7 completed, 2 unknown, 1 not yet recruiting, 1 terminated. 5 Phase 2, 2 Not applicable, 2 Phase 3, 2 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 5 | Completed 3, Terminated 1, Unknown 1 |
| Not applicable | 2 | Completed 1, Withdrawn 1 |
| Phase 3 | 2 | Not yet recruiting 1, Unknown 1 |
| Phase 4 | 2 | Completed 2 |
Follow Loiasis: new trials by email Literature Review of Loiasis trials Research Report on Loiasis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| 21-day Double-blind Trial of Albendazole in Adults With Loa Loa Microfilaremia Albendazole 400mg, Placebo - Loiasis With Positive Blood Microfilaremia, Loiasis | Phase 3 | Not yet recruiting | Programme National de Lutte contre l'Onchocercose, Republic of the Congo | 100 | 2025-01-15 | 2024-09-26 |
| A 3- to 5-day Clinical Trial of Levamisole in Loiasis Infected Subjects Levamisole 3 days, Levamisole 5 days, Placebo - Loiasis | Phase 2 / Phase 3 | Unknown | Programme National de Lutte contre l'Onchocercose, Republic of the Congo | 99 | 2024-06-21 | 2024-09-20 |
| Development of a New Rapid Diagnostic Test to Support Onchocerciasis Elimination Biological samples collection (blood drawing + feces) - Onchocerciasis, Loiasis | Not applicable | Completed | Bioaster | 1128 | 2024-04-15 | 2026-09-30 |
| Assessment and Treatment of Loiasis With Positive Microfilaremia Loiasis With Positive Blood Microfilaremia | Unknown | University Hospital, Angers | 200 | 2024-02-01 | 2024-01-08 | |
| Evaluation of the Diagnosis Performances of DEC LTS-2 Skin Patch for Onchocerciasis in Central Africa LTS-2 DEC patch, Skin snips - Onchocerciasis, Loiasis | Not applicable | Withdrawn | Center for Research on Filariasis and Other Tropical Diseases, Cameroon | 2022-09-01 | 2025-03-25 | |
| Clinical Trial Evaluating the Safety and Efficacy of Moxidectin 2 mg Ivermectin-controlled in Loa Loa Microfilaremic Patients Moxidectin 2 MG Oral Tablet, Ivermectin 3Mg Tab, Placebo oral tablet - Onchocerciasis, Ocular, Loiasis | Phase 2 | Completed | Center for Research on Filariasis and Other Tropical Diseases, Cameroon | 72 | 2022-04-07 | 2025-02-24 |
| Loiasis Cross-reactive Antigenemia and Treatment-related Adverse Events Ivermectin - Loiasis | Phase 4 | Completed | Washington University School of Medicine | 41 | 2021-07-30 | 2022-09-29 |
| Clinical Trial Evaluating the Safety and Efficacy of Levamisole in Loa Loa Microfilaremic Patients LEV 1 mg/kg, LEV 1,5 mg/kg, LEV 2,5 mg/kg - Onchocerciasis, Ocular, Loiasis | Phase 2 | Completed | Programme National de Lutte contre l'Onchocercose, Republic of the Congo | 255 | 2021-01-16 | 2021-09-20 |
| Spontaneous Antigenemia in Loiasis No intervention - Loiasis, Lymphatic Filariasis | Completed | Washington University School of Medicine | 86 | 2020-01-23 | 2026-08-21 | |
| Efficacy and Microfilaricidal Kinetics of Imatinib for the Treatment of Loa Loa Imatinib Mesylate, Placebo - Loiasis | Phase 2 | Terminated | National Institute of Allergy and Infectious Diseases (NIAID) | 20 | 2019-09-16 | 2022-06-07 |
| Post-treatment Effects of Ivermectin (IVM) or Diethylcarbamazine (DEC) in Loiasis Diethylcarbamazine, Ivermectin - Loiasis | Phase 4 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 155 | 2012-04-01 | 2016-11-09 |
| Reslizumab to Prevent Post-treatment Eosinophilia in Loiasis Reslizumab, Diethylcarbamazine, Placebo - Loiasis | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 31 | 2010-04-01 | 2022-01-27 |
Onchocerciasis (4) · Filariasis (3) · Neglected Diseases (2) · Onchocerciasis, Ocular (2) · Dipetalonema Infections (1) · Elephantiasis, Filarial (1) · Mansonelliasis (1)
Helminthiasis (12) · Infections (12) · Nematode Infections (12) · Parasitic Diseases (12) · Secernentea Infections (12) · Spirurida Infections (12) · Filariasis (9) · Skin Diseases (4) · Skin Diseases, Infectious (4) · Skin Diseases, Parasitic (4) · Skin and Connective Tissue Diseases (4) · Vector Borne Diseases (3) · Disease Attributes (2) · Eye Diseases (2) · Eye Infections (2)
Ivermectin (3) · Diethylcarbamazine (2) · Levamisole (2) · Albendazole (1) · Blood Specimen Collection (1) · Defecation (1) · Imatinib Mesylate (1) · Tablets (1) · moxidectin (1) · reslizumab (1)
National Institute of Allergy and Infectious Diseases (NIAID) (3) · Programme National de Lutte contre l'Onchocercose, Republic of the Congo (3) · Center for Research on Filariasis and Other Tropical Diseases, Cameroon (2) · Washington University School of Medicine (2) · Bioaster (1) · University Hospital, Angers (1)
Cameroon (7) · Republic of the Congo (2) · United States (1)
Amy D Klion, M.D. (2) · Elise M O'Connell, M.D. (1) · Philip Budge, MD, PhD (1)