34 completed, 20 unknown, 19 recruiting, 9 not yet recruiting. 50 Not applicable, 3 Phase 1, 3 Phase 2, 1 Early Phase 1.
Follow Frailty Syndrome: new trials by email Literature Review of Frailty Syndrome trials Research Report on Frailty Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety and Preliminary Efficacy of Adipose-Derived Stem Cell Secretome in Frailty (VinVital) VinVital - Frailty Syndrome, Aging | Phase 1 | Not yet recruiting | Vinmec Research Institute of Stem Cell and Gene Technology | 20 | 2026-10-01 | 2026-10-02 |
| Feasibility and Effects of Inspiratory Muscle Training Combined With Blood Flow Restriction for Frail Older Adults Exercise, Sham Control - Frailty Syndrome, Older Adults | Not applicable | Recruiting | Taipei Medical University | 30 | 2026-08-19 | 2026-10-05 |
| Comparıson of the Effıcacy of Conventıonal Exercıse and Pılates ın Pre-fraıl and Fraıl Older Adults PILATES EXERCISES GROUP, CONVENTIONAL EXERCISES GROUP - Frailty Syndrome, Prefrail Elderly | Not applicable | Not yet recruiting | Istanbul University - Cerrahpasa | 40 | 2026-06-22 | 2026-06-25 |
| Longitudinal Assessment of Lung Function and Respiratory Muscle Strength Following Training of the Inspiratory Muscles in Frail Older Adults (IMT-3) Inspiratory Muscle Training, Sham Inspiratory Muscle Training - Frailty Syndrome, Geriatric Health | Not applicable | Not yet recruiting | Universidad Francisco de Vitoria | 30 | 2026-05-20 | 2026-04-30 |
| URINARY INCONTINENCE AND GERIATRIC SYNDROMES Urinary Incontinence (UI), Urinary Incontinence | Recruiting | MERT UYSAL | 120 | 2026-04-08 | 2026-09-10 | |
| A Study to Evaluate the Safety and Tolerability of Intravenous Stemis™ in Elderly Subjects With Mild to Moderate Frailty Syndrome Stemis™, Normal Saline - Frailty Syndrome | Phase 1 | Not yet recruiting | Ji Yan Biomedical Co., Ltd. | 12 | 2026-04-01 | 2026-03-19 |
| Multimodal Prehabilitation of Frail Patients Undergoing Elective Knee or Hip Replacement Multimodal Prehabilitation - Frailty Syndrome, Prehabilitation | Not applicable | Recruiting | University of Iceland | 50 | 2026-03-20 | 2026-04-07 |
| The Effect of Volunteer-Engaged Lifestyle Optimisation Via ICOPE on Sarcopenia in Older Adults (VELO-S) Volunteer-Engaged Lifestyle Optimisation via ICOPE for Sarcopenia program (VELO-S), Attention control - Sarcopenia, Sarcopenia in Elderly | Not applicable | Recruiting | The University of Hong Kong | 200 | 2026-02-01 | 2026-09-08 |
| Longitudinal Assessment of Maximal Inspiratory Pressure and Functional Capacity Following Inspiratory Muscle Training in Frail Older Adults (IMT-2) Inspiratory Muscle Training, Sham Inspiratory Muscle Training - Frailty Syndrome, Geriatric Health | Not applicable | Not yet recruiting | Universidad Francisco de Vitoria | 30 | 2026-02-01 | 2026-01-09 |
| Longitudinal Ultrasound Assessment of Diaphragmatic and Respiratory Muscle Function Following Respiratory Muscle Training in Frail Older Adults Inspiratory Muscle Training, Sham Inspiratory Muscle Training - Frailty Syndrome, Respiratory Muscle Weakness | Not applicable | Active not recruiting | Universidad Francisco de Vitoria | 30 | 2026-01-12 | 2026-02-27 |
| Real World Evidence to Assess the Value of a Digital Care Coordination and Monitoring Program for Supporting Caregivers of Adults Discharged From the Emergency Department. Caregivers supporting vulnerable patients and using the MyMonka solution. - Frailty Syndrome, Caregiver Burden for Those Who Care for Adults With Impaired Functional Status | Not applicable | Recruiting | Fondation Hôpital Saint-Joseph | 100 | 2025-12-12 | 2026-01-16 |
| Physical Performance Assessment in Kidney Transplant Evaluation Frailty Syndrome | Recruiting | University Hospital, Martin | 50 | 2025-10-01 | 2026-01-14 | |
| Effectiveness of Immersive Virtual Reality Combined With Occupational Therapy in Reducing Fall Risk and Frailty Among Older Adults Inmersive Virtual Reality, Conventional occupational therapy sessions - Frailty Syndrome, Older Adults, Balance | Not applicable | Not yet recruiting | Universidad Rey Juan Carlos | 30 | 2025-09-15 | 2025-07-16 |
| Design and Validation of FEXO: A Playful Exercise Program for Institutionalized Frail Older Adults FEXO (Fun Exercise for Older Adults) - Frailty Syndrome, Sarcopenia | Not applicable | Completed | Cardenal Herrera University | 80 | 2025-09-04 | 2026-04-21 |
| Fun Exercise Intervention for Older Adults to Improve Intrinsic Capacity and Motivation Fun Exercise for Older Adults (FEXO), OTAGO - Sarcopenia, Frailty Syndrome | Not applicable | Completed | Cardenal Herrera University | 120 | 2025-09-04 | 2026-04-08 |
| PREhabilitation of Frail Elderly PAtients Undergoing majoR surgEry at HOME (PREPARE-HOME) Using Smart Wearables Supervised prehabilitation programme - Frailty Syndrome | Not applicable | Not yet recruiting | Singapore General Hospital | 190 | 2025-08-01 | 2025-05-15 |
| A Nutrition Care Model for Frailty Prevention in the Elderly Based on Design Thinking nutrition education - Malnutrition Elderly, Sarcopenia in Elderly | Not applicable | Completed | Suh-Ching, Yang | 30 | 2025-07-04 | 2026-03-31 |
| Cognitive Groove (Brought to You by GERAS DANCE) Dance Rehabilitation Intervention - Frailty, Frail Older Adults | Not applicable | Recruiting | McMaster University | 250 | 2025-06-10 | 2025-07-01 |
| Frailty and Outcomes in Older Heart Failure Patients With Ejection Fraction >40% Frailty Syndrome, Heart Failure and Mildly Reduced Ejection Fraction | Active not recruiting | Duyen Nguyen Hoang Mai | 301 | 2025-06-01 | 2025-07-17 | |
| TrackFrailty Project Less-volume, More-volume, Control - Frailty Syndrome | Not applicable | Active not recruiting | University of Beira Interior | 45 | 2025-06-01 | 2025-08-29 |
Showing 20 of 92. Sign in to see all of them.
