35 completed, 6 unknown, 2 not yet recruiting, 2 recruiting. 17 Not applicable, 14 Phase 3, 9 Phase 2, 7 Phase 1, 5 Phase 4.
Follow this drug Literature Review of Praziquantel trials Research Report on Praziquantel
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Different Treatment Frequencies for Hepatic Fibrosis Due to Schistosomiasis Praziquantel 40 mg/kg per dose given once annually, Praziquantel 40 mg/kg given three times per year - Schistosomiasis, Schistosoma Mansoni | Phase 2 / Phase 3 | Not yet recruiting | Rhode Island Hospital | 600 | 2026-11-01 | 2026-08-12 |
| Expanding Access to Preventive Chemotherapy Among Mobile and Migrant Populations Modified Mass Administration of Medicines Strategy, Albendazole 400 mg, Praziquantel 40 mg/kg - Onchocerciasis (River Blindness), Schistosomiasis | Not applicable | Recruiting | Uwemedimo Friday Ekpo | 5760 | 2026-07-01 | 2026-07-16 |
| Treatment of Clonorchiasis in Guangxi With Albendazole, Tribendimidine, and Praziquantel Albendazole, Tribendimidine, praziquantel - Clonorchiasis | Not applicable | Recruiting | First Affiliated Hospital of Guangxi Medical University | 318 | 2025-07-22 | 2026-10-01 |
| Assessment of Combined Praziquantel and Albendazole vs Albendazole Alone to Treat Active Parenchymal Neurocysticercosis albendazole and praziquantel, Albendazole - Neurocysticercosis | Phase 4 | Not yet recruiting | R-Evolution Worldwide S.r.l. Impresa Sociale | 300 | 2024-06-01 | 2024-04-23 |
| Feasibility and Safety of Combining Anti-malarial With Deworming Drugs in African Children Albendazole, Praziquantel, Amodiaquine - Malaria, Soil Transmitted Helminths | Not applicable | Unknown | London School of Hygiene and Tropical Medicine | 600 | 2022-06-16 | 2022-07-14 |
| HIV And Parasitic Infection (HAPI) Study Antiparasitic medication - HIV Coinfection | Not applicable | Completed | University of North Carolina, Chapel Hill | 120 | 2022-05-02 | 2025-07-16 |
| Clinical Evaluation of Ujiplus® Against Schistosoma Mansoni Ujiplus®, Praziquantel 400mg - Schistosoma Mansoni | Phase 2 / Phase 3 | Completed | Kenya Medical Research Institute | 400 | 2021-05-06 | 2022-07-12 |
| Praziquantel in Children Under Age 4 Praziquantel - Schistosomiasis, Schistosomiasis Mansoni | Phase 2 | Completed | Rhode Island Hospital | 354 | 2021-02-01 | 2026-04-23 |
| Bioequivalence Study of Coated Cesol Tablet Formulation Versus Biltricide Cesol (Test), Biltricide (Reference) - Healthy | Phase 1 | Completed | Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany | 36 | 2020-06-17 | 2021-08-13 |
| Evaluation of Artesunate-mefloquine as a Novel Alternative Treatment for Schistosomiasis in African Children Praziquantel, Artesunate + Mefloquine - Schistosoma Haematobium, Schistosoma Mansoni | Phase 3 | Completed | Institute of Tropical Medicine, Belgium | 726 | 2019-10-14 | 2021-04-05 |
| Treatment of Female Genital Schistosomiasis (FGS) With Praziquantel: A Proof-of-Concept Study Praziquantel 600Mg Oral Tablet x 5, Praziquantel 600Mg Oral Tablet x 1 - Schistosomiasis | Phase 2 / Phase 3 | Completed | Regionshospital Nordjylland | 116 | 2019-09-03 | 2020-05-18 |
| L-PZQ ODT in Schistosoma Infected Children L-PZQ ODT 50 mg/kg, Biltricide®, L-PZQ ODT 60 mg/kg - Schistosomiasis | Phase 3 | Completed | Merck KGaA, Darmstadt, Germany | 288 | 2019-09-02 | 2024-03-21 |
| Schistosomiasis Diagnosis Using a CAA Antigen Test Praziquantel, UCP-LF CAA, composite diagnostic - Schistosomiasis Hematobium, Diagnostic | Phase 3 | Unknown | Centre de Recherche Médicale de Lambaréné | 100 | 2019-05-01 | 2021-07-27 |
| Repeated Doses of Praziquantel in Schistosomiasis Treatment (RePST) 4x Praziquantel, 1x Praziquantel - Schistosomiasis | Phase 3 | Completed | Leiden University Medical Center | 167 | 2018-10-01 | 2020-11-18 |
