12 completed, 12 unknown, 1 recruiting. 14 Phase 3, 10 Phase 2, 2 Not applicable, 2 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 14 | Unknown 7, Completed 6, Recruiting 1 |
| Phase 2 | 10 | Completed 5, Unknown 5 |
| Not applicable | 2 | Completed 1, Unknown 1 |
| Phase 4 | 2 | Completed 1, Unknown 1 |
Follow Levamisole: new trials by email Literature Review of Levamisole trials Research Report on Levamisole
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ketamine add-on Therapy for Established Status Epilepticus Treatment Trial (KESETT) Levetiracetam (LEV) (60 mg/Kg) + 1 mg/kg Ketamine (KET), Levetiracetam (LEV) (60 mg/Kg) + 3 mg/kg Ketamine (KET), Levetiracetam (LEV) (60 mg/Kg) - Status Epilepticus | Phase 3 | Recruiting | University of Virginia | 770 | 2026-03-06 | 2026-09-17 |
| A 3- to 5-day Clinical Trial of Levamisole in Loiasis Infected Subjects Levamisole 3 days, Levamisole 5 days, Placebo - Loiasis | Phase 2 / Phase 3 | Unknown | Programme National de Lutte contre l'Onchocercose, Republic of the Congo | 99 | 2024-06-21 | 2024-09-20 |
| The Efficacy and Safety of Prednisone Combined With Huaiqihuang Granule for Primary Nephrotic Syndrome in Children Huaiqihuang granule, Prednisone, Levamisole placebo - Nephrotic Syndrome in Children | Phase 4 | Unknown | Jianhua Zhou | 402 | 2023-04-26 | 2024-06-21 |
| A Transdiagnostic Intervention for Health-related Habits (LEV) Lev - Intervention, Life Style | Not applicable | Completed | Region Stockholm | 36 | 2023-01-25 | 2024-05-07 |
| Clinical Trial Evaluating the Safety and Efficacy of Levamisole in Loa Loa Microfilaremic Patients LEV 1 mg/kg, LEV 1,5 mg/kg, LEV 2,5 mg/kg - Onchocerciasis, Ocular, Loiasis | Phase 2 | Completed | Programme National de Lutte contre l'Onchocercose, Republic of the Congo | 255 | 2021-01-16 | 2021-09-20 |
| Pharmacological Modulation of Hippocampal Activity in Psychosis 2 Levetiracetam (LEV) 500 mg, Placebo - Schizophrenia; Psychosis | Phase 2 | Completed | Vanderbilt University Medical Center | 62 | 2020-09-23 | 2024-02-05 |
| Levamisole and Isoprinosine in Immune-prophylaxis of Egyptian Healthcare Workers Facing COVID-19 Levamisole, Isoprinosine, Levamisole and Isoprinosine - Coronavirus Disease (COVID-19) | Phase 3 | Unknown | Ain Shams University | 100 | 2020-05-20 | 2020-05-05 |
| Levamisole and Isoprinosine in the Treatment of COVID19: A Proposed Therapeutic Trial Levamisole and isoprinosine, Azithromycin and hydroxychloroquine - Respiratory Tract Infections | Phase 3 | Unknown | Cairo University | 60 | 2020-05-05 | 2020-05-13 |
| Evaluation of Efficacy of Levamisole and Formoterol+Budesonide in Treatment of COVID-19 Levamisole Pill + Budesonide+Formoterol inhaler, Lopinavir/Ritonavir + hydoxychloroquine - COVID-19 | Phase 2 / Phase 3 | Unknown | Fasa University of Medical Sciences | 30 | 2020-04-04 | 2020-04-13 |
| Novel Treatment of Advanced Hepatocellular Carcinoma Anlotinib Hydrochloride Capsules, Arginine hydrochloride, levamisole - HCC | Phase 3 | Unknown | The First Affiliated Hospital of Zhengzhou University | 300 | 2019-04-10 | 2019-05-15 |
| Treatment of Advanced Intrahepatic Cholangiocarcinoma Levamisole Hydrochloride, Anlotinib Hydrochloride Capsules - ICC | Phase 3 | Unknown | The First Affiliated Hospital of Zhengzhou University | 152 | 2019-02-01 | 2019-05-07 |
| Clinical Study of Non Severe Aplastic Anemia Treated With Cyclosporine, Androgen and Levamisole levamisole hydrochloride, Androgens, Cyclosporins - Aplastic Anemia | Not applicable | Unknown | Shengyun Lin | 248 | 2018-01-01 | 2017-07-26 |
| Efficiency of Levamisole for Maintaining Remission After the First Flare of Steroid Sensitive Nephrotic Syndrome in Children Levamisole Hydrochloride, Placebo - First Manifestation of Steroid Sensitive Nephrotic Syndrome | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 86 | 2017-09-06 | 2022-06-08 |