Frailty (92) · Sarcopenia (9) · Motor Activity (8) · Cognitive Dysfunction (4) · Malnutrition (3) · Postoperative Complications (3) · Alzheimer Disease (2) · COVID-19 (2) · Coronary Artery Disease (2) · Dementia (2) · Depression (2) · Emergencies (2) · Heart Failure (2) · Hip Fractures (2) · Hypertension (2)
Pathologic Processes (92) · Pathological Conditions, Signs and Symptoms (92) · Behavior (14) · Nervous System Diseases (14) · Signs and Symptoms (13) · Neurologic Manifestations (10) · Atrophy (9) · Mental Disorders (9) · Muscular Atrophy (9) · Neuromuscular Manifestations (9) · Pathological Conditions, Anatomical (9) · Cardiovascular Diseases (8) · Neurocognitive Disorders (7) · Nutritional and Metabolic Diseases (6) · Urogenital Diseases (6)
Exercise (6) · Aging (2) · Blood Specimen Collection (2) · Nutrition Assessment (2) · Preoperative Exercise (2) · Amino Acids, Branched-Chain (1) · Cognitive Training (1) · Control Groups (1) · Deprescriptions (1) · Ghrelin (1) · Health Records, Personal (1) · Inulin (1) · Medication Review (1) · Niacinamide (1) · Nutritional Support (1)
Hospital Universitario Getafe (3) · Universidad Francisco de Vitoria (3) · University of Iceland (3) · Cardenal Herrera University (2) · Charite University, Berlin, Germany (2) · Istanbul University - Cerrahpasa (2) · Lithuanian University of Health Sciences (2) · University Hospital, Linkoeping (2) · University of Castilla-La Mancha (2) · University of Nottingham (2) · Ageless Regenerative Institute (1) · Ankara University (1) · Balnear and Rehabilitation Sanatorium Techirghiol (1) · Brigham and Women's Hospital (1) · Catholic University of Murcia (1)
Spain (18) · United States (7) · China (6) · Taiwan (5) · Italy (4) · Poland (4) · Germany (3) · Greece (3) · Iceland (3) · Sweden (3) · Turkey (Türkiye) (3) · Canada (2) · France (2) · Hong Kong (2) · Lithuania (2)
Alexandra Papaioannou, MD (1) · Anne R. Cappola, M.D.,Sc.M. (1) · Anoop Sheshadri, MD, MAS (1) · Ben Ollivere, MBBS (1) · Charalampos Tzoulis, PhD (1) · Chun-De Li (1) · Claudia Spies, MD Prof. (1) · Claudia Spies, MD, Prof. (1) · Clemente Zuniga, MD (1) · Consuelo M Borras Blasco, PhD (1) · Daniel Wilhelms, PhD (1) · Dolores Sanchez-Rodriguez, MD PhD (1)
PMID 11253156, PMID 10904038, PMID 11328886, PMID 12456735, PMID 12766979, PMID 12844499, PMID 12900694, PMID 1425649, PMID 14552938, PMID 15514517, PMID 17030755, PMID 1734182, PMID 17608902, PMID 17634318, PMID 17761436, PMID 1852160, PMID 18554394, PMID 18619805, PMID 19081667, PMID 19722256, PMID 20168974, PMID 20392703, PMID 21492469, PMID 21614316, PMID 21623466, PMID 21679320, PMID 21847576, PMID 21852286, PMID 22018588, PMID 22511289, PMID 22525196, PMID 22836700, PMID 22865205, PMID 22908189, PMID 23531689, PMID 23604898, PMID 23764209, PMID 23786540, PMID 23810110, PMID 23828275, PMID 23842964, PMID 23926426, PMID 24028357, PMID 24243442, PMID 24381719, PMID 24559204, PMID 24577456, PMID 24597624, PMID 24598478, PMID 24715426
2019 (1), 2023 (1)