| Praziquantel Bioequivalence Study Cisticid, Biltricide - Healthy | Phase 1 | Completed | Merck KGaA, Darmstadt, Germany | 60 | 2018-06-18 | 2019-09-18 |
| Relative Bioavailability Study of Emodepside IR-tablets and Solution Emodepside (BAY 44-4400) - Filariasis | Phase 1 | Completed | Drugs for Neglected Diseases | 77 | 2017-10-26 | 2020-03-09 |
| Sub Arachnoid Neurocysticercosis Treatment Outcome (SANTO) Albendazole and praziquantel, Albendazole and praziquantel placebo - Neurocysticercosis | Phase 3 | Terminated | Universidad Peruana Cayetano Heredia | 107 | 2016-11-14 | 2022-11-16 |
| An Open Label Dose Finding Safety and Efficacy in Children and Infants Infected With Schistosomiasis (S.Mansoni) Biltricide (racemate praziquantel) oral tablets, Racemate Praziquantel ODT, Levo Praziquantel ODT - Schistosomiasis | Phase 2 | Completed | Merck KGaA, Darmstadt, Germany | 444 | 2016-06-12 | 2019-11-20 |
| Effect of Concomitant Mansonella Perstans Microfilaremia on Immune Responses Following Single Dose Praziquantel in People With Schistosomiasis Praziquantel - Schistosomiasis | Phase 4 | Withdrawn | National Institute of Allergy and Infectious Diseases (NIAID) | 2016-04-06 | 2019-12-17 | |
| Effect of Schistosomiasis Mansoni on HIV Susceptibility and Female Genital Immunology Praziquantel - Schistosomiasis Mansoni, HIV | Phase 4 | Completed | University of Toronto | 34 | 2016-03-01 | 2016-10-27 |
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Schistosomiasis (24) · Schistosomiasis haematobia (6) · Schistosomiasis mansoni (6) · Malaria (5) · Anemia (3) · Coinfection (3) · HIV Infections (3) · Helminthiasis (3) · Neurocysticercosis (3) · Parasitic Diseases (3) · Epilepsy (2) · Filariasis (2) · Liver Cirrhosis (2) · Neglected Diseases (2) · Schistosomiasis japonica (2)
DBL -Institute for Health Research and Development (6) · Merck KGaA, Darmstadt, Germany (6) · National Institute of Allergy and Infectious Diseases (NIAID) (3) · Institute of Tropical Medicine, Belgium (2) · Kenya Medical Research Institute (2) · Rhode Island Hospital (2) · Universidad Peruana Cayetano Heredia (2) · Addis Ababa University (1) · Catholic University of Health and Allied Sciences (1) · Centre de Recherche Médicale de Lambaréné (1) · Dafra Pharma (1) · Drugs for Neglected Diseases (1) · First Affiliated Hospital of Guangxi Medical University (1) · Leiden University Medical Center (1) · London School of Hygiene and Tropical Medicine (1)
Uganda (7) · Tanzania (5) · Germany (4) · Kenya (4) · Côte d’Ivoire (2) · Egypt (2) · Madagascar (2) · Peru (2) · Philippines (2) · Senegal (2) · United Kingdom (2) · China (1) · Ethiopia (1) · Gabon (1) · Ghana (1)
Annette Olsen, PhD (2) · Abraham V Hodgson, MD, MPH, PhD (1) · Allen Nalugwa, PhD (1) · Amy D Klion, M.D. (1) · Ana Lucia C Domingues, MD (1) · Andrea Kreidenweiss, PhD (1) · Ayat A Haggag, MD (1) · Baraka Amuri, MD (1) · Bodo S Randrianasolo, MD (1) · Brian Greenwood, MD, FMedSci (1) · Christoph F. Hatz, MD, Prof. (1) · Cornelia J. Staehelin, MD (1)
PMID 19802383, PMID 20705516, PMID 21332573, PMID 21353271, PMID 21729382, PMID 22971323, PMID 23556009, PMID 23596262, PMID 24063608, PMID 24134221, PMID 24470560, PMID 24896815, PMID 24999157, PMID 25179171, PMID 25281761, PMID 25412334, PMID 25623258, PMID 25624403, PMID 25630808, PMID 25768005, PMID 25918212, PMID 26511959, PMID 26984901, PMID 27073857, PMID 27168759, PMID 27441564, PMID 27854250, PMID 29131820, PMID 29346385, PMID 29546300, PMID 29801483, PMID 30536632, PMID 31188820, PMID 32196506, PMID 32993559, PMID 33861768, PMID 33998661, PMID 34106922, PMID 34168029, PMID 35788749, PMID 35922819, PMID 36342912, PMID 36548444, PMID 36893784, PMID 37722662, PMID 37957702, PMID 38177851, PMID 40412398
2016 (1), 2017 (1), 2019 (1), D43TW009340 (1), R01AI184979 (1), R01HD095562 (1), R01NS054805 (1), U01AI066050 (1)