| A Single-Arm Phase 2 Study With Optimized Standard Protocol for Severe Aplastic Anemia rabbit ATG, Cyclosporine, Levamisole - Aplastic Anemia | Phase 2 | Completed | Institute of Hematology & Blood Diseases Hospital, China | 40 | 2014-08-01 | 2026-02-11 |
| Safety and Efficacy of Levamisole Combined With Cyclosporine A in Patients With Subclinical Paroxysmal Nocturnal Hemoglobinuria and PNH in the Setting of Another Bone Marrow Failure Syndromes(PNH-2013) Levamisole+cyclosporin A+Glucocorticoids, cyclosporin A+Glucocorticoids, Glucocorticoids - Paroxysmal Nocturnal Hemoglobinuria, Hemoglobinuria | Phase 2 | Unknown | Institute of Hematology & Blood Diseases Hospital, China | 50 | 2013-01-01 | 2013-01-03 |
| Safety and Efficacy of Levamisole Combined With Cyclosporine A in Patients With Classic Paroxysmal Nocturnal Hemoglobinuria Levamisole+cyclosporin A+Glucocorticoids, cyclosporin A+Glucocorticoids, Glucocorticoids - Paroxysmal Nocturnal Hemoglobinuria, Hemoglobinuria | Phase 2 | Unknown | Institute of Hematology & Blood Diseases Hospital, China | 120 | 2012-07-01 | 2013-01-03 |
| Efficacy and Safety of Levamisole Combined With Standard Prednisolone in Warm Antibody Autoimmune Hemolytic Anemia. levamisole, Prednisone - Anemia, Anemia, Hemolytic | Phase 2 | Unknown | Institute of Hematology & Blood Diseases Hospital, China | 100 | 2012-04-01 | 2012-04-19 |
| Comparison of Efficacy of Azithromycin and Levamisole Versus of Azithromycin in in the Treatment of Acne Levamisole - Acne | Phase 2 / Phase 3 | Completed | Ahvaz Jundishapur University of Medical Sciences | 169 | 2008-11-01 | 2011-05-05 |
| Effect of Levamisole Supplementation on Tetanus Vaccination Response Rates in Hemodialysis Patients Levamisole, Placebo - Renal Dialysis | Phase 2 | Completed | Shiraz University of Medical Sciences | 40 | 2008-03-01 | 2013-07-26 |
| Efficacy Albendazole and Levamisole Against STH on Unguja Albendazole, Levamisole - Ascariasis, Trichuriasis | Phase 4 | Completed | Natural History Museum, United Kingdom | 20 | 2006-06-01 | 2008-04-17 |
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Anemia, Aplastic (4) · Colonic Neoplasms (4) · Colorectal Neoplasms (4) · Anemia (3) · Anemia, Hemolytic (3) · COVID-19 (3) · Hematologic Diseases (3) · Bone Marrow Failure Disorders (2) · Hemoglobinuria (2) · Hemoglobinuria, Paroxysmal (2) · Loiasis (2) · Nephrotic Syndrome (2) · Proteinuria (2) · Rectal Neoplasms (2) · Thrombosis (2)
Institute of Hematology & Blood Diseases Hospital, China (4) · Programme National de Lutte contre l'Onchocercose, Republic of the Congo (2) · SWOG Cancer Research Network (2) · The First Affiliated Hospital of Zhengzhou University (2) · Ahvaz Jundishapur University of Medical Sciences (1) · Ain Shams University (1) · Assistance Publique - Hôpitaux de Paris (1) · Austrian Breast & Colorectal Cancer Study Group (1) · Cairo University (1) · European Institute of Oncology (1) · Fasa University of Medical Sciences (1) · Jianhua Zhou (1) · NSABP Foundation Inc (1) · Natural History Museum, United Kingdom (1) · Region Stockholm (1)
China (8) · United States (4) · Iran (3) · Canada (2) · Republic of the Congo (2) · South Africa (2) · Austria (1) · Egypt (1) · France (1) · Greece (1) · Italy (1) · Puerto Rico (1) · South Korea (1) · Sweden (1) · Tanzania (1)
Robert J. Mayer, MD, FACP (2) · Al B. Benson, MD, FACP (1) · Anthony LA Fields, MD, FRCPC (1) · Daniel G. Haller, MD (1) · Elizabeth A. Poplin, MD (1) · Francesco Tonelli, MD (1) · Jaffer A. Ajani, MD (1) · Jaideep Kapur, MD, PhD (1) · Jianhua Zhou, Dr. (1) · Joakim Lavesson, Bachelor (1)
PMID 10550154, PMID 1090310, PMID 12622583, PMID 15774775, PMID 16877719, PMID 18720689, PMID 18775092, PMID 21997132, PMID 23547851, PMID 24341659, PMID 32738928, PMID 34651190, PMID 39513526, PMID 40615414, PMID 41525256
U10CA032102 (2), U10CA012027 (1)