis With Positive Blood Microfilaremia, Loiasis | Phase 3 | Not yet recruiting | Programme National de Lutte contre l'Onchocercose, Republic of the Congo | 100 | 2025-01-15 | 2024-09-26 |
| Immune Responses in the Skin After Hookworm Infection Necator americanus L3 larvae - Necator Americanus Infection | Not applicable | Not yet recruiting | Leiden University Medical Center | 5 | 2024-10-01 | 2024-07-12 |
| A Safety and Efficacy Study of Different Doses of Oxfendazole Compared to a Single Dose of Albendazole to Treat Trichuris Trichiura Infection in Adults Albendazole, Oxfendazole - Trichuriasis | Phase 2 | Recruiting | Asociacion Benefica Prisma | 249 | 2024-09-07 | 2026-07-28 |
Showing 20 of 176. Sign in to see all of them.
Ancylostomiasis (41) · Elephantiasis, Filarial (41) · Hookworm Infections (39) · Onchocerciasis (35) · Trichuriasis (30) · Filariasis (23) · Neglected Diseases (17) · Strongyloidiasis (15) · Ascariasis (12) · Loiasis (12) · Helminthiasis (10) · Onchocerciasis, Ocular (10) · Parasitic Diseases (9) · Malaria (8) · Anemia, Iron-Deficiency (6)
Infections (171) · Parasitic Diseases (167) · Helminthiasis (166) · Secernentea Infections (161) · Spirurida Infections (87) · Filariasis (65) · Vector Borne Diseases (57) · Strongylida Infections (56) · Hemic and Lymphatic Diseases (52) · Mosquito-Borne Diseases (46) · Skin Diseases (44) · Skin and Connective Tissue Diseases (44) · Lymphatic Diseases (42) · Skin Diseases, Infectious (42)
Albendazole (58) · Ivermectin (42) · moxidectin (14) · Diethylcarbamazine (13) · Mebendazole (10) · emodepside (9) · Bay 44-4400 (7) · Albumins (6) · Doxycycline (6) · Tablets (6) · Azithromycin (5) · oxfendazole (4) · Intravital Microscopy (3) · Levamisole (3) · Praziquantel (3)
National Institute of Allergy and Infectious Diseases (NIAID) (16) · Jennifer Keiser (13) · Washington University School of Medicine (13) · Baylor College of Medicine (11) · Swiss Tropical & Public Health Institute (9) · London School of Hygiene and Tropical Medicine (7) · Medicines Development for Global Health (6) · University Hospitals Cleveland Medical Center (6) · Drugs for Neglected Diseases (4) · University Ghent (4) · Albert B. Sabin Vaccine Institute (3) · Programme National de Lutte contre l'Onchocercose, Republic of the Congo (3) · The Task Force for Global Health (3) · Universiteit Antwerpen (3) · Center for Research on Filariasis and Other Tropical Diseases, Cameroon (2)
Tanzania (19) · United States (17) · Ghana (14) · Côte d’Ivoire (10) · India (10) · Cameroon (8) · Democratic Republic of the Congo (7) · Brazil (6) · Mali (6) · Papua New Guinea (6) · United Kingdom (6) · Ethiopia (5) · Gabon (5) · Indonesia (5) · Kenya (5)
Gary Weil, MD (6) · David Diemert, MD (5) · Jennifer Keiser, PhD (4) · Amy D Klion, M.D. (3) · Ayola Adegnika, MD (3) · David J Diemert, MD (3) · Eric Ottesen, MD (3) · Gary J Weil, MD (3) · Thomas B Nutman, M.D. (3) · Benjamin Koudou, PhD (2) · Bruno Levecke, PhD (2) · Christopher King, MD PhD (2) · Christopher L King, MD, PhD (2)
PMID 11873261, PMID 22610930, PMID 32228663, PMID 42848323, PMID 10656038, PMID 28464026, PMID 35533701, PMID 37262040, PMID 18396361, PMID 18775092, PMID 18809192, PMID 19081121, PMID 19812401, PMID 21572981, PMID 22189084, PMID 22633322, PMID 23675549, PMID 23981378, PMID 24550339, PMID 24603321, PMID 24968000, PMID 25299391, PMID 25733630, PMID 25793933, PMID 25877874, PMID 26170395, PMID 26282537, PMID 26482774, PMID 26486704, PMID 26691247, PMID 27266697, PMID 28061905, PMID 28329346, PMID 28855148, PMID 28969715, PMID 29346377, PMID 29361335, PMID 29637891, PMID 29673735, PMID 29780848, PMID 30074085, PMID 30388108, PMID 30403937, PMID 30878222, PMID 30885157, PMID 31006575, PMID 31044235, PMID 31077279, PMID 31107869, PMID 31193620
2017 (2), 2015 (1), 2023 (1), R01AI155739 (1), R01HD108196 (1), U01AI129789 (1)